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Classification of broiler behaviours using triaxial accelerometer and machine learning.

Animal 2021 Jun 4;15(7):100269. Epub 2021 Jun 4.

USDA Agricultural Research Service, Poultry Research Unit, Mississippi State, MS 39762, USA.

Understanding broiler behaviours provides important implications for animal well-being and farm management. The objectives of this study were to classify specific broiler behaviours by analysing data from wearable accelerometers using two machine learning models, K-Nearest Neighbour (KNN) and Support Vector Machine (SVM). Lightweight triaxial accelerometers were used to record accelerations of nine 7-week-old broilers at a sampling frequency of 40 Hz. Read More

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Hydroxyethyl starch and acute kidney injury in high-risk patients undergoing cardiac surgery: A prospective multicenter study.

J Clin Anesth 2021 Jun 2;73:110367. Epub 2021 Jun 2.

Department of Anesthesia and Perioperative Medicine, Hospital Universitari de Girona Dr J Trueta, University of Girona, Instut d'Investigació Biomédica de Girona (IDIBGI), Spain. Electronic address:

Background: Hydroxyethyl starch (HES) solutions increase the risk of acute kidney injury (AKI) in critically ill patients admitted to intensive care unit (ICU) for medical indications. We conducted a cohort study to evaluate the renal safety of modern 6% HES solutions in high-risk patients having cardiac surgery.

Method: In this multicentre prospective cohort study, we recruited 261 consecutive patients at high-risk for developing cardiac surgery-associated AKI, based on a Cleveland score ≥ 4 points, from July to December 2017th in 14 hospitals in Spain and the United Kingdom. Read More

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Characterising the long-term clinical outcomes of 1190 hospitalised patients with COVID-19 in New York City: a retrospective case series.

BMJ Open 2021 06 2;11(6):e049488. Epub 2021 Jun 2.

Medicine, Infectious Diseases, Columbia University Irving Medical Center, New York City, New York, USA.

Objective: To characterise the long-term outcomes of patients with COVID-19 admitted to a large New York City medical centre at 3 and 6 months after hospitalisation and describe their healthcare usage, symptoms, morbidity and mortality.

Design: Retrospective cohort through manual chart review of the electronic medical record.

Setting: NewYork-Presbyterian/Columbia University Irving Medical Center, a quaternary care academic medical centre in New York City. Read More

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Preventive effects of self-administered cryotherapy on paclitaxel-induced peripheral neuropathy in patients with early-stage breast cancer: a propensity score analysis.

Pharmazie 2021 Jun;76(6):261-265

Department of Pharmacy, National Center for Global Health and Medicine, Tokyo, Japan.

We hypothesized that suppression of peripheral circulation cryotherapy may be effective in preventing paclitaxel-induced peripheral neuropathy (PIPN). Therefore, this study aimed to clarify whether self-administered cryotherapy could prevent PIPN in patients with early-stage breast cancer, using real-world data. A single-center, retrospective, observational study was conducted. Read More

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Spontaneous Non-Sustained Ventricular Tachycardia and Premature Ventricular Contractions and Their Prognostic Relevance in Patients with Cancer in Routine Care.

Cancers (Basel) 2021 May 12;13(10). Epub 2021 May 12.

Berlin Institute of Health Center for Regenerative Therapies (BCRT), 13353 Berlin, Germany.

It is largely unknown whether cancer patients seen in routine care show ventricular arrhythmias in 24 h electrocardiograms (ECGs), and whether when they are detected they carry prognostic relevance. We included 261 consecutive cancer patients that were referred to the department of cardiology for 24 h ECG examination and 35 healthy controls of similar age and sex in the analysis. To reduce selection bias, cancer patients with known left ventricular ejection fraction <45% were not included in the analysis. Read More

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Histopathological features in fatal COVID-19 acute respiratory distress syndrome.

Med Intensiva (Engl Ed) 2021 Jun-Jul;45(5):261-270

Département de Pathologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France; Centre de Ressources biologiques, Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

Background: COVID-19 acute respiratory distress syndrome (ARDS) shares the common histological hallmarks with other forms of ARDS. However, the chronology of the histological lesions has not been well established.

Objective: To describe the chronological histopathological alterations in the lungs of patients with COVID-19 related ARDS. Read More

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Description and comparison of physical activity from self-reports and accelerometry among primary school children in Kilimanjaro, Tanzania: a pilot study.

AAS Open Res 2020 17;3:40. Epub 2021 May 17.

London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.

: Self-reports are commonly used to assess physical activity in children. Existing self-reports for physical activity have not been validated for primary school children in Tanzania. To understand if primary school children can accurately report their physical activity, we examined the validity of self-reported physical activity against accelerometer measured physical activity. Read More

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Histopathological features in fatal COVID-19 acute respiratory distress syndrome.

Med Intensiva (Engl Ed) 2021 Jun-Jul;45(5):261-270. Epub 2021 Feb 27.

Département de Pathologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

Background: COVID-19 acute respiratory distress syndrome (ARDS) shares the common histological hallmarks with other forms of ARDS. However, the chronology of the histological lesions has not been well established.

Objective: To describe the chronological histopathological alterations in the lungs of patients with COVID-19 related ARDS. Read More

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Management of advanced ovarian cancer in Spain: an expert Delphi consensus.

J Ovarian Res 2021 May 26;14(1):72. Epub 2021 May 26.

Medical Oncology Department, Clínica Universidad de Navarra, Madrid, Spain.

Background: To determine the state of current practice and to reach a consensus on recommendations for the management of advanced ovarian cancer using a Delphi survey with a group of Spanish gynecologists and medical oncologists specially dedicated to gynecological tumors.

Methods: The questionnaire was developed by the byline authors. All questions but one were answered using a 9-item Likert-like scale with three types of answers: frequency, relevance and agreement. Read More

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Long-term outcomes of peripheral arterial disease patients with significant coronary artery disease undergoing percutaneous coronary intervention.

PLoS One 2021 19;16(5):e0251542. Epub 2021 May 19.

UCLA Medical Center, Los Angeles, California, United States of America.

Background: Patients with peripheral arterial disease (PAD) have known to a high risk of cardiac mortality. However, the effectiveness of the routine evaluation of coronary arteries such as routine coronary angiography (CAG) in PAD patients receiving percutaneous transluminal angioplasty (PTA) is unclear.

Methods: A total of 765 consecutive PAD patients underwent successful PTA and 674 patients (88. Read More

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Infection, dissemination, and transmission efficiencies of Zika virus in Aedes aegypti after serial passage in mosquito or mammalian cell lines or alternating passage in both cell types.

Parasit Vectors 2021 May 18;14(1):261. Epub 2021 May 18.

Laboratorio de Arbovirología, Centro de Investigaciones Regionales "Dr. Hideyo Noguchi", Universidad Autónoma de Yucatán, Mérida, México.

Background: Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) with an urban transmission cycle that primarily involves humans and Aedes aegypti. Evidence suggests that the evolution of some arboviruses is constrained by their dependency on alternating between disparate (vertebrate and invertebrate) hosts. The goals of this study are to compare the genetic changes that occur in ZIKV after serial passaging in mosquito or vertebrate cell lines or alternate passaging in both cell types and to compare the replication, dissemination, and transmission efficiencies of the cell culture-derived viruses in Ae. Read More

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External beam radiotherapy in pT4 well-differentiated thyroid cancer: A population-based study of 405 patients.

Int J Radiat Oncol Biol Phys 2021 May 15. Epub 2021 May 15.

Department of Surgery, University of British Columbia. Electronic address:

Purpose/objective: The benefit of external beam radiotherapy (EBRT) in locally advanced, well- differentiated thyroid cancer (WDTC) is uncertain. The purpose of this study is to evaluate locoregional recurrence (LRR), progression-free survival (PFS) and cause-specific survival (CSS) of patients with pT4 well-differentiated thyroid carcinoma.

Materials/methods: A population-based retrospective review was conducted of consecutive patients with pT4 (American Joint Committee on Cancer 8 edition) WDTC treated provincially between 1985 to 2013. Read More

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No increase in postoperative contacts with the healthcare system following outpatient total hip and knee arthroplasty.

Acta Orthop 2021 May 12:1-5. Epub 2021 May 12.

Department of Orthopedic Surgery, Copenhagen University Hospital, Hvidovre, Denmark.

Background and purpose - Discharge on the day of surgery (DDOS) after total hip arthroplasty (THA) and total knee arthroplasty (TKA) has been shown to be safe in selected patients. Concerns have been raised that discharging patients on the day of surgery (DOS) could lead to an increased burden on other parts of the healthcare system when compared with patients not discharged on the DOS (nDDOS). Therefore, we investigated whether discharging patients on the day of surgery (DOS) after THA and TKA leads to increased contacts with the primary care sector or other departments within the secondary care sector. Read More

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Early term birth is associated with the risk of preterm and recurrent early term birth in women with 3 consecutive deliveries.

Eur J Obstet Gynecol Reprod Biol 2021 Jun 24;261:160-165. Epub 2021 Apr 24.

Department of Obstetrics and Gynecology, Lis Hospital for Women, Sourasky Medical Center, Tel Aviv, Israel; Sackler Faculty of Medicine, Tel Aviv University, Israel. Electronic address:

Background: We assessed the association of early term at first birth (ETB) with the risk of preterm birth (PTB) and ETB in women with 3 consecutive deliveries.

Methods: We conducted a retrospective cohort study of all women with 3 consecutive singleton births at a single institute from 1994 to 2013. The risk of PTB (<37 weeks), spontaneous PTB and ETB (37-38 weeks) in the 3 delivery was explored. Read More

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Infective endocarditis and outcomes of mitral valve replacement.

Eur J Clin Invest 2021 May 1:e13577. Epub 2021 May 1.

Heart Center, Turku University Hospital and University of Turku, Turku, Finland.

Background: We investigated the long-term outcomes of mitral valve replacement (MVR) in native mitral valve infective endocarditis (IE).

Methods: Multicentre, population-based cohort register study consisted of 1233 consecutive adult patients treated with first-time MVR in Finland. Mitral valve IE was diagnosed in 170 of these patients. Read More

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Four year evaluation of therapeutic hysteroscopy under procedural sedation in an outpatient clinic.

Eur J Obstet Gynecol Reprod Biol 2021 Jun 9;261:65-71. Epub 2021 Apr 9.

Department of Gynecology, Catharina Hospital, Eindhoven, the Netherlands.

Objective: Due to the evolution of hysteroscopic instruments, therapeutic hysteroscopic procedures are increasingly performed in an outpatient, office-based setting. The most important limiting factor of performing these hysteroscopic treatments is patient discomfort. Procedural Sedation Analgesia (PSA) decreases patient discomfort and anxiety. Read More

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Conditional and cumulative live birth rates after blastocyst transfer.

Eur J Obstet Gynecol Reprod Biol 2021 Jun 7;261:46-51. Epub 2021 Apr 7.

Aagaard Fertility Clinic, Hedeager, 35 8200, Aarhus, Denmark. Electronic address:

Objective: We aimed to investigate live birth rate (LBR), cumulative live birth rate (CLBR) for consecutive fresh and frozen-thawed in vitro fertilization (IVF) cycles, and CLBR after an entire IVF programme involving multiple ovarian stimulations using blastocyst transfer only.

Study Design: From January 1 st 2014 to December 31 st 2018, we included women aged 18-45 years who initiated IVF or intracytoplasmic sperm injection at Aagaard Fertility Clinic, Denmark. The primary outcome was live birth, and secondary outcomes were a positive hCG blood test and ongoing pregnancy confirmed by ultrasonography. Read More

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A Novel Approach for Gastric Cancer Staging in Elderly Patients Based on the Lymph Node Ratio.

J Gastric Cancer 2021 Mar 26;21(1):84-92. Epub 2021 Mar 26.

Division of Gastrointestinal Surgery, Department of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Purpose: To date, no studies have been performed on staging based on the lymph node ratio (LNR) in elderly patients with gastric cancer who may require limited lymph node (LN) dissection due to morbidity and tissue fragility. We aimed to develop a new N staging system using the LNR in elderly patients with gastric cancer.

Materials And Methods: The present study included patients aged over 75 years who underwent curative gastrectomy between January 1989 and December 2018. Read More

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SPS(Kayexalate)/CPS(K-Bind) crystals in the gastrointestinal tract-An experience from a tertiary center.

Indian J Pathol Microbiol 2021 Apr-Jun;64(2):261-265

Department of Pathology, Amrita Institute of Medical Sciences, Kochi, Kerala, India.

Introduction: Kayexalate (Sodium Polystyrene Sulfonate/SPS) and K-bind (Calcium Polystyrene Sulfonate/CPS) are cation exchange resins, commonly used for treatment of hyperkalaemia. SPS/CPS induced injury of the gastrointestinal tract(GIT) is rare, can be potentially life threatening but is under-recognized. This study aims to increase awareness of pathologists and clinicians of this under-reported complication of a drug commonly used to treat hyperkalaemia. Read More

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Tentacle-type poly(hydroxamic acid)-modified macroporous cellulose beads: Synthesis, characterization, and application for heavy metal ions adsorption.

J Chromatogr A 2021 May 26;1645:462098. Epub 2021 Mar 26.

Department of Pharmaceutical & Biological Engineering, School of Chemical Engineering, Sichuan University, Chengdu 610065, PR China. Electronic address:

Herein, a facile yet efficient template method to fabricate macroporous cellulose beads (MCBs) is reported. In this method, micro-size CaCO is utilized to create macroporous structure for fast mass transfer, and tentacle-type poly(hydroxamic acid) as adsorption ligand is immobilized on the MCBs to improve adsorption capacity. The obtained tentacle-type poly(hydroxamic acid)-modified MCMs (TP-CMCBs) show uniform spherical shape (about 80 μm), bimodal pore system (macropores≈3. Read More

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Treatment for pure red cell aplasia after major ABO-incompatible allogeneic stem cell transplantation: a multicentre study.

Br J Haematol 2021 May 12;193(4):814-826. Epub 2021 Apr 12.

Haematology Transplant Unit, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France.

Pure red cell aplasia (PRCA) following allogeneic haematopoietic stem cell transplantation (aHSCT) with major ABO incompatibility is responsible for transfusion dependent anaemia, impaired quality of life and iron overload. We conducted a retrospective study, over a 10-year period, which included all consecutive patients who received a major ABO mismatched aHSCT, to assess the impact of specific treatment on PRCA. We did not observe any PRCA in the 57 aHSCT issued from cord blood. Read More

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Impact of Novel Targeted Therapies and Cytogenetic Risk Groups on Outcome After Allogeneic Transplantation for Adult ALL.

Transplant Cell Ther 2021 Feb 11;27(2):165.e1-165.e11. Epub 2020 Dec 11.

Division of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, Florida. Electronic address:

Novel high-risk groups have recently been identified in adult acute lymphoblastic leukemia (ALL), including Philadelphia-like, therapy-related, and measurable residual disease after induction therapy. Furthermore, modern targeted therapies have recently been incorporated into ALL management; rituximab for CD20-positive and blinatumomab for measurable residual disease after induction therapy or relapsed or refractory disease. Allogeneic hematopoietic cell transplantation (allo-HCT) is recommended as consolidation therapy for high-risk ALL; however, its relative benefit for these high-risk groups and after novel therapies is unclear. Read More

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February 2021

Risk analysis for early mortality in emergency acute type A aortic dissection surgery: experience of Tokyo Acute Aortic Super-network.

Eur J Cardiothorac Surg 2021 Apr 8. Epub 2021 Apr 8.

Tokyo CCU Network Scientific Committee, Tokyo, Japan.

Objectives: We investigated the various pre- and postoperative complications related to early (30-day) mortality after open surgery for acute type A aortic dissection.

Methods: Data from the Tokyo Acute Aortic Super-network database spanning January 2015 to December 2017 were retrospectively reviewed. Pre- and postoperative factors related to early postoperative mortality were assessed in 1504 of 2058 (73. Read More

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Impact of sex on outcomes of bifurcation lesion percutaneous coronary intervention: results from a single-centre prospective registry.

Coron Artery Dis 2021 Apr 5. Epub 2021 Apr 5.

Department of Cardiology, Rabin Medical Center, Petach Tikva; affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv Department of Cardiology, Meir Medical Center, Kfar Saba, Israel.

Background: Coronary bifurcation lesions are technically and clinically more challenging compared to nonbifurcation lesions. Sex-related differences in diagnostic and invasive therapeutic coronary procedures have been described in the literature. Our objective was to assess the impact of sex on outcomes of bifurcation lesion percutaneous coronary intervention (PCI). Read More

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Do Sex-Related Differences of Comorbidity Burden and/or In-Hospital Mortality Exist in Cancer Patients? A Retrospective Study in an Internal Medicine Setting.

Life (Basel) 2021 Mar 22;11(3). Epub 2021 Mar 22.

Clinica Medica Unit, Azienda Ospedaliero-University of Ferrara, 44121 Ferrara, Italy.

Cancer represents important comorbidity, and data on outcomes are usually derived from selected oncologic units. Our aim was to evaluate possible sex-related differences and factors associated with in-hospital mortality (IHM) in a consecutive cohort of elderly patients with cancer admitted to internal medicine. We included all patients admitted to our department with a diagnosis of cancer during 2018. Read More

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Central Nervous System Involvement in Epstein-Barr Virus-Related Post-Transplant Lymphoproliferative Disorders after Allogeneic Hematopoietic Stem Cell Transplantation.

Transplant Cell Ther 2021 Mar 22;27(3):261.e1-261.e7. Epub 2020 Dec 22.

Hematology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain; CIBERONC, Instituto Carlos III, Madrid, Spain.

Central nervous system (CNS) involvement in Epstein-Barr virus-related post-transplant lymphoproliferative disorders (EBV-PTLDs) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is poorly defined. We analyzed the incidence, clinical and pathological characteristics, and impact on outcomes of EBV-PTLDs with CNS involvement (CNS-PTLDs) in 1009 consecutive adult patients undergoing allo-HSCT at a single-center institution. Four hundred eighty-two patients received matched sibling donor (MSD) transplants, 388 umbilical cord blood transplants (UCBTs), 56 matched unrelated donor (MUD) transplants, and 83 haploidentical transplants. Read More

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Fast and slow progressors of infarct growth in basilar artery occlusion strokes.

J Neurointerv Surg 2021 Mar 25. Epub 2021 Mar 25.

Neurology, Barrow Neurological Institute, Phoenix, Arizona, USA

Background: Heterogeneity in the infarct growth rate among anterior circulation large vessel occlusion (LVO) strokes has triage and treatment implications. Such data are lacking for basilar artery occlusion (BAO) strokes. We aim to describe the variability in brainstem infarct volume at presentation and compute the distribution of the infarct growth rate (IGR) and rate of loss of neurons during BAO strokes. Read More

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[Histopathological features in fatal COVID-19 acute respiratory distress syndrome].

Med Intensiva (Engl Ed) 2021 Jun-Jul;45(5):261-270. Epub 2021 Feb 27.

Département de Pathologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France; Centre de Ressources biologiques, Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

Background: COVID-19 acute respiratory distress syndrome (ARDS) shares the common histological hallmarks with other forms of ARDS. However, the chronology of the histological lesions has not been well established.

Objective: To describe the chronological histopathological alterations in the lungs of patients with COVID-19 related ARDS. Read More

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Both muscle quantity and quality are predictors of waiting list mortality in patients with end-stage liver disease.

Clin Nutr ESPEN 2021 Apr 10;42:272-279. Epub 2021 Feb 10.

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands.

Background And Aims: Malnutrition is highly prevalent in patients with end-stage liver disease (ESLD) and associated with impaired clinical outcome. Previous studies focused on one component of body composition and not in combination with nutritional intake, while both are components of the nutritional status. We aimed to evaluate the most important risk factors regarding body composition (muscle mass, muscle quality and fat mass) and nutritional intake (energy and protein intake) for waiting list mortality in patients with ESLD awaiting liver transplantation (LTx). Read More

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Family history in first degree relatives of patients with premature cardiovascular disease.

Int J Cardiol 2021 06 15;333:215-218. Epub 2021 Mar 15.

Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA. Electronic address:

Background: Family history (FH) of cardiovascular disease (CVD) in first degree relatives (FDR) is a major risk factor, especially for premature events. Data are sparse on FH of different manifestations of CVD among FDRs of patients with premature myocardial infarction (MI), chronic stable angina (CSA) or peripheral vascular disease (PVD).

Methods: We obtained FHs from first degree relatives (parents or siblings) of 230 consecutive patients with premature (men < 60 and women < 65 years) CVD, including 79 wth MI, 39 CSA, 51 PVD and 61 blood donors. Read More

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