Mech Ageing Dev 2011 Apr 25;132(4):154-62. Epub 2011 Feb 25.
Thérapie des maladies du muscle strié, Institut de Myologie, Université Pierre et Marie Curie, G.H. Pitié-Salpétrière, 47 bd de l'hôpital, Paris, France.
Loss of muscle mass and strength is a major problem during aging and the expression of Mechano Growth Factor (MGF), a member of the IGF-1 (insulin-like Growth Factor 1) super family, has been shown to be both exercise and age dependent. MGF, also called IGF-1Ec, has a unique E domain with a 49bp insert in humans (52bp in rodents; IGF-1Eb), which results in a reading frame shift during the IGF-1 gene splicing to produce a distinct mature isoform. We have studied the effects of the MGF-24aa-E peptide on proliferation and differentiation of primary human muscle cell cultures isolated from healthy subjects of different ages. Read More