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Structural basis for the interaction of unstructured neuron specific substrates neuromodulin and neurogranin with Calmodulin.

Sci Rep 2013 ;3:1392

Department of Biological Sciences, National University of Singapore, Singapore.

Neuromodulin (Nm) and neurogranin (Ng) are neuron-specific substrates of protein kinase C (PKC). Their interactions with Calmodulin (CaM) are crucial for learning and memory formation in neurons. Here, we report the structure of IQ peptides (24aa) of Nm/Ng complexed with CaM and their functional studies with full-length proteins. Read More

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Mechano Growth Factor E peptide (MGF-E), derived from an isoform of IGF-1, activates human muscle progenitor cells and induces an increase in their fusion potential at different ages.

Mech Ageing Dev 2011 Apr 25;132(4):154-62. Epub 2011 Feb 25.

Thérapie des maladies du muscle strié, Institut de Myologie, Université Pierre et Marie Curie, G.H. Pitié-Salpétrière, 47 bd de l'hôpital, Paris, France.

Loss of muscle mass and strength is a major problem during aging and the expression of Mechano Growth Factor (MGF), a member of the IGF-1 (insulin-like Growth Factor 1) super family, has been shown to be both exercise and age dependent. MGF, also called IGF-1Ec, has a unique E domain with a 49bp insert in humans (52bp in rodents; IGF-1Eb), which results in a reading frame shift during the IGF-1 gene splicing to produce a distinct mature isoform. We have studied the effects of the MGF-24aa-E peptide on proliferation and differentiation of primary human muscle cell cultures isolated from healthy subjects of different ages. Read More

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Conantokin-P, an unusual conantokin with a long disulfide loop.

Toxicon 2008 Aug 3;52(2):203-13. Epub 2008 Jun 3.

Department of Biology, University of Utah, Salt Lake City, UT 84112, USA.

The conantokins are a family of Conus venom peptides (17-27AA) that are N-methyl-d-aspartate (NMDA) receptor antagonists. Conantokins lack disulfide bridges (six out of seven previously characterized peptides are linear), but contain multiple residues of gamma-carboxyglutamate. These post-translationally modified amino acids confer the largely helical structure of conantokins by coordinating divalent metal ions. Read More

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Subpopulation of dogs with severe brain parenchymal beta amyloidosis distinguished with cluster analysis.

Brain Res 1996 Jul;728(1):20-6

Department of Pathological Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA.

A study of the brains of 30 dogs, mongrels from 6.5 to 26.5 years of age, revealed that all dogs older than 13 years of age develop amyloid-beta-positive plaques. Read More

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