333 results match your criteria 230 adenomas

Circulating let-7e-5p, miR-106a-5p, miR-28-3p, and miR-542-5p as a Promising microRNA Signature for the Detection of Colorectal Cancer.

Cancers (Basel) 2021 Mar 24;13(7). Epub 2021 Mar 24.

Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza 60430-270, Brazil.

Colorectal cancer (CRC) is a disease with high incidence and mortality. Colonoscopy is a gold standard among tests used for CRC traceability. However, serious complications, such as colon perforation, may occur. Read More

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Challenging of frozen diagnoses of small sclerosing pneumocytoma.

J Clin Pathol 2021 Mar 29. Epub 2021 Mar 29.

Pathology Department, Shanghai Jiao Tong University Affiliated Chest Hospital, Shanghai, China.

Aims: An increasing number of small pulmonary nodules are being screened by CT, and an intraoperative diagnosis is necessary for preventing excessive treatment. However, there is limited literature on the frozen diagnosis of small sclerosing pneumocytomas (SPs). In particular, tumours smaller than 1 cm are challenging for pathologists performing intraoperative frozen diagnosis. Read More

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Outpatient parathyroidectomy in the pediatric population: An 18-year experience.

J Pediatr Surg 2021 Feb 25. Epub 2021 Feb 25.

Department of Surgery, Division of Endocrine Surgery, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 USA.

Background: Parathyroidectomy for primary hyperparathyroidism (pHPT) is safely performed in the outpatient setting in the adult population. However, concern that children and adolescents have higher complication rates and are unable to recognize and communicate symptoms of hypocalcemia has limited same-day discharges in the pediatric population.

Methods: Nineteen patients aged 8-18 years (14. Read More

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February 2021

Risk factor for cerebrospinal fluid leak after endoscopic endonasal skull base surgery: a single-center experience.

Acta Otolaryngol 2021 Mar 18:1-5. Epub 2021 Mar 18.

Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Shinjuku-ku, Japan.

Background: One of the major complications in endoscopic endonasal skull base surgery (EESBS) is postoperative cerebrospinal fluid (CSF) leaks. Recently, EESBS has been applied to various skull base diseases as well as more complicated cases influenced by previous treatment with or without various comorbidities.

Aims/objectives: This study aimed to assess the factors that influence the results of postoperative CSF leak after EESBS with mixed patient backgrounds. Read More

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Development of the "National Asbestos Profile" to Eliminate Asbestos-Related Diseases in 195 Countries.

Int J Environ Res Public Health 2021 02 12;18(4). Epub 2021 Feb 12.

Asbestos Diseases Research Institute, Concord, NSW 2139, Australia.

Worldwide, 230,000+ people die annually from asbestos-related diseases (ARDs). The World Health Organization (WHO) recommends that countries develop a National Asbestos Profile (NAP) to eliminate ARDs. For 195 countries, we assessed the global status of NAPs (A: NAP, B: proxy NAP, C: relevant published information, D: no relevant information) by national income (HI: high, UMI: upper-middle, LMI: lower-middle, LI: low), asbestos bans (banned, no-ban) and public data availability. Read More

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February 2021

Association of body fat distribution and metabolic syndrome with the occurrence of colorectal adenoma: A case-control study.

J Dig Dis 2021 Apr 29;22(4):222-229. Epub 2021 Mar 29.

Department of Surgery, University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong Province, China.

Objective: Visceral fat is thought to play different roles in the carcinogenesis of the colon with peripheral fat. Our aim was to evaluate the association of body fat distribution measured by bioelectrical impedance analysis (BIA) with the incidence of colorectal adenoma (CRA).

Methods: A total of 410 asymptomatic participants who underwent a screening colonoscopy from July 2017 to December 2019 in our center were recruited, including 230 with adenomas and 180 without detected adenomas. Read More

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Surgical outcomes of laparoscopic and open resection of benign liver tumours in the Netherlands: a nationwide analysis.

HPB (Oxford) 2020 Dec 29. Epub 2020 Dec 29.

Department of Surgery, University of Groningen and University Medical Center Groningen, Groningen.

Background: Data on surgical outcomes of laparoscopic liver resection (LLR) versus open liver resection (OLR) of benign liver tumour (BLT) are scarce. This study aimed to provide a nationwide overview of postoperative outcomes after LLR and OLR of BLT.

Methods: This was a nationwide retrospective study including all patients who underwent liver resection for hepatocellular adenoma, haemangioma and focal nodular hyperplasia in the Netherlands from 2014 to 2019. Read More

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December 2020

Factors related to a non-localising technetium 99m sestamibi scan result during parathyroid adenoma imaging in primary hyperparathyroidism.

Clin Otolaryngol 2021 Mar 28;46(2):357-362. Epub 2020 Dec 28.

Department of ENT, Castlehill Hospital, Cottingham, UK.

Objectives: The aim of this study is to investigate factors that are associated with having a non-localising Tc-sestamibi scan.

Design: A retrospective study was performed on patients that underwent parathyroid surgery performed within a single institution between 2001 and 2018.

Setting: Single tertiary centre for parathyroid surgery. Read More

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Endoscopic and histologic evaluation of the gastrointestinal tract in patients with sarcoidosis.

Hao Wu Bo Shen

Eur J Gastroenterol Hepatol 2021 May;33(5):639-644

Center for Inflammatory Bowel Disease, Columbia University Medical Center, New York-Presbyterian Hospital, New York.

Background: The involvement of gastrointestinal tract is rare in sarcoidosis. Endoscopic and histologic evaluation likely provides diagnostic clue in sarcoidosis patients. The aims were to assess the frequency of abnormal endoscopy and histology in patients with sarcoidosis undergoing endoscopic evaluation and to characterize the endoscopic and histologic features in sarcoidosis of the gastrointestinal tract. Read More

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Disparities in Colorectal Cancer Screening Practices in a Midwest Urban Safety-Net Healthcare System.

Dig Dis Sci 2020 Aug 20. Epub 2020 Aug 20.

MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA.

Aims: Although colorectal cancer screening (CRC) using stool-based test is well-studied, evidence on fecal immunochemical test (FIT) patterns in a safety-net healthcare system utilizing opportunistic screening is limited. We studied the FIT completion rates and adenoma detection rate (ADR) of positive FIT-colonoscopy (FIT-C) in an urban safety-net system.

Methods: We performed a retrospective cross-sectional chart review on individuals ≥ 50 years who underwent CRC screening using FIT or screening colonoscopy, 09/01/2017-08/30/2018. Read More

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Aberrant DNA Methylation of and in Stool Specimens as an Integrated Biomarker for Colorectal Cancer Early Detection.

Front Genet 2020 18;11:643. Epub 2020 Jun 18.

Zhejiang University Kunshan Biotechnology Laboratory, Zhejiang University Kunshan Innovation Institute, Kunshan, China.

Colorectal cancer (CRC) has become the second leading cause of new cancer cases and the fifth of cancer deaths in China, and early detection is the most effective way to reduce the incidence and mortality of CRC. A number of methylated DNA biomarkers have been found to associate with CRC and precancerous lesions in stool samples, indicating stool methylated DNA biomarkers are potential tools for CRC early detection. In this study, approximately 5 g of stool specimen was collected from 230 subjects (124 in the training set and 106 in the validation set). Read More

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Palpebral Pleomorphic Adenomas of the Lacrimal Gland.

Ophthalmic Plast Reconstr Surg 2021 Mar-Apr 01;37(2):125-128

Adnexal Service, Moorfields Eye Hospital, London, United Kingdom.

Aims: To report the characteristics and management for patients with palpebral pleomorphic adenoma of the lacrimal gland.

Methods: The records for patients with palpebral pleomorphic adenoma seen at Moorfields Eye Hospital between 1978 and 2019 were reviewed for demographics, presentation, imaging, histopathology, management, and outcome.

Results: Forty-three patients (25 male; 58%) with palpebral pleomorphic adenoma were identified, presenting at a mean age of 46 years (median 46. Read More

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Patients with true mixed growth hormone and prolactin-secreting pituitary adenoma: a case series of 12 patients.

Br J Neurosurg 2020 Apr 24;34(2):154-160. Epub 2020 Jan 24.

Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong, China.

Mixed growth hormone (GH) and prolactin (PRL) secreting adenomas are the most common type of plurihormonal pituitary adenomas. We assessed the clinical presentations and impacts of transsphenoidal surgery (TS) on patients with mixed GH and PRL adenomas including surgical outcomes, complications, and prognosis. Twelve patients (7 males, 5 females) were operated in the neurosurgery department of Qilu hospital affiliated to Shandong University, Shandong, China. Read More

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Ultrasound elastography score and strain index in different parathyroid lesions.

Endocr Connect 2019 Dec;8(12):1579-1590

Department of Endocrinology and Metabolism, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara, Turkey.

Background: Despite significant improvement in imaging quality and advanced scientific knowledge, it may still sometimes be difficult to distinguish different parathyroid lesions. The aims of this prospective study were to evaluate parathyroid lesions with ultrasound elastography and to determine whether strain index can help to differentiate parathyroid lesions.

Methods: Patients with biochemically confirmed hyperparathyroidism and localised parathyroid lesions in ultrasonography were included. Read More

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December 2019

Extended pleurectomy decortication for the treatment of malignant pleural mesothelioma.

Multimed Man Cardiothorac Surg 2019 Nov 5;2019. Epub 2019 Nov 5.

Department of Cardio-Thoracic Surgery Erasmus University Medical Center Rotterdam The Netherlands.

Malignant pleural mesothelioma is a cancer of the mesothelial cells lining the pleural sac. Surgery for malignant pleural mesothelioma should be part of a multimodality treatment approach and the aim of surgery should be macroscopic complete tumor resection. Lung-sparing operations, such as extended pleurectomy decortication, have gained increasing popularity in the past decade. Read More

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November 2019

Benign Intracranial Lesions - Radiotherapy: An Overview of Treatment Options, Indications and Therapeutic Results.

Rev Recent Clin Trials 2020 ;15(2):93-121

Department of Radiotherapy/Radiation Oncology, Faculty of Medicine, School of Health Sciences, University of Thessaly, University Hospital of Larisa, Biopolis, 41500 Larisa, Greece.

Background: Radiation Therapy (RT) is an established treatment option for benign intracranial lesions. The aim of this study is to display an update on the role of RT concerning the most frequent benign brain lesions and tumors.

Methods: Published articles about RT and meningiomas, Vestibular Schwannomas (VSs), Pituitary Adenomas (PAs), Arteriovenous Malformations (AVMs) and craniopharyngiomas were reviewed and extracted data were used. Read More

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January 2020

A nationwide survey of adrenal incidentalomas in Japan: the first report of clinical and epidemiological features.

Endocr J 2020 Feb 7;67(2):141-152. Epub 2019 Nov 7.

Department of Endocrinology and Diabetes Mellitus, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.

The aim of this study was to reveal clear epidemiologic and clinical characteristics of incidentally discovered adrenal masses, termed adrenal incidentalomas (AIs), and to establish appropriate managemental and therapeutic regimens in Japan. This study had been originally carried out as a project of a research proposed on behalf of the Japanese Ministry of Health, Labour and Welfare, from 1999 to 2004. This nationwide multicenter study on AIs included 3,672 cases with clinically diagnosed AIs, involving 1,874 males and 1,738 females, with mean age 58. Read More

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February 2020

Performance of Contrast-Enhanced Sonography Versus MRI With a Liver-Specific Contrast Agent for Diagnosis of Hepatocellular Adenoma and Focal Nodular Hyperplasia.

AJR Am J Roentgenol 2020 01 1;214(1):81-89. Epub 2019 Oct 1.

Department of Radiology & Nuclear Medicine, Erasmus University Medical Center, Abdominal Imaging, Rm Hs-222, 's-Gravendijkwal 230, 3000 CA Rotterdam, The Netherlands.

The purpose of this article is to compare contrast-enhanced sonography (CEUS) with sulfur hexafluoride with MRI with the liver-specific contrast agent gadobenate dimeglumine in the diagnosis of hepatocellular adenoma (HCA) and focal nodular hyperplasia (FNH) in a cohort of consecutive patients. Patients referred to a tertiary center for hepatobiliary disease who had suspected HCA or FNH on MRI performed with an extracellular gadolinium-based contrast agent underwent a prospective workup including CEUS and MRI with a liver-specific contrast agent. Diagnosis was definite when the findings of CEUS and MRI with a liver-specific contrast agent were concordant; histopathologic examination (HPE) was performed for cases with discordant findings. Read More

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January 2020

Interval Colorectal Cancer in Inflammatory Bowel Disease: The Role of Guideline Adherence.

Dig Dis Sci 2020 01 1;65(1):111-118. Epub 2019 Aug 1.

Division of Gastroenterology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.

Background: Factors associated with interval colorectal cancer (CRC) development in the inflammatory bowel disease (IBD) population remain unclear.

Aims: Among a cohort of patients with interval CRC, we aimed to evaluate IBD characteristics, colonoscopy quality indicators, and surveillance guideline adherence.

Methods: We performed a retrospective review of IBD- and non-IBD-associated interval CRCs diagnosed between January 2007 and December 2014 within a large US healthcare system. Read More

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January 2020

A twelve-year study of the prevalence, risk factors and characteristics of interval colorectal cancers after negative colonoscopy.

Clin Res Hepatol Gastroenterol 2020 04 10;44(2):230-238. Epub 2019 Jul 10.

Office de lutte contre le cancer, 38240 Meylan, France.

Introduction: The objective of our study was to describe and analyse the Post-Colonoscopy Colorectal Cancers (PCCRCs) and endoscopist performance-related risk factors in the Isère regional screening programme.

Method: This was a population-based retrospective cohort study between 2002-2013, where Post-Colonoscopy Colorectal Cancers (PCCRCs) were defined as colorectal adenocarcinoma diagnosed between six and sixty months post-colonoscopy following a positive gFOBT. We analysed the endoscopist performance-related risk factors of the 62 gastroenterologists who had carried out at least 30 colonoscopies during this period. Read More

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Pituitary adenomas in elderly patients: clinical and surgical outcome analysis in a large series.

Endocrine 2019 09 17;65(3):637-645. Epub 2019 Jun 17.

Pituitary Unit of the Department of Neurosurgery and Gamma Knife Radiosurgery, I.R.C.C.S. San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy.

Purpose: The increased life expectancy in the general population is causing rapid growth of the number of elderly patients. Pituitary adenomas (PAs) are one of those tumors whose incidence increases with age. Pituitary surgery in elderly has usually been considered riskier than in the younger population. Read More

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September 2019

The transition between a poroma and a porocarcinoma evidenced by the dermoscopy.

An Bras Dermatol 2019 Mar-Apr;94(2):230-232. Epub 2019 May 9.

Department of Dermatology, Hospital do Servidor Estadual de São Paulo, São Paulo (SP), Brazil.

Eccrine porocarcinoma (EPC) is a rare malignant skin tumor. The dermoscopy of invasive EPC reveals focal presence of whitish-pink, structureless areas surrounded by pinkish-white halos. In an eccrine poroma (EP), such areas present diffuse distribution in the "frog- eggs" pattern. Read More

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Reduction of multitasking distractions underlies the higher adenoma detection rate of water exchange compared to air insufflation - blinded analysis of withdrawal phase videos.

United European Gastroenterol J 2019 03 5;7(2):230-238. Epub 2018 Dec 5.

Sepulveda Ambulatory Care Center, Veterans Affairs Greater Los Angeles Healthcare System, North Hill, USA.

Background: Experts have hypothesized that a reduction of multitasking distractions and improved bowel cleanliness can explain why insertion water exchange enhances adenoma detection rate.

Objective: The purpose of this study was to test the role of both distractions during withdrawal and bowel cleanliness in enhancing adenoma detection rate using coded video records of colonoscopy.

Methods: The withdrawal phase of videos of 299 consecutive colonoscopies from two randomized controlled trials comparing water exchange versus air insufflation at a regional hospital in Taiwan were coded. Read More

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Adrenal tumors: when to search for a germline abnormality?

Curr Opin Oncol 2019 05;31(3):230-235

INSERM, UMR970, Equipe Génétique et Métabolisme des cancers rares.

Purpose Of Review: Over the last 20 years, the genetic landscape of adrenal tumours has been transformed by the identification of multiple susceptibility genes for the various tumour types. We review these recent developments here, and describe current recommendations for genetic testing in patients with tumours of the adrenal medulla and extra-adrenal paraganglia or the adrenal cortex.

Recent Findings: Phaeochromocytomas (adrenal medulla tumours) and paragangliomas, aldosterone-producing adenomas, primary macronodular adrenal hyperplasia, primary pigmented nodular adrenocortical disease and adrenocortical carcinoma (adrenal cortex tumours) may all be caused by a germline mutation in a specific gene, regardless of the presence/absence of a family history or syndromic disease at initial diagnosis. Read More

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Efficacy of Dual Inhibition of Glycolysis and Glutaminolysis for Therapy of Renal Lesions in Tsc2 Mice.

Neoplasia 2019 02 8;21(2):230-238. Epub 2019 Jan 8.

Institute of Medical Genetics, Division of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. Electronic address:

Tuberous sclerosis is caused by mutations in the TSC1 or TSC2 gene and characterized by development of tumors in multiple organs including the kidneys. TSC-associated tumors exhibit somatic loss of the second allele of the TSC genes, leading to aberrant activation of the mechanistic target of rapamycin (mTOR) signaling pathway. Activation of mTOR complex 1 (mTORC1) causes addiction to glucose and glutamine in Tsc1or Tsc2 mouse embryonic fibroblasts (MEFs). Read More

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February 2019

The effect of rapid infusion of cisplatin on nephrotoxicity in patients with lung carcinoma.

J Clin Pharm Ther 2019 Apr 21;44(2):249-257. Epub 2018 Dec 21.

Department of Pharmacy, OLVG Hospital, Amsterdam, The Netherlands.

What Is Known And Objective: The use of cisplatin in the treatment of lung carcinoma is limited by nephrotoxicity. The aim of this study was to determine whether the incidence of nephrotoxicity in patients with lung carcinoma is affected by the infusion rate of cisplatin (rapid infusion of cisplatin in 1 hour compared to regular infusion in 3 hours).

Methods: This observational, retrospective study was performed on patients diagnosed with non-small-cell lung carcinoma (NSCLC), small-cell lung carcinoma (SCLC) or mesothelioma receiving a cisplatin-containing chemotherapy regimen. Read More

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Acantholytic Squamous Cell Carcinoma and Salivary Duct Carcinoma Ex-pleomorphic Adenoma of the Submandibular Gland: A Report of Two Extremely Rare Cases with an Immunohistochemical Analysis.

Head Neck Pathol 2020 Mar 27;14(1):230-238. Epub 2018 Nov 27.

Pathology Division, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan.

Carcinoma ex pleomorphic adenoma (CXPA) is a malignant tumor of the salivary gland that arises from pleomorphic adenoma (PA). Squamous cell carcinoma (SCC) is extremely rare in the salivary glands. We report two cases of acantholytic SCC (ASCC) ex PA. Read More

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Successful laparotomy tumor resection and levonorgestrel-releasing intrauterine system for atypical polypoid adenomyoma.

J Obstet Gynaecol Res 2019 Jan 9;45(1):230-234. Epub 2018 Aug 9.

Department of Obstetrics and Gynecology, Jichi Medical University, Tochigi, Japan.

Hysteroscopic transcervical resection (TCR) is often performed as fertility sparing treatment for atypical polypoid adenomyoma (APA) patients. However, TCR has the risk of uterine wall perforation, especially when the tumor extends deeply into the uterine muscle layer. We report an APA patient in whom it was impossible to completely resect the tumor by TCR, but laparotomy tumor resection followed by levonorgestrel-releasing intrauterine system (LNG-IUS) was successful. Read More

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January 2019

Prognostic factors and treatment outcomes of malignant pleural mesothelioma in Eastern Asian patients - A Taiwanese study.

J Formos Med Assoc 2019 Jan 27;118(1 Pt 2):230-236. Epub 2018 Apr 27.

Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan; National Taiwan University Cancer Center, Taipei, Taiwan; Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan.

Background/purpose: There are scarce reports on the prognostic factors and treatment outcomes of patients with malignant pleural mesothelioma (MPM) in Asia. This study aimed to address these matters in a real-world setting.

Methods: Medical records of patients with histologically proven MPM diagnosed between 1977 and 2016 at the National Taiwan University Hospital were reviewed. Read More

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January 2019

Heterogeneity in Immune Cell Content in Malignant Pleural Mesothelioma.

Int J Mol Sci 2018 Mar 30;19(4). Epub 2018 Mar 30.

Erasmus MC Cancer Institute, Department of Pulmonary Medicine, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.

Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with limited therapy options and dismal prognosis. In recent years, the role of immune cells within the tumor microenvironment (TME) has become a major area of interest. In this review, we discuss the current knowledge of heterogeneity in immune cell content and checkpoint expression in MPM in relation to prognosis and prediction of treatment efficacy. Read More

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