889,965 results match your criteria 23-disubstituted-n-alkylaziridines good


Factorial validation of sense of community scale using Nigerian mathematics, science, and social science education students: Implication for educational administrators and evaluators.

J Community Psychol 2021 Sep 24. Epub 2021 Sep 24.

Department of Educational Foundations, University of Nigeria, Nsukka, Nigeria.

The ugly occurrences of security breaches have made the Nigerian populace to be leaving in fear. The most affected are the teaming adolescents of the school-age who may not have a good sense of their community. Thus, this study carried out the factorial validation of a 36-item sense of community scale (SoCS) developed by Cicognani et al. Read More

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September 2021

[Comparing Community Capacities by Local Actors and External Experts: An Audit of Health Promotion Activities in Lenzsiedlung, Hamburg].

Gesundheitswesen 2021 Sep 24. Epub 2021 Sep 24.

Institut für Medizinische Soziologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.

Aim: The questionnaire "Capacity building in Neighbourhoods (KEQ)" has five dimensions which are regarded as intermediary outcome results of community health promotion. The questionnaire was to be completed by local actors and thus has some features of self-evaluation. We wanted to find out whether external experts make similar or more critical assessments. Read More

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September 2021

Coffee Leaves: An Upcoming Novel Food?

Planta Med 2021 Sep 24. Epub 2021 Sep 24.

RD3 Department-Unit of Pharmacognosy, Bioanalysis and Drug Discovery, Faculty of Pharmacy, Université libre de Bruxelles, Brussels, Belgium.

Unlike those of coffee beans, the healthy properties of coffee leaves have been overlooked for a long time, even if they are consumed as a beverage by local communities of several African countries. Due to the presence of xanthines, diterpenes, xanthones, and several other polyphenol derivatives as main secondary metabolites, coffee leaves might be useful to prevent many daily disorders. At the same time, as for all bioactive molecules, careless use of coffee leaf infusions may be unsafe due to their adverse effects, such as the excessive stimulant effects on the central nervous system or their interactions with other concomitantly administered drugs. Read More

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September 2021

Deep Learning-Based CT Radiomics for Feature Representation and Analysis of Aging Characteristics of Asian Bony Orbit.

J Craniofac Surg 2021 Sep 24. Epub 2021 Sep 24.

School of Electronics and Information, Hangzhou Dianzi University Department of Plastic and Reconstructive Surgery Department of Radiology, People's Hospital of Hangzhou Medical College, Zhejiang Provincial People's Hospital, Hangzhou, China.

Objective: This paper puts forward a new method for automatic segmentation of bony orbit as well as automatic extraction and classification of aging features of segmented orbit contour based on depth learning, with which the aging mode of bony orbit contour is preliminarily validated.

Method: Three-dimensional reconstruction was carried out by using the craniofacial Computed Tomography scanning data of 595 adult Mongolians at different ages (119 young males, 78 young females, 109 middle-aged males, 89 middle-aged females, 95 elderly males, and 105 elderly females), the craniofacial images were exported, orbit contour images were obtained with U-Net segmentation network, and then the orbit contour features of young group, the middle-aged group and the elderly group were classified with the classification network. Next, contour area, height, and other features put forward in existing research were automatically calculated by using the connected component shape description method; and it was validated whether the aging features of the bony orbit only occur to partial or the whole orbit. Read More

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September 2021

Venoarterial Extracorporeal Membrane Oxygenation in Severe Drug Intoxication: A Retrospective Comparison of Survivors and Nonsurvivors.

ASAIO J 2021 Sep 20. Epub 2021 Sep 20.

From the Department of Intensive Care, CHU Lille, Lille, France University of Lille, Inserm U1167, Institut Pasteur de Lille, Lille, France Department of Cardiovascular Surgery, CHU Lille, Lille, France Cardiovascular Intensive Care Unit, CHU Lille, Lille, France University of Lille, Inserm U1011, Institut Pasteur de Lille, EGID, Lille, France Emergency Department and SAMU, CHU Lille, Lille, France University of Lille, Inserm U1285, CNRS UMR 8576, Lille, France.

Selecting patients most likely to benefit from venoarterial extracorporeal membrane oxygenation (V-A ECMO) to treat refractory drug-induced cardiovascular shock remains a difficult challenge for physicians. This study reported short-term survival outcomes and factors associated with mortality in V-A ECMO-treated patients for poisoning. Twenty-two patients placed on V-A ECMO after drug intoxication from January 2014 to December 2020 were retrospectively analyzed. Read More

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September 2021

Computational Fluid Dynamics Model of Continuous-Flow Total Artificial Heart: Right Pump Impeller Design Changes to Improve Biocompatibility.

ASAIO J 2021 Sep 20. Epub 2021 Sep 20.

From the SimuTech Group, Hudson, Ohio R1 Engineering LLC, Euclid, Ohio Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic, Cleveland, Ohio.

Cleveland Clinic is developing a continuous-flow total artificial heart (CFTAH). This novel design operates without valves and is suspended both axially and radially through the balancing of the magnetic and hydrodynamic forces. A series of long-term animal studies with no anticoagulation demonstrated good biocompatibility, without any thromboemboli or infarctions in the organs. Read More

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September 2021

The performance of COBRA, a decision rule to predict the need for intensive care interventions in intentional drug overdose.

Eur J Emerg Med 2021 Sep 21. Epub 2021 Sep 21.

Department of Emergency Medicine Department of Intensive care, Deventer Hospital, Deventer Department of Emergency Medicine, Rijnstate Teaching Hospital, Arnhem Department of Research and Development Department of Clinical Pharmacy, Deventer Hospital, Deventer Unit of PharmacoTherapy, Epidemiology & Economics, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Groningen, The Netherlands.

Background: COBRA was developed as a decision rule to predict which patients visiting the emergency department (ED) following intentional drug overdose will not require intensive care unit (ICU) interventions. COBRA uses parameters from five vital systems (cardiac conduction, oxygenation, blood pressure, respiration, and awareness) that are readily available in the ED. COBRA recommends against ICU admission when all these parameters are normal. Read More

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September 2021

Adaptation of stochastic microdosimetric kinetic model to hypoxia for hypo-fractionated multi-ion therapy treatment planning.

Phys Med Biol 2021 Sep 24. Epub 2021 Sep 24.

QST hospital, National Institutes for Quantum and Radiological Science and Technology, Chiba, Chiba, JAPAN.

For hypo-fractionated multi-ion therapy (HFMIT), the stochastic microdosimetric kinetic (SMK) model had been developed to estimate the biological effectiveness of radiation beams with wide linear energy transfer (LET) and dose ranges. The HFMIT will be applied to radioresistant tumors with oxygen-deficient regions. The response of cells to radiation is strongly dependent on the oxygen condition in addition to radiation type, LET and absorbed dose. Read More

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September 2021

A case report detailing the use of 3D printing technology in surgical planning and decision making in ENT surgery-an axial 3D first in Northern Ireland.

Int J Surg Case Rep 2021 Sep 15;87:106407. Epub 2021 Sep 15.

ENT Department, Craigavon Hospital 68 Lurgan Rd, Portadown BT63 5QQ, Craigavon, United Kingdom of Great Britain and Northern Ireland. Electronic address:

Introduction And Importance: This case report details the first use of Axial 3D printing technology in Northern Ireland for surgical planning and decision making in ENT skull base surgery.

Case Presentation: 39 year old male seen at ENT clinic with nasal congestion. CT showed multi-sinus mucosal thickening. Read More

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September 2021

Neural network surgery: Combining training with topology optimization.

Neural Netw 2021 Sep 7;144:384-393. Epub 2021 Sep 7.

Helmholtz-Zentrum Hereon, Institute of Material Systems Modeling, Dept. of Machine Learning and Data, Max-Planck-Straße 1, 21502 Geesthacht, Germany.

With ever increasing computational capacities, neural networks become more and more proficient at solving complex tasks. However, picking a sufficiently good network topology usually relies on expert human knowledge. Neural architecture search aims to reduce the extent of expertise that is needed. Read More

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September 2021

Experiences from implementing an Lessons from teaching psychiatry trainees at a tertiary care hospital in Karachi, Pakistan.

Asian J Psychiatr 2021 Sep 17;65:102865. Epub 2021 Sep 17.

Department of Psychiatry, Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan. Electronic address:

Early childhood trauma can have adverse effects on brain development. This results in higher rates of mental health and medical problems in adults. Unfortunately, psychiatry trainees are not adequately trained in dealing with trauma survivors. Read More

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September 2021

Nursing assistants and resident satisfaction in long-term care: A systematic review.

Geriatr Nurs 2021 Sep 21;42(6):1323-1331. Epub 2021 Sep 21.

College of Health and Public Service, University of North Texas, 410 S. Avenue C, Denton, TX 76201, United States.

Background: The number of nursing assistants (NAs) in the long-term care industry is on the rise, helping to service the needs of an increasingly aging population. Understanding influences on NAs service qualities and resident satisfaction is important to sustainable long-term care services. To date, the research evidence about NAs factors and resident satisfaction has not been synthesized. Read More

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September 2021

Off-the-shelf thermoluminescent silica glass media for use in medical diagnostic dosimetry applications.

Appl Radiat Isot 2021 Sep 16;178:109953. Epub 2021 Sep 16.

Centre for Nuclear and Radiation Physics, Department of Physics, University of Surrey, Guildford, Surrey, GU2 7XH, UK; University College London, Gower Street, London, WC1E 6BT, London, UK; Sunway University, Centre for Applied Physics and Radiation Technologies, Jalan Universiti, 47500, Subang Jaya, Malaysia.

In respect of radiation exposure assessments, thermoluminescent dosimeters (TLD) represent a notable and important subset of passive detector technology, gaining widespread use over a period of many decades, not least for medical applications. TLDs are available in a range of physical and chemical forms, in particular the popularity of phosphor-based commercial products arising from features that include availability down to low mm dimensions, soft-tissue equivalence in some cases, and relatively low TL fading. Novel doped silica glass TL material fabricated as fibres also offer favourable responses, recent developments in co-doping leading to their ability to also provide for diagnostic radiology applications, adding to the attractive features of being impervious to water, of good sensitivity, and generally offering wide dynamic range. Read More

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September 2021

Techno-economic analysis of livestock urine and manure as a microalgal growth medium.

Waste Manag 2021 Sep 21;135:276-286. Epub 2021 Sep 21.

School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology, 50 UNIST-gil, Eonyang-eup, Ulju-gun, Ulsan 44919, Republic of Korea. Electronic address:

Microalgae have the potential to utilize the nutrients in livestock urine and manure (LUM) for the production of useful biomass, which can be used as a source of bioindustry. This study aims to evaluate the economic benefits of LUM feedstock that have not been clearly discussed before. Two types of photobioreactors were designed with a capacity of 200 m d. Read More

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September 2021

Development of mathematical model and experimental Validation for batch bio-drying of municipal solid waste: Mass balances.

Chemosphere 2021 Sep 18;287(Pt 3):132272. Epub 2021 Sep 18.

Department of Chemical Engineering, National Institute of Technology, Tiruchirappalli, 620 015, Tamil Nadu, India. Electronic address:

Bio-drying of solid waste is a complex process that involves anoxic hydrolysis, aerobic oxidation, evaporation, absorption, and condensation. To understand the interaction between different variables (concentration of volatile matter, moisture, microbial biomass, and temperature) and to predict the system performance, a powerful tool is necessary for improved drying rates. Hence, a mathematical model of mass balances of the batch bio-drying of municipal solid waste (MSW), associated with rate equations of evaporation of moisture from the waste matrix and absorption of leachate on absorbents is developed which is the novelty of the present study. Read More

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September 2021

One-step fabrication of dual functional Tb coordinated polymeric micro/nano-structures for Cr(VI) adsorption and detection.

J Hazard Mater 2021 Sep 10;423(Pt B):127166. Epub 2021 Sep 10.

School of Materials and Energy, University of Electronic Science and Technology of China, 610054 Chengdu, China.

Hexavalent chromium Cr(VI) has been considered as one of the most hazardous heavy metals because of its strong and persistent toxicity to the ecosystem and human beings. Herein, we have synthesized a double hydrophilic block co-polyarylene ether nitriles (abbreviated as dhPEN) bearing aromatic backbone as well as pendent carboxyl and sulfonate groups. Afterward, the synthesized dhPEN has been co-assembled with the lanthanide Tb via a one-step solvent exchange protocol, leading to generation of Tb coordinated dhPEN (Tb-dhPEN) micro/nano-structures that exhibit good adsorption capacity and detection sensitivity towards Cr(VI). Read More

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September 2021

Machine learning-based biomarkers identification from toxicogenomics - Bridging to regulatory relevant phenotypic endpoints.

J Hazard Mater 2021 Sep 11;423(Pt B):127141. Epub 2021 Sep 11.

Department of Civil and Environmental Engineering, Northeastern University, 360 Huntington Ave, Boston, MA 02115, USA; School of Civil and Environmental Engineering, Cornell University, 263 Hollister Hall, Ithaca, NY 14853, USA. Electronic address:

One of the major challenges in realization and implementations of the Tox21 vision is the urgent need to establish quantitative link between in-vitro assay molecular endpoint and in-vivo regulatory-relevant phenotypic toxicity endpoint. Current toxicomics approach still mostly rely on large number of redundant markers without pre-selection or ranking, therefore, selection of relevant biomarkers with minimal redundancy would reduce the number of markers to be monitored and reduce the cost, time, and complexity of the toxicity screening and risk monitoring. Here, we demonstrated that, using time series toxicomics in-vitro assay along with machine learning-based feature selection (maximum relevance and minimum redundancy (MRMR)) and classification method (support vector machine (SVM)), an "optimal" number of biomarkers with minimum redundancy can be identified for prediction of phenotypic toxicity endpoints with good accuracy. Read More

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September 2021

MarR-type transcription factor RosR regulates glutamate metabolism network and promotes accumulation of L-glutamate in Corynebacterium glutamicum G01.

Bioresour Technol 2021 Sep 15;342:125945. Epub 2021 Sep 15.

The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China. Electronic address:

Transcription factors (TFs) perform a crucial function in the regulation of amino acids biosynthesis. Here, TFs involved in L-glutamate biosynthesis in Corynebacterium glutamicum were investigated. Compared to transcriptomic results of C. Read More

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September 2021

Family functioning as a moderator in the relation between perceived stress and psychotic-like experiences among adolescents during COVID-19.

Compr Psychiatry 2021 Sep 17;111:152274. Epub 2021 Sep 17.

Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; China National Clinical Research Center on Mental Disorders, Changsha, Hunan, China. Electronic address:

Background: The COVID-19 pandemic has increased psychological stress among adolescents, and the relation between perceived stress (PS) and psychotic-like experiences (PLEs) has been well-established. However, little is known about the role of family functioning (FF) in this relation, especially when adolescents experienced the extended lockdown period with family members.

Methods: A total of 4807 adolescents completed this retrospective paper-and-pencil survey after school reopening between May 14th and June 6th, 2020 in Hunan Province, China. Read More

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September 2021

Effects of food matrix elements (dietary fibres) on grapefruit peel flavanone profile and on faecal microbiota during in vitro fermentation.

Food Chem 2021 Sep 6;371:131065. Epub 2021 Sep 6.

Freeze-dried Food Processing Engineering Technology Research Center, Jian 343000, China.

Citrus fruits are a good source of flavanones. The present study aimed to assess the effect of food matrix elements [dietary fibres (DFs)] on the flavanone profile of grapefruit peel (GFP) and on the gut microbiota during in vitro digestion and simulated colonic fermentation. The contents of low-molecular-weight metabolites (dihydrocaffeic acid and 3-phenylpropionic acid) were increased by pectin, konjac and chitosan in medium- and high-viscosity matrices. Read More

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September 2021

Discovery of thiazolidin-4-one analogue as selective GSK-3β inhibitor through structure based virtual screening.

Bioorg Med Chem Lett 2021 Sep 21:128375. Epub 2021 Sep 21.

Department of Pharmacy, Central University of Rajasthan, Bandarsindari, Ajmer, Rajasthan 305817, India. Electronic address:

GSK-3β directly phosphorylate tubulin binding site of tau protein, indicating its importance in tau aggregation and, therefore, in Alzheimer's disease pathology. New GSK-3β inhibitors were identified using a structure-based screening, ADMET analysis. These studies revealed that ZINC09036109, ZINC72371723, ZINC72371725, and ZINC01373165 approached optimal ADMET properties along with good MM-GBSA dG binding. Read More

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September 2021

A lifespan approach to osteoarthritis prevention.

Osteoarthritis Cartilage 2021 Sep 21. Epub 2021 Sep 21.

Department of Sports Science and Clinical Biomechanics(,) Musculoskeletal Function and Physiotherapy(,) University of Southern Denmark, Denmark. Electronic address:

Prevention is an attractive solution for the staggering and increasingly unmanageable burden of osteoarthritis. Despite this, the field of osteoarthritis prevention is relatively immature. To date, most of what is known about preventing osteoarthritis and risk factors for osteoarthritis is relative to the disease (underlying biology and pathophysiology) of osteoarthritis, with few studies considering risk factors for osteoarthritis illness, the force driving the personal, financial and societal burden. Read More

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September 2021

Efficacy of hydrophilic resin-based sealant: A systematic review and meta-analysis.

J Dent 2021 Sep 21:103816. Epub 2021 Sep 21.

Restorative Dentistry, Department of Oral Rehabilitation, The Medical University of South Carolina, James B. Edwards College of Dental Medicine, 173 Ashley Avenue, Charleston, SC, 29425, USA. Electronic address:

Objectives: This meta-analysis review aims to answer two questions: 1) What is the effectiveness of hydrophilic resin-based sealant (RBS) in preventing/arresting pits and fissures caries in permanent teeth, and 2) What is the retention rate of a hydrophilic RBS as compared to alternative treatments.

Data: Randomized control trials investigating the efficacy of hydrophilic RBS compared to any other (placebo) treatment for permanent teeth. Outcomes were retention rate and caries prevention/arresting. Read More

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September 2021

Improving the measurement of oral health-related quality of life: Rasch model of the Oral Health Impact Profile-14.

J Dent 2021 Sep 21:103819. Epub 2021 Sep 21.

Section for Outcomes Research, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria; Ludwig Boltzmann Institute for Arthritis and Rehabilitation, 1090, Vienna, Austria. Electronic address:

Objectives: The 14-item Oral Health Impact Profile (OHIP-14) is the most frequently used instrument to measure oral health-related quality-of-life (OHRQoL) in adults. Despite its popularity, its psychometric properties have been predominantly investigated based on the classical test theory while the fundamental principles of measurement have not been fully assessed. Therefore, our aim was to investigate to what extent the OHIP-14 meets the fundamental requirments of measurements. Read More

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September 2021

Mechanism by which Huoxue Tongluo Qiwei Decoction improves the erectile function of rats with diabetic erectile dysfunction.

J Ethnopharmacol 2021 Sep 21:114674. Epub 2021 Sep 21.

First Clinical Medical College, Beijing University of Chinese Medicine, Beijing, 100029, China; Andrology Department, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China. Electronic address:

Ethnopharmacological Relevance: Huoxue Tongluo Qiwei Decoction is a classical herbal formula, which can improve the symptoms of erectile dysfunction (ED) patients and has a good therapeutic effect on patients with diabetic erectile dysfunction (DIED). The main function of Huoxue Tongluo Qiwei Decoction is to stimulate the blood circulation and dredge collaterals, remove blood stasis, and calm wind.

Rationale: To further explore the mechanism of Huoxue Tongluo Qiwei Decoction in the treatment of DIED, related animal experiments were designed. Read More

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September 2021

Insight into Shenqi Jiangtang Granule on the improved insulin sensitivity by integrating in silico and in vivo approaches.

J Ethnopharmacol 2021 Sep 21:114672. Epub 2021 Sep 21.

Department of Endocrinology, Jining No. 1 People's Hospital, Jining, Shandong, 272000, China; Institute for Chronic Disease Management, Jining No. 1 People's Hospital, Jining, Shandong, 272000, China. Electronic address:

Ethnopharmacological Relevance: Presently, insulin resistance has been a growing concern that urgently needs to be addressed, because it not only places patients at risk of developing type 2 diabetes mellitus but also results in metabolic syndrome and different aspects of cardiovascular diseases. Shenqi Jiangtang Granule (SJG) is a classic traditional Chinese medicine (TCM) prescription that is widely used to treat diabetes mellitus and its complications in clinical practice. While studies have revealed that SJG with multi-ingredients and multi-targets characteristics possesses potential anti-insulin resistance pharmacological properties, its mechanisms of action and molecular targets for the treatment of insulin resistance are still obscure, which prompt us to conduct an in-depth research. Read More

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September 2021

In vitro Fourier transform infrared spectroscopic study of the effect of glycerol on the uptake of beclomethasone dipropionate in living respiratory cells.

Int J Pharm 2021 Sep 21:121118. Epub 2021 Sep 21.

Institute of Pharmaceutical Science, King's College London, London SE1 9NH, United Kingdom. Electronic address:

The quantification of drug in living cells is of increasing interest in pharmaceutical research because of its importance in understanding drug efficacy and toxicity. Label-free in situ measurement methods are advantageous for their ability to obtain chemical and time profiles without the need of labelling or extraction steps. We have previously shown that Fourier transform infrared (FTIR) spectroscopy has the potential to quantify drug in situ within living cells at micromolar level when a simple solution of drug was added to the medium. Read More

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September 2021

Screening of a Plesiomonas shigelloides Phage and Study of the Activity of Its Lysis System.

Virus Res 2021 Sep 21:198581. Epub 2021 Sep 21.

Helmholtz International Lab for Anti-Infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, P.R. China. Electronic address:

Plesiomonas shigelloides is an important fish pathogen that causes significant losses in aquaculture. Phage therapy is a new approach to overcome the problem of multidrug-resistant bacteria. Herein, a virulent phage of P. Read More

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September 2021

Semysinthetic biflavonoid Morelloflavone-7,4',7″,3‴,4‴-penta-O-butanoyl is a more potent inhibitor of Proprotein Convertases Subtilisin/Kex PC1/3 than Kex2 and Furin.

Biochim Biophys Acta Gen Subj 2021 Sep 21:130016. Epub 2021 Sep 21.

Centro Interdisciplinar de Investigação Bioquímica, Universidade de Mogi das Cruzes, 08780-911 Mogi das Cruzes, SP, Brazil. Electronic address:

Background: Garcinia brasiliensis is a species native to the Amazon forest. The white mucilaginous pulp is used in folk medicine as a wound healing agent and for peptic ulcer, urinary, and tumor disease treatments. The activity of the proprotein convertases (PCs) Subtilisin/Kex is associated with the development of viral, bacterial and fungal infections, osteoporosis, hyperglycemia, atherosclerosis, cardiovascular, neurodegenerative and neoplastic diseases. Read More

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September 2021

NIR as a "trigger switch" for rapid phase change, on-demand release, and photothermal synergistic antibacterial treatment with chitosan-based temperature-sensitive hydrogel.

Int J Biol Macromol 2021 Sep 21. Epub 2021 Sep 21.

College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, PR China. Electronic address:

Temperature-sensitive hydrogels have shown good performances as wound dressing owing to their ability to fill wounds in the liquid state and to release drugs in a solid state. However, their treatment efficiency is restricted by the phase transition time. In this study, we developed a photothermal synergistic chitosan-based temperature-sensitive hydrogel, h-EGF-CS/β[email protected], with the unique properties of rapid phase transition and drug release under near-infrared light (NIR). Read More

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September 2021