20 results match your criteria 2268 articles

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Use of therapeutic caffeine in acute care postoperative and critical care settings: a scoping review.

BMC Anesthesiol 2021 Mar 31;21(1):100. Epub 2021 Mar 31.

Department of Intensive Care Services, Royal Brisbane and Women's Hospital and Faculty of Health, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.

Background: Caffeine is the most utilised psychoactive drug worldwide. However, caffeine withdrawal and the therapeutic use of caffeine in intensive care and in the perioperative period have not been well summarised. Our objective was to conduct a scoping review of caffeine withdrawal and use in the intensive care unit (ICU) and postoperative patients. Read More

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Neuroprotective mechanisms of chronic physical exercise via reduction of β-amyloid protein in experimental models of Alzheimer's disease: A systematic review.

Life Sci 2021 Jun 18;275:119372. Epub 2021 Mar 18.

Laboratório de Bioquímica e Expressão Gênica, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil.

Aims: Alzheimer's disease (AD) is the most common irreversible chronic neurodegenerative disease. It is characterized by the abnormal accumulation of β-amyloid protein (Aβ), which triggers homeostatic breakage in several physiological systems. However, the effect of chronic exercise on the formation of Aβ as an alternative therapy has been investigated. Read More

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Efficacy and safety evaluation of benzalkonium chloride preserved eye-drops compared with alternatively preserved and preservative-free eye-drops in the treatment of glaucoma: a systematic review and meta-analysis.

Br J Ophthalmol 2020 11 12;104(11):1512-1518. Epub 2020 Feb 12.

Department of Ophthalmology, Copenhagen University Hospital, Rigshospitalet-Glostrup, Glostrup, Denmark

Background/aims: This systematic review compared the efficacy and safety of benzalkonium chloride (BAK)-preserved eye-drops with alternatively preserved (AP) and preservative-free (PF) eye-drops.

Methods: PubMed, EMBASE and MEDLINE were searched for randomised controlled trials in June and October 2019. Study selection, data extraction and risk of bias assessment were made by two independent reviewers using the Cochrane Handbook. Read More

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November 2020

Reflectance confocal microscopy diagnostic accuracy for malignant melanoma in different clinical settings: systematic review and meta-analysis.

J Eur Acad Dermatol Venereol 2020 Oct 27;34(10):2268-2279. Epub 2020 Feb 27.

Dermatology Unit, University of Modena and Reggio Emilia, Modena, Italy.

Background: The diagnostic accuracy of reflectance confocal microscopy (RCM) of cutaneous malignant melanoma (MM) seems promising. However, clinical scenarios in which RCM is most useful are still to be established.

Objectives: To assess the diagnostic accuracy of RCM for MM diagnosis according to study design, lesion type and diagnostic modality. Read More

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October 2020

Bevacizumab in the neoadjuvant treatment of human epidermal growth factor receptor 2-negative breast cancer: A meta-analysis of randomized controlled trials.

Mol Clin Oncol 2019 Mar 2;10(3):357-365. Epub 2019 Jan 2.

American University of Beirut Medical Center, Beirut 1107-2020, Lebanon.

Several randomized clinical trials have suggested the effectiveness of bevacizumab (Bev) in early and advanced breast cancer; however, due to the increased toxicity and lack of a clear long-term survival benefit, there is currently no defined role for Bev in breast cancer in the USA, while it has been approved in Europe. We herein sought to conduct a meta-analysis of large randomized trials comparing the efficacy and long-term outcome of neoadjuvant chemotherapy with Bev compared with chemotherapy without Bev in human epidermal factor receptor 2 (HER2)-negative breast cancer. A search was conducted through PubMed and Ovid Medline databases. Read More

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Post-operative paralysis and elective ventilation reduces anastomotic complications in esophageal atresia: a systematic review and meta-analysis.

Pediatr Surg Int 2019 Jan 10;35(1):87-95. Epub 2018 Nov 10.

Division of General and Thoracic Surgery, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.

Aim Of Study: The repair of esophageal atresia (EA) carries an increased risk of anastomotic leak and stricture formation, especially in patients with anastomotic tension. To minimize this risk, pediatric surgeons perform elective post-operative muscle paralysis, positive-pressure ventilation, and head flexion (PVF) to reduce movement and tension at the anastomosis. We systematically reviewed and analyzed the effect of post-operative PVF on reducing anastomotic complications. Read More

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January 2019

Diagnostic Value of lncRNAs as Biomarker in Hepatocellular Carcinoma: An Updated Meta-Analysis.

Can J Gastroenterol Hepatol 2018 15;2018:8410195. Epub 2018 Oct 15.

Key Laboratory of Carcinogenesis of the Chinese Ministry of Health and the Key Laboratory of Carcinogenesis and Cancer Invasion of Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha, China.

Some long noncoding RNAs (lncRNAs) display aberrantly high or low expression in hepatocellular carcinoma (HCC) and have the potential to serve as diagnostic biomarkers. Here, we accomplished a meta-analysis based on current studies to assess the diagnostic value of lncRNAs in HCC. Eligible literatures were systematically selected from PubMed, Web of Science, and Embase (up to January 20, 2018) according to defined inclusion and exclusion criteria. Read More

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Training Surgeons and Anesthesiologists to Facilitate End-of-Life Conversations With Patients and Families: A Systematic Review of Existing Educational Models.

J Surg Educ 2018 May - Jun;75(3):702-721. Epub 2017 Sep 20.

Center for Surgery and Public Health, Brigham and Women's Hospital, Boston, Massachusetts; Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:

Objective: Despite caring for patients near the end-of-life (EOL), surgeons and anesthesiologists report low confidence in their ability to facilitate EOL conversations. This discrepancy exists despite competency requirements and professional medical society recommendations. The objective of this systematic review is to identify articles describing EOL communication training available to surgeons and anesthesiologists, and to assess their methodological rigor to inform future curricular design and evaluation. Read More

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September 2019

Systematic Review: The Association between Late Life Depression and Hypotension.

J Am Med Dir Assoc 2016 12 11;17(12):1076-1088. Epub 2016 Aug 11.

The Irish Longitudinal Study on Aging (TILDA), Trinity College Dublin, Dublin, Ireland; Department of Age-Related Health Care, Tallaght Hospital, Dublin, Ireland.

Background: Late life depression (LLD), defined as depressive illness in people aged 60 years or older, is more complex than depression presenting in earlier life, with different clinical features and a poorer response to therapy. Different biological factors underlie LLD and hypotension may be an important modifiable risk factor. The aim of this systematic review is to clarify the relationship between hypotension and LLD. Read More

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December 2016

Home telemonitoring and remote feedback between clinic visits for asthma.

Cochrane Database Syst Rev 2016 Aug 3(8):CD011714. Epub 2016 Aug 3.

Population Health Research Institute, St George's, University of London, Cranmer Terrace, London, UK, SW17 0RE.

Background: Asthma is a chronic disease that causes reversible narrowing of the airways due to bronchoconstriction, inflammation and mucus production. Asthma continues to be associated with significant avoidable morbidity and mortality. Self management facilitated by a healthcare professional is important to keep symptoms controlled and to prevent exacerbations. Read More

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Incidentally detected non-palpable testicular tumours in adults at scrotal ultrasound: impact of radiological findings on management Radiologic review and recommendations of the ESUR scrotal imaging subcommittee.

Eur Radiol 2016 Jul 24;26(7):2268-78. Epub 2015 Oct 24.

Royal Sussex County Hospital Brighton and Brighton and Sussex Medical School, East Sussex, UK.

Objectives: The increasing detection of small testicular lesions by ultrasound (US) in adults can lead to unnecessary orchiectomies. This article describes their nature, reviews the available literature on this subject and illustrates some classical lesions. We also suggest recommendations to help characterization and management. Read More

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The current status of theory evaluation in nursing.

Authors:
Eun-Ok Im

J Adv Nurs 2015 Oct 28;71(10):2268-78. Epub 2015 May 28.

School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Aims: To identify the current status of theory evaluation in nursing and provide directions for theory evaluation for future development of theoretical bases of nursing discipline.

Background: Theory evaluation is an essential component in development of nursing knowledge, which is a critical element in development of nursing discipline. Despite earlier significant efforts for theory evaluation in nursing, a recent decline in the number of theory evaluation articles was noted and there have been few updates on theory evaluation in nursing. Read More

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October 2015

Parent-targeted mobile phone intervention to increase physical activity in sedentary children: randomized pilot trial.

JMIR Mhealth Uhealth 2014 Nov 10;2(4):e48. Epub 2014 Nov 10.

Pennington Biomedical Research Center, Population and Public Health, Baton Rouge, LA, United States.

Background: Low levels of moderate-to-vigorous physical activity are associated with adverse health consequences.

Objective: The intent of the study was to determine the feasibility and efficacy of a 12-week physical activity promotion program targeting children, which was delivered to parents through mobile phones.

Methods: Potential participants were recruited through advertisements placed in the newspaper, local hospitals and schools, and an email listserv. Read More

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November 2014

Culturally appropriate health education for people in ethnic minority groups with type 2 diabetes mellitus.

Cochrane Database Syst Rev 2014 Sep 4(9):CD006424. Epub 2014 Sep 4.

Cochrane Institute of Primary Care and Public Health, 3rd Floor Neuadd Meirionnydd, Cardiff University, Heath Park, Cardiff, UK, CF14 4YS.

Background: Ethnic minority groups in upper-middle-income and high-income countries tend to be socioeconomically disadvantaged and to have a higher prevalence of type 2 diabetes than is seen in the majority population.

Objectives: To assess the effectiveness of culturally appropriate health education for people in ethnic minority groups with type 2 diabetes mellitus.

Search Methods: A systematic literature search was performed of the following databases: The Cochrane Library, MEDLINE, EMBASE, PsycINFO, the Education Resources Information Center (ERIC) and Google Scholar, as well as reference lists of identified articles. Read More

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September 2014

THAM for control of ICP.

Neurocrit Care 2014 Oct;21(2):332-44

Section of Neurosurgery, Department of Surgery, University of Manitoba, Winnipeg, Canada,

Our goal was to perform a systematic review of the literature on the use of tromethamine (THAM) and its effects on intracranial pressure (ICP) in patients with neurological illness. All articles from MEDLINE, BIOSIS, EMBASE, Global Health, HealthStar, Scopus, Cochrane Library, the International Clinical Trials Registry Platform (inception to February 2014), reference lists of relevant articles, and gray literature were searched. Two reviewers independently identified all manuscripts pertaining to the administration of THAM in human patients that recorded effects on ICP. Read More

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October 2014

Combination ketamine and propofol for procedural sedation and analgesia.

Pharmacotherapy 2007 Nov;27(11):1588-98

Department of Pharmacy, Kelowna General Hospital, Interior Health Authority, 2268 Pandosy Street, Kelowna, British Columbia, Canada V1Y 1T2.

The combination of ketamine and propofol for procedural sedation and analgesia theoretically may be beneficial, with the rationale being that using lower doses of each agent may result in a reduction of the undesirable adverse effects of both agents while maintaining optimal conditions for performing procedures. To examine the current evidence for the efficacy and safety of ketamine and propofol in combination for procedural sedation and analgesia, we searched the MEDLINE (1966-March 2007), EMBASE (1980-March 2007), and Cochrane Database of Systematic Reviews (through the first quarter of 2007) databases for reports describing the use of ketamine and propofol in combination for procedural sedation and analgesia. Additional published reports were identified through a manual search of references from retrieved articles. Read More

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November 2007

Lichen sclerosus: review of the literature and current recommendations for management.

J Urol 2007 Dec 15;178(6):2268-76. Epub 2007 Oct 15.

Department of Surgery, Urology Service, Madigan Army Medical Center, Tacoma, Washington 98431, USA.

Purpose: We reviewed the literature regarding the clinical presentation, etiology, natural history, and medical and surgical management of lichen sclerosus in men.

Materials And Methods: We performed a comprehensive search of the literature in PubMed, MEDLINE and other electronic databases between 1950 and 2006 using the key words lichen sclerosis, balanitis xerotica obliterans and urethral stricture. Our search resulted in 1,268 sources containing the words lichen sclerosus or balanitis xerotica obliterans. Read More

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December 2007

Assessing observational studies of spinal fusion and chemonucleolysis.

Spine (Phila Pa 1976) 2003 Oct;28(19):2268-75

Department of Family Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242-1097, USA.

Study Design: Literature review and survey of spine surgeons.

Objectives: To identify reasons for variation in results among observational studies of spinal surgery.

Summary And Background Data: Orthopedic treatments are often evaluated by observational studies rather than randomized controlled trials. Read More

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October 2003

Day hospital versus admission for acute psychiatric disorders.

Cochrane Database Syst Rev 2003 (1):CD004026

Department of Community Psychiatry, University of Manchester, Academic Unit, Royal Preston Hospital, Sharoe Green Lane, Fulwood, Preston., Lancashire, UK, PR2 4HT.

Background: Inpatient treatment is an expensive way of caring for people with acute psychiatric disorders. It has been proposed that many of those currently treated as inpatients could be cared for in acute psychiatric day hospitals.

Objectives: To assess the effects of day hospital versus inpatient care for people with acute psychiatric disorders. Read More

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Systematic reviews of the effectiveness of day care for people with severe mental disorders: (1) acute day hospital versus admission; (2) vocational rehabilitation; (3) day hospital versus outpatient care.

Health Technol Assess 2001 ;5(21):1-75

University of Manchester, Guild Trust, Preston, UK.

Unlabelled: ***ACUTE DAY HOSPITAL VERSUS ADMISSION FOR ACUTE PSYCHIATRIC DISORDERS***

Background: Inpatient treatment is an expensive way of caring for people with acute psychiatric disorders. It has been proposed that many of those currently treated as inpatients could be cared for in acute psychiatric day hospitals.

Objective: The aim of this review was to assess the effectiveness and feasibility of day hospital versus inpatient care for people with acute psychiatric disorders. Read More

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September 2001
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