22,484 results match your criteria 220 patients

Minimally Invasive Short-Segment Anteroposterior Surgery for Thoracolumbar Osteoporotic Fractures with Canal Compromise: A Prospective Study with a Minimum 2-Year Follow-up.

Asian Spine J 2021 May 7. Epub 2021 May 7.

Department of Spine Surgery, Zentralklinik Bad Berka, Bad Berka, Germany.

Study Design: A prospective study with a minimum follow-up of 24 months.

Purpose: This study aimed to evaluate the results of minimally invasive anteroposterior surgery for osteoporotic vertebral fractures (OVFs) associated with bony spinal canal compromise in elderly patients.

Overview Of Literature: There is a recent increase in the incidence of osteoporosis with OVFs, causing an increasing burden on medical systems. Read More

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Ubiquitin-proteasome-system and enzymes of energy metabolism in skeletal muscle of patients with HFpEF and HFrEF.

ESC Heart Fail 2021 May 5. Epub 2021 May 5.

Department of Internal Medicine and Cardiology, Technische Universität Dresden, Heart Center Dresden - University Hospital, Herzzentrum Dresden, Universitätsklinik, Fetscherstraße 76, Dresden, 01307, Germany.

Background: Skeletal muscle (SM) alterations contribute to exercise intolerance in heart failure patients with preserved (HFpEF) or reduced (HFrEF) left ventricular ejection fraction (LVEF). Protein degradation via the ubiquitin-proteasome-system (UPS), nuclear apoptosis, and reduced mitochondrial energy supply is associated with SM weakness in HFrEF. These mechanisms are incompletely studied in HFpEF, and a direct comparison between these groups is missing. Read More

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Proliferative Glomerulonephritis: Risk Factor for Hypertension in Lupus.

Int J Hypertens 2021 15;2021:6691821. Epub 2021 Apr 15.

Department of Nephrology, Dalal Jamm University Hospital, Dakar, Senegal.

Studies report a high prevalence of hypertension in lupus, reaching up to 74%. The incidence of hypertension in SLE patients is increased with the severity of the kidney damage. This work was carried out with the objective of determining the prevalence of hypertension in lupus nephritis and to seek the existence of an association between the presence of a proliferative glomerulonephritis and hypertension. Read More

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Consultation-liaison psychiatry in Japan: a nationwide retrospective observational study.

BMC Psychiatry 2021 May 5;21(1):235. Epub 2021 May 5.

Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 1138519, Japan.

Background: Consultation-liaison psychiatry (CLP)-professional psychiatric care provided to coordinate with surgical or medical treatment of inpatients with psychiatric disorders-was included in universal health coverage in Japan in 2012. Despite evidence of benefits of CLP, basic data and geographic distribution information regarding CLP at the national level remain unclear. This study aimed to 1) identify the geographic disparity of CLP in Japan and 2) investigate the association between number of consultations per CLP patient and region. Read More

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Radiotherapy for locally advanced head and neck cancer in elderly patients: results and prognostic factors a single cohort.

Rep Pract Oncol Radiother 2021 25;26(1):12-19. Epub 2021 Feb 25.

Philosophy Sciences and Letters of Ribeirao Preto, University of São Paulo, Brazil.

Background: The objective of this study was to assess the treatment outcomes and prognostic factors of elderly patients with locally advanced head and neck cancer (LAHNC) undergoing radiotherapy (RT).

Materials And Methods: A retrospective cohort from a single institution, from 2000 to 2015, including patients older than 65 years old with LAHNC (stage III-IVa) treated by RT combined or not with chemotherapy (CRT). Univariate and multivariate analysis (MVA) were performed to identify prognostic factors associated with overall survival (OS), cancer-specific survival (CS), and locoregional control (LRC). Read More

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February 2021

Reliability and structural validity of the Dutch version of Perceived Stigmatization Questionnaire in adults with burns.

Burns 2020 Dec 11. Epub 2020 Dec 11.

Association of Dutch Burn Centres, P.O. Box 1015, 1940 EA Beverwijk, The Netherlands; Department of Clinical Psychology, Utrecht University, P.O. Box 80140, 3508 TC Utrecht, The Netherlands.

Objective: Burn scars can attract attention from others which can be perceived as stigmatizing behavior with negative psychological consequences. The Perceived Stigmatization Questionnaire (PSQ) is a validated instrument measuring the perception of stigmatization in burn survivors. The objective of this study was to examine the psychometric properties of the Dutch version of the PSQ, specifically its factor structure, reliability, and associations with other relevant constructs. Read More

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December 2020

Evaluation of the effectiveness and safety of adding ivermectin to treatment in severe COVID-19 patients.

BMC Infect Dis 2021 May 4;21(1):411. Epub 2021 May 4.

Gulhane Faculty of Medicine, University of Health Sciences, Ankara, Turkey.

Background And Objectives: An effective treatment option is not yet available for SARS-CoV2, which causes the COVID-19 pandemic and whose effects are felt more and more every day. Ivermectin is among the drugs whose effectiveness in treatment has been investigated. In this study; it was aimed to investigate the presence of gene mutations that alter ivermectin metabolism and cause toxic effects in patients with severe COVID-19 pneumonia, and to evaluate the effectiveness and safety of ivermectin use in the treatment of patients without mutation. Read More

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Platelet-Lymphocyte ratio is a predictor for the development of no-reflow phenomenon in patients with ST-segment elevation myocardial infarction after thrombus aspiration.

J Clin Lab Anal 2021 May 4:e23795. Epub 2021 May 4.

Department of Cardiology, Tepecik Training and Research Hospital, Izmir, Turkey.

Backround: We aimed to evaluate the utility of the preprocedural platelet-lymphocyte ratio (PLR) for predicting the no-reflow phenomenon after thrombus aspiration during percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI).

Method: We retrospectively analyzed postprocedural thrombolysis in myocardial infarction (TIMI) flow grades and myocardial blush grades (MBG) of 247 patients who underwent a PCI procedure with thrombus aspiration.We divided these patients into two groups according to whether they had no-reflow (TIMI < 3, MBG < 2) or not (TIMI 3, MBG ≥ 2). Read More

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Associations Between Blood Trace Element Levels and Nutritional Status in Maintenance Hemodialysis.

J Ren Nutr 2021 Apr 30. Epub 2021 Apr 30.

Department of Nephrology, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, Guangdong, China; Guangzhou Institute of Disease-Oriented Nutritional Research, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, Guangdong, China.

Objective(s): We aimed to investigate the associations between blood trace element levels and nutritional status in patients undergoing maintenance hemodialysis (MHD).

Methods: This cross-sectional study included patients undergoing MHD who were treated at our center in September 2019. Clinical and demographic data and blood samples were collected before hemodialysis sessions, and the levels of manganese, lead, selenium, zinc, and copper were measured by inductively coupled plasma mass spectrometry. Read More

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Allogeneic hematopoietic cell transplantation with cord blood versus mismatched unrelated donor with post-transplant cyclophosphamide in acute myeloid leukemia.

J Hematol Oncol 2021 May 3;14(1):76. Epub 2021 May 3.

EBMT ALWP Office, Hôpital Saint-Antoine, Paris, France.

Background: Allogeneic hematopoietic cell transplantation (allo-HCT) using a mismatched unrelated donor (MMUD) and cord blood transplantation (CBT) are valid alternatives for patients without a fully human leukocyte antigen (HLA)-matched donor. Here, we compared the allo-HCT outcomes of CBT versus single-allele-mismatched MMUD allo-HCT with post-transplant cyclophosphamide (PTCy) in acute myeloid leukemia.

Methods: Patients who underwent a first CBT without PTCy (N = 902) or allo-HCT from a (HLA 9/10) MMUD with PTCy (N = 280) were included in the study. Read More

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J Vasc Surg 2021 Apr 30. Epub 2021 Apr 30.

Vascular Surgery Unit, First Department of Propedeutic Surgery, National and Kapodistrian University of Athens, Hippocration Hospital, Athens, Greece.

Introduction: ExtraCranial Carotid artery Aneurysms (ECCAs) are rare, although they are associated with a high stroke and mortality risk if untreated. This review aims to compare major outcomes between open and endovascular repair of ECCAs.

Methods: We systematically searched PubMed, Embase, Scopus, and the Cochrane Library for clinical studies published online up to September 2020 that evaluated major outcomes after both open and endovascular repair of ECCAs. Read More

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Clinical Outcomes of COVID-19 Patients Treated with Convalescent Plasma or Remdesivir Alone and in Combination at a Community Hospital in California's Central Valley.

J Pharm Pharm Sci 2021 ;24:210-219

University of the Pacific, Thomas J. Long School of Pharmacy, Stockton CA, USA.

Purpose: The purpose of this study was to compare how treatment with convalescent plasma (CP) monotherapy, remdesivir (RDV) monotherapy, and combination therapy (CP + RDV) in patients with COVID-19 affected clinical outcomes.

Methods: Patients with COVID-19 infection who were admitted to the hospital received CP, RDV, or combination of both. Mortality, discharge disposition, hospital length of stay (LOS), intensive care unit (ICU) LOS, and total ventilation days were compared between each treatment group and stratified by ABO blood group. Read More

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January 2021

Clinical Characteristics and Transmission of COVID-19 in Children and Youths During 3 Waves of Outbreaks in Hong Kong.

JAMA Netw Open 2021 05 3;4(5):e218824. Epub 2021 May 3.

Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.

Importance: Schools were closed intermittently across Hong Kong to control the COVID-19 outbreak, which led to significant physical and psychosocial problems among children and youths.

Objective: To compare the clinical characteristics and sources of infection among children and youths with COVID-19 during the 3 waves of outbreaks in Hong Kong in 2020.

Design, Setting, And Participants: This cross-sectional study involved children and youths aged 18 years or younger with COVID-19 in the 3 waves of outbreaks from January 23 through December 2, 2020. Read More

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Comparative Trial of the Effects of Left Ventricular and Biventricular Pacing on Indices of Cardiac Function and Clinical Course of Patients With Heart Failure: Rationale and Design of the READAPT Randomized Trial.

Angiology 2021 May 3:33197211012520. Epub 2021 May 3.

First University Department of Cardiology, Hippokration Hospital, Athens, Greece.

Nonresponse to cardiac resynchronization therapy (CRT) has been related with right ventricular dysfunction. Ventriculoarterial coupling (VAC) assesses energy efficiency of the failing heart and stroke work maximization for a given contractility, for both systemic and pulmonary circulations. Preferential left ventricular pacing (pLVP) can overcome iatrogenic right ventricular dysfunction by achieving left ventricle resynchronization and by allowing for intrinsic activation of the right side, with ramifications extending beyond cardiac output and atrial fibrillation occurrence. Read More

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Bile Acids Impair Vaccine Response in Children With Biliary Atresia.

Front Immunol 2021 16;12:642546. Epub 2021 Apr 16.

Department of Liver Surgery and Liver Transplantation, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: Vaccination is the best way to protect children under 5 years from death or disability. Children with biliary atresia (BA), which is the most common pediatric cholestatic end-stage liver disease (PELD), are more vulnerable to infectious diseases. However, the vaccination coverage and factors modulating vaccine responses in children with BA are largely unknown. Read More

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Differentiation between hepatocellular carcinoma and intrahepatic cholangiocarcinoma using contrast-enhanced ultrasound: A systematic review and meta-analysis.

Clin Hemorheol Microcirc 2021 Apr 28. Epub 2021 Apr 28.

Zhongshan Hospital, Fudan University, Shanghai, China.

Aim: To explore the diagnostic ability of contrast-enhanced ultrasound (CEUS) in distinguishing intrahepatic cholangiocarcinoma (ICC) from hepatocellular carcinoma (HCC).

Materials And Methods: PubMed, EMBASE, Cochrane Library, and Web of Science were systematically searched for studies reporting the diagnostic accuracy of CEUS in differentiating ICC from HCC. The diagnostic ability of CEUS was assessed based on the pooled sensitivity, specificity, diagnostic odds ratio (DOR), positive likelihood ratio (PLR), negative likelihood ratio (NLR) and area under the curve (AUC) with 95% confidence intervals (CIs). Read More

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A functional variant of the lncRNA AL110200 is associated with the risk of ischemic stroke recurrence.

Eur J Neurol 2021 May 1. Epub 2021 May 1.

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: This study aimed to test the hypothesis that lncRNA AL110200 exerts a proinflammatory effect on atherosclerosis and that the variant rs901681 contributes to ischemic stroke incidence and recurrence.

Methods: The expression of AL110200 was analyzed in THP-1 cells treated with oxidized low-density lipoprotein (ox-LDL) and in human peripheral blood in a coronary heart disease (CHD)-control population to determine the role of AL110200 in atherosclerosis. The effect of AL110200 on cell adhesion and invasion was tested. Read More

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The effects of breathing training on dyspnea and anxiety among patients with acute heart failure at emergency department.

Int Emerg Nurs 2021 Apr 29;56:101008. Epub 2021 Apr 29.

Adult Nursing Department, Faculty of Nursing, KhonKaen University, Thailand. Electronic address:

Background: Anxiety-related dyspnea is a compelling symptom among patients with acute heart failure (AHF). Breathing training is a nonpharmacological intervention to relieve dyspnea and anxiety. This study aimed to investigate the effects of breathing training on dyspnea and anxiety among patients with AHF at the emergency department (ED). Read More

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Application of methane and hydrogen-based breath test in the study of gestational diabetes mellitus and intestinal microbes.

Diabetes Res Clin Pract 2021 Apr 28:108818. Epub 2021 Apr 28.

Department of Obstetrics and Gynaecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan ,China.

Objective: Gestational diabetes mellitus (GDM) is a common complication of pregnancy. The purpose of this study was to compare the incidence of small intestinal bacterial overgrowth (SIBO) in patients with GDM and the control group by methane and hydrogen lactulose breath test (LBT), and to explore its relationship with inflammation, vitamins, and the outcomes of maternal and child.

Methods: LBT was detected in 220 GDM patients, 160 pregnancy control patients and 160 pre-pregnancy control patients. Read More

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Comparing Botulinum Toxin Injections with Extraocular Muscle Surgery in Toddlers with Esotropia: A Retrospective Analysis.

Klin Monbl Augenheilkd 2021 Apr 30;238(4):478-481. Epub 2021 Apr 30.

Ophthalmology, Universitätsspital Basel Augenklinik, Basel, Switzerland.

Background: In toddlers with esotropia, early alignment of the visual axes either with extraocular muscle surgery (EOMS) or botulinum toxin injections (BTIs) into both medial rectus muscles may result in improved depth perception. We compared the outcome of BTIs with EOMS in toddlers in order to gain further insight into the advantages and disadvantages of either method.

Patients And Methods: In this retrospective study, our encrypted database was searched for toddlers with esotropia aged 35 months or younger at the time of initial treatment with either BTIs or EOMS and who had a follow-up of at least 2 years. Read More

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Frame-based and robot-assisted insular stereo-electroencephalography via an anterior or posterior oblique approach.

J Neurosurg 2021 Apr 30:1-10. Epub 2021 Apr 30.

1Department of Neurosurgery.

Objective: There is an increasing interest in stereo-electroencephalography (SEEG) for invasive evaluation of insular epilepsy. The implantation of insular SEEG electrodes, however, is still challenging due to the anatomical location and complex functional segmentation in both an anteroposterior and ventrodorsal (i.e. Read More

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Mechanisms of PhotoBioModulation (PBM) focused on oral mucositis prevention and treatment: a scoping review.

BMC Oral Health 2021 Apr 29;21(1):220. Epub 2021 Apr 29.

Département de Radiothérapie, Institut de Cancérologie de La Loire - Lucien Neuwirth, 42270, St Priest en Jarez, France.

Background: Oral mucositis (OM) is a severe complication cancer patients undergo when treated with chemoradiotherapy. Photobiomodulation (PBM) therapy also known as low-level laser therapy has been increasingly used for the treatment of such oral toxicity. The aim of this review is to discuss the mechanisms of photobiomodulation (PBM) regarding OM prevention and treatment, and more precisely to focus on the effect of PBM on tumor and healthy cells. Read More

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Rota-Lithotripsy-A Novel Bail-Out Strategy for Calcified Coronary Lesions in Acute Coronary Syndrome. The First-in-Man Experience.

J Clin Med 2021 Apr 26;10(9). Epub 2021 Apr 26.

Department of Internal Medicine, Hypertension and Clinical Oncology, Wroclaw Medical University, 50-556 Wroclaw, Poland.

Heavy calcification remains one of the greatest challenges in the treatment of coronary artery disease (CAD), especially in subjects with an acute coronary syndrome (ACS). In the present case series study of high-risk patients with ACS, including both STEMI and NSTEMI, we performed a rota-lithotripsy-a combination of rotational atherectomy with subsequent intravascular lithotripsy-as a novel bail-out strategy to facilitate stent delivery in a tortuous calcified coronary artery. Read More

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Novel App-Based Portable Spirometer for the Early Detection of COPD.

Diagnostics (Basel) 2021 Apr 27;11(5). Epub 2021 Apr 27.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

Chronic obstructive pulmonary disease (COPD) is preventable and treatable. However, many patients remain undiagnosed and untreated due to the underutilization or unavailability of spirometers. Accordingly, we used Spirobank Smart, an app-based spirometer, for facilitating the early detection of COPD in outpatient clinics. Read More

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Long-Acting Reversible Contraception: Placement, Continuation, and Removal Rates at an Inner-City Academic Medical Center Clinic.

J Clin Med 2021 Apr 28;10(9). Epub 2021 Apr 28.

NIH-Women's Reproductive Health Research (WRHR) Scholar, Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48202, USA.

Long-Acting Reversible Contraception (LARCs) has the potential to decrease unintended pregnancies but only if women can easily access a requested method. Retrospective electronic chart review identified women desiring LARC placement over a one-year period ending 31 December 2016. Most of the 311 insertions were for family planning, with 220 new insertions and 60 replacements. Read More

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Complex Liver Resections for Intrahepatic Cholangiocarcinoma.

J Clin Med 2021 Apr 13;10(8). Epub 2021 Apr 13.

Asklepios Campus Hamburg, Semmelweis University of Medicine, 20099 Hamburg, Germany.

The only curative treatment option for intrahepatic cholangiocarcinoma (iCCA) is liver resection. Due to central tumor localization and vascular invasion, complex liver resections play an important role in curative treatment. However, the long-term outcomes after complex liver resection are not known. Read More

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rs2234237 (Thr25Ser) Polymorphism in Patients with Cutaneous Leishmaniasis Caused by : A Case-Control Study in the State of Amazonas, Brazil.

Pathogens 2021 Apr 20;10(4). Epub 2021 Apr 20.

Programa de Pós-Graduação em Imunologia Básica e Aplicada, Universidade Federal do Amazonas, Manaus 69080-900, AM, Brazil.

Background: Leishmaniasis is an infectious disease caused by parasites. A Th1 immune response is necessary in the acute phase to control the pathogen. The triggering receptor expressed on myeloid cells (TREM)-1 is a potent amplifier of inflammation. Read More

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A Smartcard-Based User-Controlled Single Sign-On for Privacy Preservation in 5G-IoT Telemedicine Systems.

Sensors (Basel) 2021 Apr 20;21(8). Epub 2021 Apr 20.

Department of Information Management, Chang Gung University, Taoyuan 333, Taiwan.

Healthcare is now an important part of daily life because of rising consciousness of health management. Medical professionals can know users' health condition if they are able to access information immediately. Telemedicine systems, which provides long distance medical communication and services, is a multi-functional remote medical service that can help patients in bed in long-distance communication environments. Read More

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New Sequence Type ST3449 in Multidrug-Resistant Isolates from a Cystic Fibrosis Patient.

Antibiotics (Basel) 2021 Apr 23;10(5). Epub 2021 Apr 23.

Instituto de Investigación Sanitaria Marqués de Valdecilla (IDIVAL), 39011 Santander, Spain.

is one of the most critical bacterial pathogens associated with chronic infections in cystic fibrosis patients. Here we show the phenotypic and genotypic characterization of five consecutive multidrug-resistant isolates of collected during a month from a CF patient with end-stage lung disease and fatal outcome. The isolates exhibited distinct colony morphologies and pigmentation and differences in their capacity to produce biofilm and virulence potential evaluated in larvae of . Read More

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