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Age- and gender-related normative value of whole-body sagittal alignment based on 584 asymptomatic Chinese adult population from age 20 to 89.

Stud Health Technol Inform 2021 Jun;280:66-71

SH Ho Scoliosis Research Laboratory, Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.

To establish the age- and sex-related normative values of sagittal alignment in asymptomatic Chinese adults, and to investigate the changes and possible associated compensation mechanisms across age groups. 584 asymptomatic Chinese adults aged 20-89 years were recruited. Subjects were grouped according to age and gender. Read More

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Machine-driven simulation of removing luting agent remnants from implant surfaces: An investigator-independent assessment of cleaning protocols.

J Mech Behav Biomed Mater 2021 09 25;121:104584. Epub 2021 May 25.

Department of Prosthodontics, University Hospital Regensburg, Germany.

Introduction: To simulate removing luting agent remnants from crowns fixed onto implant-abutment analogs using a standardized machine-driven protocol including a scaler and air polishing or sonic.

Material And Methods: A motor-driven device was constructed that controlled the rotational speed of the specimens, machining distance, contact pressure, and working time. A standardized layer of cement (Provicol, VOCO; Cuxhaven, G; Ketac Cem, 3MEspe; Seefeld, G; or Rely X Unicem, 3MEspe, Seefeld, G) was placed onto the finishing line of the crowns luted onto titanium-abutment analogs. Read More

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September 2021

Identification of novel mutation in RANKL by whole-exome sequencing in a Thai family with osteopetrosis; a case report and review of RANKL osteopetrosis.

Mol Genet Genomic Med 2021 May 30:e1727. Epub 2021 May 30.

Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Osteopetrosis is a rare form of skeletal dysplasia characterized by increased bone density that leads to bone marrow failure, compressive neuropathy, and skeletal dysmorphism. Molecular diagnosis is essential as it guides treatment and prognosis. We report Thai siblings with an ultra-rare form of osteopetrosis. Read More

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Laparoscopic gynaecological surgery in the context of maintaining normal intracranial pressure.

BMJ Case Rep 2021 May 12;14(5). Epub 2021 May 12.

Epworth Hospital, Richmond, Victoria, Australia.

A nulliparous patient in her early 20s was referred to a fertility specialist for fertility preservation, before commencing chemo-radiation therapy for a recently diagnosed malignant brain tumour. Two weeks prior, she had presented with seizures and undergone emergency craniotomy and tumour resection. Taking into consideration of the tight time frame and her comorbidities, several measures were undertaken to minimise the potential increase in intracranial pressure that may lead to cerebral oedema during laparoscopy. Read More

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Utilization of Nivolumab in Adenoid Cystic Carcinoma After Progression on Platinum-Based Chemotherapy.

Perm J 2021 May;25

Ochsner Cancer Institute, New Orleans, LA.

Introduction: Adenoid cystic carcinoma (ACC) is a rare malignant neoplasm within the secretory glands of the head and neck. Clinical findings include a lump on the palate, tongue, or bottom of the mouth. Because symptoms can be mild, patients go for long periods of time without investigation. Read More

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Different Etching Times of a One-step Ceramic Primer: Effect on the Resin Bond Strength Durability to a CAD/CAM Lithium-Disilicate Glass-Ceramic.

J Adhes Dent 2021 Apr;23(2):133-143

Purpose: To evaluate the effect of different etching times of a self-etching ceramic primer on the microshear bond strength (µSBS) and topographic surface pattern of a lithium-disilicate glass-ceramic.

Materials And Methods: Ceramic slices were subjected to an in-lab simulation of CAD/CAM milling and randomly allocated to 10 groups (n = 35) considering two factors: "surface treatment" in 5 levels - one control group (5% hydrofluoric acid + silane application [HF5+SIL]), and 4 experimental groups using ceramic etching/primer (Monobond Etch & Prime, E&P) with different passive application times (40 s, 2 min, 5 min, or 10 min); and "aging" factor in 2 levels - short-term (after 24 h), or long-term (storage for 180 days + 12,000 thermal cycles). Composite cement cylinders were built and µSBS tests were run in a universal testing machine. Read More

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Psoriasis: Pathogenesis, Comorbidities, and Therapy Updated.

Naoko Kanda

Int J Mol Sci 2021 Mar 15;22(6). Epub 2021 Mar 15.

Department of Dermatology, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Chiba 2701694, Japan.

Psoriasis is a chronic inflammatory skin disease characterized by IL-17-dominant abnormal innate and acquired immunity, and the hyperproliferation and aberrant differentiation of epidermal keratinocytes, and comorbid arthritis or cardiometabolic diseases. This Special Issue presented updated information on pathogenesis, comorbidities, and therapy of psoriasis. The pathogenesis of psoriasis may involve the dysfunction of indoleamine 2,3-dioxygenase 2 or of UBA domain containing 1-mediated regulation of CARD14/CARMA2. Read More

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Analysis of the Dynamic Proteasome Structure by Cross-Linking Mass Spectrometry.

Biomolecules 2021 03 27;11(4). Epub 2021 Mar 27.

Proteomics of Cellular Signaling, Department of Infection and Immunity, Luxembourg Institute of Health, 1a Rue Thomas Edison, 1445 Strassen, Luxembourg.

The 26S proteasome is a macromolecular complex that degrades proteins maintaining cell homeostasis; thus, determining its structure is a priority to understand its function. Although the 20S proteasome's structure has been known for some years, the highly dynamic nature of the 19S regulatory particle has presented a challenge to structural biologists. Advances in cryo-electron microscopy (cryo-EM) made it possible to determine the structure of the 19S regulatory particle and showed at least seven different conformational states of the proteasome. Read More

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Successful management of three cases of interstitial pregnancies with local instillation of potassium chloride: avoiding a potential cornuostomy.

BMJ Case Rep 2021 Mar 23;14(3). Epub 2021 Mar 23.

Obstetrics and Gynecology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Here, we present three cases of women with interstitial pregnancy who were managed with local instillation of potassium chloride. These women were in their 20s-30s and presented in stable condition. Of them, two had a history of previous ectopic pregnancy. Read More

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A mucinous cystic neoplasm of the pancreas containing an undifferentiated carcinoma component and harboring the NRAS driver mutation.

Clin J Gastroenterol 2021 Jun 12;14(3):910-917. Epub 2021 Mar 12.

Clinical Department of Pathology, Gunma University Hospital, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8511, Japan.

A woman in her 20s visited our hospital with a chief complaint of abdominal distension and back pain. She was diagnosed with a cystic tumor (diameter 16 cm) in the tail of the pancreas and underwent a combined distal pancreatectomy, splenectomy, and left adrenalectomy. Histopathologically, the tumor presented as a mucinous cystic neoplasm with an undifferentiated carcinoma component of the pancreas. Read More

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Recurrent Syncope Caused by a Dural Arteriovenous Fistula: A Case Report and Review of the Literature.

Neurologist 2021 Mar 4;26(2):62-65. Epub 2021 Mar 4.

Department of Neurosurgery, University of Miami, Miami, FL.

Background: Dural arteriovenous fistulas (DAVFs) are pathologic vascular connections that shunt dural arterial flow directly to dural venous drainage. Only a few isolated case reports describe syncope on presentation. We report the first case of DAVF causing recurrent, progressive syncope in an otherwise asymptomatic patient. Read More

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Demographic and clinical phenotypic differences between people with dissociative seizures and those with other psychiatric disorders.

BJPsych Open 2021 Feb 24;7(2):e61. Epub 2021 Feb 24.

Institute of Medical and Biomedical Education, St George's University of London, UK; and Atkinson Morley Regional Neuroscience Centre, St George's University Hospitals NHS Foundation Trust, London, UK.

Background: A large amount of literature surrounds the differences between dissociative neurological symptom disorder with non-epileptic seizures (DNSD-S) and epilepsy.

Aims: To explore the research gap on phenotypic differences between DNSD-S and other psychiatric disorders.

Method: We conducted a case-control study of 1860 patients (620 patients with DNSD-S and 1240 controls with other psychiatric disorders) seen at the South London and Maudsley Hospital NHS Trust between 2007 and 2019. Read More

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February 2021

Methicillin-resistant (MRSA) panniculitis in a patient undergoing stem cell mobilisation.

BMJ Case Rep 2021 Feb 9;14(2). Epub 2021 Feb 9.

Department of Haematology, National University Cancer Institute Singapore, National University Health System, Singapore.

Methicillin-resistant (MRSA) can cause a wide range of skin infections, however MRSA panniculitis without bacteremia is a rare manifestation. Here, we report a woman in her 20s with relapsed Hodgkin lymphoma undergoing stem cell mobilisation who presented with bilateral subcutaneous nodules over her shins. Ultrasound scan of one nodule showed non-specific inflammatory changes. Read More

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February 2021

Cautery Disbudding Iron Application Time and Brain Injury in Goat Kids: A Pilot Study.

Front Vet Sci 2020 18;7:568750. Epub 2021 Jan 18.

Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, United States.

Cautery disbudding is a painful procedure performed on goat kids to prevent horn growth that may result in brain injury. Thermal damage to the cerebral cortex of the brain and subsequent neurologic disease is a primary concern. Cautery iron application time may affect transmission of heat to the brain; however, research in this area is scarce. Read More

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January 2021

Otospondylomegaepiphyseal Dysplasia: A Case Report of Clinical and Radiographic Findings.

JBJS Case Connect 2020 10 16;10(4):e20.00140. Epub 2020 Oct 16.

Department of Orthopedic Surgery, University of Minnesota, Minneapolis, Minnesota.

Case: We present a long-term follow-up on a woman with otospondylomegaepiphyseal dysplasia (OSMED). At the age of 46 years, she is one of the oldest patients with the syndrome in the literature to date. We focus on the musculoskeletal anatomy and orthopaedic interventions over her lifetime. Read More

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October 2020

Chronic pain susceptibility is associated with anhedonic behavior and alterations in the accumbal ubiquitin-proteasome system.

Pain 2021 06;162(6):1722-1731

Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.

Abstract: It remains unknown why on similar acute/subacute painful conditions, pain persists in some individuals while in others it resolves. Genetic factors, mood, and functional alterations, particularly involving the mesolimbic network, seem to be key. To explore potential susceptibility or resistance factors, we screened a large population of rats with a peripheral neuropathy and we isolated a small subset (<15%) that presented high thresholds (HTs) to mechanical allodynia (reduced pain manifestation). Read More

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Retina 2021 Jul;41(7):1373-1378

Vitreous Retina Macula Consultants of New York, New York.

Purpose: To analyze swept-source optical coherence angiography images acquired at different depths above and below the default location of the Zeiss PLEX Elite 9000.

Methods: Normal eyes of subjects in their 20s and 30s were evaluated. Angiographic slab images were taken at the default location of 29 µm to 49 µm below the retinal pigment epithelium and 21 µm to 41 µm through 52 µm to 72 µm below in steps. Read More

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Synthesis of Alkaloid Demissidine Stereoisomers and Analogues.

J Org Chem 2021 01 4;86(2):1575-1582. Epub 2021 Jan 4.

Faculty of Chemistry, University of Białystok, Ciołkowskiego 1K, 15-245 Białystok, Poland.

Demissidine is an indolizidine alkaloid isolated from several potato species. A simple synthesis of demissidine stereoisomers and analogues from a common steroidal sapogenin tigogenin is presented in the paper. The key intermediate in the synthesis of these compounds is readily available tigogenoic acid. Read More

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January 2021

Multiple Cerebrovascular Insults in Pseudoxanthoma Elasticum.

J Stroke Cerebrovasc Dis 2021 Mar 24;30(3):105524. Epub 2020 Dec 24.

Department of Neurology, University of Virginia Health System, P.O. Box 800394, Charlottesville, VA 22908, United States. Electronic address:

Pseudoxanthoma elasticum (PXE) is a rare systemic genetic disorder and an uncommon cause of ischaemic and haemorrhagic strokes. Its rarity and variable presentation may delay recognition and diagnosis of the primary disorder or associated conditions. Here, we describe a patient of European ancestry diagnosed with PXE in her 20s who presented in her 50s with a haemorrhagic stroke. Read More

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Effect of different surface treatments and multimode adhesive application on the Weibull characteristics, wettability, surface topography and adhesion to CAD/CAM lithium disilicate ceramic.

J Appl Oral Sci 2020 27;28:e20200122. Epub 2020 Nov 27.

Universidade Federal do Rio Grande do Norte (UFRN), Departamento de Odontologia, Natal / RN, Brasil.

Methodology: This paper aims to evaluate the effect of different surface treatments on surface topography, wettability, and shear bond strength of resin cement to glass ceramic. For SBS test, 32 blocks (7x7x2 mm) of lithium disilicate were obtained and randomly divided into eight groups (four blocks per group) according to each surface treatment (HF 20 s, 60 s, 120 s + silanization/S or Scotch Bond Universal/ SBU) and the Monobond Etch & Prime - MEP application followed or not by SBU. On each treated surface ceramic block, up to four dual-curing resin cement cylinders were prepared and light-cured for 40s (N=120/n=15). Read More

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January 2021

Two Cases of Female Chinese Adult-Onset Krabbe Disease with One Novel Mutation and a Review of Literature.

J Mol Neurosci 2021 Jun 14;71(6):1185-1192. Epub 2020 Nov 14.

Neurology Department, Xuanwu Hospital, No 45, Changchun Road, Beijing, 100053, People's Republic of China.

This study presented two Chinese adult female patients who were diagnosed with adult-onset Krabbe disease (KD) and reviewed this disease in Chinese patients. Two young female adults in their 20s were enrolled in this study. Clinical data, including symptoms, magnetic resonance imaging (MRI) scanning, and laboratory studies were collected. Read More

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A germline 1;3 translocation disrupting the gene: a novel genetic cause for von Hippel-Lindau.

J Med Genet 2020 Oct 16. Epub 2020 Oct 16.

Urologic Oncology Branch, National Cancer Institue, Bethesda, Maryland, USA

Von Hippel-Lindau (VHL) disease is an autosomal dominant hereditary tumour susceptibility disease caused by germline pathogenic variation of the tumour suppressor gene. Affected individuals are at risk of developing multiple malignant and benign tumours in a number of organs.In this report, a male patient in his 20s who presented to the Urologic Oncology Branch at the National Cancer Institute with a clinical diagnosis of VHL was found to have multiple cerebellar haemangioblastomas, bilateral epididymal cysts, multiple pancreatic cysts, and multiple, bilateral renal tumours and cysts. Read More

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October 2020

Red and Processed Meat Consumption and Risk of Depression: A Systematic Review and Meta-Analysis.

Int J Environ Res Public Health 2020 09 14;17(18). Epub 2020 Sep 14.

School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.

Depression is one of the leading causes of disability worldwide, with more than 264 million people affected. On average, depression first appears during the late teens to mid-20s as result of a complex interaction of social, psychological and biological factors. The aim of this systematic review with meta-analysis is to assess the association between red and processed meat intake and depression (both incident and prevalent). Read More

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September 2020

Arthritis in the hands of saints shown in 15th century Venetian altarpieces by Bartolomeo Vivarini.

Rheumatol Int 2021 Sep 15;41(9):1701-1704. Epub 2020 Sep 15.

School of Humanities and Social Sciences, University of New England, Armidale, NSW, 2351, Australia.

Bartolomeo Vivarini (1432-1499) was the most prolific member of a prominent 15th-century Venetian family of artists who specialised in religious art, particularly altarpieces. Unlike their Florentine counterparts, Venetian artists of this period were typically more concerned with decorative effects than with accuracy of description, so their paintings often lacked detailed anatomical information. Bartolomeo, however, began the move toward anatomical realism in the Vivarini family. Read More

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September 2021

Fluorescent Probes with Unnatural Amino Acids to Monitor Proteasome Activity in Real-Time.

ACS Chem Biol 2020 09 26;15(9):2588-2596. Epub 2020 Aug 26.

Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 West Stadium Avenue, West Lafayette, Indiana 47907, United States.

The proteasome is an essential protein complex that, when dysregulated, can result in various diseases in eukaryotic cells. As such, understanding the enzymatic activity of the proteasome and what can alter it is crucial to elucidating its roles in these diseases. This can be done effectively by using activity-based fluorescent substrate probes, of which there are many commercially available that target the individual protease-like subunits in the 20S CP of the proteasome. Read More

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September 2020

Glass table injuries: A silent public health problem.

Am J Surg 2020 11 26;220(5):1296-1299. Epub 2020 Jul 26.

Department of Surgery, Rutgers New Jersey Medical School, Newark, NJ, USA.

Background: Glass tables can break and cause traumatic injury. This public health issue is avoidable by adequate regulatory measures. We describe the burden and characteristics of these injuries using the National Electronic Injury Surveillance System (NEISS) database and data from a level 1 trauma center. Read More

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November 2020

Extensive Pneumorrhachis After Spontaneous Pneumomediastinum.

World Neurosurg 2020 10 18;142:392-395. Epub 2020 Jul 18.

Department of Neurosurgery, Mount Sinai Hospital System, New York, New York, USA. Electronic address:

Background: Pneumorrhachis is the presence of air within the spinal canal and is most often traumatic or iatrogenic in etiology. Rarely, a small amount of pneumorrhachis can be seen with spontaneous pneumomediastinum. Here we describe a case of asymptomatic longitudinally extensive pneumorrhachis associated with spontaneous pneumomediastinum. Read More

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October 2020

Identification of the Novel Target Genes for Osteosarcoma Therapy Based on Comprehensive Bioinformatic Analysis.

DNA Cell Biol 2020 Jul 23;39(7):1172-1180. Epub 2020 Jun 23.

Department of Orthopaedic Surgery, Peking Union Medical College and Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China.

Osteosarcoma is one of the most common primary malignant tumors of the bone and tends to develop in teenage years. Although multitreatments for the diagnosis and therapy of osteosarcoma have been developed, there are still needs of new methods to prevent and treat the osteosarcoma. Here, we performed bioinformatic analysis to screen for the key genes, molecules, and pathways involved in osteosarcoma survival. Read More

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Severe cardiac involvement with preserved truncated dystrophin expression in Becker muscular dystrophy by +1G>A DMD splice-site mutation: a case report.

J Hum Genet 2020 Oct 5;65(10):903-909. Epub 2020 Jun 5.

Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Japan.

Becker muscular dystrophy (BMD) is caused by specific mutations in the DMD gene that causes progressive muscle weakness and primarily affects skeletal and cardiac muscle. Although cardiac involvement is a significant cause of mortality in BMD, the genetic-phenotype correlation for skeletal and cardiac muscles has not been elucidated. Here, we described a 39-year-old man with BMD, who presented with subtle skeletal muscle weakness in the right leg in his 20s and underwent left ventricular restoration for severe dilated cardiomyopathy at the age of 29. Read More

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October 2020