222,450 results match your criteria 2019 pathological


Analytical and clinical performance of cPass neutralizing antibodies assay.

Clin Biochem 2021 Sep 21. Epub 2021 Sep 21.

Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, 77030, United States; Section of Clinical Chemistry, Division of Laboratory Medicine, Department of Pathology, Texas Children's Hospital, Houston, TX, 77030, United States. Electronic address:

Serological tests for SARS-CoV-2 are a critical component of disease control strategies. SARS-CoV-2 serology tests used in clinical diagnostic should not accurately evaluate total levels the antibodies but also closely correlate with neutralizing antibodies titers. However, only limited data is available reporting correlation of neutralization antibody assays with commercial high-throughput serological assays widely used in clinical laboratories. Read More

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September 2021

Collapsing glomerulopathy in a patient with APOL1 intermediate-risk genotype triggered by lupus nephritis and SARS-CoV-2 infection: lessons for the clinical nephrologist.

J Nephrol 2021 Sep 24. Epub 2021 Sep 24.

Department of Nephrology and Transplantation, Institut de Transplantation Urologie Néphrologie (ITUN), CHU de Nantes, 30 boulevard Jean Monnet, 44000, Nantes, France.

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September 2021

Are open surgery and total resection good choices for traumatic myositis ossificans in children?

Int Orthop 2021 Sep 24. Epub 2021 Sep 24.

Orthopedics Department, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, Children's Hospital of Chongqing Medical University, Yuzhong District Zhongshan 2road 136#, Chongqing, 400014, People's Republic of China.

Background: Traumatic myositis ossificans is a self-limited, non-neoplastic, ectopic bone formation in the soft tissues caused by trauma. Conservative treatment is the mainstay of management. However, open surgery and complete resection should be considered in patients with limited joint function and constant pain. Read More

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September 2021

Laparoscopic radical hysterectomy with enclosed colpotomy without the use of uterine manipulator for early-stage cervical cancer.

J Minim Access Surg 2021 Oct-Dec;17(4):570-572

Department of Obstetrics and Gynecoloty, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.

Background: We report the application of transuterine suspension sutures (TUSSs) for manipulation and vaginal closure before colpotomy in laparoscopic radical hysterectomy for early-stage cervical cancer.

Methodology: Eight patients with clinical stage IB1 cervical squamous cell cancer were treated with laparoscopic radical hysterectomy between October 2019 and May 2020. The procedure was performed without a traditional uterine manipulator, and the vaginal cuff was closed with a stapler before colpotomy to prevent tumour spillage. Read More

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September 2021

Pivotal role of video-assisted thoracoscopic surgery in improving survival outcome of stage I non-small cell lung cancer in day surgery patients.

Thorac Cancer 2021 Sep 23. Epub 2021 Sep 23.

Department of Thoracic Surgery, Sichuan University West China Hospital, Chengdu, China.

Background: Lung cancer, the leading cause of cancer-related deaths worldwide, has high morbidity rates. Video-assisted thoracoscopic surgery (VATS) as day surgery makes surgical treatment ideally in time with the same quality of medical care. This study aimed to assess the safety of stage I NSCLC patients who underwent VATS at a day surgery center. Read More

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September 2021

Axillary management based on American college of surgeons oncology group Z0011 criteria makes it possible to omit intraoperative diagnosis of sentinel lymph nodes in early breast cancer patients.

Breast J 2021 Sep 23. Epub 2021 Sep 23.

Department of Breast and Endocrine Surgery, Osaka International Cancer Institute, Osaka, Japan.

The ACOSOG Z0011 trial has resulted in the omission of axillary lymph node dissection (ALND) in early breast cancer patients with one or two metastatic sentinel lymph nodes (SLNs). There has been increasing interest in the necessity of intraoperative assessment of SLNs in patients treated based on the Z0011 criteria. We evaluated the utility of intraoperative assessment in these eligible patients. Read More

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September 2021

Transfusion management of trauma from the 2019 El Paso mass shooting incident.

Vox Sang 2021 Sep 23. Epub 2021 Sep 23.

Department of Pathology, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA.

Background And Objectives: Mortality rates, transfusion ratios, trauma management logistics, and assault characteristics from the El Paso mass shooting incident (MSI) are evaluated in comparison to other MSIs. In 2019, El Paso, TX experienced the eighth-deadliest MSIs in modern US history. In this 21st mass killing in the United States of 2019, 19 people died immediately, and four of 27 injured, later died from ballistic injuries. Read More

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September 2021

Learning from Few Subjects with Large Amounts of Voice Monitoring Data.

Proc Mach Learn Res 2019 Aug;106:704-720

University of Toronto, Vector Institute.

Recently, researchers have started training high complexity machine learning models to clinical tasks, often improving upon previous benchmarks. However, more often than not, these methods require large amounts of supervision to provide good generalization guarantees. When applied to data coming from small cohorts and long monitoring periods these models are prone to overfit to subject-identifying features. Read More

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Circulating Vascular Adhesion Protein-1 Level Predicts the Risk of Cardiovascular Events and Mortality in Hemodialysis Patients.

Front Cardiovasc Med 2021 7;8:701079. Epub 2021 Sep 7.

Division of Nephrology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea.

Vascular adhesion protein-1 (VAP-1) is an oxidative enzyme of primary amines that facilitates the transmigration of inflammatory cells. Its oxidative and inflammatory effects are prominently increased in pathological conditions, such as metabolic, atherosclerotic, and cardiac diseases. However, the clinical significance of circulating VAP-1 levels in hemodialysis (HD) patients is unclear. Read More

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September 2021

Longitudinal Characterization of Cytokine Overproduction: A Case Report in Critically Ill COVID-19 Patients With Hyperinflammation in Bronchoalveolar Lavage.

Front Med (Lausanne) 2021 7;8:690523. Epub 2021 Sep 7.

Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, China.

The longitudinal characterization and risk of poor outcomes related to cytokine overproduction in critical coronavirus disease 2019 (COVID-19) patients with hyperinflammation in bronchoalveolar lavage requires further investigation. We enrolled two critically ill patients with comorbidities diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detected by RT-PCR during hospitalization. Clinical characteristics, longitudinal immunological, and biochemical parameters of each critical COVID-19 case were collected. Read More

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September 2021

Effectiveness of a Simulation-Based Training Program in Improving the Preparedness of Health Care Workers Involved in the Airway Management of COVID-19 Patients.

Cureus 2021 Aug 20;13(8):e17323. Epub 2021 Aug 20.

Pathology, Advanced Center of Continuous Professional Development, All India Institute of Medical Sciences, Rishikesh, IND.

Background Coronavirus disease 2019 (COVID-19) has currently emerged as a global threat and a significant public health issue. The role of simulation-based training (SBT) during such a pandemic becomes more relevant for teaching a team approach and building capacity especially when there is a threat to health care workers due to aerosol generation and there is a huge demand for manpower during the pandemic. Objective To assess the effectiveness of a simulation-based training program in improving knowledge and concept of teamwork of health care workers involved in airway management of suspected or confirmed COVID-19 patients. Read More

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Gaucher's Disease in an Adult Female: A Rare Entity.

Cureus 2021 Aug 20;13(8):e17318. Epub 2021 Aug 20.

General Medicine, All India Institute of Medical Sciences, Raipur, IND.

Gaucher's disease is a rare inborn error of metabolism with an autosomal recessive pattern of inheritance. With over 26 million births occurring per annum, extrapolation of this figure would give us an estimated burden of 17,000 babies born with lysosomal storage disorder (LSD). Given the large population of India and the high rates of consanguineous marriage that takes place in the subcontinent, LSD might not be as rare as we perceive it to be. Read More

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Association of Low Molecular Weight Plasma Aminothiols with the Severity of Coronavirus Disease 2019.

Oxid Med Cell Longev 2021 18;2021:9221693. Epub 2021 Sep 18.

Institute of General Pathology and Pathophysiology, Baltiyskaya St., 8, 125315 Moscow, Russia.

Objective: Aminothiols (glutathione (GSH), cysteinylglycine (CG)) may play an important role in the pathogenesis of coronavirus disease 2019 (COVID-19), but the possible association of these indicators with the severity of COVID-19 has not yet been investigated.

Methods: The total content () and reduced forms () of aminothiols were determined in patients with COVID-19 ( = 59) on admission. Lung injury was characterized by computed tomography (CT) findings in accordance with the CT0-4 classification. Read More

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September 2021

Clinico-radio-pathological Features and Biological Behavior of Breast Cancer in Young Indian Women: A Prospective Study.

Indian J Radiol Imaging 2021 Apr 30;31(2):323-332. Epub 2021 Jul 30.

Department of Radio-Diagnosis, Basavatarkam Indo-American Cancer Hospital and Research Centre, Hyderabad, Telangana, India.

The aim of the study is to evaluate the characteristic imaging features of breast cancer on mammogram, ultrasound, and magnetic resonance imaging (MRI) in women less than 40 years of age and to assess the degree of correlation between clinico-radio-pathological features and biological behavior. A prospective observational study on consecutive women under 40 years of age evaluated with ultrasound of breast, digital mammogram, or contrast-enhanced breast MRI, diagnosed with breast cancer on histopathology and molecular analysis done at our center between January and December 2019 were included. Patient demographics, clinical presentation, family history, BRCA mutation status, imaging, pathological findings, and molecular status were determined. Read More

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Seroprevalence of antibodies against severe acute respiratory coronavirus 2 (SARS-CoV-2) in household dogs in Japan.

J Vet Med Sci 2021 Sep 24. Epub 2021 Sep 24.

Department of Veterinary Clinical Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo.

We investigated the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among dogs in the Tokyo area via enzyme-linked immunosorbent assay (ELISA) using the spike protein as the target antigen. Plasma samples from 494 household dogs and blood-donor dogs were tested from July 2020 to January 2021. Of these samples, three showed optical densities that were higher than the mean plus two standard deviations of the mean of the negative-control ODs. Read More

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September 2021

How Coronavirus Disease 2019 Changed Dermatology Practice in 1 Year Around the World: Perspectives from 11 Countries.

Dermatol Clin 2021 Oct 31;39(4):639-651. Epub 2021 May 31.

Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA. Electronic address:

Coronavirus disease 2019 (COVID-19) brought the world to its knees. As each nation grappled with launching an effective response while simultaneously minimizing repercussions on health care systems, economies, and societies, the medical and scientific landscape shifted forever. In particular, COVID-19 has challenged and transformed the field of dermatology and the way we practice. Read More

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October 2021

Cutaneous Pathology of COVID-19 as a Window into Immunologic Mechanisms of Disease.

Dermatol Clin 2021 Oct 22;39(4):533-543. Epub 2021 Jul 22.

Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA; Department of Dermatology, University of California, San Francisco, 513 Parnassus Avenue, Room HSE1001E, San Francisco, CA 94143, USA. Electronic address:

Many skin manifestations of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection reflect activation of cutaneous and systemic immune responses involving effector pathways of both the innate and adaptive arms of the immune system. This article reviews evidence from the recent clinical and scientific literature that informs the current understanding of the consequences of coronavirus disease 2019 (COVID-19)-induced immune cell activation, as relevant to dermatology. Topics include the clinical consequences of autoantibody production in patients with COVID-19, immunologic evidence for chilblains as a manifestation of SARS-CoV-2 infection, and the relationship between type I interferons and COVID-19 disease severity. Read More

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October 2021

Ten-year epidemiological study of ocular and orbital tumors in Chiba University Hospital.

BMC Ophthalmol 2021 Sep 23;21(1):344. Epub 2021 Sep 23.

Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Inohana 1-8-1, Chuo-ku, Chiba, 260-8670, Japan.

Background: The purpose of this study is to determine the epidemiology of tumors of the ocular adnexa and orbit in Japan.

Methods: We conducted a retrospective study on the histopathological reports in the medical records of the Chiba University Hospital from April 2009 to March 2019. Three hundred and seventy two records were examined. Read More

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September 2021

Changes in magnetic resonance imaging relaxation time on postmortem magnetic resonance imaging of formalin-fixed human normal heart tissue.

BMC Med Imaging 2021 Sep 23;21(1):134. Epub 2021 Sep 23.

Department of Radiology, Faculty of Medical Science, University of Fukui, 23-3 Matsuoka Shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui, 910-1193, Japan.

Background: Postmortem magnetic resonance imaging (MRI) has been used to investigate the cause of death, but due to time constraints, it is not widely applied to the heart. Therefore, MRI analysis of the heart after formalin fixation was previously performed. However, the changes in MRI signal values based on the fixation time of formalin were not investigated. Read More

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September 2021

The Utility of Indocyanine Green Dye Fluorescence Lymphography and Angiography During Wide Excision of Cutaneous Melanoma.

Surg Innov 2021 Sep 24:15533506211020226. Epub 2021 Sep 24.

Division of Plastic Surgery, Department of Surgery, 63452Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

. Lymph node status is the most important prognostic factor in cutaneous melanoma patients. Recent studies showed that indocyanine green (ICG) fluorescence lymphography helps locating sentinel nodes better. Read More

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September 2021

Minimally invasive management of juvenile cystic adenomyoma: report of three cases.

Facts Views Vis Obgyn 2021 Sep;13(3):271-276

Background: Juvenile cystic adenomyosis (JCA) represents a rare form of focal adenomyosis in young women.

Objectives: To determine safety and effectiveness of minimally invasive surgery (MIS for JCA).

Materials And Methods: Three patients aged 16-30 years old presented with chronic pelvic pain [2016 - 2019]. Read More

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September 2021

The spatially resolved transcriptional profile of acute T-cell mediated rejection in a kidney allograft.

Kidney Int 2021 Sep 20. Epub 2021 Sep 20.

Analysis of the transcriptional profile of graft biopsies represents a promising strategy to study T cell mediated-rejection (TCMR), also known as acute cellular rejection. However, bulk RNA sequencing of graft biopsies may not capture the focal nature of acute rejection. Herein, we used the whole exome GeoMX Digital Space Profiling platform to study five tubular and three glomerular regions of interest in the kidney graft biopsy from a patient with a chronic-active TCMR episode and in analogous areas from two different normal kidney control biopsies. Read More

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September 2021

Oxygen sensing, anaesthesia and critical care: a narrative review.

Anaesthesia 2021 Sep 23. Epub 2021 Sep 23.

Nuffield Department of Anaesthetics, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

In 2019, the scientists who discovered how cells sense and adapt to oxygen availability were awarded the Nobel Prize. This elegant sensing pathway is conserved throughout evolution, and it underpins the physiology and pathology that we, as clinicians in anaesthesia and critical care, encounter on a daily basis. The purpose of this review is to bring hypoxia-inducible factor, and the oxygen-sensing pathway as a whole, to the wider clinical community. Read More

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September 2021

SARS-CoV-2 coinfection with additional respiratory virus does not predict severe disease: a retrospective cohort study.

J Antimicrob Chemother 2021 Sep;76(Supplement_3):iii12-iii19

Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.

Background: The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) claimed over 4 million lives by July 2021 and continues to pose a serious public health threat.

Objectives: Our retrospective study utilized respiratory pathogen panel (RPP) results in patients with SARS-CoV-2 to determine if coinfection (i.e. Read More

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September 2021

Atypical Lobular Hyperplasia and Classic Lobular Carcinoma In Situ Can Be Safely Managed Without Surgical Excision.

Ann Surg Oncol 2021 Sep 23. Epub 2021 Sep 23.

Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA.

Background: Based on modern series demonstrating low upgrade rates for pure lobular neoplasia (LN) diagnosed on core needle biopsy (CNB), our institution no longer recommends routine excision, provided imaging is concordant. This study describes outcomes in patients managed without surgical excision.

Methods: From an institutional database, we identified all patients with a diagnosis of pure atypical lobular hyperplasia and/or classic lobular carcinoma in situ on CNB managed without surgical excision (i. Read More

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September 2021

Prognosis Associated With Luminal and Basal Subtypes of Metastatic Prostate Cancer.

JAMA Oncol 2021 Sep 23. Epub 2021 Sep 23.

Department of Human Oncology, University of Wisconsin, Madison.

Importance: Luminal and basal subtypes of primary prostate cancer have been shown to be molecularly distinct and clinically important in predicting response to therapy. These subtypes have not been described in metastatic prostate cancer.

Objectives: To identify clinical and molecular correlates of luminal and basal subtypes in metastatic castration-resistant prostate cancer (mCRPC) and investigate differences in survival, particularly after treatment with androgen-signaling inhibitors (ASIs). Read More

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September 2021

Detection of rabbit hemorrhagic disease virus 2 in formalin-fixed, paraffin-embedded tissues via in situ hybridization.

J Vet Diagn Invest 2021 Sep 23:10406387211047561. Epub 2021 Sep 23.

Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.

Formalin-fixed, paraffin-embedded tissues from European rabbits () that succumbed to rabbit hemorrhagic disease virus 2 (RHDV2; GI.2) during the 2019 outbreak in Washington, USA, were utilized for in situ hybridization via RNAscope (ACDBio). This detection method was both sensitive and specific, with no staining in tissues from RHDV- ( GI. Read More

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September 2021

Recherche sur la fin de vie, la nécessité d’un consensus : premiers résultats.

Sante Publique 2021 March-April;33(2):191-198

During the past 15 years, in France, like in many European countries, the attention paid to patients at the end of their lives has continued to grow. But in the meantime, only a few researchers have managed to collect reliable data on End-of-Life Care and to implement scientific studies describing the reality of these situations. This difficulty is due in particular to the lack of a recognized and operational definition of the end of life. Read More

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September 2021

HLA-B*15:11 status and carbamazepine-induced severe cutaneous adverse drug reactions in HLA-B*15:02 negative Chinese.

Int J Dermatol 2021 Sep 22. Epub 2021 Sep 22.

Division of Transplantation and Immunogenetics, Department of Pathology, Queen Mary Hospital, Hong Kong, Hong Kong.

Background: HLA-B*15:11 is associated with carbamazepine (CBZ)-induced severe cutaneous adverse drug reactions (SCARs) in Japanese and some Asian populations, but such data remains relatively limited in Chinese. Routine HLA-B*15:02 screening is mandatory before CBZ commencement, however, SCARs related to CBZ were still observed in non-HLA*B-15:02 carriers.

Objective: We aimed to find out the prevalence of HLA-B*15:11 in Chinese patients and its associations with CBZ-induced SCARs. Read More

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September 2021

Benefits and harms of implementing [F]FDG-PET/CT for diagnosing recurrent breast cancer: a prospective clinical study.

EJNMMI Res 2021 Sep 22;11(1):93. Epub 2021 Sep 22.

Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.

Background: [F]-fluorodeoxyglucose-positron emission tomography/computed tomography ([F]FDG-PET/CT) has been implemented sporadically in hospital settings as the standard of care examination for recurrent breast cancer. We aimed to explore the clinical impact of implementing [F]FDG-PET/CT for patients with clinically suspected recurrent breast cancer and validate the diagnostic accuracy.

Methods: Women with suspected distant recurrent breast cancer were prospectively enrolled in the study between September 2017 and August 2019. Read More

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September 2021