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Comparison of percutaneous endoscopic lumbar discectomy and open lumbar discectomy in the treatment of adolescent lumbar disc herniation: A retrospective analysis.

World Neurosurg 2021 May 11. Epub 2021 May 11.

Department of Orthopedics, Peking University Third Hospital, Beijing, China. Electronic address:

Objective: To compare and analyze the efficacy and safety of percutaneous endoscopic lumbar discectomy (PELD) and open lumbar discectomy (OLD) for adolescent lumbar disc herniation (ALDH).

Methods: The clinical data of 257 patients with single-segment ALDH who underwent surgical treatment at our hospital from January 2015 to December 2019 were retrospectively collected. According to different surgical methods, these patients were divided into PELD group and OLD group. Read More

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Measuring the impact of cardiotocograph decision support software on neonatal outcomes: A propensity score-matched observational study.

Aust N Z J Obstet Gynaecol 2021 May 13. Epub 2021 May 13.

Mater Mothers' Hospital, South Brisbane, Queensland, Australia.

Background: This study follows the 2017 UK INFANT Collaborative Group RCT, which compared neonatal outcomes with and without the use of the INFANT cardiotocograph decision support system for over 46 000 patients in labour. The original trial failed to demonstrate a significant improvement to neonatal outcomes; however, the study design was subject to methodological critique.

Aims: This Australian retrospective cohort study aimed to report perinatal outcomes before and after the introduction of INFANT decision support software for cardiotocograph use in labour. Read More

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Immune checkpoint inhibitor plus tyrosine kinase inhibitor for unresectable hepatocellular carcinoma in the real world.

Ann Transl Med 2021 Apr;9(8):652

Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.

Background: This study aimed to evaluate safety and efficacy of programmed death-1 (PD-1) inhibitor sintilimab plus tyrosine kinase inhibitors (TKI) in a real-word cohort of patients with unresectable hepatocellular carcinoma (uHCC).

Methods: A total of 60 patients treated with sintilimab plus TKI between February 2019 and December 2019 were enrolled. Radiological response was recorded by computed tomography (CT) or magnetic resonance imaging (MRI) at baseline and every 6-12 weeks after treatment initiation. Read More

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Similar outcomes after newly implemented rats approach compared to standard vats for anatomical lung resection. A propensity-score matched analysis.

Cir Esp 2021 May 10. Epub 2021 May 10.

Service of Thoracic Surgery, Salamanca University Hospital, Salamanca, Spain; Salamanca Institute of Biomedical Research, Spain.

Introduction: Outcomes after the introduction of surgical innovations can be impaired by learning periods. The aim of this study is to compare the short-term outcomes of a recently implemented RATS approach to a standard VATS program for anatomical lung resections.

Methods: Retrospective review of consecutive patients undergoing pulmonary anatomical resection through a minimally invasive approach since RATS approach was applied in our department (June 01, 2018, to November 30, 2019). Read More

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Minimally invasive aortic valve replacement: short-term efficacy of sutureless compared with stented bioprostheses.

Interact Cardiovasc Thorac Surg 2021 May 13. Epub 2021 May 13.

Department of Cardiac Surgery, Anthea Hospital, GVM Care &Research, Bari, Italy.

Objectives: Sutureless aortic valve prostheses have been introduced to facilitate the implant process, speed up the operating time and improve haemodynamic performance. The goal of this study was to assess the potential advantages of using sutureless prostheses during minimally invasive aortic valve replacement in a large multicentre population.

Methods: From 2011 to 2019, a total of 3402 patients in 11 hospitals underwent isolated aortic valve replacement with minimal access approaches using a bioprosthesis. Read More

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COVID19-CT-dataset: an open-access chest CT image repository of 1000+ patients with confirmed COVID-19 diagnosis.

BMC Res Notes 2021 May 12;14(1):178. Epub 2021 May 12.

Department of Medical Informatics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Objectives: The ongoing Coronavirus disease 2019 (COVID-19) pandemic has drastically impacted the global health and economy. Computed tomography (CT) is the prime imaging modality for diagnosis of lung infections in COVID-19 patients. Data-driven and Artificial intelligence (AI)-powered solutions for automatic processing of CT images predominantly rely on large-scale, heterogeneous datasets. Read More

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Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials.

Lancet Healthy Longev 2021 May 6;2(5):e250-e262. Epub 2021 May 6.

resTORbio, Boston, MA, USA.

Background: The COVID-19 pandemic highlights the need for therapies that improve immune function in older adults, including interferon (IFN)-induced antiviral immunity that declines with age. In a previous phase 2a trial, RTB101 (previously known as BEZ235), an oral mechanistic target of rapamycin (mTOR) inhibitor, was observed to increase IFN-induced antiviral gene expression and decrease the incidence of respiratory tract infections (RTIs) in older adults. Therefore, we aimed to investigate whether oral RTB101 upregulated IFN-induced antiviral responses and decreased the incidence of viral RTIs when given once daily for 16 weeks during winter cold and flu season. Read More

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Modified "Blumgart-Type" Suture for Wirsung-Pancreaticogastrostomy: Technique and Results of a Pilot Study.

Eur Surg Res 2021 May 11:1-10. Epub 2021 May 11.

University of Bari "Aldo Moro" Medical School, Bari, Italy.

Introduction: Postoperative pancreatic fistula (POPF) represents the principal determinant of morbidity and mortality after pancreaticoduodenectomy. Since 1994 we have been performing pancreaticogastrostomy with duct-to-mucosa anastomosis (Wirsung-pancreaticogastric anastomosis [WPGA]), but postoperative morbidity, although limited, was still a concern. An original pancreas-transfixing suture technique, named "Blumgart's anastomosis" (BA), has shown efficacy at reducing fistula rates from pancreaticojejunostomy. Read More

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Extrapleural Pneumonectomy versus Pleurectomy/Decortication for Malignant Pleural Mesothelioma.

Ann Thorac Surg 2021 May 7. Epub 2021 May 7.

Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

Background: Whether extrapleural pneumonectomy (EPP) or extended pleurectomy/decortication (P/D) is the optimal resection for malignant pleural mesothelioma (MPM) remains controversial. We therefore compared perioperative outcomes and long-term survival of patients who underwent EPP vs P/D.

Methods: Patients with the diagnosis of MPM who underwent either EPP or P/D from 2000 to 2019 were identified from our departmental database. Read More

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Predictors for inpatient mortality during the first wave of the SARS-CoV-2 pandemic: A retrospective analysis.

PLoS One 2021 10;16(5):e0251262. Epub 2021 May 10.

White Plains Hospital, White Plains, New York, United States of America.

Background: The coronavirus disease 2019 (COVID-19) pandemic overwhelmed healthcare systems, highlighting the need to better understand predictors of mortality and the impact of medical interventions.

Methods: This retrospective cohort study examined data from every patient who tested positive for COVID-19 and was admitted to White Plains Hospital between March 9, 2020, and June 3, 2020. We used binomial logistic regression to analyze data for all patients, and propensity score matching for those treated with hydroxychloroquine and convalescent plasma (CP). Read More

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Controller Medication Use and Exacerbations for Children and Adults With Asthma in High-Deductible Health Plans.

JAMA Pediatr 2021 May 10. Epub 2021 May 10.

Harvard Pilgrim Health Care Institute, Department of Population Medicine, Harvard Medical School, Boston, Massachusetts.

Importance: High-deductible health plans (HDHPs) are increasingly common and associated with decreased medication use in some adult populations. How children are affected is less certain.

Objective: To examine the association between HDHP enrollment and asthma controller medication use and exacerbations. Read More

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Efficacy Evaluation of Thymosin Alpha 1 in Non-severe Patients With COVID-19: A Retrospective Cohort Study Based on Propensity Score Matching.

Front Med (Lausanne) 2021 23;8:664776. Epub 2021 Apr 23.

Department of Liver Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

Thymosin alpha 1 (Thymosin-α1) is a potential treatment for patients with COVID-19. We aimed to determine the effect of Thymosin-α1 in non-severe patients with COVID-19. We retrospectively enrolled 1,388 non-severe patients with COVID-19. Read More

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The Impact of COVID-19 on Psychiatric Emergency and Inpatient Services in the First Month of the Pandemic in a Large Urban Mental Health Hospital in Ontario, Canada.

Front Psychiatry 2021 23;12:563906. Epub 2021 Apr 23.

Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

The World Health Organization characterized COVID-19 (coronavirus disease 2019) as a pandemic on March 11, 2020 (WHO). Within a couple of days, all Canadian provinces announced the implementation of social distancing measures. We evaluated the immediate effect of COVID-19 on psychiatric emergency and inpatient services in Canada's largest psychiatric hospital in the first month of the pandemic. Read More

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Systemic inflammatory response index as an independent risk factor for ischemic stroke in patients with rheumatoid arthritis: a retrospective study based on propensity score matching.

Clin Rheumatol 2021 May 9. Epub 2021 May 9.

Science and Education Section, Wujin Hospital Affiliated with Jiangsu University, Changzhou City, Jiangsu Province, China.

Objective: To investigate the relationship between systemic inflammatory response index (SIRI) and ischemic stroke (IS) in rheumatoid arthritis (RA) patients.

Methods: Fifty-two RA patients with IS, who were admitted to Wujin Hospital Affiliated with Jiangsu University between 2015 and 2019, were selected as the study group, and 236 RA patients without IS were selected as the control group. Propensity score matching (PSM) function of SPSS 26. Read More

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Comparative study of Japanese frozen elephant trunk device for open aortic arch repairs.

J Thorac Cardiovasc Surg 2021 Apr 1. Epub 2021 Apr 1.

Center for Cerebral and Cardiovascular Disease Information, National Cerebral and Cardiovascular Center, Osaka, Japan.

Objective: We performed a multicenter prospective comparative study to determine the impact of a Japanese frozen elephant trunk device on total arch replacement compared with conventional repair without it.

Methods: Between 2016 and 2019, a total of 684 patients (frozen elephant trunk procedure; n = 369; conventional repair, n = 315) from 41 institutions were enrolled. The 2 procedures were selected according to each center's strategy. Read More

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Optimizing transfusion management of multiple myeloma patients receiving daratumumab-based regimens.

Transfusion 2021 May 7. Epub 2021 May 7.

Department of Pathology, University of California San Diego, La Jolla, California, USA.

Background: Daratumumab, a human anti-CD38 monoclonal antibody used to treat multiple myeloma, interferes with pretransfusion testing and can mask alloantibodies. Incidence of alloimmunization in patients on daratumumab has not been well characterized, and optimal transfusion guidelines regarding prophylactic antigen matching, accounting for both patient safety and efficiency, have not been well established for these patients.

Methods: Records of patients who received daratumumab between January 1, 2014 and July 2, 2019 were reviewed. Read More

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Update on Immunology of COVID-19 Disease and Potential Strategy for Controlling.

Tanaffos 2020 Dec;19(4):274-290

Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Coronavirus disease 2019 (COVID-19) is caused by a novel form of the coronavirus that caused severe acute respiratory syndrome (SARS). SARS-CoV-2 raised in China and has broadcast to 261 countries globally. SARS-CoV-2 a member of β-coronavirus family and has an almost matching genome sequence to a bat coronavirus, pointing to the bat as the natural host before it was transmitted to humans. Read More

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December 2020

Taxonomic studies on the sac spider genus (Araneae, Clubionidae) from Xishuangbanna Rainforest, China.

Zookeys 2021 26;1034:1-163. Epub 2021 Apr 26.

School of Biological Sciences, Guizhou Education University, Guiyang, Guizhou, China.

Spiders of the genus Latreille, 1804 from Xishuangbanna, Yunnan Province, China are studied. A total of 47 species is reported and illustrated, including 14 new species and two new synonyms. Twelve of the new species belong to four species groups: Yu & Li, , Yu & Li, , Yu & Li, , Yu & Li, , Yu & Li, , Yu & Li, , Yu & Li, and Yu & Li, from the group; Yu & Li, and Yu & Li, from the group; Yu & Li, from the group; and Yu & Li, from the group. Read More

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Tofacitinib versus tocilizumab in the treatment of biological-naïve or previous biological-failure patients with methotrexate-refractory active rheumatoid arthritis.

RMD Open 2021 May;7(2)

Rheumatic and Collagen Disease Center, Sasebo Chuo Hospital, Sasebo, Japan.

Objectives: To compare effectiveness between tofacitinib and tocilizumab treatments for biological disease-modifying antirheumatic drug (bDMARD)-naïve patients or previous bDMARD-failure patients with active rheumatoid arthritis (RA) refractory to methotrexate (MTX).

Methods: We used two ongoing real-world registries of patients with RA who had first started tofacitinib or tocilizumab between August 2013 and February 2019 at our institutions. Clinical disease activity index (CDAI)-based improvements at 12 months were used for comparisons between tofacitinib and tocilizumab treatments, separately for bDMARD-naïve and previous bDMARD-failure patients. Read More

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Clinical Efficacy of the Preservation of the Hepatic Branch of the Vagus Nerve on Delayed Gastric Emptying After Laparoscopic Pancreaticoduodenectomy.

J Gastrointest Surg 2021 May 5. Epub 2021 May 5.

Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave., Wuhan, 430030, Hubei, China.

Background: Delayed gastric emptying (DGE) is a common complication following laparoscopic pancreaticoduodenectomy (LPD), although it remains incompletely understood, and only few studies have investigated the clinical benefits of hepatic branch of the vagus nerve (HBVN) preservation on DGE after LPD until now. We intended to evaluate the effect of preservation of the HBVN during LPD on the incidence of DGE.

Methods: A total of 274 consecutive LPDs performed at a single center between July 2014 and December 2019 with available videos were retrospectively reviewed. Read More

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Diversifying the health workforce: a mixed methods analysis of an employment integration strategy.

Hum Resour Health 2021 05 5;19(1):62. Epub 2021 May 5.

School of Nursing, McMaster University, 1280 Main Street West, MDCL 3500, Hamilton, ON, L8S 4K1, Canada.

Background: Historically, immigration has been a significant population driver in Canada. In October 2020, immigration targets were raised to an unprecedented level to support economic recovery in response to COVID-19. In addition to the economic impact on Canada, the pandemic has created extraordinary challenges for the health sector and heightened the demand for healthcare professionals. Read More

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Coronary lesion complexity in patients with heterozygous familial hypercholesterolemia hospitalized for acute myocardial infarction: data from the RICO survey.

Lipids Health Dis 2021 May 4;20(1):45. Epub 2021 May 4.

PEC2, EA 7460, UFR Health Sciences, University of Bourgogne Franche Comté, Dijon, France.

Background: Although patients with familial heterozygous hypercholesterolemia (FH) have a high risk of early myocardial infarction (MI), the coronary artery disease (CAD) burden in FH patients with acute MI remains to be investigated.

Methods: The data for all consecutive patients hospitalized in 2012-2019 for an acute MI and who underwent coronary angiography were collected from a multicenter database (RICO database). FH (n = 120) was diagnosed using Dutch Lipid Clinic Network criteria (score ≥ 6). Read More

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Effects of the Head Start Program on Socioecological Obesogenic Factors in American Children.

Int J Environ Res Public Health 2021 Apr 29;18(9). Epub 2021 Apr 29.

Department of Administration, Yuk-buk Elementary School, Yongin 17061, Korea.

Head Start is a nationwide developmental program for low-income families. This study aimed to investigate the association between the Head Start program and children's BMI status, as well as their quality of life with respect to socioecological obesogenic factors. This cross-sectional study employed the Early Childhood Longitudinal Study-Kindergarten cohort (ECLS-K) in which the data were collected in 2007 and analyzed in 2019. Read More

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Intra-tracheal surfactant/budesonide versus surfactant alone: Comparison of two consecutive cohorts of extremely preterm infants.

Pediatr Pulmonol 2021 May 4. Epub 2021 May 4.

Department of Women's and Children's Health, Neonatal Intensive Care Unit, University of Padua School of Medicine, Padua, Italy.

Objectives: To compare the efficacy of intra-tracheal (IT) surfactant/budesonide (SB) with that of surfactant alone (S) in reducing the rate of bronchopulmonary dysplasia (BPD) at 36 weeks post-menstrual age (PMA), we included extremely preterm very low birth weight (VLBW) infants with severe respiratory distress syndrome (RDS) in our tertiary neonatal level of care unit (Padua, Italy).

Study Design: A retrospective chart review of two cohorts of extremely preterm VLBW neonates (<28  gestation weeks, birth weight [BW] < 1500 g) born in two consequent epochs (2017-2018/2018-2019) were compared. The SB group received surfactant (200 mg/kg 1st dose) and budesonide (0. Read More

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Multiple arterial conduits for multi-vessel coronary artery bypass grafting in patients with mild to moderate left ventricular systolic dysfunction: a multicenter retrospective study.

J Cardiothorac Surg 2021 May 3;16(1):123. Epub 2021 May 3.

Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing, 210006, China.

Background: Advantages of multiple arterial conduits for coronary artery bypass grafting (CABG) have been reported previously. We aimed to evaluate the mid-term outcomes of multiple arterial CABG (MABG) among patients with mild to moderate left ventricular systolic dysfunction (LVSD).

Methods: This multicenter study using propensity score matching took place from January 2013 to June 2019 in Jiangsu Province and Shanghai, China, with a mean and maximum follow-up of 3. Read More

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Type II hybrid arch repair versus total arch replacement with frozen elephant trunk: a propensity score-matched analysis.

Eur J Cardiothorac Surg 2021 Apr 10. Epub 2021 Apr 10.

Department of Vascular Surgery, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Objectives: The aim of this study was to evaluate the objective outcomes of type II hybrid arch repair (HAR) and total arch replacement with frozen elephant trunk (TAR with FET).

Methods: Data from 528 patients who underwent aortic arch repair from January 2017 to June 2019 were collected, which consisted of 175 type II HAR and 353 TAR with FET. The propensity score-matched analysis identified a subgroup of 90 pairs. Read More

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Comparison of Treatment Outcomes Between Gemcitabine With Nab-Paclitaxel and Modified FOLFIRINOX for First-Line Chemotherapy in Metastatic and Recurrent Pancreatic Cancer: Propensity Score Matching.

Pancreas 2021 Apr;50(4):595-601

From the Department of Hepato-Biliary-Pancreatic Medicine, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.

Objectives: To compare the treatment outcomes of gemcitabine with nab-paclitaxel (GnP) and modified FOLFIRINOX (mFFX; a combination of fluorouracil, leucovorin, irinotecan, and oxaliplatin) for metastatic pancreatic cancer.

Methods: We retrospectively analyzed consecutive patients with metastatic or recurrent pancreatic cancer treated with GnP or mFFX as the first-line chemotherapy between March 2014 and December 2019 in our hospital. Treatment outcomes were compared using propensity score matching to adjust for age, sex, performance status, carcinoembryonic antigen levels, carbohydrate antigen 19-9 levels, and disease status (metastatic or recurrent). Read More

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Outcomes of Surgical Repair of Total Anomalous Pulmonary Venous Drainage: Role of Primary Sutureless Technique.

Pediatr Cardiol 2021 May 3. Epub 2021 May 3.

Department of Cardiothoracic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, 325027, People's Republic of China.

To evaluate the surgical outcomes of total anomalous pulmonary venous drainage focusing on survival, postoperative and pulmonary venous obstruction. Further investigate the role of primary sutureless technique in patients with preoperative pulmonary venous obstruction. Consecutive patients underwent total anomalous pulmonary venous drainage repair in our institution during Jan 2000 to Dec 2019 were enrolled into this retrospective analysis. Read More

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Association Between Intracerebral Hemorrhage and Subsequent Arterial Ischemic Events in Participants From 4 Population-Based Cohort Studies.

JAMA Neurol 2021 May 3. Epub 2021 May 3.

Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute, Department of Neurology, Weill Cornell Medicine, New York, New York.

Importance: Intracerebral hemorrhage and arterial ischemic disease share risk factors, to our knowledge, but the association between the 2 conditions remains unknown.

Objective: To evaluate whether intracerebral hemorrhage was associated with an increased risk of incident ischemic stroke and myocardial infarction.

Design, Setting, And Participants: An analysis was conducted of pooled longitudinal participant-level data from 4 population-based cohort studies in the United States: the Atherosclerosis Risk in Communities (ARIC) study, the Cardiovascular Health Study (CHS), the Northern Manhattan Study (NOMAS), and the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study. Read More

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Artificial Intelligence for Classification of Soft-Tissue Masses at US.

Radiol Artif Intell 2021 Jan 2;3(1):e200125. Epub 2020 Dec 2.

Department of Radiology, Division of Musculoskeletal Radiology, NYU Langone Health, 301 E 17th St, 6th Floor, New York, NY, 10003 (B.W., C.B., R.S.A.); and Department of Musculoskeletal Imaging, Hôpital Lariboisière, Paris, France (L.P.).

Purpose: To train convolutional neural network (CNN) models to classify benign and malignant soft-tissue masses at US and to differentiate three commonly observed benign masses.

Materials And Methods: In this retrospective study, US images obtained between May 2010 and June 2019 from 419 patients (mean age, 52 years ± 18 [standard deviation]; 250 women) with histologic diagnosis confirmed at biopsy or surgical excision ( = 227) or masses that demonstrated imaging characteristics of lipoma, benign peripheral nerve sheath tumor, and vascular malformation ( = 192) were included. Images in patients with a histologic diagnosis ( = 227) were used to train and evaluate a CNN model to distinguish malignant and benign lesions. Read More

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January 2021