Search Our Scientific Publications & Authors

Ann Vasc Surg 2021 Apr 7. Epub 2021 Apr 7.

Department of Surgery, Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, CA, USA.

Objective: Although the use of closure devices (CD) for femoral artery antegrade access (AA) is not in the instructions for use (IFU) for many devices, AA has been reported to be associated with a lower incidence of access site complications compared to manual compression alone. We hypothesized that CD use for AA would not be associated with a clinically significant increased odds of access site complications compared to CD use for retrograde access (RA).

Methods: This was a retrospective review of the Vascular Quality Initiative from 2010 to 2019 for infrainguinal peripheral vascular interventions with common femoral artery access closed with a CD. Read More

Int J Cardiol 2021 Apr 7. Epub 2021 Apr 7.

Cardiac Surgery Division, IRCCS Azienda Ospedaliero-Universitaria di Bologna - S. Orsola Policlinic, University of Bologna, Bologna, Italy.

Background: The aims of this study were to analyse the incidence of visceral malperfusion syndrome (MPS) following Frozen Elephant trunk operations in patients affected by chronic aortic dissection and the associated risk factors.

Methods: Between January 2007 and February 2019, 165 patients underwent surgery with FET for chronic aortic dissection. Post-operative computer tomography angiogram parameters (diameters, early post-operative false lumen enhancement and involving of aortic branches by the dissection) were collected and analysed to evaluate their impact on the occurrence of visceral malperfusion. Read More

J Pediatr Endocrinol Metab 2021 Apr 12. Epub 2021 Apr 12.

National Center for Birth Defects Monitoring of China, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P. R. China.

Background: Tetrahydrobiopterin deficiency (BH4D), a less common form of hyperphenylalaninemia (HPA), can lead to severe developmental retardation if untreated. Little has been reported on the prevalence of BH4D among live births worldwide. This study examined its prevalence across China and between geographical areas within the country. Read More

Int J Nurs Pract 2021 Apr 10:e12942. Epub 2021 Apr 10.

Department of Surgery, The First Affiliated Hospital of Soochow University, Suzhou City, China.

Background: Incorrect surgical counts are closely related to retained surgical items, which pose a threat to patients. However, the risk factors for incorrect surgical counts have not been identified yet.

Aim: To identify the risk factors associated with incorrect surgical counts during surgery in a tertiary hospital. Read More

J Neurooncol 2021 Apr 10. Epub 2021 Apr 10.

Centre Léon Bérard, 28 Prom. Lea et Napoleon Bullukian, 69008, Lyon, France.

Purpose: Brain metastases (BM) usually represent a poor prognostic factor in solid tumors. About 10% of patients with renal cancer (RCC) will present BM. Local therapies such as stereotactic radiotherapy (SRT), whole brain radiotherapy (WBRT), and surgery are used to achieve brain control. Read More

World J Urol 2021 Apr 10. Epub 2021 Apr 10.

Department of Urology, University of Montreal Hospital Center CHUM, Montreal, QC, Canada.

Introduction: Greenlight photo-selective vaporization of the prostate (GL-PVP) has gained international acceptance as a safe and effective alternative procedure for the treatment of benign prostatic hyperplasia (BPH), especially in anticoagulated men. This descriptive analysis aims to characterize the current state of GL-PVP, pooling data from international centers.

Methods: Data from 3627 patients who underwent GL-PVP with the XPS-180 W system in seven international centers performed by eight expert surgeons between 2011 and 2019 were retrospectively analyzed. Read More

Nurs Leadersh (Tor Ont) 2021 Mar;34(1):45-59

Doctoral Student, Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, ON.

In the spring of 2019, Canada's House of Commons Standing Committee on Health reviewed the issue of workplace violence in healthcare and issued a report with nine recommendations. By summer that year, the Canadian Federation of Nurses Unions had two active campaigns on workplace violence characterized by a strong social media presence. In 2020, a private member's bill was sponsored to amend Canada's Criminal Code in cases of assault against a healthcare worker. Read More

J Pathol Clin Res 2021 Apr 9. Epub 2021 Apr 9.

Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.

While coronavirus disease 2019 (COVID-19) primarily affects the respiratory tract, pathophysiological changes of the cardiovascular system remain to be elucidated. We performed a retrospective cardiopathological analysis of the heart and vasculature from 23 autopsies of COVID-19 patients, comparing the findings with control tissue. Myocardium from autopsies of COVID-19 patients was categorised into severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive (n = 14) or negative (n = 9) based on the presence of viral RNA as determined by reverse transcriptase polymerase chain reaction (RT-PCR). Read More

Eur J Neurol 2021 Apr 9. Epub 2021 Apr 9.

Second Department of Neurology, "Attikon" University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Background: Mounting evidence supports an association between Guillain-Barré syndrome spectrum (GBSs) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. However, GBSs in the setting of coronavirus disease-2019 (COVID-19) remains poorly characterized, while GBSs prevalence among COVID-19 patients has not been previously systematically evaluated using a meta-analytical approach.

Methods: We performed a systematic review and meta-analysis of observational cohort and case-series studies reporting on the occurrence, clinical characteristics and outcomes of patients with COVID-19-associated GBSs. Read More

Int J Cancer 2021 Apr 9. Epub 2021 Apr 9.

Department of Medical Microbiology, Laboratory Medicine Region Skåne, Lund University, Lund, Sweden.

HPV73 is classified as possibly oncogenic and is not recognised by most commercial primary HPV screening platforms. The aim was to determine the prevalence of HPV73 among invasive cervical cancers, formalin fixed paraffin embedded (FFPE) samples (N = 69), from southern Sweden during 2009-2010. Another aim was to determine proportions of HPV73 among Aptima HPV assay negative cervical cancers (N = 9, out of 206 cancers), and of high grade cytological cervical diagnosis (N = 75, out of 5807 high grade lesions) in liquid based cytology (LBC) samples collected between 2016-2019. Read More

World J Urol 2021 Apr 9. Epub 2021 Apr 9.

Department of Urology, Austin Health, Melbourne, VIC, Australia.

Purpose: To review the evolution of female continence surgical practice in Australia over the last 20 years and observe whether vaginal mesh controversies impacted these trends.

Materials And Methods: From January 2000 to December 2019, medicare benefit schedule codes for female continence procedures were identified and extracted for: mesh sling, fascial sling, bulking agent, female urethral prosthesis, colposuspension, and removal of sling. Population-adjusted incidences per 100,000 persons were calculated using publicly available demographic data. Read More

HNO 2021 Apr 9. Epub 2021 Apr 9.

Hals-Nasen-Ohrenklinik, Kopf- und Hals-Chirurgie, Universitätskliniken Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Waldstraße 1, 91054, Erlangen, Deutschland.

Background: Recurrent and residual laryngeal cancer after organ-preserving radio- or radiochemotherapy is associated with a poor prognosis. Salvage surgery is the most important therapeutic option in these cases.

Objective: The study assessed rates of recurrence and residual tumor as well as survival and complication rates after salvage laryngectomy at the authors' academic cancer center. Read More

Sci Rep 2021 Apr 9;11(1):7811. Epub 2021 Apr 9.

College of Urban and Environmental Sciences, Northwest University, Xi'an, 710127, China.

The novel coronavirus pneumonia (COVID-19) outbreak that emerged in late 2019 has posed a severe threat to human health and social and economic development, and thus has become a major public health crisis affecting the world. The spread of COVID-19 in population and regions is a typical geographical process, which is worth discussing from the geographical perspective. This paper focuses on Shandong province, which has a high incidence, though the first Chinese confirmed case was reported from Hubei province. Read More

J Immunother Cancer 2021 Apr;9(4)

Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Science and Medical Center; Department of Pathology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

The ongoing pandemic caused by the novel coronavirus SARS-CoV-2 has disrupted the global economy and strained healthcare systems to their limits. After the virus first emerged in late 2019, the first intervention that demonstrated significant reductions in mortality for severe COVID-19 in large-scale trials was corticosteroids. Additional options that may reduce the burden on the healthcare system by reducing the number of patients requiring intensive care unit support are desperately needed, yet no therapy has conclusively established benefit in randomized studies for the management of moderate or mild cases of disease. Read More

CMAJ 2021 Apr 9. Epub 2021 Apr 9.

Cadham Provincial Laboratory (Bullard, Dust, Hedley, Alexander, Van Caeseele), Manitoba Health; Department of Pediatrics & Child Health (Bullard, Strong, Lee, Van Caeseele, Poliquin), University of Manitoba; National Microbiology Laboratory (Funk, Garnett, Tran, Bello, Strong, Poliquin), Public Health Agency of Canada; Departments of Anesthesiology and Medicine (Funk), Section of Critical Care, University of Manitoba; Department of Medical Microbiology & Infectious Diseases (Garnett, Tran, Bello, Alexander), University of Manitoba; Communicable Disease Control, Public Health (Lee), Manitoba Health; Epidemiology and Surveillance Unit (Waruk, Loeppky), Manitoba Health; Department of Community Health Science (Loeppky), University of Manitoba. Winnipeg, Man.

Background: The role of children in the transmission and community spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unclear. We aimed to quantify the infectivity of SARS-CoV-2 in nasopharyngeal samples from children compared with adults.

Methods: We obtained nasopharyngeal swabs from adult and pediatric cases of coronavirus disease 2019 (COVID-19) and from their contacts who tested positive for SARS-CoV-2 in Manitoba between March and December 2020. Read More

J Fr Ophtalmol 2021 Apr 6. Epub 2021 Apr 6.

Department of Ophthalmology, Hôpital Necker-Enfants malades, 149, rue de Sèvres, 75015 Paris, France.

Study Objective: To study the performance of a pre-loaded Monoka stent in the management of congenital nasolacrimal duct obstruction (CNLDO).

Study Design: Non-randomized study of consecutive cases.

Materials And Methods: A preloaded classic Monoka silicone stent contained entirely inside its introducer (Lacrijet) was used to treat a consecutive series of subjects with CNLDO over an 11-month period (May 2019-March 2020). Read More

Radiologia 2021 Mar 14. Epub 2021 Mar 14.

Centro de Investigación de Gastroenterología y Enfermedades Hepáticas, Instituto de Investigación de Gastroenterología y Enfermedades Hepáticas, Universidad de Ciencias Médicas Shahid Beheshti, Teherán, Irán.

Introduction And Objectives: The pivotal role of chest computed tomographic (CT) to diagnosis and prognosis coronavirus disease-2019 (COVID-19) is still an open field to be explored. This study was conducted to assess the CT features in confirmed cases with COVID-19.

Materials And Methods: Retrospectively, initial chest CT data of 363 confirmed cases with COVID-19 were reviewed. Read More

Transplant Cell Ther 2021 Apr 9;27(4):340.e1-340.e6. Epub 2021 Jan 9.

Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan. Electronic address:

Most acute leukemia patients receive consecutive intensive chemotherapy, which usually takes several months before allogeneic hematopoietic stem cell transplantation (allo-HCT). Intensive chemotherapy often induces gastrointestinal adverse events. These adverse events leave patients in a state of malnutrition, leading to a reduction in body weight. Read More

Arch Public Health 2021 Apr 9;79(1):47. Epub 2021 Apr 9.

Department of Pediatric Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor Town, Ethiopia.

Background: The effect of short birth interval on socio-economic, negative maternal and child health outcomes remains common in developing countries. This study aimed to assess determinants of short birth interval among reproductive age women, who gave birth in health institution for last six-month in South Gondar, Ethiopia 2019.

Methods: Community-based unmatched case control study design was conducted from February 1 to March 30, 2019. Read More

J Cardiothorac Surg 2021 Apr 9;16(1):73. Epub 2021 Apr 9.

Department of Cardiac Surgery and Transplantation, The Cardinal Stefan Wyszyński National Institute of Cardiology, Alpejska 42, 04-628, Warszawa, Poland.

Background: The ongoing coronavirus disease 2019 (Covid-19) pandemic presents challenges for surgeons of all disciplines, including cardiologists. The volume of cardiac surgery cases has to comply with the mandatory constraints of healthcare capacities. The treatment of Covid-19-positive patients must also be considered. Read More

Nutr Metab (Lond) 2020 Jan 17;17(1). Epub 2020 Jan 17.

Department of Laboratory Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

Objective: We aimed to describe the 25-hydroxyvitamin D (25(OH)D) status of southern Chinese individuals by a high-accuracy liquid chromatography tandem mass spectrometry (LC-MS/MS) method which can trace to reference measurement procedure.

Materials And Methods: From January 2018 to June 2019, a total of 4775 southern Chinese individuals were evaluated in our study. The serum levels of parathyroid hormone (PTH) were detected simultaneously in 162 cases. Read More

Orphanet J Rare Dis 2021 Apr 9;16(1):167. Epub 2021 Apr 9.

Department of Clinical Chemistry and Clinical Pharmacology, University of Bonn, 53127, Bonn, Germany.

Background: The triad of a presacral mass, sacral agenesis and an anorectal anomaly constitutes the rare Currarino syndrome (CS), which is caused by dorsal-ventral patterning defects during embryonic development. The major causative CS gene is MNX1, encoding a homeobox protein.

Main Body: In the majority of patients, CS occurs as an autosomal dominant trait; however, a female predominance observed, implies that CS may underlie an additional mode(s) of inheritance. Read More

Ann Diagn Pathol 2021 Mar 31;52:151740. Epub 2021 Mar 31.

Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, United States of America. Electronic address:

Ground-glass (GG) hepatocytes are classically associated with chronic hepatitis B (HBV) infection, storage disorders, or cyanamide therapy. In a subset of cases, an exact etiology cannot be identified. In this study, we sought to characterize the clinical, histological, and ultrastructural findings associated with HBV-negative GG hepatocytes. Read More

Am J Emerg Med 2021 Apr 2;48:1-11. Epub 2021 Apr 2.

Department of Internal Medicine, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, 08036 Barcelona, Spain.

Purpose: Patients evaluated in the emergency department (ED) who have concerning symptoms suggestive of a cancer diagnosis are mostly referred to the quick diagnosis unit of our tertiary hospital. This study analyzed the impact of the Covid-19 pandemic on the volume, disease patterns, and accessibility to essential investigations of patients with suspected cancer referred by the ED to this unit.

Methods: Trends in referrals were analyzed from January 1 to July 8, 2020 and the corresponding dates of 2019. Read More

Photodiagnosis Photodyn Ther 2021 Apr 6:102287. Epub 2021 Apr 6.

School of Physics, Universiti Sains Malaysia, 11800, Pulau, Pinang, Malaysia.

The 2019 novel coronavirus (2019-nCoV; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)) has witnessed a rapid and global proliferation since its early identification in patients with severe pneumonia in Wuhan, China. As of 27th May 2020, 2019-nCoV cases have risen to >5 million, with confirmed deaths of 350,000. However, Coronavirus disease (COVID-19) diagnostic and treatment measures are yet to be fully unraveled, given the novelty of this particular coronavirus. Read More

Ann Vasc Surg 2021 Apr 6. Epub 2021 Apr 6.

Department of Surgery, Division of Vascular & Endovascular Surgery, Stanford University School of Medicine, Stanford, CA.

Objectives: Iliac branch devices (IBDs) are modular, bifurcated endografts designed to preserve hypogastric flow during endovascular aortoiliac aneurysm repair. We report our single center outcomes, and describe the unique complications of these devices: inability to cannulate the hypogastric artery (technical failure), occlusion of the internal branch, and type III endoleak from separation of components between the main body and IBD.

Methods: A prospectively maintained institutional database of patients undergoing IBD implantation between 2014 and 2019 was reviewed. Read More

PLoS One 2021 9;16(4):e0250017. Epub 2021 Apr 9.

Private Gynecologic Oncology Clinic, Ankara, Turkey.

The coronavirus disease 2019 (COVID-19) outbreak spread to over 100 countries with a total of 100,000 cases during the first week of March 2020. Health care workers, as those on the frontline of the COVID-19 pandemic, are more susceptible to infection. Inadequate related knowledge and preventive behaviors among health care workers might lead to delayed treatment and result in the rapid spread of the infection. Read More

J Adolesc Young Adult Oncol 2021 Apr 9. Epub 2021 Apr 9.

Department of Gynecologic Oncology, Adana City Training and Research Hospital, Adana, Turkey.

Choriocarcinoma is an aggressive malignant trophoblastic neoplasm. The rapid growth of neoplastic tissue and myometrial invasion can cause uterine perforation. It is important to quickly diagnose the disease and plan treatment because these tumors are nearly always curable, and fertility can be preserved in most cases with proper management. Read More

N Engl J Med 2021 Apr 9. Epub 2021 Apr 9.

From the Departments of Hematology (N.H.S., G.E.T., P.A.H.), Immunology (L.A.M., F.L.-J.), Neurosurgery (M.W.), Neurology (A.-H.A.), and Radiology and Nuclear Medicine (T.H.S.), and the Research Institute of Internal Medicine (N.H.S., A.E.M., P.A.H.), Oslo University Hospital, and the Faculty of Medicine (A.E.M., G.E.T., P.A.H.), the KG Jebsen Center for B Cell Malignancy (L.A.M., G.E.T.), Institute of Clinical Medicine, and the ImmunoLingo Convergence Center (F.L.-J.), University of Oslo, the Department of Hematology, Akershus University Hospital, Lørenskog (N.H.S.), and the Norwegian National Unit for Platelet Immunology, Division of Diagnostics, University Hospital of North Norway, Tromsø (I.H.S., M.T.A.) - all in Norway.

We report findings in five patients who presented with venous thrombosis and thrombocytopenia 7 to 10 days after receiving the first dose of the ChAdOx1 nCoV-19 adenoviral vector vaccine against coronavirus disease 2019 (Covid-19). The patients were health care workers who were 32 to 54 years of age. All the patients had high levels of antibodies to platelet factor 4-polyanion complexes; however, they had had no previous exposure to heparin. Read More

J Zhejiang Univ Sci B 2021 Apr;22(4):330-340

Department of Laboratory Medicine, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Epidemiological evidence suggests that patients with hypertension infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are at increased risk of acute lung injury. However, it is still not clear whether this increased risk is related to the usage of renin-angiotensin system (RAS) blockers. We collected medical records of coronavirus disease 2019 (COVID-19) patients from the First Affiliated Hospital, Zhejiang University School of Medicine (Hangzhou, China), and evaluated the potential impact of an angiotensin II receptor blocker (ARB) on the clinical outcomes of COVID-19 patients with hypertension. Read More