6,453 results match your criteria 2018 summarized


Trends and characteristics of ocular exposures related to e-cigarettes and e-liquids reported to Poison Control Centers in the United States, 2010-2019.

Clin Toxicol (Phila) 2021 Jul 30:1-7. Epub 2021 Jul 30.

Center for Tobacco Products, Office of Science, United States Food and Drug Administration, Silver Spring, MD, USA.

Introduction: Ocular injuries and unintended exposures involving electronic nicotine delivery systems (ENDS), also known as e-cigarettes, have been reported. However, trends and characteristics of ENDS-related ocular exposures at the population level are not well documented. This study was designed to describe trends and characteristics of ENDS-related ocular exposure cases reported to poison control centers (PCCs) in the U. Read More

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Live donor kidney transplantation. Situation analysis and roadmap.

Nefrologia 2021 Jul 19. Epub 2021 Jul 19.

Clínica Universitaria de Navarra, Pamplona, España.

Living donor kidney transplantation (LDKT) is the best treatment option for end stage renal disease in terms of both patient and graft survival. However, figures on LDKT in Spain that had been continuously growing from 2005 to 2014, have experienced a continuous decrease in the last five years. One possible explanation for this decrease is that the significant increase in the number of deceased donors in Spain during the last years, both brain death and controlled circulatory death donors, might have generated the false idea that we have coped with the transplant needs. Read More

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Clinical and pathological features and risk factors for primary breast cancer patients.

World J Clin Cases 2021 Jul;9(19):5046-5053

Department of Mammary Disease, Zhuhai Hospital of Guangdong Provincial Hospital of Traditional Chinese Medicine, Zhuhai 519015, Guangdong Province, China.

Background: Breast cancer is the most common malignancy in women all around the world. According to the latest statistics in 2018, there were more than 2.08 million new breast cancer cases all around the world and more than 620000 deaths; the proportion of breast cancer deaths in women with cancer is 15%. Read More

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Imaging Cytokine Concentration Fields Using PlaneView Imaging Devices.

Bio Protoc 2018 Apr 5;8(7):e2788. Epub 2018 Apr 5.

Physics Department, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

We describe here a method to visualize concentration fields of cytokines around cytokine-secreting cells. The main challenge is that physiological cytokine concentrations can be very low, in the pico-molar range. Since it is currently impossible to measure such concentrations directly, we rely on cell's response to the cytokines-the phosphorylation of a transcription factor-that can be visualized through antibody staining. Read More

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Osteoclastogenesis Assays Using Primary Mouse Bone Marrow Cells.

Bio Protoc 2018 Jun 5;8(11):e2875. Epub 2018 Jun 5.

Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.

Osteoclasts are a group of bone-absorbing cells to degenerate bone matrix and play pivotal roles in bone growth and homeostasis. The unbalanced induction of osteoclast differentiation (osteoclastogenesis) in pathological conditions, such as osteoporosis, arthritis and skeleton metastasis of cancer, causes great pain, bone fracture, hypercalcemia or even death to patients. osteoclastogenesis analysis is useful to better understand osteoclast formation in physiological and pathological conditions. Read More

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Evaluation of the reporting quality of guidelines for gastric cancer using the RIGHT checklist.

Ann Transl Med 2021 Jun;9(12):1003

Department of Internal Medicine, Henan Cancer Hospital Affiliated to Zhengzhou University, Zhengzhou, China.

Background: Gastric cancer is the fifth most common type of cancer globally. We aimed to evaluate the reporting quality of clinical practice guidelines in the field of gastric cancer.

Methods: We searched Medline (via PubMed), China Biology Medicine, Chinese National Knowledge Infrastructure and WanFang databases and the websites of the main guideline development organizations from 2018 to 2020 for guidelines on gastric cancer. Read More

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Intermittent preventive treatment for malaria in infants.

Cochrane Database Syst Rev 2021 Jul 17;7:CD011525. Epub 2021 Jul 17.

Department of Paediatrics, University of Calabar Teaching Hospital, Calabar, Nigeria.

Background: Intermittent preventive treatment could help prevent malaria in infants (IPTi) living in areas of moderate to high malaria transmission in sub-Saharan Africa. The World Health Organization (WHO) policy recommended IPTi in 2010, but its adoption in countries has been limited.

Objectives: To evaluate the effects of intermittent preventive treatment (IPT) with antimalarial drugs to prevent malaria in infants living in malaria-endemic areas. Read More

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Exacerbations in US Severe Asthma: Incidence, Characteristics, Predictors, and Effects of Biologic Treatments.

Ann Allergy Asthma Immunol 2021 Jul 14. Epub 2021 Jul 14.

AstraZeneca, Gaithersburg, Maryland.

Background: Patients with severe asthma (SA) have a heightened risk of exacerbations, including hospitalization. The real-world, specialist-verified incidence and characteristics of exacerbations among patients with SA in the United States (US) have not been described.

Objective: To describe the real-world incidence, characteristics, and predictors of exacerbations among patients with SA in the US. Read More

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Anti-obesity Medication Use Among Adults with Overweight and Obesity in the United States: 2015-2018.

Endocr Pract 2021 Jul 12. Epub 2021 Jul 12.

Eli Lilly & Company, Indianapolis, IN.

Objective: To estimate utilization of FDA-approved prescription anti-obesity medications (AOMs) and identify factors associated with AOM use in the United States.

Methods: Respondents >18 years-old meeting AOM eligibility criteria in 2015-2016 and 2017-2018 National Health and Nutrition Examination Survey (NHANES) and 2016 Medical Expenditure Panel Survey (MEPS) were included in the study. AOM eligibility was defined as having a body mass index (BMI) >30 kg/m, or a BMI between 27 to 29. Read More

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Evaluating Chinese Mobile Health Apps for Ankylosing Spondylitis Management: Systematic App Search.

JMIR Mhealth Uhealth 2021 Jul 14;9(7):e27234. Epub 2021 Jul 14.

West China School of Nursing/West China Hospital, Sichuan University, Chengdu, China.

Background: Patients with ankylosing spondylitis (AS), a chronic systematic inflammatory disease, require long-term treatment and management. Mobile health (mHealth) apps can deliver health services through mobile devices, facilitate long-term disease management, support patient-health care provider communication, and enable patients to engage in disease management. There are some apps targeted at patients with AS, but the feature and quality of these apps have not been systematically examined. Read More

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Preserving extracellular vesicles for biomedical applications: consideration of storage stability before and after isolation.

Drug Deliv 2021 Dec;28(1):1501-1509

Hunan Testing Institute for Medical Devices, Changsha, China.

Extracellular vesicles (EVs) are nanovesicles released by various cell types. EVs are known for cell-to-cell communications and have potent biological activities. Despite great progress in recent years for studies exploring the potentials of EVs for early disease detection, therapeutic application and drug delivery, determination of the favorable storage conditions of EVs has been challenging. Read More

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December 2021

An update of the long-term outcome of patients with nonspecific pleurisy at medical thoracoscopy.

BMC Pulm Med 2021 Jul 12;21(1):226. Epub 2021 Jul 12.

Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.

Background: Medical thoracoscopy (MT) is recommended in patients with undiagnosed exudative pleural effusion and offers a degree of diagnostic sensitivity for pleural malignancy. However, not all patients who undergo MT receive an exact diagnosis. Our previous investigation from 2014 summarized the long-term outcomes of these patients with nonspecific pleurisy (NSP); now, we offer updated data with the goal of refining our conclusions. Read More

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Outcomes of Bariatric Surgery: Patients with Body Mass Index 60 or Greater.

JSLS 2021 Apr-Jun;25(2)

Department of Surgery, NYU Langone Hospital-Long Island, Mineola, NY.

Introduction: Perioperative outcomes of bariatric surgery in patients with super super obesity (SSO) (BMI ≥ 60 kg/m) merit further investigation.

Methods: A retrospective review was conducted of patients with SSO who underwent surgery from Jun 2005 through Jun 2018 at a Metabolic and Bariatric Surgery Center of Excellence. Quantitative demographic data was summarized using descriptive statistics; categorical variables were compared using Fisher's exact test. Read More

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Characteristics of Deaths Among Individuals in US Immigration and Customs Enforcement Detention Facilities, 2011-2018.

JAMA Netw Open 2021 Jul 1;4(7):e2116019. Epub 2021 Jul 1.

Department of Emergency Medicine, Keck School of Medicine of the University of Southern California, Los Angeles.

Importance: Concerns have been raised that substandard medical care has contributed to deaths in US Immigration and Customs Enforcement (ICE) detention facilities. After each in-custody death, ICE produces detainee death reviews, which describe the circumstances of the death and determine whether ICE Performance-Based National Detention Standards (PBNDS) were violated.

Objective: To describe factors associated with deaths in ICE detention facilities. Read More

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Outcome for Patients with Acetabular Fractures Treated Using Only Modified Stoppa Approach or in Combination with Iliac Wing Approach: 10-Year Experience.

Acta Chir Orthop Traumatol Cech 2021 ;88(3):191-195

Riga Stradins University, Department of Orthopaedics, Riga, Latvia.

PURPOSE OF THE STUDY This retrospective study presents our experience in treatment of polytrauma patients with acetabular fractures treated with only modified Stoppa approach or in combination with iliac wing approach. The purpose of this study was to evaluate the outcome of polytrauma patients with acetabular fractures operated with only modified Stoppa approach or in combination with iliac wing approach. MATERIAL AND METHODS Polytrauma patients who suffered from acetabular fractures treated in our hospital during 2008-2018, operated by using only modified Stoppa or in combination with iliac wing approach, were included in the study. Read More

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Prognostic value of natriuretic peptides in heart failure: systematic review and meta-analysis.

Heart Fail Rev 2021 Jul 5. Epub 2021 Jul 5.

Ted Rogers Center for Heart Research, University Health Network, Toronto, ON, Canada.

Risk models, informing optimal long-term medical management, seldom use natriuretic peptides (NP) in ascertaining the absolute risk of outcomes for HF patients. Individual studies evaluating the prognostic value of NPs in HF patients have reported varying effects, arriving at best estimates requires a systematic review. We systematically summarized the best evidence regarding the prognostic value of brain natriuretic peptide (BNP) and NT-proBNP in predicting mortality and hospitalizations in ambulatory heart failure (HF) patients. Read More

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Pharmacokinetics of Commonly Used Antimicrobials in Critically Ill Adults During Extracorporeal Membrane Oxygenation: A Systematic Review.

Drugs 2021 Jul 5;81(11):1307-1329. Epub 2021 Jul 5.

Faculté de Pharmacie, Université de Montréal, Montreal, Canada.

Purpose: Adequate dosing of antimicrobials is critical to properly treat infections and limit development of resistance and adverse effects. Limited guidance exists for antimicrobial dosing adjustments in patients requiring extracorporporeal membrane oxygenation (ECMO) therapy. A systematic review was conducted to delineate the pharmacokinetics (PK) and pharmacodynamics (PD) of antimicrobials in critically ill adult patients requiring ECMO. Read More

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Critical Review of the Evolution of Extracellular Vesicles' Knowledge: From 1946 to Today.

Int J Mol Sci 2021 Jun 15;22(12). Epub 2021 Jun 15.

Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.

Extracellular vesicles (EVs) are a family of particles/vesicles present in blood and body fluids, composed of phospholipid bilayers that carry a variety of molecules that can mediate cell communication, modulating crucial cell processes such as homeostasis, induction/dampening of inflammation, and promotion of repair. Their existence, initially suspected in 1946 and confirmed in 1967, spurred a sharp increase in the number of scientific publications. Paradoxically, the increasing interest for EV content and function progressively reduced the relevance for a precise nomenclature in classifying EVs, therefore leading to a confusing scientific production. Read More

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Spatiotemporal Patterns of Tuberculosis in Hunan Province, China.

Int J Environ Res Public Health 2021 Jun 24;18(13). Epub 2021 Jun 24.

Faculty of Health Sciences, Curtin University, Perth 6102, Australia.

Tuberculosis (TB) is the leading cause of death from a bacterial pathogen worldwide. China has the third highest TB burden in the world, with a high reported burden in Hunan Province (amongst others). This study aimed to investigate the spatial distribution of TB and identify socioeconomic, demographic, and environmental drivers in Hunan Province, China. Read More

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Reactive Arthritis Update: Spotlight on New and Rare Infectious Agents Implicated as Pathogens.

Curr Rheumatol Rep 2021 07 1;23(7):53. Epub 2021 Jul 1.

Department of Biochemistry, Microbiology, and Immunology, Wayne State University School of Medicine, Detroit, MI, USA.

Purpose Of Review: This article presents a comprehensive narrative review of reactive arthritis (ReA) with focus on articles published between 2018 and 2020. We discuss the entire spectrum of microbial agents known to be the main causative agents of ReA, those reported to be rare infective agents, and those reported to be new candidates causing the disease. The discussion is set within the context of changing disease terminology, definition, and classification over time. Read More

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Practical in-storage interventions to control foodborne pathogens on fresh produce.

Compr Rev Food Sci Food Saf 2021 Jun 30. Epub 2021 Jun 30.

School of Food Science, Washington State University, Pullman, Washington, USA.

Although tremendous efforts have been made to ensure fresh produce safety, various foodborne outbreaks and recalls occur annually. Most of the current intervention strategies are evaluated within a short timeframe (less than 1 h), leaving the behavior of the remaining pathogens unknown during subsequent storages. This review summarized outbreak and recall surveillance data from 2009 to 2018 obtained from government agencies in the United States to identify major safety concerns associated with fresh produce, discussed the postharvest handling of fresh produce and the limitations of current antimicrobial interventions, and reviewed the intervention strategies that have the potential to be applied in each storage stage at the commercial scale. Read More

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Importance of fish for food and nutrition security among First Nations in Canada.

Can J Public Health 2021 Jun 28;112(Suppl 1):64-80. Epub 2021 Jun 28.

Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, ON, K1N 6N5, Canada.

Objective: To investigate the relationships between fish/seafood consumption patterns and food security status among First Nations (FN) communities in Canada. We estimated the contribution of fish/seafood to daily nutrient requirements. Barriers to traditional food (TF) access including fish were summarized. Read More

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[Clinical observation of homemade splint external fixation in the treatment of metacarpal fractures].

Zhongguo Gu Shang 2021 Jun;34(6):568-72

Guangzhou Orthopaedic Hospital, Guangzhou 510015, Guangdong, China.

Objective: To explore the clinical effect of manual reduction combined with homemade splint external fixation in the treatment of metacarpal fractures.

Methods: A retrospective analysis was performed in 126 patients with metacarpal fracture treated by manual reduction and homemade splint external fixation in the emergency department of our hospital from January 2018 to December 2018, including 102 male, 24 female, ranging in age from 9 to 73 year old, with an average of (33.2±14. Read More

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Biological Function of Long Non-coding RNA (LncRNA) Xist.

Front Cell Dev Biol 2021 10;9:645647. Epub 2021 Jun 10.

Department of Biology and Chemistry, College of Liberal Arts and Sciences, National University of Defense Technology, Changsha, China.

Long non-coding RNAs (lncRNAs) regulate gene expression in a variety of ways at epigenetic, chromatin remodeling, transcriptional, and translational levels. Accumulating evidence suggests that lncRNA X-inactive specific transcript (lncRNA Xist) serves as an important regulator of cell growth and development. Despites its original roles in X-chromosome dosage compensation, lncRNA Xist also participates in the development of tumor and other human diseases by functioning as a competing endogenous RNA (ceRNA). Read More

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European guideline and expert statements on the management of narcolepsy in adults and children.

Eur J Neurol 2021 Jun 25. Epub 2021 Jun 25.

Sleep Wake Centre SEIN, Heemstede, The Netherlands.

Background And Aim: Narcolepsy is an uncommon hypothalamic disorder of presumed autoimmune origin that usually requires lifelong treatment. This paper aims to provide evidence-based guidelines for the management of narcolepsy in both adults and children.

Methods: The European Academy of Neurology (EAN), European Sleep Research Society (ESRS) and European Narcolepsy Network (EU-NN) nominated a task force of 18 narcolepsy specialists. Read More

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European guideline and expert statements on the management of narcolepsy in adults and children.

J Sleep Res 2021 Jun 25:e13387. Epub 2021 Jun 25.

Sleep Wake Centre SEIN, Heemstede, The Netherlands.

Background And Purpose: Narcolepsy is an uncommon hypothalamic disorder of presumed autoimmune origin that usually requires lifelong treatment. This paper aims to provide evidence-based guidelines for the management of narcolepsy in both adults and children.

Methods: The European Academy of Neurology (EAN), European Sleep Research Society (ESRS), and European Narcolepsy Network (EU-NN) nominated a task force of 18 narcolepsy specialists. Read More

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Implications of the Antiplatelet Therapy Gap Left With Discontinuation of Prasugrel in Canada.

CJC Open 2021 Jun 16;3(6):814-821. Epub 2020 Dec 16.

University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

Background: The current Canadian Cardiovascular Society antiplatelet therapy guidelines recommend the use of ticagrelor or prasugrel over clopidogrel as first-line platelet P2Y12 receptor antagonists for treatment of moderate- to high-risk acute coronary syndromes. Recently, Effient (prasugrel [Eli Lilly Canada Inc, Toronto, Canada]) was discontinued by its distributor in Canada.

Methods: Five members of the Canadian Cardiovascular Society antiplatelet therapy 2018 guidelines committee undertook an independent, evidence-based review to outline patients for whom prasugrel should be the optimal P2Y12 agent and discuss alternative strategies to consider without prasugrel. Read More

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International Evidence on the Impact of Health-Justice Partnerships: A Systematic Scoping Review.

Public Health Rev 2021 26;42:1603976. Epub 2021 Apr 26.

Department of Applied Health Research, University College London, London, United Kingdom.

Health-justice partnerships (HJPs) are collaborations between healthcare and legal services which support patients with social welfare issues such as welfare benefits, debt, housing, education and employment. HJPs exist across the world in a variety of forms and with diverse objectives. This review synthesizes the international evidence on the impacts of HJPs. Read More

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Strength and Comprehensiveness of Drinking Water Language in California School District Wellness Policies.

J Nutr Educ Behav 2021 Jun 21. Epub 2021 Jun 21.

School of Medicine, Stanford University, Stanford, CA; Philip R. Lee Institute for Health Policy Studies, University of California San Francisco, San Francisco, CA. Electronic address:

Objective(s): Assess the quality of water language in California school district wellness policies and examine how language quality relates to school drinking water access.

Design: Cross-sectional study.

Participants: Random sample of 240 schools selected from all California public schools, stratified by geography and grades served. Read More

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