189,520 results match your criteria 2016 total


Exposure to legacy and novel perfluoroalkyl substance disturbs the metabolic homeostasis in pregnant women and fetuses: A metabolome-wide association study.

Environ Int 2021 May 12;156:106627. Epub 2021 May 12.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, People's Republic of China.

Background: Perfluoroalkyl substances (PFASs) exist extensively and several of these have been verified to be toxic. Prenatal exposure to PFASs has attracted much attention. Metabolome-wide association analyses can be used to explore the toxicity mechanisms of PFASs by identifying associated biomarkers. Read More

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Monitoring Antibiotic Resistance Profiles of Fecal Isolates of Enterobacteriaceae and the Prevalence of Carbapenem-Resistant Enterobacteriaceae Among Food handlers in Kuwait.

J Glob Antimicrob Resist 2021 May 12. Epub 2021 May 12.

Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait. Electronic address:

Background: Carbapenem-resistant Enterobacteriaceae (CRE) have become one of the most challenging problems in infectious diseases worldwide. Unrecognized personnel colonized as food handlers (FHs) with CRE serve as a reservoir for transmission. This study assessed the prevalence and susceptibility pattern of CRE isolates from FHs working in commercial eateries in the community (CFHs) and healthcare settings (HCFHs) in Kuwait over a period between 2016-2018. Read More

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Total knee arthroplasty is associated with greater immediate post-surgical pain and opioid use than total hip arthroplasty.

Arch Orthop Trauma Surg 2021 May 15. Epub 2021 May 15.

New York University Langone Orthopaedic Hospital, 301 East 17 St, Manhattan, New York, NY, 10003, USA.

Background: As greater emphasis is being placed on opioid reduction strategies and implementation of multimodal analgesia, we sought to determine whether immediate post-surgical opioid consumption was different between THA and TKA.

Methods: A single-institution total joint arthroplasty database was used to identify patients who underwent elective THA and TKA from 2016 to July 2019. Baseline demographic data, operative time (defined by incision time), and American Society of Anesthesiologist (ASA) class were collected. Read More

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Can MRI differentiate surrounding vertebral invasion from reactive inflammatory changes in superior sulcus tumor?

Eur Radiol 2021 May 15. Epub 2021 May 15.

Department of Radiology, Gustave Roussy Cancer Campus, 114 Rue Edouard Vaillant, Villejuif, 94800, Paris, France.

Objectives: Vertebral invasion is a key prognostic factor and a critical aspect of surgical planning for superior sulcus tumors. This study aims to further evaluate MRI features of vertebral invasion in order to distinguish it from reactive inflammatory changes.

Methods: Between 2000 and 2016, a retrospective study was performed at a single institution. Read More

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Increasing consensus on terminology of Achilles tendon-related disorders.

Knee Surg Sports Traumatol Arthrosc 2021 May 15. Epub 2021 May 15.

Department of Orthopedic Surgery, Amsterdam UMC, PO Box 22660, 1100 DD, Amsterdam, The Netherlands.

Purpose: Aims of this study are to evaluate the current terminology and assess the influence of the latest proposals on the terminology used for Achilles tendon-related disorders in both daily practice and literature.

Methods: (1) All orthopedic surgeons experienced in the field of foot and ankle surgery of the Ankleplatform Study Group were invited to participate in this survey by email. They were requested to fill out a survey on terminology in six typical cases with Achilles tendon-related disorders. Read More

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Effects of the new fasting standard on sedation in the pediatric emergency room.

Pediatr Int 2021 May 15. Epub 2021 May 15.

National Center for Global Health and Medicine. Bureau of International Health Cooperation. Department of Human Resources Development.

Background: The present study compared adherence to the fasting-time guidelines of the International Committee for the Advancement of Procedural Sedation (ICAPS) and the North American Society of Anesthesiologists (ASA) and complication rates in pediatric patients requiring procedure sedation and analgesia during treatment in the emergency room (ER).

Methods: The present, retrospective, single-center study was performed between 2016 and 2020 and enrolled patients who received procedural sedation and analgesia in the ER with the fasting times recommended in the ICAPS and ASA guidelines.

Results: In total, 857 patients were included. Read More

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Incidence and trends of ophthalmic cancer in Singapore: Data from Singapore Cancer Registry.

Ann Acad Med Singap 2021 Apr;50(4):297-305

Department of Ophthalmology, National University Hospital, Singapore.

Introduction: Limited data are available on the incidence of primary ophthalmic cancers worldwide. We describe the incidence and trends of primary ophthalmic cancers in Singapore.

Methods: Data on ophthalmic cancers diagnosed in Singapore from 1996 to 2016 were retrieved from the Singapore Cancer Registry for analysis. Read More

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Influence of Minimally Invasive Resection Technique on Sphincter Preservation and Short-term Outcome in Low Rectal Cancer in the Netherlands.

Dis Colon Rectum 2021 May 13. Epub 2021 May 13.

Department of Surgery, Amsterdam University Medical Centers, University of Amsterdam, Cancer Center Amsterdam, Meibergdreef 9, Amsterdam, Netherlands Department of Surgery, Amphia, Breda, Netherlands Department of Surgery, Reinier de Graaf Hospital, Delft, the Netherlands. Department of Surgery, Amsterdam University Medical Centers, Free University Amsterdam, Cancer Center Amsterdam, De Boelelaan 1117, Amsterdam, the Netherlands Department of Surgery, Gelderse Vallei Hospital, Ede, the Netherlands.

Background: Transanal and robotic-assisted total mesorectal excision are techniques that can potentially overcome challenges encountered with a pure laparoscopic approach in patients with rectal cancer.

Objective: The aim of this study was to evaluate the proportion and predictive factors of restorative procedures and subsequent short-term outcomes of three minimally invasive techniques to treat low rectal cancer.

Design: This is a nationwide observational comparative registry study. Read More

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Use of historical high-sensitivity cardiac troponin T levels to rule out myocardial infarction.

Open Heart 2021 May;8(1)

Department of Emergency and Reparative Medicine, Karolinska University Hospital, Huddinge, Karolinska Universitetssjukhuset, Stockholm, Sweden.

Objective: Several high-sensitivity cardiac troponin (hs-cTn)-based strategies exist for rule-out of myocardial infarction (MI). It is unknown whether historical hs-cTnT concentrations can be used. This study aim to evaluate the performance of a rule-out strategy based on the European Society of Cardiology (ESC) 0/1-hour algorithm, using historical hs-cTnT concentrations. Read More

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Exercise capacity in patients with repaired Tetralogy of Fallot aged 6 to 63 years.

Heart 2021 May 14. Epub 2021 May 14.

Department of Paediatric Cardiology and Congenital Heart Disease, Technical University Munich, German Heart Centre Munich, München, Germany.

Objectives: This study aimed to provide a perspective for the interpretation of exercise capacity (peakVO) in patients with repaired Tetralogy of Fallot (patients with rTOF) by describing the course of peakVO from patients aged 6-63 years.

Methods: A retrospective study was performed between September 2001 and December 2016 in the German Heart Centre Munich, Germany, and in the University Medical Centre Groningen, the Netherlands. A total of 1175 cardiopulmonary exercise tests (CPETs) were collected from 586 patients with rTOF, 46% female. Read More

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Uptake of influenza vaccination among persons with inflammatory bowel disease, multiple sclerosis or rheumatoid arthritis: a population-based matched cohort study.

CMAJ Open 2021 Apr-Jun;9(2):E510-E521. Epub 2021 May 14.

Department of Internal Medicine (Marrie, Hitchon, Marriott, Bernstein), Department of Community Health Sciences (Marrie, Lix, Katz), Manitoba Centre for Health Policy (Walld, Katz), Department of Psychiatry (Bolton, Sareen), Department of Family Medicine (Singer, Katz), Department of Clinical Health Psychology (El-Gabalawy) and Department of Anesthesiology and Perioperative and Pain Medicine (El-Gabalawy), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Man.; Department of Community Health Sciences (Patten), Cumming School of Medicine, University of Calgary, Calgary, Alta.; Departments of Psychiatry (Fisk), of Psychology and Neuroscience (Fisk) and of Medicine (Fisk), Dalhousie University, Halifax, NS.

Background: Individuals with immune-mediated inflammatory diseases, such as inflammatory bowel disease, multiple sclerosis and rheumatoid arthritis, are at increased risk for influenza and related complications. We examined and compared the uptake of influenza vaccination among people with and without these diseases, as well as the influence of psychiatric comorbidity on vaccine uptake.

Methods: Using administrative data from Apr. Read More

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Comprehensive analysis of clinical, pathological, and genomic characteristics of follicular helper T-cell derived lymphomas.

Exp Hematol Oncol 2021 May 14;10(1):33. Epub 2021 May 14.

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-Gu, Seoul, 06351, Korea.

Background: The 2016 World Health Organization (WHO) classification introduced nodal lymphomas of T follicular helper (Tfh) cell origin, such as angioimmunoblastic T-cell lymphoma (AITL), follicular peripheral T-cell lymphoma (F-PTCL), and nodal peripheral T-cell lymphoma with T follicular helper phenotype (nodal PTCL with TFH phenotype). However, the accurate incidence rate and clinical characteristics of F-PTCL and nodal PTCL with TFH are unstudied.

Methods: Between February 2012 to June 2020, a total of 207 cases diagnosed with nodal lymphomas of T follicular helper (Tfh) cell origin and PTCL-NOS were reviewed for clinical and histopathologic data. Read More

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Using Weibo and WeChat social media channels to assess public awareness and practices related to antimicrobial resistance, China, 2019.

BMC Public Health 2021 May 14;21(1):921. Epub 2021 May 14.

Health Communication Center (National 12320 Health Hotline Management Office), Chinese Center for Disease Control and Prevention, No.155 Changbai Rd, Changping District, Beijing, China.

Background: Antimicrobial resistance (AMR) is a global healthcare problem, including in China where high rates of resistance to common bacterial infections have been documented. In 2016, the National Health and Family Planning Commission (NHFPC) in China established a comprehensive strategic plan to increase awareness about AMR through education programs.

Methods: We conducted an online survey to assess changes in public knowledge, awareness and practices related to AMR in China since 2016. Read More

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Impact of concomitant medication on clinical outcomes in patients with advanced non-small cell lung cancer treated with immune checkpoint inhibitors: A retrospective study.

Thorac Cancer 2021 May 14. Epub 2021 May 14.

Department of Pharmacometrics and Pharmacokinetics, Meiji Pharmaceutical University, Tokyo, Japan.

Background: It has recently been suggested that concomitant medication may affect the clinical outcome of patients treated with immune checkpoint inhibitors (ICIs). However, only a few studies on the impact of concomitant medication on immune-related adverse events (irAEs) have previously been reported. Here, we aimed to determine the impact of concomitant medication on the efficacy and safety of ICIs. Read More

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Greenspace exposure and cancer incidence: A 27-year follow-up of the French GAZEL cohort.

Sci Total Environ 2021 May 6;787:147553. Epub 2021 May 6.

Univ. Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-35000 Rennes, France. Electronic address:

Background: Greenspace exposure has been suggested to be associated with a range of health outcomes. The available evidence on the association of this exposure with cancer is still very scarce and inconsistent.

Objectives: We aimed to study the association between greenspace exposure and all-site and site-specific (prostate, breast, colorectal, bladder, lung, and malignant melanoma of skin) cancer incidence in the GAZEL cohort. Read More

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Effect of Internet use for searching information on vaccination on the uptake of human papillomavirus vaccine in France: A path-analysis approach.

Prev Med 2021 May 11:106615. Epub 2021 May 11.

INSERM CIC 1417, F-CRIN, I REIVAC, Assistance Publique- Hôpitaux de Paris, Hôpital Cochin, Paris, France; Université de Paris, Faculté de médecine Paris Descartes, Paris, France.

Internet is a popular source of information regarding vaccination. This study aimed to determine whether there is a negative association between Internet use among French vaccine-hesitant mothers and HPV vaccine uptake by their daughters, and to gain insight into the pathways that would link Internet use to the lack of HPV vaccine uptake. We conducted a pooled cross-sectional analysis across the 2015, 2016, 2017 and 2018 Vaccinoscopie® Survey. Read More

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Predictors and Sequelae of Postoperative Delirium in a Geriatric Patient Population With Hip Fracture.

J Am Acad Orthop Surg Glob Res Rev 2021 May 14;5(5). Epub 2021 May 14.

From the Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT (Ms. Haynes, Mr. Alder, Dr. Toombs, Dr. Rubin, and Dr. Grauer), and the Department of Orthopaedics, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire (Mr. Amakiri).

Introduction: Postoperative delirium is common for patients with hip fracture. Predictors of postoperative delirium and its association with preexisting dementia and adverse postoperative outcomes in a geriatric hip fracture population were assessed.

Methods: Patients with hip fracture aged 60 years and older were identified in the 2016 and 2017 National Surgical Quality Improvement Program Procedure Targeted Databases. Read More

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Trends in U.S. Health Care Spending on Inflammatory Bowel Diseases, 1996-2016.

Inflamm Bowel Dis 2021 May 14. Epub 2021 May 14.

Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada.

Background: Inflammatory bowel diseases (IBD) are rising in prevalence and are associated with high health care costs. We estimated trends in U.S. Read More

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Center-level Utilization of Hepatitis C Virus Positive Donors for Orthotopic Heart Transplantation.

Transplantation 2021 Feb 8. Epub 2021 Feb 8.

1 Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA. 2 Division of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA. 3 Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA. 4 Division of Cardiology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA.

Background: The use of hepatitis C virus (HCV) positive donors has expanded the donor pool for orthotopic heart transplantation (OHT). This study evaluated center-level trends and utilization of HCV+ donors for OHT.

Methods: Data were extracted from the Scientific Registry of Transplant Recipients on adults (≥18 years) undergoing OHT between January 1, 2016 and December 31, 2019. Read More

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February 2021

Development and psychometric evaluation of the Caregiver Caregiving Self-Efficacy Scale for family members with oral cancer.

Int J Nurs Pract 2021 May 13:e12957. Epub 2021 May 13.

College of Nursing, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.

Aim: The aim of this study was to develop and initially assess the psychometric properties of the Caregiver Caregiving Self-Efficacy Scale-Oral Cancer (CSES-OC).

Methods: In total, 28 items in the Caregiver Caregiving Self-Efficacy Scale-Oral Cancer were originally employed for a reliability and validity test based on expert suggestions and qualitative findings. The Cronbach's alpha coefficient and test-retest reliability were evaluated with the pilot sample, which included 30 caregivers. Read More

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Intrapartum antibiotic prophylaxis for women who are screened positive for group B streptococcal colonisation: Clinical compliance with the guideline.

Aust N Z J Obstet Gynaecol 2021 May 13. Epub 2021 May 13.

Hunter New England Local Health District, Nurses and Midwives Research Centre, The University of Newcastle, Callaghan, New South Wales, Australia.

Background: In high income countries, ~30% of pregnant women are provided with intrapartum antibiotic prophylaxis (IAP) for early-onset group B streptococcal infection (EOGBSI). The infection rate is low, 0.2/1000 livebirths in our jurisdiction, and others. Read More

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Long-term cosmetic results of video-assisted thyroidectomy: a comparison with conventional surgery.

Langenbecks Arch Surg 2021 May 13. Epub 2021 May 13.

Klinik für Chirurgie und Zentrum für Minimal Invasive Chirurgie, Evang. Kliniken Essen-Mitte, Henricistrasse 92, 45136, Essen, Germany.

Purpose: We present the long-term cosmetic results of the video-assisted thyroidectomy (MIVAT) in comparison to the conventional operation.

Methods: Forty-eight patients (four males, 44 females; mean age 47.4 ± 12. Read More

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Chronic obstructive pulmonary disease is associated with worse outcomes in ischemic colitis: a nationwide retrospective study.

Int J Colorectal Dis 2021 May 13. Epub 2021 May 13.

Department of Gastroenterology and Hepatology, MercyOne Des Moines Medical Center, Des Moines, IA, USA.

Background: Ischemic colitis (IC) occurs when the blood supply of the large intestine becomes compromised. Several cardiovascular conditions, such as coronary artery disease, congestive heart failure, and atrial fibrillation, are well-established risk factors for the development of IC. The effects of pulmonary conditions, namely chronic obstructive pulmonary disease (COPD), on IC have not been well studied. Read More

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Longitudinal Assessment of Right Ventricular Function in Hypoplastic Left Heart Syndrome.

Pediatr Cardiol 2021 May 13. Epub 2021 May 13.

Division of Cardiology, Department of Pediatrics, Stanford Medical School, 750 Welch Road, Stanford, CA, USA.

Overall survival of patients with hypoplastic left heart syndrome (HLHS) has shown continued improvement. Right ventricular (RV) dysfunction, in the long term, adversely affects prognosis in these patients. This study examines changes in echocardiographic markers of RV function in a longitudinal cohort. Read More

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Postoperative follow-up strategy based on event dynamics for esophageal squamous cell carcinoma.

Ann Transl Med 2021 Apr;9(8):699

Fujian Key Laboratory of Cardiothoracic Surgery (Fujian Medical University), Fuzhou, China.

Background: Despite the improvements in radical surgery for esophageal squamous cell carcinoma (ESCC), a large number of patients still develop recurrence. This research sought to graphically depict patterns in ESCC recurrence following curative surgical treatment using event dynamics and clarify approaches to postsurgical follow-up on the basis of recurrence time.

Methods: This study included 717 individuals with ESCC who received radical surgery in the Thoracic Department at Fujian Medical University Union Hospital between 2013 and 2016. Read More

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Efficacy and safety of vinorelbine and cisplatin regimen of different doses and intensities for neoadjuvant chemotherapy in patients with locally advanced esophageal carcinoma.

Ann Transl Med 2021 Apr;9(8):660

Department of Cardiothoracic Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China.

Background: There are few studies focused on comparing the toxicity, postoperative complication rate, and survival among patients with locally advanced esophageal squamous cell cancer receiving a different dose and intensity of vinorelbine plus cisplatin for neoadjuvant chemoradiotherapy (nCRT) followed by surgery.

Methods: In total, 78 patients diagnosed with locally advanced esophageal squamous cell cancer that had received a vinorelbine and cisplatin (VP)1 or VP2 regimen for nCRT followed by surgery in Taizhou Hospital of Zhejiang Province between June 2008 and December 2016 were retrospectively analyzed. The VP1 regimen involved cisplatin 75 mg/m on day 1, and vinorelbine 25 mg/m on days 1 and 8, for two cycles. Read More

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Guiding the conversation-types of regret after gender-affirming surgery and their associated etiologies.

Ann Transl Med 2021 Apr;9(7):605

Division of Plastic & Reconstructive Surgery, Oregon Health & Science University, Portland, OR, USA.

Background: A rare, but consequential, risk of gender affirming surgery (GAS) is post-operative regret resulting in a request for surgical reversal. Studies on regret and surgical reversal are scarce, and there is no standard terminology regarding either etiology and/or classification of the various forms of regret. This study includes a survey of surgeons' experience with patient regret and requests for reversal surgery, a literature review on the topic of regret, and expert, consensus opinion designed to establish a classification system for the etiology and types of regret experienced by some patients. Read More

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A prognostic nomogram for women with primary ovarian signet-ring cell carcinoma.

Ann Transl Med 2021 Apr;9(7):525

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China.

Background: Primary ovarian signet-ring cell carcinoma (POSRCC) is a rare subtype of ovarian carcinoma that is characterized by abundant mucin accumulation. POSRCC is aggressive, and the prognostic factors associated with its clinical outcome remain poorly defined. This study aimed to elucidate the clinical characteristics and survival of patients with POSRCC, and to establish an effective prognostic nomogram and risk stratification model to predict the risks associated with patient outcomes. Read More

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Target Calorie Intake Achievements for Patients Treated in the Surgical Intensive Care Unit.

Clin Nutr Res 2021 Apr 19;10(2):107-114. Epub 2021 Apr 19.

Department of Anesthesiology and Pain Medicine, College of Medicine, Chung-Ang University, Seoul 06973, Korea.

Adequate nutritional support in critically ill patients is important, however, sometimes it has been neglected in perioperative period of patients at surgical intensive care units (SICU). The aim of this study was to investigate whether approaching target calorie intake of surgical patients influences on their clinical outcomes. A total of 279 patients who admitted at SICU in perioperative period from August 2014 to July 2016 at our hospital were analyzed. Read More

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Ceftriaxone as an Alternative Therapy for the Treatment of Methicillin-Susceptible Bacteremia after Initial Clearance of Bloodstream Infection.

Case Rep Infect Dis 2021 26;2021:8884685. Epub 2021 Apr 26.

University of Mississippi School of Pharmacy, Department of Pharmacy Practice, 2500 North State Street, Jackson, MS 39216, USA.

Introduction: spp. represent the leading cause of hospital-acquired infections and second-most frequent pathogen in bloodstream infections. Methicillin-susceptible (MSSA) comprise approximately half of all isolates. Read More

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