AIDS 2021 Jul 22. Epub 2021 Jul 22.
Central Clinical School, University of Sydney, Camperdown, NSW 2050, Australia Wagga Wagga Base Hospital, Wagga Wagga, NSW, 2650 Australia Kirby Institute, UNSW Sydney, Sydney, NSW 2052, Australia Department of Renal Medicine, Royal Prince Alfred Hospital, Camperdown, NSW, Australia Westmead Clinical School, Faculty of Medicine and Health, University of Sydney, Westmead, NSW 2145, Australia Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Westmead, NSW 2145, Australia Western Sydney Sexual Health Centre, Western Sydney Local Health District, Parramatta, NSW, 2150, Australia Holdsworth House Medical Practice, Darlinghurst, NSW 2010, Australia.
Background: HIV pre-exposure prophylaxis (PrEP) with fixed-dose tenofovir disoproxil fumarate (TDF) and emtricitabine has been associated with low rates of renal impairment in clinical trials. Large-scale PrEP implementation may result in higher rates, as the prevalence of associated risk factors may be higher than in trial populations.
Methods: A post-hoc analysis of EPIC-NSW, a large Australian multi-centre PrEP implementation trial for patients at high-risk of HIV infection. Read More