39 results match your criteria 2011-2013 2014-2015


Association of Medicaid expansion and insurance status, cancer stage, treatment and mortality among patients with cervical cancer.

Cancer Rep (Hoboken) 2021 May 2:e1407. Epub 2021 May 2.

Harvard Medical School, Boston, Massachusetts, USA.

Background: Currently, little is known about the effect of the Patient Protection and Affordable Care Act's Medicaid expansion on care delivery and outcomes in cervical cancer.

Aim: We evaluated whether Medicaid expansion was associated with changes in insurance status, stage at diagnosis, timely treatment, and survival outcomes in cervical cancer.

Methods And Results: Using the National Cancer Database, we performed a difference-in-differences (DID) cross-sectional analysis to compare insurance status, stage at diagnosis, timely treatment, and survival outcomes among cervical cancer patients residing in Medicaid expansion and nonexpansion states before (2011-2013) and after (2014-2015) Medicaid expansion. Read More

View Article and Full-Text PDF

SAP130 and CSN1 interact and regulate male gametogenesis in Arabidopsis thaliana.

J Plant Res 2021 Mar 8;134(2):279-289. Epub 2021 Feb 8.

Molecular Biology Laboratory, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto, 611-0011, Japan.

COP9 signalosome (CSN) is a nuclear complex composed of eight distinct subunits that governs vast developmental processes in Arabidopsis thaliana (L.) Heynh. The null alleles of csn mutants display pleiotropic phenotypes that result in seedling lethality. Read More

View Article and Full-Text PDF

The impact of global budget payment reform on systemic overuse in Maryland.

Healthc (Amst) 2020 Dec 4;8(4):100475. Epub 2020 Oct 4.

Johns Hopkins University Bloomberg School of Public Health, Department of Health Policy and Management, Baltimore, MD, USA; Center for Health Services and Outcomes Research of the Bloomberg School of Public Health, Baltimore, MD, USA; Johns Hopkins University School of Medicine, Department of Medicine, Baltimore, MD, USA.

Background: Medical overuse is a leading contributor to the high cost of the US health care system and is a definitive misuse of resources. Elimination of overuse could improve health care efficiency. In 2014, the State of Maryland placed the majority of its hospitals under an all-payer, annual, global budget for inpatient and outpatient hospital services. Read More

View Article and Full-Text PDF
December 2020

National tuberculosis prevalence surveys in Africa, 2008-2016: an overview of results and lessons learned.

Trop Med Int Health 2020 11 12;25(11):1308-1327. Epub 2020 Oct 12.

Global Tuberculosis Programme, World Health Organization, Geneva, Switzerland.

Objective And Methods: Worldwide, tuberculosis (TB) is the leading cause of death from a single infectious agent. In many countries, national TB prevalence surveys are the only way to reliably measure the burden of TB disease and can also provide other evidence to inform national efforts to improve TB detection and treatment. Our objective was to synthesise the results and lessons learned from national surveys completed in Africa between 2008 and 2016, to complement a previous review for Asia. Read More

View Article and Full-Text PDF
November 2020

Has the Affordable Care Act Been Associated with Increased Insurance Coverage and Early-stage Diagnoses of Bone and Soft-tissue Sarcomas in Adults?

Clin Orthop Relat Res 2021 03;479(3):493-502

A. T. Malik, J. Alexander, S. N. Khan, T. J. Scharschmidt, The James Cancer Hospital and Solove Research Institute, the Ohio State University Wexner Medical Center, Columbus, OH, USA.

Background: Treatment of bone and soft-tissue sarcomas can be costly, and therefore, it is not surprising that insurance status of patients is a prognostic factor in determining overall survival. Furthermore, uninsured individuals with suspected bone and/or soft-tissue masses routinely encounter difficulty in obtaining access to basic healthcare (such as office visits, radiology scans), and therefore are more likely to be diagnosed with later stages at presentation. The Patient Protection and Affordable Care Act (ACA) mandate of 2010 aimed to increase access to care for uninsured individuals by launching initiatives, such as expanding Medicaid eligibility, subsidizing private insurance, and developing statewide mandates requiring individuals to have a prescribed minimum level of health insurance. Read More

View Article and Full-Text PDF

Change in stage of presentation of head and neck cancer in the United States before and after the affordable care act.

Cancer Epidemiol 2020 08 24;67:101763. Epub 2020 Jun 24.

Saint Louis University School of Medicine, Department of Otolaryngology-Head and Neck Surgery, Saint Louis, MO, USA; Saint Louis University Cancer Center, Saint Louis, MO, USA. Electronic address:

Objective/hypothesis: Early diagnosis and stage at presentation, two prognostic factors for survival among patients with head and neck cancer (HNC), are significantly impacted by a patient's health insurance status. We aimed to assess the impact of the Patient Protection and Affordable Care Act (ACA) on stage at presentation across socioeconomic and demographic subpopulations of HNC patients in the United States.

Study Design: Retrospective data analysis. Read More

View Article and Full-Text PDF

Emergency department and inpatient utilization among U.S. older adults with multiple chronic conditions: a post-reform update.

BMC Health Serv Res 2020 Feb 3;20(1):77. Epub 2020 Feb 3.

Center for Population Health and Aging, Texas A&M University, College Station, 212 Adriance Lab Rd, 1266 TAMU, College Station, TX, 77843, USA.

Background: The Affordable Care Act (ACA) was enacted to enhance access to care primarily among nonelderly and low-income populations; however, several provisions addressed key determinants of emergency department (ED) and inpatient visits among Medicare beneficiaries over age 65 years. We take stock of the overall changes in these visits among older Medicare beneficiaries, focusing on those with multiple chronic conditions (MCCs), and provide a nationally representative post-reform update.

Methods: We analyzed a sample of 32,919 older adults (65+) on Medicare from the 2006-2015 Medical Expenditure Panel Survey (MEPS). Read More

View Article and Full-Text PDF
February 2020

OPTN/SRTR 2018 Annual Data Report: Heart.

Am J Transplant 2020 01;20 Suppl s1:340-426

Scientific Registry of Transplant Recipients, Hennepin Healthcare Research Institute, Minneapolis, MN.

The new adult heart allocation policy was approved in 2016 and implemented in October 2018, so its effect was not yet evident in 2018 data. However, the more granular data being collected are anticipated to allow for improved analyses. In 2018, new listings continued to increase; 3883 new adult and 685 new pediatric candidates were added. Read More

View Article and Full-Text PDF
January 2020

Impacts of Health Reform Plan in Iran on Health Payments Distributions and Catastrophic Expenditure.

Iran J Public Health 2019 Oct;48(10):1861-1869

Department of Health Economics, School of Medicine, Shahed University, Tehran, Iran.

Background: Health reform in Iran began in 2014, aimed at improving financing pattern of health services. We assessed the reform by changes in variables representing distribution of health payments and catastrophic expenditures.

Methods: Using data from households' income-expenditure survey, this study computed the financial variables, representing poverty line and households at poor state, household's catastrophic health expenditure, fairness in financial contribution (FFC) index, and household's impoverishment state, in the years 2010-2016, in urban and rural areas. Read More

View Article and Full-Text PDF
October 2019

Long-term virological and adherence outcomes to antiviral treatment in a 4-year cohort chronic HBV study.

Antivir Ther 2019 ;24(8):567-579

Divisão de Gastroenterologia e Hepatologia Clínica do Hospital das Clínicas HCFMUSP, Departamento de Gastroenterologia da Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil.

Background: Chronic hepatitis B (CHB) treatment adherence has been poorly studied worldwide. We evaluated long-term virological and adherence outcomes to antiviral treatment in CHB patients.

Methods: A prospective 183 Brazilian CHB patient cohort treated with monotherapy or combination adefovir dipivoxil, entecavir, lamivudine and/or tenofovir disoproxil fumarate was studied in a reference tertiary centre. Read More

View Article and Full-Text PDF
October 2020

Overwintering of Piezodorus guildinii (Heteroptera, Pentatomidae) Populations.

Neotrop Entomol 2020 Apr 3;49(2):179-190. Epub 2019 Dec 3.

EMBRAPA Trigo, Passo Fundo, Brasil.

Piezodorus guildinii (Westwood) is a soybean pest that causes significant economic losses in the Americas. The variability of overwintering (diapause) traits was evaluated in populations of the Southwest (SW) (33°55'-34°17'S, 57°13'-57°46'W) during 2-year period (2011-2013) and of the Northwest (NW) (32°01'-33°02'S, 57°50'-57°24'W) during 1-year period (2014-2015) Regions of Uruguay. Samples were taken from different plant species (cultivated legumes, wild shrubs, and trees) and from overwintering sites (leaf litter and bark). Read More

View Article and Full-Text PDF

Analysis of GII.P7 and GII.6 noroviruses circulating in Italy during 2011-2016 reveals a replacement of lineages and complex recombination history.

Infect Genet Evol 2019 11 5;75:103991. Epub 2019 Aug 5.

Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro", Università di Palermo, Italy.

Noroviruses are important human enteric pathogens and monitoring their genetic diversity is important for epidemiological surveillance, vaccine development, and understanding of RNA viruses evolution. Epidemiological investigations have revealed that genogroup II, genotype 6 noroviruses (GII.6) are common agents of gastroenteritis. Read More

View Article and Full-Text PDF
November 2019

Uptake of endoscopic screening for gastroesophageal varices and factors associated with variceal bleeding in patients with chronic hepatitis C infection and compensated cirrhosis, 2005-2016: a national database linkage study.

Aliment Pharmacol Ther 2019 08 3;50(4):425-434. Epub 2019 Jun 3.

Royal Infirmary of Edinburgh, Edinburgh, UK.

Background: Primary measures for preventing morbidity and mortality associated with bleeding gastroesophageal varices in cirrhotic patients include endoscopic screening.

Aim: To identify factors associated with (a) screening and (b) first hospital admission for variceal bleeding among cirrhotic hepatitis C virus (HCV) patients attending specialist care in Scotland.

Methods: The Scottish Hepatitis C Clinical Database was linked to national hospitalisation and deaths records to identify all chronic HCV patients diagnosed with compensated cirrhosis in 2005-2016 (n = 2741). Read More

View Article and Full-Text PDF

Increased Risk of Death in First Year After Liver Transplantation Among Patients With Nonalcoholic Steatohepatitis vs Liver Disease of Other Etiologies.

Clin Gastroenterol Hepatol 2019 12 17;17(13):2759-2768.e5. Epub 2019 Apr 17.

Gastroenterology, Henry Ford Hospital, Detroit, Michigan.

Background & Aims: An increasing number of patients with non-alcoholic steatohepatitis (NASH) require liver transplantation. We compared outcomes of patients with liver diseases of different etiologies (NASH, hepatitis C virus [HCV]-associated liver disease, and alcohol-associated liver disease [ALD]).

Methods: We analyzed data from the United Network for Organ Sharing registry on 6344 patients who underwent liver transplantation for NASH, 17,037 for cirrhosis from chronic HCV infection, and 9279 for ALD. Read More

View Article and Full-Text PDF
December 2019

Associations of depressive symptoms and history with three a priori diet quality indices in middle-aged and older adults.

J Affect Disord 2019 Apr 6;249:394-403. Epub 2019 Feb 6.

Department of Health Sciences, Faculty of Science, Amsterdam Public Health research institute, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands.

Background: Evidence for the diet-depression link is growing but longitudinal studies on the reverse association are scarce. We investigated associations of (1) current depressive symptoms, (2) short-term changes in and (3) long-term history of depressive symptoms with three a priori diet quality indices.

Methods: Data were from participants (≥ 55 years) of the Longitudinal Aging Study Amsterdam (LASA). Read More

View Article and Full-Text PDF

Variation in outcomes among 24/7 percutaneous coronary intervention centres for patients resuscitated from out-of-hospital cardiac arrest.

Resuscitation 2019 02 24;135:14-20. Epub 2018 Dec 24.

Department of Pediatrics, University of California Davis, Sacramento, CA, United States.

Background: Patients treated at 24/7 percutaneous coronary intervention (PCI) centres following out-of-hospital cardiac arrest (OHCA) have better outcomes than those treated at non-24/7 PCI centres. However, variation in outcomes between 24/7 PCI centres is not well studied.

Objectives: To evaluate variation in outcomes among 24/7 PCI centres and to assess stability of 24/7 PCI centre performance. Read More

View Article and Full-Text PDF
February 2019

Impact of healthcare reform on the payer mix among young adult emergency department utilizers across the United States (2005-2015).

Medicine (Baltimore) 2018 Dec;97(49):e13556

Betty and Guy Beatty Center for Integrated Research, Inova Health System.

Before the patient protection and affordable care act (ACA), young adults (20 to 34) had the highest uninsured rates in the United States (US) and frequently sought care in emergency departments (EDs).We aimed to determine if there was a measurable effect of expanded coverage, specifically the dependent coverage provision and Medicaid expansion, on the payer mix of young adults in EDs.We performed a retrospective cross-sectional study of ED utilization among young adults across the US using the national hospital ambulatory medical care survey (NHAMCS) (2005-2015). Read More

View Article and Full-Text PDF
December 2018

Incidence of Thyroid Cancer Among Children and Young Adults in Fukushima, Japan, Screened With 2 Rounds of Ultrasonography Within 5 Years of the 2011 Fukushima Daiichi Nuclear Power Station Accident.

JAMA Otolaryngol Head Neck Surg 2019 01;145(1):4-11

Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima, Japan.

Importance: Ultrasonographic (US) screening for thyroid cancer was performed in the Fukushima Health Management Survey after the 2011 Fukushima Daiichi nuclear power station accident. Clinical characteristics of thyroid cancers screened by US among children and young adults during the first 5 years after the accident were analyzed.

Objectives: To evaluate the number of detected thyroid cancers by age group within 5 years of the Fukushima Daiichi nuclear power station accident and to compare the basic clinical characteristics and demographic patterns in first- and second-round examinations. Read More

View Article and Full-Text PDF
January 2019

ART initiation in an outpatient treatment center in Dakar, Senegal: A retrospective cohort analysis (1998-2015).

PLoS One 2018 19;13(9):e0202984. Epub 2018 Sep 19.

Transvihmi, UMI 233-Institut de Recherche pour le Developpement, U1175-Inserm, University of Montpellier, Montpellier, France.

Objective: To examine how patient characteristics combined with ART eligibility expansions affect the initiation of antiretroviral therapy (ART) among eligible patients attending a referral center in Senegal from 1998 to 2015.

Methods: This is a retrospective observational study carried out at the outpatient treatment Centre (Centre de Traitement Ambulatoire) in Dakar, Senegal, based on computerized medical records, gathered from 1998 to 2015, of ART-naïve patients over 15 years of age. ART eligibility was defined as (CD4 count below 200) or as (WHO stage 4) or as (WHO stage 3 with (CD4 count below 350 or with unavailable CD4 count)) in 1998-2010; as (CD4 count below 350) or as (WHO stage 3 or 4) in 2011-2013; as (CD4 count below 500) or as (WHO stage 3 or 4) in 2014-2015. Read More

View Article and Full-Text PDF
February 2019

Associations between pneumonia and residential distance to livestock farms over a five-year period in a large population-based study.

PLoS One 2018 17;13(7):e0200813. Epub 2018 Jul 17.

Wageningen Bioveterinary Research, Lelystad, The Netherlands.

In a recent study of electronic health records (EHR) of general practitioners in a livestock-dense area in The Netherlands in 2009, associations were found between residential distance to poultry farms and the occurrence of community-acquired pneumonia (CAP). In addition, in a recent cross-sectional study in 2494 adults in 2014/2015 an association between CAP and proximity to goat farms was observed. Here, we extended the 2009 EHR analyses across a wider period of time (2009-2013), a wider set of health effects, and a wider set of farm types as potential risk sources. Read More

View Article and Full-Text PDF
January 2019

Emergence of uncommon HIV-1 non-B subtypes and circulating recombinant forms and trends in transmission of antiretroviral drug resistance in patients with primary infection during the 2013-2015 period in Marseille, Southeastern France.

J Med Virol 2018 10 11;90(10):1559-1567. Epub 2018 Jun 11.

IRD, APHM, MEPHI, IHU-Méditerranée Infection, Aix Marseille University, Marseille, France.

Primary HIV-1 infections (PHI) with non-B subtypes are increasing in developed countries while transmission of HIV-1 harboring antiretroviral resistance-associated mutations (RAMs) remains a concern. This study assessed non-B HIV-1 subtypes and RAMs prevalence among patients with PHI in university hospitals of Marseille, Southeastern France, in 2005-2015 (11 years). HIV-1 sequences were obtained by in-house protocols from 115 patients with PHI, including 38 for the 2013-2015 period. Read More

View Article and Full-Text PDF
October 2018

De Novo Hepatocellular Carcinoma Among Liver Transplant Registrants in the Direct Acting Antiviral Era.

Hepatology 2018 10;68(4):1288-1297

Departments of Medicine and Public Health Sciences, Queen's University, Kingston, Ontario, Canada.

The risk of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV) receiving direct acting antivirals (DAAs) has been debated. This study aims to describe the incidence of HCC among patients listed for liver transplantation (LT) in the DAA era. Individuals with cirrhosis listed for LT from January 2003 to December 2015 were identified using the Scientific Registry for Transplant Recipients database. Read More

View Article and Full-Text PDF
October 2018

Epidemiology and molecular characterization of influenza viruses in Burkina Faso, sub-Saharan Africa.

Influenza Other Respir Viruses 2018 07 24;12(4):490-496. Epub 2018 Apr 24.

Infectious Diseases Research Unit, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.

Background: The importance of influenza viruses in respiratory infections in sub-Saharan Africa has been historically overlooked, including in Burkina Faso.

Objectives: This study therefore aimed at evaluating the prevalence and seasonal occurrence of influenza viruses in children under 5 years old, at risk of influenza-related complications, presenting with influenza-like illness (ILI) or severe acute respiratory infection (SARI). The study also aimed at identifying the periods with increased influenza transmission for vaccination recommendations in Burkina Faso. Read More

View Article and Full-Text PDF

Ten-Year Surveillance of Measles Virus from 2007-2016 in Osaka City, Japan.

Jpn J Infect Dis 2018 Mar 26;71(2):152-154. Epub 2017 Dec 26.

Division of Microbiology, Osaka Institute of Public Health.

Measles is a highly contagious infection caused by the measles virus (MV). This study performed long-term surveillance in order to survey the prevalence of MV. A total of 417 patients diagnosed with or suspected of having measles were tested for MV between January 2007 and December 2016 in Osaka City, Japan. Read More

View Article and Full-Text PDF

Early impact of 13-valent pneumococcal conjugate vaccine on pneumococcal meningitis-Burkina Faso, 2014-2015.

J Infect 2018 03 15;76(3):270-279. Epub 2017 Dec 15.

National Center for Immunization and Respiratory Diseases, CDC, Atlanta, GA, USA.

Objectives: We evaluate early impact of 13-valent pneumococcal conjugate vaccine (PCV13) on pneumococcal meningitis in Burkina Faso.

Methods: Nationwide surveillance gathered demographic/clinical information and cerebrospinal fluid (CSF) results for meningitis cases. Pneumococcal cases were confirmed by culture, polymerase chain reaction (PCR), or latex agglutination, and strains serotyped using PCR. Read More

View Article and Full-Text PDF

Ross River Virus Seroprevalence, French Polynesia, 2014-2015.

Emerg Infect Dis 2017 10;23(10):1751-1753

Ross River virus (RRV), spread by Aedes and Culex mosquitoes, is the most commonly transmitted arbovirus in Australia. A serosurvey of blood donors in French Polynesia during 2011-2013 suggested that RRV circulated without being detected. We report RRV circulation in French Polynesia based on further screening of blood samples collected during 2014-2015. Read More

View Article and Full-Text PDF
October 2017

Medicaid expansion and chronic obstructive pulmonary disease among low-income adults in the United States.

Clin Respir J 2018 Apr 6;12(4):1398-1406. Epub 2017 Aug 6.

Department of Pediatrics, The Ohio State University, Columbus, Ohio.

Introduction: Chronic obstructive pulmonary disease (COPD) is common but often underdiagnosed in the United States (US). Public health insurance coverage expansion may increase the prevalence of diagnosed COPD due to improved access to care and diagnosis.

Objective: We sought to determine the effects of Medicaid expansion on the prevalence of diagnosed COPD among low-income US adults. Read More

View Article and Full-Text PDF

Insurance Coverage and Well-Child Visits Improved for Youth Under the Affordable Care Act, but Latino Youth Still Lag Behind.

Acad Pediatr 2018 Jan - Feb;18(1):35-42. Epub 2017 Jul 21.

Department of Health Services Administration, School of Public Health, University of Maryland, College Park, MD.

Objective: To examine whether there have been changes in insurance coverage and health care utilization for youth before and after the national implementation of the Patient Protection and Affordable Care Act (ACA) and to assess whether racial and ethnic inequities have improved.

Methods: Data are from 64,565 youth (ages 0-17 years) participants in the 2011 to 2015 National Health Interview Survey. We conducted multivariate logistic regression analyses to determine how the period after national implementation of the ACA (years 2011-2013 vs years 2014-2015) was associated with health insurance coverage and utilization of health care services (well-child visits, having visited an emergency department, and having visited a physician, all in the past 12 months), and whether changes over the pre- and post-ACA periods varied according to race and Latino ethnicity. Read More

View Article and Full-Text PDF

Population trends in prenatal detection of transposition of great arteries: impact of obstetric screening ultrasound guidelines.

Ultrasound Obstet Gynecol 2018 May;51(5):659-664

Fetal & Neonatal Cardiology Program, Division of Cardiology, Department of Pediatrics, Stollery Children's Hospital and Royal Alexandra Hospital, Women & Children's Health Research and Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada.

Objectives: Dextro-transposition of the great arteries (d-TGA) is one of the most common critical neonatal heart defects, with a low detection rate antenatally. We sought to evaluate trends in the prenatal detection of d-TGA with or without ventricular septal defect (VSD) in Alberta over the past 13 years, examining the potential impact of ultrasound guidelines incorporating screening of cardiac outflow tracts, updated in 2009-2010 and in 2013, and factors affecting detection of the condition.

Methods: All fetuses and neonates with d-TGA, with or without VSD, encountered between 2003 and 2015 in the province of Alberta, were identified retrospectively. Read More

View Article and Full-Text PDF