12,307 results match your criteria 2011 november

Patient, hospital and country-level risk factors of all-cause mortality among patients with chronic heart failure: Prospective international cohort study.

PLoS One 2021 10;16(5):e0250931. Epub 2021 May 10.

Maria Cecilia Hospital-GVM Care & Research, Cotignola, Italy.

Background: Although many studies have described patient-level risk factors for outcomes in heart failure (HF), health care structural determinants remain largely unexplored. This research reports patient-, hospital- and country-level characteristics associated with 1-year all-cause mortality among patients with chronic HF, and investigates geographic and hospital variation in mortality.

Methods And Findings: We included 9,277 patients with chronic HF enrolled between May 2011 and November 2017 in the prospective cohort study European Society of Cardiology Heart Failure Long Term registry across 142 hospitals, located in 22 countries. Read More

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A phase I/II study of bevacizumab, irinotecan and erlotinib in children with progressive diffuse intrinsic pontine glioma.

J Neurooncol 2021 May 7. Epub 2021 May 7.

Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Pediatric Oncology, Amsterdam, The Netherlands.

Introduction: This study investigates the safety, tolerability, and preliminary efficacy of combined treatment with VEGF inhibitor bevacizumab, topoisomerase I inhibitor irinotecan, and EGFR inhibitor erlotinib in children with progressive diffuse intrinsic pontine glioma (DIPG).

Methods: Biweekly bevacizumab (10 mg/kg) and irinotecan (125 mg/m) were combined with daily erlotinib. Two cohorts received increasing doses of erlotinib (65 and 85 mg/m) following a 3 + 3 dose-escalation schedule, until disease progression with a maximum of one year. Read More

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Interventions to Reduce Pediatric Prescribing Errors in Professional Healthcare Settings: A Systematic Review of the Last Decade.

Paediatr Drugs 2021 May 7. Epub 2021 May 7.

Hospital Pharmacy, RWTH Aachen University Hospital, Steinbergweg 20, 52074, Aachen, Germany.

Introduction: Pediatric medication therapy is prone to errors due to the need for pharmacokinetic and pharmacodynamic individualization and the diverse settings in which pediatric patients are treated. Prescribing errors have been reported as the most common medication error.

Objectives: The aim of this review was to systematically identify interventions to reduce prescribing errors and corresponding patient harm in pediatric healthcare settings and to evaluate their impact. Read More

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Clinical significance and risk factors of International Society of Urological Pathology (ISUP) grade upgrading in prostate cancer patients undergoing robot-assisted radical prostatectomy.

BMC Cancer 2021 May 4;21(1):501. Epub 2021 May 4.

Department of Urology, Graduate School of Medicine, The University of Tokyo, Hongo7-3-1, Bunkyo-Ku, Tokyo, Japan.

Background: The objective of this study is to investigate the clinical significance and risk factors of upgrading in the International Society of Urological Pathology (ISUP) Grade Group System in men undergoing robot-assisted radical prostatectomy (RARP) for prostate cancer.

Methods: A total of 583 patients diagnosed with prostate cancer by systematic biopsy were treated with RARP without neoadjuvant therapy from November 2011 to December 2018. Clinicopathological data were obtained from our clinical records. Read More

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A review of Leila Rose Foundation support for families affected by rare childhood cancer in Australia over the past decade.

Cancer Rep (Hoboken) 2021 May 3:e1381. Epub 2021 May 3.

CEO, Leila Rose Foundation and Business Unit Manager, ANZ at ITL Australia Pty Ltd, an Australian Medical Device Manufacturer, Melbourne, Victoria, Australia.

Background: The Leila Rose Foundation ("the Foundation") was established in April 2011, to address financial toxicity as well as the gaps in knowledge and support for families affected by a rare childhood cancer diagnosis in Australia.

Aim: The aim of this brief report is to analyze the diagnostic trends surrounding the rare cancer diagnoses for patients referred to the Foundation over the past decade and to present case studies evaluating the role of the Foundation's Family Support Coordinator in providing tailored, individualized support for families.

Methods: Eligibility for family support is restricted to children ≤ 14 years of age at diagnosis with a cancer that has an incidence less than 5% of all childhood cancers in Australia as reflected by national registry data. Read More

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Establishment and verification of a prediction model based on clinical characteristics and positron emission tomography/computed tomography (PET/CT) parameters for distinguishing malignant from benign ground-glass nodules.

Quant Imaging Med Surg 2021 May;11(5):1710-1722

Department of Nuclear Medicine, the Third Affiliated Hospital of Soochow University, Changzhou, China.

Background: To develop and verify a prediction model for distinguishing malignant from benign ground-glass nodules (GGNs) combined with clinical characteristics and F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) parameters.

Methods: We retrospectively analyzed 170 patients (56 males and 114 females) with GGNs who underwent PET/CT and high-resolution CT examination in our hospital from November 2011 to December 2019. The clinical and imaging data of all patients were collected, and the nodules were randomly divided into a derivation set and a validation set. Read More

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500 Meters Is a Result of 6-Minute Walk Test Which Differentiates Patients with High and Low Risk of Postoperative Complications after Lobectomy-A Validation Study.

J Clin Med 2021 Apr 14;10(8). Epub 2021 Apr 14.

Thoracic Surgery Department, Medical University of Gdansk, Sklodowskiej-Curie 3A, 80-211 Gdansk, Poland.

The 6-min walk test (6MWT) is a simple method of identifying patients with a high risk of postoperative complications. In this study, we internally validated the previously obtained threshold value of 500 m in the 6MWT as differentiating populations with a high and a low risk of postoperative complications after a lobectomy. Between November 2011 and November 2016, 624 patients who underwent a lobectomy and performed the 6MWT preoperatively entered this study. Read More

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Detecting Digoxin Toxicity by Artificial Intelligence-Assisted Electrocardiography.

Int J Environ Res Public Health 2021 Apr 6;18(7). Epub 2021 Apr 6.

School of Public Health, National Defense Medical Center, Taipei 11490, Taiwan.

Although digoxin is important in heart rate control, the utilization of digoxin is declining due to its narrow therapeutic window. Misdiagnosis or delayed diagnosis of digoxin toxicity is common due to the lack of awareness and the time-consuming laboratory work that is involved. Electrocardiography (ECG) may be able to detect potential digoxin toxicity based on characteristic presentations. Read More

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A Comparison of Predicted Ipsilateral Tumor Recurrence Risks in Patients With Ductal Carcinoma in Situ of the Breast After Breast-Conserving Surgery by Breast Radiation Oncologists, the Van Nuys Prognostic Index, the Memorial Sloan Kettering Cancer Center DCIS Nomogram, and the 12-Gene DCIS Score Assay.

Adv Radiat Oncol 2021 Mar-Apr;6(2):100607. Epub 2020 Nov 1.

Rocky Mountain Cancer Centers, Littleton, Colorado.

Purpose: To compare ipsilateral breast event (IBE) risks in patients with ductal carcinoma in situ of the breast (DCIS) post-lumpectomy, as estimated by breast radiation oncologists, the Van Nuys Prognostic Index, the Memorial Sloan Kettering Cancer Center (MSKCC) DCIS nomogram, and the 12-gene Oncotype DX DCIS score assay.

Methods And Materials: Consecutive DCIS cases treated with lumpectomy from November 2011 to August 2014 with available DCIS score results were identified. Three radiation oncologists independently estimated the 10-year IBE risk. Read More

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November 2020

Reduction of toxicity in brachytherapy using a new technique.

Brachytherapy 2021 Apr 22. Epub 2021 Apr 22.

Department of Radiology, Wakayama Medical University, Wakayama.

Purpose: The purpose of the study was to elucidate the usefulness of a dose evaluation method for reducing late genitourinary (GU) toxicity in high-dose-rate brachytherapy (HDR-BT) of prostate cancer.

Methods And Materials: GU toxicity was scored in accordance with the Common Terminology Criteria for Adverse Events version 4.0. Read More

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Estimation of risk of neuropsychiatric adverse events from varenicline, bupropion and nicotine patch versus placebo: secondary analysis of results from the EAGLES trial using Bayes factors.

Addiction 2021 Apr 22. Epub 2021 Apr 22.

Research Department of Behavioural Science and Health, University College London, London, UK.

Background And Aims: Analysed using classical frequentist hypothesis testing with alpha set to 0.05, the Evaluating Adverse Events in a Global Smoking Cessation Study (EAGLES) did not find enough evidence to reject the hypothesis of no difference in neuropsychiatric adverse events (NPSAEs) attributable to varenicline, bupropion, or nicotine patch compared with placebo. This might be because the null hypothesis was true or because the data were insensitive. Read More

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Prognostic Factors for Patients with Esophageal Cancer Receiving Definitive Radiotherapy Alone: A Retrospective Analysis.

Cancer Manag Res 2021 13;13:3229-3234. Epub 2021 Apr 13.

The First School of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu, 210000, People's Republic of China.

Purpose: Intensity-modulated radiotherapy (IMRT) can improve the prognosis of patients with esophageal cancer. This study aimed to evaluate clinical factors relevant to the prognosis of patients with esophageal cancer who received intensity-modulated radiotherapy (IMRT) alone.

Patient And Methods: Data of 103 patients with pathologically confirmed esophageal cancer who were admitted to our hospital between October 2011 and November 2017 were retrospectively reviewed. Read More

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Can the electricity price subsidy policy curb NO emissions from China's coal-fired power industry? A difference-in-differences approach.

J Environ Manage 2021 Apr 18;290:112367. Epub 2021 Apr 18.

Research Institute for the Development of Shanghai, Shanghai University of Finance and Economics, Shanghai, 200433, China. Electronic address:

Air pollution currently poses a serious threat to human health and sustainable development in China. In an attempt to reduce nitrogen oxides (NO) emissions which are the major anthropogenic contributors to air pollution, China initiated an electricity price subsidy (EPS) policy in November 2011 for incentivizing coal-fired power plants to install denitrification units. However, the effectiveness of the policy in the reduction of NO emissions and its sustainability are yet to be investigated. Read More

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Epidemiological Profile of Meningitis following Pentavalent Vaccination in Iran: Impact of Vaccine Introduction.

J Epidemiol Glob Health 2021 Apr 3. Epub 2021 Apr 3.

Center for Communicable Diseases Control, Ministry of Health & Medical Education, Tehran, Iran.

Ensuring the effectiveness of the (DTwP-Hib-HepB) vaccine in reducing meningitis is an essential approach in evaluating the effectiveness of the vaccine. The study aimed to address the epidemiology of meningitis following pentavalent vaccination in Iran. Data on meningitis patients from 21st March 2011 to 21st July 2018 were extracted from the National Notifiable Diseases Surveillance System. Read More

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Utilization Rates of Pancreatectomy, Radical Prostatectomy, and Nephrectomy in New York, Ontario, and New South Wales, 2011 to 2018.

JAMA Netw Open 2021 Apr 1;4(4):e215477. Epub 2021 Apr 1.

Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Importance: Few studies have compared surgical utilization between countries or how rates may differ according to patients' socioeconomic status.

Objective: To compare population-level utilization of 3 common nonemergent surgical procedures in New York State (US), Ontario (Canada), and New South Wales (Australia) and how utilization differs for residents of lower- and higher-income neighborhoods.

Design, Setting, And Participants: This cohort study included all adults aged 18 years and older who were hospitalized for pancreatectomy, radical prostatectomy, or nephrectomy between 2011 and 2016 in New York, between 2011 and 2018 in Ontario, and between 2013 and 2018 in New South Wales. Read More

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Rotavirus vaccination in Japan: Efficacy and safety of vaccines, changes in genotype, and surveillance efforts.

J Infect Chemother 2021 Apr 15. Epub 2021 Apr 15.

Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, 060-8543, Japan.

In Japan, a monovalent rotavirus vaccine (RV1) and a pentavalent rotavirus vaccine (RV5) were launched as voluntary vaccinations in November 2011 and July 2012, respectively. Rotavirus (RV) vaccine coverage in Japan increased from 30.0% in 2012 to 78. Read More

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Spatial and temporal analysis of water quality from 1991 to 2011 in Miyun Reservoir.

Environ Geochem Health 2021 Apr 17. Epub 2021 Apr 17.

College of Resources Environment and Tourism, Capital Normal University, Beijing, 100048, China.

Cluster analysis, discriminant analysis-DA, and principal component analysis/factor analysis were used to analyze temporal-spatial variations and sources of water quality from 1991 to 2011 in the Miyun Reservoir. Water quality analysis was conducted in three interannual (IA) groups: IA I (1991-1993, 1995), IA II (1994, 1996-2000, 2002-2006), and IA III (2001, 2007-2011); two seasonal clusters: non-flood season (NF, November-December and January-April) and flood season (FL, May-October); and two spatial clusters (MP-main part of Kuxi and Kudong and NH-Neihu), based on spatial I (I-Kudong, I-Kuxi, and I-Neihu), spatial II (II-Kudong, II-Kuxi, and II-Neihu), spatial III (III-Kudong, III-Kuxi, and III-Neihu), spatial NF (NF-Kudong, NF-Kuxi, and NF-Neihu), and spatial FL (FL-Kudong, FL-Kuxi, and FL-Neihu). Spatial variations between MP and NH were lower than those between seasonal and IA variations. Read More

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Association of low birth weight and polyparasitic infection during pregnancy in Lambaréné, Gabon.

Trop Med Int Health 2021 Apr 15. Epub 2021 Apr 15.

Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.

Objective: To report the prevalence of polyparasitism during pregnancy in the Lambaréné region of Gabon and its association with newborn birth weight.

Method: Pregnant women in their third trimester were recruited in a prospective study between November 2011 and March 2015. Parasite infection status was assessed microscopically in stool, urine and blood samples. Read More

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Clinical usefulness of combination therapy with polidocanol injection and argon plasma coagulation for gastric antral vascular ectasia.

JGH Open 2021 Apr 6;5(4):465-469. Epub 2021 Mar 6.

Department of Gastroenterology and Metabolism Hiroshima University Hospital Hiroshima Japan.

Background And Aim: Gastric antral vascular ectasia (GAVE) causes gastrointestinal bleeding. The initial treatment for GAVE bleeding is endoscopic hemostasis, and currently, the most performed technique to achieve hemostasis is argon plasma coagulation (APC). However, APC is associated with a high recurrence rate. Read More

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Long-term patterns of cave-exiting activity of hibernating bats in western North America.

Sci Rep 2021 Apr 14;11(1):8175. Epub 2021 Apr 14.

Air Resources Laboratory Field Research Division, National Oceanic and Atmospheric Administration, 1750 Foote Drive, Idaho Falls, ID, USA.

Understanding frequency and variation of cave-exiting activity after arousal from torpor of hibernating bats is important for bat ecology and conservation, especially considering white-nose syndrome. In winter from 2011 to 2018, we acoustically monitored, and counted in hibernacula, two species of conservation concern-western small-footed myotis (Myotis ciliolabrum) and Townsend's big-eared bats (Corynorhinus townsendii)-in 9 caves located in important habitat for these species in western North America. We investigated if cave-exiting activity differed by species, cave, number of hibernating bats, moon phase, and weather variables. Read More

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Changes in quality of life (QoL) and other patient-reported outcome measures (PROMs) in living-donor and deceased-donor kidney transplant recipients and those awaiting transplantation in the UK ATTOM programme: a longitudinal cohort questionnaire survey with additional qualitative interviews.

BMJ Open 2021 Apr 14;11(4):e047263. Epub 2021 Apr 14.

Health Psychology Research Unit, Royal Holloway University of London, Egham, UK

Objective: To examine quality of life (QoL) and other patient-reported outcome measures (PROMs) in kidney transplant recipients and those awaiting transplantation.

Design: Longitudinal cohort questionnaire surveys and qualitative semi-structured interviews using thematic analysis with a pragmatic approach.

Setting: Completion of generic and disease-specific PROMs at two time points, and telephone interviews with participants UK-wide. Read More

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The evolution and distribution of pneumococcal serotypes in adults hospitalized with community acquired pneumonia in Spain using serotype specific urinary antigen detection test: the CAPA study, 2011-2018.

Clin Infect Dis 2021 Apr 14. Epub 2021 Apr 14.

Pfizer S.L.U., Madrid, Spain; 8. Pfizer Vaccines, Collegeville, PA, USA.

Background: Spain introduced 13-valent pneumococcal conjugate vaccine (PCV13) in the childhood national immunization programme (NIP) in 2015-2016 with coverage of three doses of 94.8% in 2018. We assessed the evolution of all pneumococcal, PCV13 vaccine type (VT), and experimental PCV20-VT (PCV13 + serotypes 8, 10A, 11A, 12F, 15B, 22F, 33F) hospitalized community acquired pneumonia (CAP) in adults in Spain from 2011-2018. Read More

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Evolution of Non-alcoholic Fatty Liver Disease (NAFLD) Biomarkers in Response to Weight Loss 1 Year After Bariatric Surgery-a Post Hoc Analysis of the FibroTest Prospective Study.

Obes Surg 2021 Apr 12. Epub 2021 Apr 12.

Department of Digestive Surgery, Rouen University Hospital, 1 rue de Germont, 76000, Rouen, France.

Background: Bariatric surgery is among the therapeutic options for non-alcoholic fatty liver disease (NAFLD), affecting 90% of patients with obesity. The aim of this study was to evaluate the evolution of NAFLD lesions 1 year after surgery using noninvasive markers.

Methods: From November 2011 to November 2012, 253 patients with obesity undergoing bariatric surgery in three French University Hospitals were included. Read More

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Effectiveness of Treatment in Children With Cerebral Palsy.

Cureus 2021 Mar 7;13(3):e13754. Epub 2021 Mar 7.

Orthopedics and Traumatology, King Edward Medical University/Mayo Hospital Lahore, Lahore, PAK.

Objective:  The objective of this study was to assess the effectiveness of conservative and surgical treatment in cerebral palsy children by evaluating the Medical Research Council (MRC) grading system, modified Ashworth scale, and Barthel Activities of Daily Life (ADL) scale.

Method: This prospective case series was performed using a non-probability consecutive sampling technique at the Department of Orthopedic Surgery and Traumatology, King Edward Medical University/Mayo Hospital, Lahore from October 2011 to November 2013. Two hundred children of all ages, having cerebral palsy diagnosed on history and clinical examination were enrolled in the study. Read More

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Learning curve in robotic-assisted lobectomy for non-small cell lung cancer is not steep after experience in video-assisted lobectomy; single-surgeon experience using cumulative sum analysis.

Cancer Treat Res Commun 2021 Apr 2;27:100362. Epub 2021 Apr 2.

Department of General Thoracic and Esophageal Surgery, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland; Department of Surgery, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Background: Robotic assistance in lung lobectomy has been suggested to enhance the adoption of minimally invasive techniques among surgeons. However, little is known of learning curves in different minimally invasive techniques. We studied learning curves in robotic-assisted versus video- assisted lobectomies for lung cancer. Read More

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Lower reoperation rates after open and laparoscopic groin hernia repair when performed by high-volume surgeons: a nationwide register-based study.

Hernia 2021 Apr 9. Epub 2021 Apr 9.

Center for Perioperative Optimization, Department of Surgery, Herlev Hospital, University of Copenhagen, Borgmester Ib Juuls Vej 1, 2730, Herlev, Denmark.

Purpose: Previous studies have shown a correlation between surgeons with high annual volume and better outcomes after various surgical procedures. However, the preexisting literature regarding groin hernia repair and annual surgeon volume is limited. The aim was to investigate how annual surgeon volume affected the reoperation rates for recurrence after primary groin hernia repair. Read More

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Unrecognized Heart Failure in Elderly Patient with COPD.

Mymensingh Med J 2021 Apr;30(2):514-522

Dr Hasan Hafizur Rahman, Assistant Professor, Department of Medicine, Sheikh Hasina Medical College, Tangail, Bangladesh; E-mail:

Both of heart failure and chronic obstructive pulmonary diseases are in the elderly. They have an important impact on quality of life and functional status, show high morbidity and mortality rates and lead to extensive health-care costs. Although both diseases have been studied extensively, information about the prevalence of heart failure in stable chronic obstructive pulmonary disease (COPD) patients is lacking. Read More

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Depression among Patients Presenting with Gastrointestinal Symptoms: Prevalence and Associated Factors.

Mymensingh Med J 2021 Apr;30(2):415-419

Dr Madhusudan Saha, Professor, Department of Gastroenterology, North East Medical College, Sylhet, Bangladesh; E-mail:

Gastrointestinal diseases frequently affect patients' physical and emotional wellbeing as being heavily affected by stress. This study was conducted to find out prevalence and severity of depressive symptoms among patients presenting with gastrointestinal symptoms. This cross sectional study was conducted at Outpatients Department jointly by Department of Gastroenterology and Department of Psychiatry of a tertiary care hospital in north east part of Bangladesh from November 2011 to June 2012. Read More

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Temperate approach to ASD closure in pulmonary arterial hypertension: the fenestrated patch technique.

Cardiol Young 2021 Apr 8:1-5. Epub 2021 Apr 8.

Pediatric Cardiovascular Surgery Department, Kartal Koşuyolu High Speciality Educational and Research Hospital, İstanbul, Turkey.

The most common CHD in the adult patient population is an atrial septal defect due to its asymptomatic nature in early life. However, when diagnosis and treatment are delayed, pulmonary arterial hypertension may develop as a long-term complication, sometimes before adulthood. The presence of PAH adversely affects the results of surgical treatment and may even eliminate the feasibility of surgery in some patients. Read More

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Modelling forest fire and firebreak scenarios in a mediterranean mountainous catchment: Impacts on sediment loads.

J Environ Manage 2021 Jul 3;289:112497. Epub 2021 Apr 3.

Water Research Institute, National Research Council, Francesco De Blasio 5, 70132, Bari, Italy.

Forests provide a number of ecological and hydrological services, for instance, contributing to decreased water and sediment yields through increased infiltration and reduced soil erosion. However, forest fires can turn positive forest services into drawbacks, enhancing surface runoff and soil erosion and damaging both hillslopes and downstream aquatic life in rivers. Therefore, appropriate mitigation strategies should be developed to limit these negative effects. Read More

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