3,847 results match your criteria 2010 dutch

Temporal improvements noted in life expectancy of patients with colorectal cancer; a Dutch population-based study.

J Clin Epidemiol 2021 Apr 6. Epub 2021 Apr 6.

Department of Surgical Oncology, Radboud university medical center, Nijmegen, The Netherlands; Department of Research and Development, Comprehensive Netherlands Cancer Organization, Utrecht, The Netherlands.

Objective: Specific survival estimates are needed for the increasing number of colorectal cancer (CRC) survivors. The aim of this population-based study was to determine conditional loss in expectation of life (LEL) due to CRC.

Study Design And Setting: All surgically treated patients with CRC registered in the Netherlands Cancer Registry with stage I-III between 1990-2016, were included (N=203,216). Read More

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FDG-PET/CT in intensive care patients with bloodstream infection.

Crit Care 2021 04 7;25(1):133. Epub 2021 Apr 7.

Department of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Background: 2-Deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography (PET)/computed tomography (CT) is an advanced imaging technique that can be used to examine the whole body for an infection focus in a single examination in patients with bloodstream infection (BSI) of unknown origin. However, literature on the use of this technique in intensive care patients is scarce. The purpose of this study was to evaluate the diagnostic yield of FDG-PET/CT in intensive care patients with BSI. Read More

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Septum resection versus expectant management in women with a septate uterus: an international multicentre open-label randomized controlled trial.

Hum Reprod 2021 Apr 1. Epub 2021 Apr 1.

Centre for Reproductive Medicine, Amsterdam University Medical Centre, Location AMC, Amsterdam, the Netherlands.

Study Question: Does septum resection improve reproductive outcomes in women with a septate uterus?

Summary Answer: Hysteroscopic septum resection does not improve reproductive outcomes in women with a septate uterus.

What Is Known Already: A septate uterus is a congenital uterine anomaly. Women with a septate uterus are at increased risk of subfertility, pregnancy loss and preterm birth. Read More

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Associations Between Uncertainties Identified by the European Medicines Agency and National Decision-making on Reimbursement by HTA Agencies.

Clin Transl Sci 2021 Mar 30. Epub 2021 Mar 30.

Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.

We aimed to determine whether uncertainties identified by the European Medicines Agency (EMA) were associated with negative relative effectiveness assessments (REA) and negative overall reimbursement recommendations by national health technology assessment (HTA) agencies. Therefore, we identified all HTA reports from HAS (France), NICE (England), SMC (Scotland) and ZIN (the Netherlands) for a cohort of innovative medicines that EMA had approved in 2009-2010 (excluding vaccines). Uncertainty regarding pivotal trial methodology, clinical outcomes and their clinical relevance were combined to reflect a low, medium or high level of uncertainty. Read More

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Insulin Therapy in Type 2 Diabetes Is Associated With Barriers to Activity and Worse Health Status: A Cross-Sectional Study in Primary Care.

Front Endocrinol (Lausanne) 2021 10;12:573235. Epub 2021 Mar 10.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.

Introduction: Many individuals with type 2 diabetes mellitus (T2DM) experience "psychological insulin resistance". Consequently, it could be expected that insulin therapy may have negative effects on psychological outcomes and well-being. Therefore, this study compared health status and psychosocial functioning of individuals with T2DM using only oral antihyperglycemic agents (OHA) and on insulin therapy (with or without OHA). Read More

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Characteristics and Absolute Survival of Metastatic Colorectal Cancer Patients Treated With Biologics: A Real-World Data Analysis From Three European Countries.

Front Oncol 2021 5;11:630456. Epub 2021 Mar 5.

Department of Clinical Epidemiology, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.

Biologics were approved for the treatment of advanced colorectal cancer (CRC) based on favorable benefit-risk-assessments from randomized controlled trials (RCTs), but evidence on their use in the real-world setting is scarce. Based on descriptive analyses we therefore aimed to assess characteristics and survival of CRC patients treated with biologics using large healthcare databases from three European countries (Netherlands, Italy, Germany). We included CRC patients treated with a biologic in 2010 or 2014 and characterized them regarding age, sex, comorbidities, and absolute survival. Read More

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Second intravenous immunoglobulin dose in patients with Guillain-Barré syndrome with poor prognosis (SID-GBS): a double-blind, randomised, placebo-controlled trial.

Lancet Neurol 2021 04 17;20(4):275-283. Epub 2021 Mar 17.

Department of Neurology, Erasmus MC University Medical Center, Rotterdam, Netherlands. Electronic address:

Background: Treatment with one standard dose (2 g/kg) of intravenous immunoglobulin is insufficient in a proportion of patients with severe Guillain-Barré syndrome. Worldwide, around 25% of patients severely affected with the syndrome are given a second intravenous immunoglobulin dose (SID), although it has not been proven effective. We aimed to investigate whether a SID is effective in patients with Guillain-Barré syndrome with a predicted poor outcome. Read More

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Rheumatology (Oxford) 2021 Mar 16. Epub 2021 Mar 16.

Department of Rheumatology, Erasmus MC, Rotterdam, the Netherlands.

Objectives: To evaluate the 1-year cost-effectiveness between three different initial treatment strategies in autoantibody-negative rheumatoid arthritis(RA-) patients, according to 2010 criteria.

Materials And Methods: For this analysis we selected all RA- patients within the intermediate probability stratum of the tREACH trial. The tREACH had a treat-to-target approach, aiming for low disease activity(DAS<2. Read More

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A population-based study on incidence, treatment, and survival in ampullary cancer in the Netherlands.

Eur J Surg Oncol 2021 Mar 6. Epub 2021 Mar 6.

Department of Internal Medicine, Division of Medical Oncology, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, 6202 AZ, the Netherlands. Electronic address:

Introduction: Ampullary cancer is rare and as a result epidemiological data are scarce. The aim of this population-based study was to determine the trends in incidence, treatment and overall survival (OS) in patients with ampullary adenocarcinoma in the Netherlands between 1989 and 2016.

Methods: Patients diagnosed with ampullary adenocarcinoma were identified from the Netherlands Cancer Registry. Read More

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Subjective Cognitive Functioning in Silicone Breast Implant Patients: A Cohort Study.

Plast Reconstr Surg Glob Open 2021 Feb 17;9(2):e3394. Epub 2021 Feb 17.

Department of Plastic, Reconstructive and Hand Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.

Cognitive impairment is frequently reported by silicone breast implant (SBI) patients. The aim of our study is to investigate whether subjective cognitive failure indeed is more frequent in a cohort of SBI patients compared with healthy controls (HCs). Furthermore, the severity of this cognitive failure and a possible relation to other symptoms as well as the duration of SBI exposure was examined. Read More

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February 2021

BMP Receptor Inhibition Enhances Tissue Repair in Endoglin Heterozygous Mice.

Int J Mol Sci 2021 Feb 18;22(4). Epub 2021 Feb 18.

Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands.

Hereditary hemorrhagic telangiectasia type 1 (HHT1) is a severe vascular disorder caused by mutations in the TGFβ/BMP co-receptor . Endoglin haploinsufficiency results in vascular malformations and impaired neoangiogenesis. Furthermore, HHT1 patients display an impaired immune response. Read More

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February 2021

Prophylactic cranial irradiation in patients with small cell lung cancer in The Netherlands: A population-based study.

Clin Transl Radiat Oncol 2021 Mar 12;27:157-163. Epub 2021 Feb 12.

Department of Radiation Oncology, University Medical Center Utrecht, The Netherlands.

Introduction: Controversy has arisen regarding the benefit of prophylactic cranial irradiation (PCI) in patients with small cell lung cancer (SCLC), particularly since the 2017 Takahashi trial publication that supports MRI surveillance in extensive-stage (ES-)SCLC. The primary aim of this study was to assess trends and determinants in PCI use over the years 2010-2018. A secondary aim was to determine contemporary practice considerations among radiation oncologists (ROs). Read More

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Misdiagnosis and diagnostic pitfalls of chronic inflammatory demyelinating polyradiculoneuropathy.

Eur J Neurol 2021 Mar 3. Epub 2021 Mar 3.

Department of Neurology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background And Purpose: The aim of this study was to determine the frequency of over- and underdiagnosis of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and to identify related diagnostic pitfalls.

Methods: We conducted a retrospective study in Dutch patients referred to the Erasmus University Medical Centre Rotterdam between 2011 and 2017 with either a diagnosis of CIDP or another diagnosis that was revised to CIDP. We used the European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) 2010 diagnostic criteria for CIDP to classify patients into three groups: overdiagnosis, underdiagnosis, or confirmed diagnosis of CIDP. Read More

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Risk-Based and Adaptive Invasive Mosquito Surveillance at Lucky Bamboo and Used Tire Importers in the Netherlands.

J Am Mosq Control Assoc 2020 06;36(2):89-98

Wageningen University & Research, Department of Plant Sciences, Laboratory of Entomology, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.

The detection of Aedes albopictus in Lucky bamboo (Dracaena sanderiana) greenhouses and Ae. atropalpus at used tire importers illustrates that the Netherlands is exposed to the risk of introductions of invasive mosquito species (IMS). In this study we implemented a risk-based and adaptive surveillance (2010-16) in order to detect introductions and prevent potential proliferation of IMS at these locations. Read More

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Nationwide treatment and outcomes of perihilar cholangiocarcinoma.

Liver Int 2021 Feb 28. Epub 2021 Feb 28.

Department of Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.

Background: Perihilar cholangiocarcinoma (pCCA) is a rare tumour that requires complex multidisciplinary management. All known data are almost exclusively derived from expert centres. This study aimed to analyse the outcomes of patients with pCCA in a nationwide cohort. Read More

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February 2021

Long-term prognosis after intracerebral haemorrhage.

Eur Stroke J 2020 Dec 2;5(4):336-344. Epub 2020 Sep 2.

Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.

Introduction: The aim of this study was to determine the risk of recurrent intracerebral haemorrhage (ICH), ischaemic stroke, all stroke, any vascular event and all-cause mortality in 30-day survivors of ICH, according to age and sex.

Patients And Methods: We linked national hospital discharge, population and cause of death registers to obtain a cohort of Dutch 30-day survivors of ICH from 1998 to 2010. We calculated cumulative incidences of recurrent ICH, ischaemic stroke, all stroke and composite vascular outcome, adjusted for competing risk of death and all-cause mortality. Read More

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December 2020

Poor Taste and Smell Are Associated with Poor Appetite, Macronutrient Intake, and Dietary Quality but Not with Undernutrition in Older Adults.

J Nutr 2021 Mar;151(3):605-614

Amsterdam Public Health Research Institute, Amsterdam, Netherlands.

Background: Age-related declines in taste and smell function are widely assumed to contribute to the decrease in appetite and the development of undernutrition in older adults.

Objectives: Here we aim to assess the associations of both taste and smell function with several nutrition-related outcomes in a single study, with poor appetite and undernutrition as primary outcomes.

Methods: This is a cross-sectional cohort study of 359 community-dwelling Dutch older adults, aged 65-93 y. Read More

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The Value of Early Tumor Size Response to Chemotherapy in Pediatric Rhabdomyosarcoma.

Cancers (Basel) 2021 Jan 29;13(3). Epub 2021 Jan 29.

Princess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands.

Rhabdomyosarcoma is the most common soft tissue sarcoma in childhood. Results of clinical trials, with three-year event-free and overall survival as primary outcomes, often take 7 to 10 years. Identification of an early surrogate biomarker, predictive for survival, is therefore crucial. Read More

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January 2021

General health status of Dutch elderly receiving implant-retained overdentures: A 9-year big data cross-sectional study.

Clin Implant Dent Relat Res 2021 Feb 7. Epub 2021 Feb 7.

Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: Very little information is available on the general health of elderly who are provided with an implant-retained overdenture (IOD).

Purpose: The general health status of three groups of elderly (≥75 years) were compared: those with a natural dentition (ND), those treated with an implant-retained overdenture (IOD), and those wearing a conventional denture (CD).

Materials And Methods: Data on healthcare costs were obtained from records of Dutch health insurers that are collected by Vektis. Read More

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February 2021

Respiratory distress syndrome and bronchopulmonary dysplasia after fetal growth restriction: Lessons from a natural experiment in identical twins.

EClinicalMedicine 2021 Feb 29;32:100725. Epub 2021 Jan 29.

Neonatology, Dept. of Pediatrics, Leiden University Medical Center, Leiden, the Netherlands.

Background: Fetal growth restriction (FGR) is thought to negatively affect lung development resulting in increased respiratory morbidity. However, research performed in singletons is often limited by a certain level of bias caused by individual differences in genetic constitution, obstetrical and maternal factors.

Methods: Respiratory morbidity was compared between the smaller and the larger twin in monochorionic twins with selective fetal growth restriction (sFGR), defined as a birth weight discordance ≥ 20%, born in our center between 2010 and 2019 in this retrospective study. Read More

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February 2021

Predictors for remission after transsphenoidal surgery in acromegaly: a Dutch multicenter study.

J Clin Endocrinol Metab 2021 Feb 5. Epub 2021 Feb 5.

Department of Medicine, Endocrinology section, Pituitary Center Rotterdam, Erasmus University Medical Center, Rotterdam, The Netherlands.

Context: Transsphenoidal surgery (TSS) is the primary treatment of choice in acromegaly. It is important to identify patients in whom surgical cure is not attainable at an early stage, both to inform patients on expected treatment outcome and to select those who are more likely to need additional therapy.

Objective: To identify predictors for remission after TSS in acromegaly. Read More

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February 2021

Effect of comorbidities on survival in patients >80 years of age at onset of renal replacement therapy: data from the ERA-EDTA Registry.

Nephrol Dial Transplant 2021 Mar;36(4):688-694

Finnish Registry for Kidney Diseases, Helsinki, Finland.

Background: The number of elderly patients on renal replacement therapy (RRT) is increasing. The survival and quality of life of these patients may be lower if they have multiple comorbidities at the onset of RRT. The aim of this study was to explore whether the effect of comorbidities on survival is similar in elderly RRT patients compared with younger ones. Read More

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Practice variations in the management of childhood nephrotic syndrome in the Netherlands.

Eur J Pediatr 2021 Feb 3. Epub 2021 Feb 3.

Department of Pediatric Nephrology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Amalia Children's Hospital, 804, P.O. Box 9101, 6500, HB, Nijmegen, The Netherlands.

Nephrotic syndrome in childhood is a common entity in the field of pediatric nephrology. The optimal treatment of children with nephrotic syndrome is often debated. Previously conducted studies have shown significant variability in nephrotic syndrome management, especially in the choice of steroid-sparing drugs. Read More

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February 2021

Dutch Translation and Validation of the FACE-Q Rhinoplasty Module.

Facial Plast Surg 2021 Jan 27. Epub 2021 Jan 27.

Department of Otorhinolaryngology, GZA Ziekenhuizen Campus Sint-Vincentius, Antwerp, Belgium.

FACE-Q was developed by Klassen et al in 2010 as a validated psychometric evaluation instrument for patients undergoing aesthetic surgery. The aim of this study was to translate, adapt, and validate the FACE-Q rhinoplasty module into a Dutch version of the FACE-Q questionnaire conceptually equivalent to the original English version. "Satisfaction with nose" and "satisfaction with nostrils" questionnaires were used and translated from English into Dutch. Read More

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January 2021

Post-traumatic stress disorder symptoms and pain intensity in persons with spinal cord injury.

Spinal Cord 2021 Mar 25;59(3):328-335. Epub 2021 Jan 25.

Centre of Excellence for Rehabilitation Medicine, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht University and De Hoogstraat Rehabilitation, Utrecht, The Netherlands.

Study Design: Cross-sectional.

Objectives: To examine the association between post-traumatic stress disorder (PTSD) symptoms and pain intensity, taking symptoms of anxiety and depression into account within persons with spinal cord injury (SCI).

Setting: Persons with SCI, who visited a Dutch rehabilitation centre between 2005 and 2010, were invited to complete a survey. Read More

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The decline of butterflies in Europe: Problems, significance, and possible solutions.

Proc Natl Acad Sci U S A 2021 Jan;118(2)

Butterfly Conservation, East Lulworth, Dorset BH20 5QP, United Kingdom.

We review changes in the status of butterflies in Europe, focusing on long-running population data available for the United Kingdom, the Netherlands, and Belgium, based on standardized monitoring transects. In the United Kingdom, 8% of resident species have become extinct, and since 1976 overall numbers declined by around 50%. In the Netherlands, 20% of species have become extinct, and since 1990 overall numbers in the country declined by 50%. Read More

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January 2021

Cost-Effectiveness of Quadrivalent Versus Trivalent Influenza Vaccination in the Dutch National Influenza Prevention Program.

Value Health 2021 01;24(1):3-10

Department of Health Sciences, University of Groningen, University Medical Centre, Groningen, The Netherlands; Unit of PharmacoTherapy, Epidemiology, and Economics, University of Groningen, Department of Pharmacy, Groningen, The Netherlands; Department of Economics, Econometrics, and Finance, University of Groningen, Faculty of Economics and Business, Groningen, The Netherlands.

Objectives: As of 2019, quadrivalent influenza vaccine (QIV) has replaced trivalent influenza vaccine (TIV) in the national immunization program in The Netherlands. Target groups are individuals of 60+ years of age and those with chronic diseases. The objective was to estimate the incremental break-even price of QIV over TIV at a threshold of €20 000 per quality-adjusted life-year (QALY). Read More

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January 2021

Cost-Effectiveness of Pediatric Influenza Vaccination in The Netherlands.

Value Health 2021 01 11;24(1):19-31. Epub 2020 Dec 11.

Unit of PharmacoTherapy, -Epidemiology, and -Economics (PTE2), Department of Pharmacy, University of Groningen, Groningen, The Netherlands; Department of Health Sciences, University Medical Center Groningen, Groningen, The Netherlands; Department of Economics, Econometrics, and Finance, Faculty of Economics and Business, University of Groningen, Groningen, The Netherlands.

Objective: This study evaluates the cost-effectiveness of extending the Dutch influenza vaccination program for elderly and medical high-risk groups to include pediatric influenza vaccination, taking indirect protection into account.

Methods: An age-structured dynamic transmission model was used that was calibrated to influenza-associated GP visits over 4 seasons (2010-2011 to 2013-2014). The clinical and economic impact of different pediatric vaccination strategies were compared over 20 years, varying the targeted age range, the vaccine type for children or elderly and high-risk groups. Read More

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January 2021

The addition of an anti-rotation screw to the dynamic hip screw.

Acta Orthop Belg 2020 Jun;86(2):233-238

The aim of this study is to assess if there is a difference in outcomes between a dynamic hip screw with or without an anti-rotation screw in the treatment of hip fractures. All patients with an intracapsular hip fracture who underwent dynamic hip screw osteosynthesis between January 2010 and December 2013 in three Dutch hospitals were reviewed. Minimal follow-up was one year. Read More

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Temporomandibular disorders in patients with early rheumatoid arthritis and at-risk individuals in the Dutch population: a cross-sectional study.

RMD Open 2021 Jan;7(1)

Department of Orofacial pain and Dysfunction, Academic Centre for Dentistry Amsterdam, Amsterdam, The Netherlands.

Objective: To evaluate the prevalence of temporomandibular disorders (TMD) in patients with early rheumatoid arthritis (ERA) and individuals at-risk of RA.

Methods: 150 participants were recruited in three groups (50 per group): (1) patients with ERA (2010 EULAR criteria) (2) at-risk individuals and (3) healthy controls. All participants were tested for seropositivity of rheumatoid factor and anticitrullinated protein antibodies. Read More

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January 2021