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Effect of the electric field at 50 Hz and variable intensities on biochemical markers in the honey bee's hemolymph.

PLoS One 2021 24;16(6):e0252858. Epub 2021 Jun 24.

Department of Environment Hygiene and Animal Welfare, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland.

The amount of artificial electromagnetic fields of various parameters in the honey bee's environment increases globally. So far, it had been proven that exposure to an E-field at 50 Hz can cause changes in bee's behavior, alter the activity of proteases, and enzymatic antioxidants. Due to the potentially harmful effect of this factor on honey bees, we decided to investigate the activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP), and the concentration of albumin and creatinine in bee's hemolymph after exposure to 50 Hz E-field. Read More

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Association of Funding and Meal Preparation Time With Nutritional Quality of Meals of Supplemental Nutritional Assistance Program Recipients.

JAMA Netw Open 2021 Jun 1;4(6):e2114701. Epub 2021 Jun 1.

Industrial Engineering and Operations Research, University of California, Berkeley.

Importance: The Supplemental Nutrition Assistance Program (SNAP) is a federal program that provides food-purchasing assistance to low-income people; however, its current design does not account for the time availability of SNAP recipients to prepare meals.

Objective: To evaluate the association of the availability of funding for food purchases and time for meal preparation with the nutritional quality of meals of SNAP recipients.

Design, Setting, And Participants: This study used decision analytical modeling to evaluate the nutritional quality of meals of SNAP recipients. Read More

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Formulation and evaluation of raloxifene hydrochloride dry emulsion tablet using solid carrier adsorption technique.

Ther Deliv 2021 Jun 24. Epub 2021 Jun 24.

Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, GH Patel Building, Fatehgunj Vadodara, Gujarat, India.

The present study focused on the development of a dry emulsion tablet of raloxifene hydrochloride (RXF) using a solid carrier adsorption technique to enhance oral bioavailability. An oil-in-water emulsion was formulated and converted into dry powder using HPMC K4M plus Aerosil 200, then compressed into tablets. The prepared emulsion was evaluated for globule size, drug content and zeta potential. Read More

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Study design of a randomised, placebo-controlled trial of nintedanib in children and adolescents with fibrosing interstitial lung disease.

ERJ Open Res 2021 Apr 21;7(2). Epub 2021 Jun 21.

Division of Pulmonary and Sleep Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Childhood interstitial lung disease (chILD) comprises >200 rare respiratory disorders, with no currently approved therapies and variable prognosis. Nintedanib reduces the rate of forced vital capacity (FVC) decline in adults with progressive fibrosing interstitial lung diseases (ILDs). We present the design of a multicentre, prospective, double-blind, randomised, placebo-controlled clinical trial of nintedanib in patients with fibrosing chILD (1199-0337 or InPedILD; ClinicalTrials. Read More

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Neonatal Resuscitation With T-Piece Systems: Risk of Inadvertent PEEP Related to Mechanical Properties.

Front Pediatr 2021 7;9:663249. Epub 2021 Jun 7.

Department of Pediatrics and Child Health, The University of Sydney, Sydney, NSW, Australia.

Resuscitation of infants using T-piece resuscitators (TPR) allow positive pressure ventilation with positive end-expiratory pressure (PEEP). The adjustable PEEP valve adds resistance to expiration and could contribute to inadvertent PEEP. The study indirectly investigated risk of inadvertent peep by determining expiratory time constants. Read More

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A new anesthesia scheme for parathyroidectomy under neuromonitoring: a retrospective cohort study.

Gland Surg 2021 May;10(5):1576-1586

Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, China.

Background: Parathyroidectomy under nerve monitoring has been carried out for nearly ten years in the China-Japan Union Hospital of Jilin University. We retrospectively evaluated patients' prognosis with secondary hyperparathyroidism (SH) under neuro- and non-neuro-monitored parathyroidectomy anesthesia. The purpose of this study is to summarize and introduce a new anesthesia scheme for parathyroidectomy under nerve monitoring. Read More

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Phenazines as model low-midpoint potential electron shuttles for photosynthetic bioelectrochemical systems.

Chem Sci 2021 Jan 15;12(9):3328-3338. Epub 2021 Jan 15.

Department of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK

Bioelectrochemical approaches for energy conversion rely on efficient wiring of natural electron transport chains to electrodes. However, state-of-the-art exogenous electron mediators give rise to significant energy losses and, in the case of living systems, long-term cytotoxicity. Here, we explored new selection criteria for exogenous electron mediation by examining phenazines as novel low-midpoint potential molecules for wiring the photosynthetic electron transport chain of the cyanobacterium sp. Read More

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January 2021

Impact of the macrocyclic structure and dynamic solvent effect on the reactivity of a localised singlet diradicaloid with π-single bonding character.

Chem Sci 2020 Nov 10;12(2):613-625. Epub 2020 Nov 10.

Department of Chemistry, Graduate School of Science, Hiroshima University 1-3-1 Kagamiyama, Higashi-Hiroshima Hiroshima 739-8526 Japan

Localised singlet diradicals are key intermediates in bond homolysis processes. Generally, these highly reactive species undergo radical-radical coupling reaction immediately after their generation. Therefore, their short-lived character hampers experimental investigations of their nature. Read More

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November 2020

Single cell imaging reveals cisplatin regulating interactions between transcription (co)factors and DNA.

Chem Sci 2021 Feb 25;12(15):5419-5429. Epub 2021 Feb 25.

Beijing National Laboratory for Molecular Sciences, CAS Research/Education Center for Excellence in Molecular Sciences, National Centre for Mass Spectrometry in Beijing, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences Beijing 100190 People's Republic of China

Cisplatin is an extremely successful anticancer drug, and is commonly thought to target DNA. However, the way in which cisplatin-induced DNA lesions regulate interactions between transcription factors/cofactors and genomic DNA remains unclear. Herein, we developed a dual-modal microscopy imaging strategy to investigate, , the formation of ternary binding complexes of the transcription cofactor HMGB1 and transcription factor Smad3 with cisplatin crosslinked DNA in single cells. Read More

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February 2021

Rapid and ultrasensitive electrochemical detection of circulating tumor DNA by hybridization on the network of gold-coated magnetic nanoparticles.

Chem Sci 2021 Mar 3;12(14):5196-5201. Epub 2021 Mar 3.

School of Chemistry, The University of New South Wales Sydney NSW 2052 Australia

An accurate and robust method for quantifying the levels of circulating tumor DNA (ctDNA) is vital if this potential biomarker is to be used for the early diagnosis of cancer. The analysis of ctDNA presents unique challenges because of its short half-life and ultralow abundance in early stage cancers. Here we develop an ultrasensitive electrochemical biosensor for rapid detection of ctDNA in whole blood. Read More

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Real-world treatment patterns and disease control over one year in patients with inflammatory bowel disease in Brazil.

World J Gastroenterol 2021 Jun;27(23):3396-3412

IBD Unit, Federal University of Bahia, Salvador 41150-000, Bahia, Brazil.

Background: Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBDs) with a remission-relapsing presentation and symptomatic exacerbations that have detrimental impacts on patient quality of life and are associated with a high cost burden, especially in patients with moderate-to-severe disease. The Real-world Data of Moderate-to-Severe Inflammatory Bowel Disease in Brazil (RISE BR) study was a noninterventional study designed to evaluate disease control, treatment patterns, disease burden and health-related quality of life in patients with moderate-to-severe active IBD. We report findings from the prospective follow-up phase of the RISE BR study in patients with active UC or CD. Read More

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Acute urinary retention in pediatric cerebral palsy: Is there an optimal management strategy?

J Pediatr Urol 2021 Jun 5. Epub 2021 Jun 5.

Department of Urology, University of California San Diego, 200 West Arbor Drive MC 7897, San Diego, CA 92103, USA; Rady Children's Hospital - San Diego, 3020 Childrens Way MC 5120, San Diego, CA 92123, USA.

Introduction And Objective: Cerebral palsy (CP) patients commonly have lower urinary tract dysfunction. Urinary retention (UR), which has been associated with dysfunctional voiding in CP can correlate to chronic upper tract dysfunction. We sought to provide insight into the pediatric presentation of acute UR in patients with CP and subsequent outcomes in this at-risk population. Read More

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Safety and Efficacy of Intravenous Ferric Derisomaltose Compared to Iron Sucrose for Iron Deficiency Anemia in Patients with Chronic Kidney Disease With and Without Heart Failure.

Am J Cardiol 2021 Jun 20. Epub 2021 Jun 20.

Robertson Centre for Biostatistics & Clinical Trials Unit, University of Glasgow, United Kingdom; National Heart & Lung Institute, Imperial College, London, United Kingdom.

Ferric derisomaltose (FDI) is an intravenous (IV) high-dose iron formulation approved in the US for the treatment of iron deficiency anemia in adults who are intolerant of/have had an unsatisfactory response to oral iron, or who have non-dialysis-dependent chronic kidney disease (NDD-CKD). FERWON-NEPHRO was a randomized, open-label, multicenter clinical trial evaluating the safety and efficacy of a single infusion of FDI 1,000 mg versus up to 5 doses of iron sucrose (IS) 200 mg (recommended cumulative dose, 1,000 mg) over 8 weeks in patients with NDD-CKD and iron deficiency anemia. Of 1,525 patients included in the safety analysis, 244 (16%) had a history of heart failure (HF). Read More

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Deep learning for semi-automated unidirectional measurement of lung tumor size in CT.

Cancer Imaging 2021 Jun 23;21(1):43. Epub 2021 Jun 23.

Department of Public Health Sciences, Clemson University, 501 Edwards Hall, Clemson, SC, 29634, USA.

Background: Performing Response Evaluation Criteria in Solid Tumor (RECISTS) measurement is a non-trivial task requiring much expertise and time. A deep learning-based algorithm has the potential to assist with rapid and consistent lesion measurement.

Purpose: The aim of this study is to develop and evaluate deep learning (DL) algorithm for semi-automated unidirectional CT measurement of lung lesions. Read More

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Transfer of patients in hospital units: impacts on nursing workload.

Rev Esc Enferm USP 2021 18;55:e0327. Epub 2021 Jun 18.

Faculdade de Medicina de São José do Rio Preto, Programa de Pós-Graduação em Enfermagem, São José do Rio Preto, SP, Brazil.

Objective: To measure the average time spent by the nursing team in transferring patients; to compare the activities observed during the performance of this intervention with those described by the Nursing Interventions Classification and to investigate the intensity of its influence on the workload.

Method: Observational study using timekeeping software conducted in two hospitals in the northwest region of the State of São Paulo. 200 patient transfers were monitored by the team using two validated instruments. Read More

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Resistance mechanisms and fitness of pyraclostrobin-resistant isolates of Lasiodiplodia theobromae from mango orchards.

PLoS One 2021 23;16(6):e0253659. Epub 2021 Jun 23.

Institute of Plant Protection, Hainan University, Haikou, China.

Background: Stem-end rot, caused by Lasiodiplodia theobromae (Pat.) Griffon & Maubl is a serious postharvest disease in mango. In China, a high prevalence of the QoI fungicides resistance has been reported in the last decade. Read More

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Unaccounted CO leaks downstream of a large tropical hydroelectric reservoir.

Proc Natl Acad Sci U S A 2021 Jun;118(25)

Institute of Biogeochemistry and Pollutant Dynamics, ETH Zurich, 8092 Zurich, Switzerland.

Recent studies show that tropical hydroelectric reservoirs may be responsible for substantial greenhouse gas emissions to the atmosphere, yet emissions from the surface of released water downstream of the dam are poorly characterized if not neglected entirely from most assessments. We found that carbon dioxide (CO) emission downstream of Kariba Dam (southern Africa) varied widely over different timescales and that accounting for downstream emissions and their fluctuations is critically important to the reservoir carbon budget. Seasonal variation was driven by reservoir stratification and the accumulation of CO in hypolimnetic waters, while subdaily variation was driven by hydropeaking events caused by dam operation in response to daily electricity demand. Read More

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Measuring lncRNA Expression by Real-Time PCR.

Methods Mol Biol 2021 ;2348:93-111

Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, New Delhi, India.

Long noncoding RNAs are defined as transcripts longer than 200 nt with no protein coding potential. Most lncRNAs are expressed in a tissue-specific manner and barring a few, their absolute expression is lower compared to most coding transcripts. Differential expression studies have contributed the most to the functional characterisation of the lncRNAs we know. Read More

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January 2021

Donafenib treatment for hepatocellular carcinoma: A case report.

Qiaoqi Li Hong Zhu

Medicine (Baltimore) 2021 Jun;100(25):e26373

Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.

Rationale: Hepatocellular carcinoma (HCC) is the most common liver cancer. The efficacy of the present treatment is disappointing, and the prognosis is poor. Donafenib, a novel multikinase inhibitor, is a new deuterated derivative of sorafenib. Read More

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HIV viral exposure and mortality in a multicenter ambulatory HIV adult cohort, United States, 1995-2016.

Medicine (Baltimore) 2021 Jun;100(25):e26285

Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA.

Abstract: The aim of this study was to identify viral exposure (VE) measures and their relationship to mortality risk among persons with HIV.Prospective multicenter observational study to compare VE formulae.Eligible participants initiated first combination antiretroviral therapy (cART) between March 1, 1995 and June 30, 2015. Read More

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Laparoscopic mechanical latero-lateral oesophagojejunostomy after total gastrectomy for cancer in the elderly: technical notes and results.

Minerva Surg 2021 Jun 23. Epub 2021 Jun 23.

Città di Castello Hospital, Department of General Surgery, Città di Castello, Italy.

Background: The realization of a oesophagojejunostomy is a critical step in total gastrectomy. Several techniques based on a Roux-En-Y restoration of gastrointestinal continuity were described with similar results. We here report our laparoscopic experience in intracorporeal oesophagojejunostomy. Read More

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Respiratory dysfunction in a mouse model of spinocerebellar ataxia type 7.

Dis Model Mech 2021 Jun 23. Epub 2021 Jun 23.

Department of Pediatrics, School of Medicine, Duke University, Durham, NC 27708, USA.

Spinocerebellar ataxia type 7 (SCA7) is an autosomal dominant neurodegenerative disorder caused by a CAG repeat expansion in the coding region of the ataxin-7 gene. Infantile-onset SCA7 patients display extremely large repeat expansions (>200 CAGs) and exhibit progressive ataxia, dysarthria, dysphagia and retinal degeneration. Severe hypotonia, aspiration pneumonia and respiratory failure often contribute to death in affected infants. Read More

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Detection of organic and inorganic gunshot residues from hands using complexing agents and LC-MS/MS.

Anal Methods 2021 Jun 23. Epub 2021 Jun 23.

Department of Forensic and Investigative Sciences, West Virginia University, USA.

Gunshot residue (GSR) refers to a conglomerate consisting of both organic molecules (OGSR) and inorganic species (IGSR). Historically, forensic examiners have focused only on identifying the IGSR particles by their morphology and elemental composition. Nonetheless, modern ammunition formulations and challenges with the GSR transference (such as secondary and tertiary transfer) have driven research efforts for more comprehensive examinations, requiring alternative analytical techniques. Read More

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Molnupiravir, an Oral Antiviral Treatment for COVID-19.

medRxiv 2021 Jun 17. Epub 2021 Jun 17.

Background: Easily distributed oral antivirals are urgently needed to treat coronavirus disease-2019 (COVID-19), prevent progression to severe illness, and block transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report the results of a Phase 2a trial evaluating the safety, tolerability, and antiviral efficacy of molnupiravir in the treatment of COVID-19 ( ClinicalTrials.gov NCT04405570 ). Read More

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A Hemostatic Technique in Robot-Assisted Laparoscopic Partial Nephrectomy and Its Impact on Renal Function.

Cureus 2021 May 19;13(5):e15122. Epub 2021 May 19.

Urology, Apollo Hospitals, Chennai, IND.

Purpose Robot-assisted partial nephrectomy (RAPN) has become popular in recent years for small renal masses. We describe a technique of suturing renal defects during RAPN that is reliable and quick, does not necessitate the need for hemostatic agents, and reduces perioperative complications. Materials and methods A total of 24 patients who underwent RAPN were included in the study period between 2013 and 2018 and data were analyzed. Read More

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Workplace based assessment: A review of available tools and their relevance.

Ind Psychiatry J 2020 Jul-Dec;29(2):200-204. Epub 2021 Mar 15.

Department of Psychiatry, Armed Forces Medical College, Pune, Maharashtra, India.

Workplace-based assessment (WPBA) appears to be a promising tool for more comprehensive assessment of the learners. Relevant literature in this direction was collated and analyzed for its relevance, salience, and merit. Many WPBA tools are being used by various educational institutions which spans across multiple domains and over the entire duration of the workplace learning. Read More

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Virtual external implementation facilitation: successful methods for remotely engaging groups in quality improvement.

Implement Sci Commun 2021 Jun 22;2(1):66. Epub 2021 Jun 22.

Tuscaloosa Veterans Affairs Medical Center, Tuscaloosa, AL, 35404, USA.

Background: Relatively little guidance exists on how to use virtual implementation facilitation to successfully implement evidence-based practices and innovations into clinical programs. Yet virtual methods are increasingly common. They have potentially wider reach, emergent public health situations necessitate their use, and restrictions on resources can make them more attractive. Read More

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The effect of acute intermittent hypoxia on postprandial triglyceride levels in humans: a randomized crossover trial.

J Transl Med 2021 Jun 22;19(1):268. Epub 2021 Jun 22.

School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada.

Background: Obstructive sleep apnea (OSA), a sleep disorder frequently observed in individuals living with obesity, consists of repeated involuntary breathing obstructions during sleep, leading to intermittent hypoxia (IH). In humans, acute continuous hypoxia slightly increases plasma triglycerides (TG). However, no study yet compared the postprandial TG response of individuals with or without OSA under intermittent hypoxia. Read More

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Cutaneous T-cell-attracting chemokine as a novel biomarker for predicting prognosis of idiopathic pulmonary fibrosis: a prospective observational study.

Respir Res 2021 Jun 17;22(1):181. Epub 2021 Jun 17.

Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrotic lung disease that leads to respiratory failure and death. Although there is a greater understanding of the etiology of this disease, accurately predicting the disease course in individual patients is still not possible. This study aimed to evaluate serum cytokines/chemokines as potential biomarkers that can predict outcomes in IPF patients. Read More

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Impact of switching to TAF/FTC/RPV, TAF/FTC/EVG/cobi and ABC/3TC/DTG on cardiovascular risk and lipid profile in people living with HIV: a retrospective cohort study.

BMC Infect Dis 2021 Jun 22;21(1):595. Epub 2021 Jun 22.

Department of Infectious Diseases, ASST Fatebenefratelli-Sacco, Luigi Sacco University Hospital, Milan, Italy.

Background: We aimed to assess the overall cardiovascular and metabolic effect of the switch to three different single tablet regimens (STRs) [tenofovir alafenamide/emtricitabine/rilpivirine (TAF/FTC/RPV), TAF/FTC/elvitegravir/cobi (TAF/FTC/EVG/cobi) and ABC/lamivudine/dolutegravir (ABC/3TC/DTG)] in a cohort of people living with HIV/AIDS (PLWH) under effective ART.

Methods: All PLWH aged above 18 years on antiretroviral treatment with an HIV-RNA < 50 cp/mL at the time of the switch to TAF/FTC/RPV, TAF/FTC/EVG/cobi and ABC/3TC/DTG were retrospectively included in the analysis. Framingham risk score modification after 12 months from the switch such as lipid profile and body weight modification were assessed. Read More

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