4 results match your criteria 1ptel region

  • Page 1 of 1

Detection of deletions in 1q25, 1p36 and 1pTEL and chromosome 17 aneuploidy in oral epithelial dysplasia and oral squamous cell carcinoma by fluorescence in situ hybridization (FISH).

Oral Oncol 2021 Feb 17;116:105221. Epub 2021 Feb 17.

Department of Oral Pathology, University of Fortaleza / Universidade de Fortaleza, School of Dentistry, Fortaleza, Brazil.

Objective: To identify chromosome deletions in 1q25, 1p36 and 1pTEL, and chromosome 17 ploidy status in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC).

Material And Methods: Samples from 57 OED and 63 OSCC were selected. FISH was performed using centromeric probes 17 and n LSIR 1p36/LSI 1q25 Dual Color Probe. Read More

View Article and Full-Text PDF
February 2021

The telomere of human chromosome 1p contains at least two independent autosomal dominant congenital cataract genes.

Br J Ophthalmol 2005 Jul;89(7):831-4

Genome analysis team, International Agency for Research on Cancer, Lyons, France.

Aims: Multiple genetic causes of congenital cataract have been identified, both as a component of syndromes and in families that present with isolated congenital cataract. Linkage analysis was used to map the genetic locus in a six generation Australian family presenting with total congenital cataract.

Methods: Microsatellite markers located across all known autosomal dominant congenital cataract loci were genotyped in all recruited family members of the Tasmanian family. Read More

View Article and Full-Text PDF

Clinical categories of neuroblastoma are associated with different patterns of loss of heterozygosity on chromosome arm 1p.

J Mol Diagn 2000 Feb;2(1):37-46

Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

Deletion of the short arm of chromosome 1 is frequently observed in neuroblastoma (NB). We performed loss of heterozygosity (LOH) analysis of 120 well characterized NB to better define specific regions of 1p loss and any association with clinical and biological prognostic features (DNA index, MYCN, age, and stage). All categories of disease were represented including 7 ganglioneuromas, 8 stage 4S, 33 local-regional (stages 1, 2, and 3), and 72 stage 4 NB according to the International Neuroblastoma Staging System. Read More

View Article and Full-Text PDF
February 2000

Candidate tumor suppressor RIZ is frequently involved in colorectal carcinogenesis.

Proc Natl Acad Sci U S A 2000 Mar;97(6):2662-7

Division of Human Cancer Genetics and Department of Pathology, Ohio State University, Comprehensive Cancer Center, Columbus, OH 43210, USA.

The distal portion of chromosome 1p is one of the most commonly affected regions in human cancer. In this study of hereditary and sporadic colorectal cancer, a region of frequent deletion was identified at 32.2 centimorgans from 1ptel. Read More

View Article and Full-Text PDF
  • Page 1 of 1