14 results match your criteria 1863 cad

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Genetic association analysis between IL9 and coronary artery disease in a Chinese Han population.

Cytokine 2021 Nov 20;150:155761. Epub 2021 Nov 20.

Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:

Interleukin-9 (IL-9) plays important role in coronary artery disease (CAD). However, the exact relationship between them is not explored yet. Here, four tag SNPs covering IL9 (rs31563, rs2069868, rs2069870 and rs31564) were selected to conduct case-control association analyses in a total of 3704 individuals from Chinese Han population (1863 CAD vs 1841 control). Read More

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November 2021

Binless Kernel Machine: Modeling Spike Train Transformation for Cognitive Neural Prostheses.

Neural Comput 2020 10 14;32(10):1863-1900. Epub 2020 Aug 14.

College of Computer Science and State Key Laboratory of CAD&CG, Zhejiang University, Hangzhou 310027, P.R.C.

Modeling spike train transformation among brain regions helps in designing a cognitive neural prosthesis that restores lost cognitive functions. Various methods analyze the nonlinear dynamic spike train transformation between two cortical areas with low computational eficiency. The application of a real-time neural prosthesis requires computational eficiency, performance stability, and better interpretation of the neural firing patterns that modulate target spike generation. Read More

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October 2020

Successful treatment of influenza B associated acute necrotizing encephalopathy in an adult using combination of high dose oseltamivir-IVIG-pulse metylprednisolone.

Acta Neurol Belg 2021 Dec 9;121(6):1863-1865. Epub 2020 Aug 9.

Marmara University School of Medicine, Neurology, Erenköy İstasyon Cad. Derya Apt. No:40/11 Kadıkoy, 34738, Istanbul, Turkey.

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December 2021

Multistate Models to Predict Development of Late Complications of Type 2 Diabetes in an Open Cohort Study.

Diabetes Metab Syndr Obes 2020 28;13:1863-1872. Epub 2020 May 28.

Department of Biostatistics, Physiotherapy Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Increase in the prevalence of type 2 diabetic mellitus (T2DM) as a complex disease, its complications, and spread has become a dominant global health threat in recent decades.

Objective: The aim of the current study was to investigate the impact of risk factors and transition probability on the development and progression of the late complications of T2DM.

Methods: This study was an open cohort one which was conducted at Isfahan Endocrine and Metabolism Research Center (IEMRC). Read More

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A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction.

Cardiovasc Res 2020 09;116(11):1863-1874

Division of Cardiovascular Medicine, Radcliffe Department of Medicine, BHF Centre of Research Excellence, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.

Aims: Genome-wide association studies (GWAS) have consistently identified an association between coronary artery disease (CAD) and a locus on chromosome 10 containing a single gene, JCAD (formerly KIAA1462). However, little is known about the mechanism by which JCAD could influence the development of atherosclerosis.

Methods And Results: Vascular function was quantified in subjects with CAD by flow-mediated dilatation (FMD) and vasorelaxation responses in isolated blood vessel segments. Read More

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September 2020

IL-13 may be involved in the development of CAD via different mechanisms under different conditions in a Chinese Han population.

Sci Rep 2018 04 18;8(1):6182. Epub 2018 Apr 18.

Department of cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Interleukin-13 (IL-13) has important functions in atherosclerosis, but its role in coronary artery disease (CAD) is unclear. Here, we studied the genetic role of IL-13 in CAD in a Chinese Han population using tag SNPs covering the whole IL13 gene (i.e. Read More

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Androgen inhibits key atherosclerotic processes by directly activating ADTRP transcription.

Biochim Biophys Acta Mol Basis Dis 2017 09 20;1863(9):2319-2332. Epub 2017 Jun 20.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Cardio-Institute, Huazhong University of Science and Technology, Wuhan 430074, PR China; Center for Cardiovascular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 44195, USA. Electronic address:

Low androgen levels are associated with an increased risk of coronary artery disease (CAD), thrombosis and myocardial infarction (MI), suggesting that androgen has a protective role. However, little is known about the underlying molecular mechanism. Our genome-wide association study identified the ADTRP gene encoding the androgen-dependent TFPI regulating protein as a susceptibility gene for CAD and MI. Read More

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September 2017

Identification of a molecular signaling gene-gene regulatory network between GWAS susceptibility genes ADTRP and MIA3/TANGO1 for coronary artery disease.

Biochim Biophys Acta Mol Basis Dis 2017 06 21;1863(6):1640-1653. Epub 2017 Mar 21.

The Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Cardio-X Institute, Huazhong University of Science and Technology, Wuhan 430074, Hubei Province, PR China; Center for Cardiovascular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Molecular Medicine, Department of Genetics and Genome Science, Case Western Reserve University, Cleveland, OH 44195, USA. Electronic address:

Coronary artery disease (CAD) is the leading cause of death worldwide. GWAS have identified >50 genomic loci for CAD, including ADTRP and MIA3/TANGO1. However, it is important to determine whether the GWAS genes form a molecular network. Read More

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Targeting acetaldehyde dehydrogenase 2 (ALDH2) in heart failure-Recent insights and perspectives.

Biochim Biophys Acta Mol Basis Dis 2017 08 11;1863(8):1933-1941. Epub 2016 Oct 11.

Department of Emergency, Qilu Hospital, Shandong University, Jinan, China; Chest Pain Center, Qilu Hospital, Shandong University, Jinan, China; Institute of Emergency and Critical Care Medicine, Shandong University, Jinan, China; Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital, Shandong University, Jinan, China; Key Laboratory of Cardiovascular Remodeling & Function Research, Chinese Ministry of Education & Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, China. Electronic address:

Heart failure is one of the major causes of the ever-rising mortality globally. ALDH2 rs671 polymorphism is proven to be closely related to the prevalence of CAD, hypertension, diabetes mellitus and alcoholism, which are etiological factors of heart failure. In addition, growing evidence supports a possible role for ALDH2 in different forms of heart failure. Read More

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Load-bearing capacity and the recommended thickness of dental monolithic zirconia single crowns.

J Mech Behav Biomed Mater 2014 Jul 2;35:93-101. Epub 2014 Apr 2.

Department of Stomatology, Nanfang Hospital, Southern Medical University, No.1838, North of Guangzhou Street, Guangzhou 510515, Guangdong, China. Electronic address:

Purpose: The aim of this study was to evaluate the load bearing capacity and a reasonable thicknesss of dental monolithic zirconia crowns.

Materials And Methods: Polymethyl methacrylate (PMMA) abutment tooth specimens were made by CAD/CAM technic. Monolithic zirconia crowns (MZC), monolithic lithium disilicate crowns (MLC), layered zirconia crowns (LZC) and metal ceramic crowns(MCC), of which the occlusal thickness was 1. Read More

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Calcium score, coronary artery disease extent and severity, and clinical outcomes among low Framingham risk patients with low vs high lifetime risk: results from the CONFIRM registry.

J Nucl Cardiol 2014 Feb 3;21(1):29-37; quiz 38-9. Epub 2014 Jan 3.

Brigham and Women's Hospital, Boston, MA, USA,

Background: Short-term risk scores, such as the Framingham risk score (FRS), frequently classify younger patients as low risk despite the presence of uncontrolled cardiovascular risk factors. Among patients with low FRS, estimation of lifetime risk is associated with significant differences in coronary arterial calcium scores (CACS); however, the relationship of lifetime risk to coronary atherosclerosis on coronary CT angiography (CCTA) and prognosis has not been studied.

Methods And Results: We evaluated asymptomatic 20-60-year-old patients without diabetes or known coronary artery disease (CAD) within an international CT registry who underwent ≥64-slice CCTA. Read More

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February 2014

Association between C1431T polymorphism in peroxisome proliferator-activated receptor-γ gene and coronary artery disease in Chinese Han population.

Mol Biol Rep 2012 Feb 4;39(2):1863-8. Epub 2011 Jun 4.

Department of Cardiology, The Second Affiliated Hospital of Soochow University, No.1055 Sanxiang Road, Suzhou, Jiangsu 215004, China.

The C1431T polymorphism in peroxisome proliferator-activated receptor-γ (PPARγ) has been shown to be associated with diabetes, obesity, and metabolic syndrome. However, it is unclear whether this polymorphism is associated with coronary artery disease (CAD). Therefore, we conducted a hospital-based case-control study with 864 CAD patients and 1008 controls to explore the association between the PPARγ C1431T polymorphism and risk of CAD in Chinese Han population. Read More

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February 2012

Toward total structural analysis of cardiolipins: multiple-stage linear ion-trap mass spectrometry on the [M - 2H + 3Li]+ ions.

J Am Soc Mass Spectrom 2010 Nov 7;21(11):1863-9. Epub 2010 Aug 7.

Mass Spectrometry Resource, Division of Endocrinology, Diabetes, Metabolism, and Lipid research, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

ESI multiple-stage linear ion-trap (LIT) mass spectrometric approaches for a near-complete structural characterization of cardiolipins (CLs), including identification of the fatty acyl substituents, assignment of the fatty acid substituents on the glycerol backbone, and location of the double-bond(s) or cyclopropyl group along the fatty acid chain are described. Upon collisionally activated dissociation (CAD) on the [M - 2H + 3Li](+) ions of CL in an ion-trap (MS(2)), two sets of fragment ions (designated as (a + 136) and (b + 136) ions) analogous to those previously reported for the [M - 2H + 3Na](+) ions were observed, leading to assignment of the phosphatidyl moieties attached to 1'- or 3'-position of the central glycerol. Further dissociation of the (a + 136) (or (b + 136)) ions (MS(3)) gives rise to the (a + 136 - R(1(or 2))CO(2)Li) (or b + 136 - R(1(or 2))CO(2)Li) ion pairs that identify the fatty acid moieties and their position on the glycerol backbone. Read More

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November 2010

[A profile of researchers in public health with productivity grants from the Brazilian National Research Council (CNPq)].

Cad Saude Publica 2003 Nov-Dec;19(6):1863-76. Epub 2004 Mar 3.

Departamento de Medicina Social, Faculdade de Ciências Médicas, Santa Casa de São Paulo, São Paulo, SP, 01221-020, Brasil.

Based on information provided by the Lattes curriculum, this study analyzes the profile of researchers in public health with productivity grants from the Brazilian National Research Council (CNPq). The analysis considered the researcher s undergraduate and graduate degrees, field of expertise, scientific output, and publications. The article discusses comparisons between different categories of researchers and data provided by the CNPq Research Group Directory. Read More

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