565 results match your criteria 1841 control

Clinical Features, Biochemical Profile, and Response to Standard Treatment in Lean, Normal-Weight, and Overweight/Obese Indian Type 2 Diabetes Patients.

Rev Diabet Stud 2021 Nov;17(2):68-74

Former Professor of Endocrinology & Dean Faculty of Medicine, Ex-Director, Rajiv Gandhi Centre for Diabetes & Endocrinology, Aligarh Muslim University, Aligarh Diabetes & Endocrinology Super-Speciality Centre, Aligarh, India.

Much evidence is available on the relationship between type 2 diabetes mellitus (T2D) and obesity, but less on T2D in lean individuals. This study was conducted in 12,069 T2D patients from northern India to find out which clinical and biochemical features are related to lean, normal weight, and overweight/obese T2D patients. The study was conducted at two endocrine clinics in northern India as a retrospective cross-sectional study. Read More

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November 2021

Genetic association analysis between IL9 and coronary artery disease in a Chinese Han population.

Cytokine 2021 Nov 20;150:155761. Epub 2021 Nov 20.

Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:

Interleukin-9 (IL-9) plays important role in coronary artery disease (CAD). However, the exact relationship between them is not explored yet. Here, four tag SNPs covering IL9 (rs31563, rs2069868, rs2069870 and rs31564) were selected to conduct case-control association analyses in a total of 3704 individuals from Chinese Han population (1863 CAD vs 1841 control). Read More

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November 2021

The neural control of volitional vocal production-from speech to identity, from social meaning to song.

Sophie K Scott

Philos Trans R Soc Lond B Biol Sci 2022 Jan 15;377(1841):20200395. Epub 2021 Nov 15.

Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London, UK.

The networks of cortical and subcortical fields that contribute to speech production have benefitted from many years of detailed study, and have been used as a framework for human volitional vocal production more generally. In this article, I will argue that we need to consider speech production as an expression of the human voice in a more general sense. I will also argue that the neural control of the voice can and should be considered to be a flexible system, into which more right hemispheric networks are differentially recruited, based on the factors that are modulating vocal production. Read More

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January 2022

The shallow of your smile: the ethics of expressive vocal deep-fakes.

Philos Trans R Soc Lond B Biol Sci 2022 Jan 15;377(1841):20210083. Epub 2021 Nov 15.

FEMTO-ST, UBFC/CNRS, Besançon, France.

Rapid technological advances in artificial intelligence are creating opportunities for real-time algorithmic modulations of a person's facial and vocal expressions, or 'deep-fakes'. These developments raise unprecedented societal and ethical questions which, despite much recent public awareness, are still poorly understood from the point of view of moral psychology. We report here on an experimental ethics study conducted on a sample of = 303 participants (predominantly young, western and educated), who evaluated the acceptability of vignettes describing potential applications of expressive voice transformation technology. Read More

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January 2022

The impact of the SARS-CoV-2 pandemic on out-of-hospital and in-hospital cardiac arrest

Orv Hetil 2021 11 14;162(46):1831-1841. Epub 2021 Nov 14.

3 Semmelweis Egyetem, Általános Orvostudományi Kar, Városmajori Szív- és Érgyógyászati Klinika, Budapest, Városmajor u. 68., 1122.

Összefoglaló. A koronavírus-betegség (COVID-19) okozta közvetlen mortalitáson túl, a járvány közvetett úton is hatással lehet a hirtelen szívhalálra. Egyre növekvő számú közlemény foglalkozik a járványnak a hirtelen szívhalálra kifejtett közvetett hatásával. Read More

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November 2021

Testing potential disclosures for e-cigarette sponsorship on social media.

Addict Behav 2022 Feb 11;125:107146. Epub 2021 Oct 11.

Truth Initiative, 900 G Street NW, Washington, DC 20001, USA.

Objectives: Few e-cigarette social media posts are authentic posts to friends; most come from commercially sponsored influencers. Potential disclosure strategies need to be tested to confirm whether users recognize such posts as commercially sponsored.

Methods: Between July - August 2019, young adult (ages 16-24; n = 200) participants were recruited to view their native Instagram feed on a laboratory mobile device. Read More

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February 2022

Narrow-spectrum antibiotics for community-acquired pneumonia in Dutch adults (CAP-PACT): a cross-sectional, stepped-wedge, cluster-randomised, non-inferiority, antimicrobial stewardship intervention trial.

Lancet Infect Dis 2021 Oct 7. Epub 2021 Oct 7.

Department of Medical Microbiology, University Medical Centre Utrecht, Utrecht, Netherlands; Julius Centre for Health Sciences and Primary Care, Utrecht, Netherlands.

Background: Adults hospitalised to a non-intensive care unit (ICU) ward with moderately severe community-acquired pneumonia are frequently treated with broad-spectrum antibiotics, despite Dutch guidelines recommending narrow-spectrum antibiotics. Therefore, we investigated whether an antibiotic stewardship intervention would reduce the use of broad-spectrum antibiotics in patients with moderately severe community-acquired pneumonia without compromising their safety.

Methods: In this cross-sectional, stepped-wedge, cluster-randomised, non-inferiority trial (CAP-PACT) done in 12 hospitals in the Netherlands, we enrolled immunocompetent adults (≥18 years) who were admitted to a non-ICU ward and had a working diagnosis of moderately severe community-acquired pneumonia. Read More

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October 2021

Borage oil intake by overweight young adults: no effect on metabolic rate; beneficial effects on plasma triglyceride and HDL cholesterol readings.

Food Funct 2021 Oct 4;12(19):8882-8886. Epub 2021 Oct 4.

Human Nutrition, The Ohio State University, 1787 Neil Ave, Columbus, OH 43210, USA.

Some research has raised the possibility that gamma linolenic acid (GLA) can increase resting metabolic rate (RMR), which can help with weight control. However, in overweight young adults with a family history of obesity, no effect on RMR was seen after a 6 weeks treatment with borage oil (880 mg GLA per day) or evening primrose oil (540 mg GLA per day). On the other hand, borage oil did lower plasma triglyceride readings and raise HDL cholesterol readings (mean starting values in normal range for triglycerides, borderline low for HDL). Read More

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October 2021

Efficacy of a mobile technology-based intervention for increasing parents' safety knowledge and actions: a randomized controlled trial.

Inj Epidemiol 2021 Oct 1;8(1):56. Epub 2021 Oct 1.

Bloomberg School of Public Health, Johns Hopkins Center for Injury Research and Policy, 624 N. Broadway, Baltimore, MD, 21205, USA.

Background: Leading causes of unintentional child injury such as poisoning and falls are preventable, and the majority occur in the home. Numerous home safety interventions have been developed and tested to increase safety behaviors; however, no smart phone-based applications (apps) have been developed and evaluated for this purpose. The objective of this study was to evaluate whether a mobile technology-based health behavior change intervention, the Make Safe Happen® app, was an effective tool to increase safety knowledge and safety actions/behaviors for the prevention of child unintentional injuries in and around the home. Read More

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October 2021

The bile acid-sensitive ion channel (BASIC) mediates bile acid-dependent currents in bile duct epithelial cells.

Pflugers Arch 2021 12 21;473(12):1841-1850. Epub 2021 Sep 21.

Institute of Physiology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.

The bile acid-sensitive ion channel (BASIC) is a member of the Deg/ENaC family of ion channels that is activated by bile acids. Despite the identification of cholangiocytes in the liver and unipolar brush cells in the cerebellum as sites of expression, the physiological function of BASIC in these cell types is not yet understood. Here we used a cholangiocyte cell line, normal rat cholangiocytes (NRCs), which expresses BASIC to study the role of the channel in epithelial transport using Ussing chamber experiments. Read More

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December 2021

A cluster randomised controlled trial of a web-based youth mental health service in Australian schools.

Lancet Reg Health West Pac 2021 Jul 12;12:100178. Epub 2021 Jun 12.

Black Dog Institute, Hospital Road, Randwick, NSW, Australia, 2031.

Background: Secondary schools have attempted to address gaps in help-seeking for mental health problems with little success. This trial evaluated the effectiveness of a universal web-based service (Smooth Sailing) for improving help-seeking intentions for mental health problems and other related outcomes among students.

Methods: A cluster randomised controlled trial was conducted to evaluate the 12-week outcomes of the Smooth Sailing service among 1841 students from 22 secondary schools in New South Wales, Australia. Read More

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From "mentally ill" to "citizens": historical analysis of the construction of political categories in mental health in Brazil.

Cien Saude Colet 2021 30;26(suppl 2):3467-3479. Epub 2021 Aug 30.

Escola de Administração de Empresas de São Paulo, Fundação Getulio Vargas. Av. 9 de julho 2029, Bela Vista. 01313-902. São Paulo SP Brasil.

Public policies are based on categories that have a double effect: build eligibility for rights and generate symbolic effects, reproducing or fighting social stigmas. This article aims to analyze the historical setup of categories targeted in mental health policies in Brazil. Based in a study of the legislation from 1841 to 2017, we observed how was the processes of constructing the political categories of mental health - passing from users to citizens or mentally ill. Read More

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September 2021

High Exhaustion in Geriatric Healthcare Professionals During the COVID-19 Second Lockdown.

J Alzheimers Dis 2021 ;83(4):1841-1848

Nantes Université, Univ Angers, Laboratoire de Psychologie des Pays de la Loire, Nantes, France.

Background: In a previous study, we assessed burnout in geriatric healthcare workers during the first lockdown that lasted from March to May 2020 in France, in response to the COVID-19 crisis.

Objective: We carried out a follow-up study to assess burnout in the same population during the second lockdown that was implemented at the end of October 2020.

Methods: We used an online survey to assess burnout in terms of exhaustion and disengagement in a sample of 58 geriatric healthcare workers. Read More

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November 2021

Indonesia-Based Study of the Clinical and Cost-Saving Benefits of Subcutaneous Allergen Immunotherapy for Children with Allergic Rhinitis in Private Practice.

Cells 2021 07 20;10(7). Epub 2021 Jul 20.

Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya 60235, Indonesia.

Background: Until now, the cost of allergy treatment in the insured public health care system and the non-insured self-financing private health care system in Indonesia has not been well documented and published, as well as the cost of allergy treatment with subcutaneous immunotherapy.

Objective: To evaluate the clinical and cost benefits of allergic rhinitis treatment in children with subcutaneous immunotherapy in a non-insured self-financing private health care system.

Methods: A retrospective cohort study conducted from 2015 until 2020 that compared the clinical improvement and health care costs over 18 months in newly diagnosed AR children who received SCIT versus matched AR control subjects who did not receive SCIT, with each group consisting of 1098 subjects. Read More

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Prenatal and Perinatal Factors and Risk of Cancer in Middle and Older Adulthood among Men.

Cancer Epidemiol Biomarkers Prev 2021 Oct 16;30(10):1841-1845. Epub 2021 Jul 16.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Background: Prenatal factors have been associated with risk of cancers later in life, although studies in men have largely been case-control and focused on birth size only.

Methods: We used data from 5,845 men in the Health Professionals Follow-up Study (HPFS) to prospectively examine associations between several prenatal and perinatal factors and incident adult cancer risk. In 1994, mothers of participants reported information on characteristics and behaviors related to their pregnancy with their sons. Read More

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October 2021

Effects of flavophospholipol on conjugation and plasmid curing of multidrug-resistant Enteritidis in broiler chickens.

JAC Antimicrob Resist 2021 Mar 11;3(1):dlab022. Epub 2021 Mar 11.

Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, A100R Sisson Hall, 1920 Coffey Rd, Columbus, OH 43210, USA.

Background: Early studies suggested that flavophospholipol has plasmid-curing effects and could inhibit conjugation by disrupting pilus formation between bacteria.

Objectives: This 36-day controlled-challenge study aimed to evaluate the anti-conjugative and plasmid-curing effect of flavophospholipol on plasmid-mediated antimicrobial resistance (AMR) in MDR transconjugant Enteritidis in chickens.

Methods: A total of 270-day-old chicks were randomly assigned to four control and four treatment groups with two doses of in-feed flavophospholipol (10 ppm and 64 ppm) and in the presence and absence of ampicillin in drinking water. Read More

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Moms in motion: weight loss intervention for postpartum mothers after gestational diabetes: a randomized controlled trial.

BMC Pregnancy Childbirth 2021 Jun 29;21(1):461. Epub 2021 Jun 29.

Department of Obstetrics and Gynecology, College of Medicine, The Ohio State University, 370 W. 9th Avenue, Columbus, OH, 43210, USA.

Background: Up to 50 % of women with gestational diabetes mellitus (GDM) will receive a diagnosis of type 2 diabetes mellitus (T2DM) within a decade after pregnancy. While excess postpartum weight retention exacerbates T2DM risk, lifestyle changes and behavior modifications can promote healthy postpartum weight loss and contribute to T2DM prevention efforts. However, some women have difficulty prioritizing self-care during this life stage. Read More

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Microdroplet Mass Spectrometry Enables Extremely Accelerated Pepsin Digestion of Proteins.

J Am Soc Mass Spectrom 2021 Jul 8;32(7):1841-1845. Epub 2021 Jun 8.

Institute of Organic Chemistry and Center for Molecular Biosciences (CMBI), Leopold-Franzens University Innsbruck, 6020 Innsbruck, Austria.

In microdroplets, rates of chemical or biomolecular reactions can exceed those in the bulk phase by more than a million times. As electrospray ionization-based mass spectrometry (MS) involves the formation of charged microdroplets, reaction acceleration and online MS monitoring of reaction products can readily be performed at the same time. We investigated accelerated enzymatic reactions in microdroplets and focused on the proteolytic enzyme pepsin. Read More

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Viral Metagenome-Based Precision Surveillance of Pig Population at Large Scale Reveals Viromic Signatures of Sample Types and Influence of Farming Management on Pig Virome.

mSystems 2021 Jun 8;6(3):e0042021. Epub 2021 Jun 8.

Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun, Jilin Province, China.

Pigs are a major meat source worldwide and a pillar of Chinese animal husbandry; hence, their health and safety are a prioritized concern of the national economy. Although pig viruses have been continuously investigated, the full extent of the pig virome has remained unknown and emerging viruses are still a major threat to the pig industry. Here, we report a comprehensive study to delineate the pig virome of 1,841 healthy weaned pigs from 45 commercial farms collected from 25 major pig-producing regions across China. Read More

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Arthropods as potential vectors of African swine fever virus outbreaks in pig farms in the Republic of Korea.

Vet Med Sci 2021 Sep 4;7(5):1841-1844. Epub 2021 Jun 4.

Department of Animal Disease Control and Quarantine, Animal and Plant Quarantine Agency, Gimcheon, Republic of Korea.

The seasonality of African swine fever (ASF) in the summers and outbreaks in farms with high biosecurity levels suggest that the ASF virus (ASFV) may be transmitted by arthropod vectors. Arthropods were collected in this study from 14 pig farms with ASF outbreaks in Korea in 2019 to explore the role of arthropods as potential ASFV vectors. A total of 28,729 arthropods, including 28,508 (99. Read More

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September 2021

Interferon-induced protein with tetratricopeptide repeats 3 may be a key factor in primary biliary cholangitis.

Sci Rep 2021 06 1;11(1):11413. Epub 2021 Jun 1.

Department of Pathology, Fukui Saiseikai Hospital, Fukui, 918-8503, Japan.

Accumulating studies suggest that senescent biliary epithelial cells (BECs) produce senescence-associated secretory phenotypes (SASPs) and play various roles in the pathogenesis of primary biliary cholangitis (PBC) and other cholangiopathies. We examined comprehensive profiles of senescent BECs and its contribution to the pathogenesis of PBC taking advantage of microarray analysis. cDNA microarray analysis revealed that 1841 genes including CCL2, IFIT3, CPQ were commonly up-regulated in senescent BECs cultured in serum depleted media or media with glycochenodeoxycholic acid. Read More

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A randomised controlled trial to assess the clinical effectiveness and safety of the endometrial scratch procedure prior to first-time IVF, with or without ICSI.

Hum Reprod 2021 06;36(7):1841-1853

Hull Health Trials Unit, The University of Hull, Hull, HU6 7RX, UK.

Study Question: What is the clinical-effectiveness and safety of the endometrial scratch (ES) procedure compared to no ES, prior to usual first time in vitro fertilisation (IVF) treatment?

Summary Answer: ES was safe but did not improve pregnancy outcomes when performed in the mid-luteal phase prior to the first IVF cycle, with or without intracytoplasmic sperm injection (ICSI).

What Is Known Already: ES is an 'add-on' treatment that is available to women undergoing a first cycle of IVF, with or without ICSI, despite a lack of evidence to support its use.

Study Design, Size, Duration: This pragmatic, superiority, open-label, multi-centre, parallel-group randomised controlled trial involving 1048 women assessed the clinical effectiveness and safety of the ES procedure prior to first time IVF, with or without ICSI, between July 2016 and October 2019. Read More

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Addressing Emotional Wellness During the COVID-19 Pandemic: the Role of Promotores in Delivering Integrated Mental Health Care and Social Services.

Prev Chronic Dis 2021 05 27;18:E53. Epub 2021 May 27.

Center for Health Outcomes and Policy Evaluation Studies, Ohio State University College of Public Health, Columbus, Ohio.

Introduction: The disproportionate impact of the COVID-19 pandemic on Latino communities has resulted in greater reports of depression, anxiety, and stress. We present a community-led intervention in Latino communities that integrated social services in mental health service delivery for an equity-based response.

Methods: We used tracking sheets to identify 1,436 unique participants (aged 5-86) enrolled in Latino Health Access's Emotional Wellness program, of whom 346 enrolled in the pre-COVID-19 period (March 2019-February 2020) and 1,090 in the COVID-19 period (March-June 2020). Read More

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A Computational Model for Estimating the Speech Motor System's Sensitivity to Auditory Prediction Errors.

Ayoub Daliri

J Speech Lang Hear Res 2021 06 27;64(6):1841-1854. Epub 2021 May 27.

College of Health Solutions, Arizona State University, Tempe.

Purpose The speech motor system uses feedforward and feedback control mechanisms that are both reliant on prediction errors. Here, we developed a state-space model to estimate the error sensitivity of the control systems. We examined (a) whether the model accounts for the error sensitivity of the control systems and (b) whether the two systems have similar error sensitivity. Read More

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American Diabetes Association Framework for Glycemic Control in Older Adults: Implications for Risk of Hospitalization and Mortality.

Diabetes Care 2021 07 18;44(7):1524-1531. Epub 2021 May 18.

Department of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD.

Objective: The 2021 American Diabetes Association (ADA) guidelines recommend different A1C targets in older adults that are based on comorbid health status. We assessed risk of mortality and hospitalizations in older adults with diabetes across glycemic control (A1C <7%, 7 to <8%, ≥8%) and ADA-defined health status (healthy, complex/intermediate, very complex/poor) categories.

Research Design And Methods: Prospective cohort analysis of older adults aged 66-90 years with diagnosed diabetes in the Atherosclerosis Risk in Communities (ARIC) study. Read More

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Effect of Antimicrobial Therapy on Respiratory Hospitalization or Death in Adults With Idiopathic Pulmonary Fibrosis: The CleanUP-IPF Randomized Clinical Trial.

JAMA 2021 05;325(18):1841-1851

Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville.

Importance: Alteration in lung microbes is associated with disease progression in idiopathic pulmonary fibrosis.

Objective: To assess the effect of antimicrobial therapy on clinical outcomes.

Design, Setting, And Participants: Pragmatic, randomized, unblinded clinical trial conducted across 35 US sites. Read More

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Microbial Ecosystem in Diabetes Mellitus: Consideration of the Gastrointestinal System.

Diabetes Metab Syndr Obes 2021 28;14:1841-1854. Epub 2021 Apr 28.

Pharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Berhan University, Debre Berhan, Ethiopia.

Intestinal microbiota is established to be a crucial element in the control of human health, and keeping the symbiotic relationship between the human body and intestinal microbes will have paramount importance. A number of investigations illustrated that many chronic diseases are associated with intestinal micro-ecological disorders implying intestinal floras as an important component among the environmental factors, and perturbations in their composition are correlated with metabolic disorders, including obesity and diabetes mellitus (DM). Increased evidence suggests that alterations in the gut microbial ecosystem have been involved in part in the pathogenesis of both type 1 and type 2 DM. Read More

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A Targeted-Covalent Inhibitor of 17β-HSD1 Blocks Two Estrogen-Biosynthesis Pathways: In Vitro (Metabolism) and In Vivo (Xenograft) Studies in T-47D Breast Cancer Models.

Cancers (Basel) 2021 Apr 13;13(8). Epub 2021 Apr 13.

Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit, CHU de Québec-Research Center, Québec, QC G1V 4G2, Canada.

17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) plays an important role in estrogen-dependent breast tumor growth. In addition to being involved in the production of estradiol (E2), the most potent estrogen in women, 17β-HSD1 is also responsible for the production of 5-androsten-3β,17β-diol (5-diol), a weaker estrogen than E2, but whose importance increases after menopause. 17β-HSD1 is therefore a target of choice for the treatment of estrogen-dependent diseases such as breast cancer and endometriosis. Read More

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Understanding low chemoprevention uptake by women at high risk of breast cancer: findings from a qualitative inductive study of women's risk-reduction experiences.

BMC Womens Health 2021 04 16;21(1):157. Epub 2021 Apr 16.

Division of Health Services Management and Policy, College of Public Health, The Ohio State University, Columbus, OH, USA.

Background: Chemoprevention is one of several methods that have been developed to help high-risk women reduce their risk of breast cancer. Reasons for the low uptake of chemoprevention are poorly understood. This paper seeks a deeper understanding of this phenomenon by drawing on women's own narratives about their awareness of chemoprevention and their risk-related experiences. Read More

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