4,922 results match your criteria 184 days


Thrombosis is associated with worse survival in children with acute lymphoblastic leukemia: a report from CYP-C.

Am J Hematol 2021 Apr 13. Epub 2021 Apr 13.

Division of Haematology/Oncology, Department of Paediatrics, SickKids Hospital, Ontario, Canada.

There are conflicting data about whether the development of cancer-associated thrombo-embolism (TE) negatively impacts survival in children. The objective was to determine whether TE during treatment was associated with overall survival (OS) and event-free survival (EFS) in children with acute lymphoblastic leukemia (ALL). We performed a population-based retrospective cohort study using the Cancer in Young People-Canada registry. Read More

View Article and Full-Text PDF

Short term heat acclimation reduces heat strain during a first, but not second, consecutive exercise-heat exposure.

J Sci Med Sport 2021 Apr 6. Epub 2021 Apr 6.

Korey Stringer Institute, Department of Kinesiology, University of Connecticut, USA.

Objectives: Determine whether five days of heat acclimation reduces cardiovascular and thermoregulatory strain during consecutive exercise-heat exposures on the sixth day in the heat.

Design: Pair-matched randomized control trial.

Methods: Twenty-four males completed two, 120min exercise sessions (Session 1, Session 2) in a single day before (Day 1) and after (Day 6) four additional days of exercise in either hot (HOT: 40°C, 40% relative humidity, n=16) or temperate (CON: 23°C, 25% relative humidity, n=8) environments. Read More

View Article and Full-Text PDF

[Cost-effectiveness of ceftazidime/avibactam versus colistin + meropenem for treatment of carbapenemic-resistant enterobacteria infections in Chile].

Rev Chilena Infectol 2021 Feb;38(1):7-14

Pfizer Chile S.A. laboratorio fabricante del principio activo ceftazidima/avibactam, Chile.

Background: Ceftazidime-avibactam (C/A), has shown reduction in mortality rates and risk of nephrotoxicity, compared to colistin, conventional therapy.

Aim: To estimate the cost-effectiveness of C/A versus colistin + meropenem in the treatment of infections due to carbapenem-resistant Enterobacteriaceae (CRE) in Chile.

Methods: An economic decision tree type model was adapted. Read More

View Article and Full-Text PDF
February 2021

Time Till Viral Clearance of Severe Acute Respiratory Syndrome Coronavirus 2 Is Similar for Asymptomatic and Non-critically Symptomatic Individuals.

Front Med (Lausanne) 2021 26;8:616927. Epub 2021 Mar 26.

Royal College of Surgeons in Ireland, Manama, Bahrain.

Despite the modeled estimations of the burden of asymptomatic spread, the duration of viral positivity and infectiousness of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains understudied. The objective of the present study was to estimate and compare the time till viral clearance of SARS-CoV-2 in asymptomatic and non-critical symptomatic individuals. We studied 184 SARS-CoV-2-positive participants, of whom 145 were asymptomatic. Read More

View Article and Full-Text PDF

Role of Small Gauge Proportionate Reflux (SGPR) assisted hydro-dissection in elevated symptomatic Vitreo Foveal Traction (VFT).

Retina 2021 Apr 2. Epub 2021 Apr 2.

Dept of Vitreoretina, Disha Eye Hospitals Pvt Ltd, 88(63A) Ghosh Para Road, Barrackpore, Kolkata.

Title: Role of Small Gauge Proportionate Reflux (SGPR) assisted hydro-dissection in elevated symptomatic Vitreo Foveal Traction (VFT).

Purpose: To describe a new technique to release the elevated symptomatic Vitreo-Foveal Traction (VFT).

Methods: This was a retrospective, interventional case series where a new technique of hydro-dissection by Proportionate Reflux (PR) property of small gauge vitrectomy cutter was used in cases of elevated symptomatic VFT as evident on Optical Coherence Tomography. Read More

View Article and Full-Text PDF

Impairment of right ventricular longitudinal strain associated with severity of pneumonia in patients recovered from COVID-19.

Int J Cardiovasc Imaging 2021 Apr 11. Epub 2021 Apr 11.

Istanbul Medical Faculty, Department of Cardiology, Istanbul University, Topkapi Mahallesi, Turgut Ozal Millet Caddesi, 34093, Fatih/Istanbul, Turkey.

Myocardial injury caused by COVID-19 was reported in hospitalized patients previously. But the information about cardiac consequences of COVID-19 after recovery is limited. The aim of the study was comprehensive echocardiography assessment of right ventricular (RV) in patients recovered from COVID-19. Read More

View Article and Full-Text PDF

Dietary Factors and Sleep Quality Among Hemodialysis Patients in Malaysia.

J Ren Nutr 2021 Apr 7. Epub 2021 Apr 7.

Department of Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Seri Kembangan, Selangor, Malaysia; Research Centre of Excellence, Nutrition and Non-communicable Diseases, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Seri Kembangan, Selangor, Malaysia.

Objectives: Poor sleep quality is a commonly seen problem in hemodialysis patients. This study investigated the associations between dietary factors and sleep quality among hemodialysis patients.

Design And Methods: This is a cross-sectional study conducted among 184 eligible hemodialysis patients at four dialysis units in Malaysia. Read More

View Article and Full-Text PDF

Laparoscopic cholecystectomy after endoscopic trans-papillary gallbladder stenting for acute cholecystitis: a pilot study of surgical feasibility.

BMC Surg 2021 Apr 7;21(1):184. Epub 2021 Apr 7.

Department of Hepatobiliary-Pancreatic Surgery, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Background: Percutaneous transhepatic gallbladder drainage (PTGBD) is indicated for patients with acute cholecystitis (AC) who are not indicated for urgent surgery, but external tubes reduce quality of life (QOL) while waiting for elective surgery. The objective of the present study was to investigate the feasibility of laparoscopic cholecystectomy after endoscopic trans-papillary gallbladder stenting (ETGBS) comparing with after PTGBD.

Methods: Intraoperative and postoperative outcomes of patients with ETGBS and PTGBD were retrospectively compared. Read More

View Article and Full-Text PDF

Peri-operative blood management of Jehovah's Witnesses undergoing cytoreductive surgery for advanced ovarian cancer.

Blood Transfus 2021 Feb 25. Epub 2021 Feb 25.

Department of Maternal and Child Health and Urological Sciences, Sapienza University, Policlinico Umberto I, Rome, Italy.

Background: The aim of this study was to evaluate the efficacy and feasibility of a peri-operative bloodless medicine and surgery (BMS) protocol in reducing severe post-operative anaemia (haemoglobin [Hb] <7 g/dL) in Jehovah's Witnesses undergoing cytoreductive surgery for advanced epithelial ovarian cancer.

Materials And Methods: This was a single-institution retrospective study enrolling Jehovah's Witnesses who underwent elective bloodless surgery for advanced epithelial ovarian cancer between October 2017 and April 2020. All patients followed a standardised bloodless medicine and surgery protocol based on ferric carboxymaltose and erythropoietin if indicated. Read More

View Article and Full-Text PDF
February 2021

Lipid Testing, Lipid-Modifying Therapy, and PCSK9 (Proprotein Convertase Subtilisin-Kexin Type 9) Inhibitor Eligibility in 27 979 Patients With Incident Acute Coronary Syndrome.

Circ Cardiovasc Qual Outcomes 2021 Apr 5:CIRCOUTCOMES120006646. Epub 2021 Apr 5.

St Michael's Hospital, University of Toronto, Canada (B.S., A.T.Y., S.G.G.).

Background: While registry-based studies have shown that as many as 1 in 2 patients with stable atherosclerotic cardiovascular disease would be eligible for PCSK9i (proprotein convertase subtilisin-kexin type 9 inhibitor) therapy, this has not been studied in a large population-based postacute coronary syndrome (ACS) cohort.

Methods: We examined lipid testing performed in hospital or within 90 days of discharge and lipid-lowering therapies dispensed within 90 days of discharge in patients surviving for at least 1 year after their first ACS between 2012 and 2018 in the province of Alberta, Canada. We estimated the proportion of patients eligible for PCSK9i and the expected benefits of treatment. Read More

View Article and Full-Text PDF

The safety and efficacy of a novel method for treatment of HSIL.

Arch Gynecol Obstet 2021 Apr 3. Epub 2021 Apr 3.

Department of Obstetrics and Gynecology, Peking University First Hospital, Xicheng District, Beijing, 100034, China.

Purpose: To investigate the efficacy and safety of Nr-CWS on treatment of cervical HSIL.

Method: In this observational study, 16 patients were treated with Nr-CWS 1 time every 2 days for 6 times as one-course group (OC group), the other 184 patients were treated with Nr-CWS 1 time every 2 days for 12 times between 2 menstruations as two-course group (TC group). The medical information including age, HPV assay, vaginal-cervical cytology, and the pathological result of biopsy before and after treatment was collected. Read More

View Article and Full-Text PDF

COVID-19 Infection-Related Weight Loss Decreases Eating/Swallowing Function in Schizophrenic Patients.

Nutrients 2021 Mar 29;13(4). Epub 2021 Mar 29.

Musashino Central Hospital, Tokyo 184-8585, Japan.

Background: In older people with psychoneurological diseases, COVID-19 infection may be associated with a risk of developing or exacerbating dysphagia. The aim of the present study was to examine the relationship between eating/swallowing function and COVID-19 infection.

Methods: Subjects were 44 inpatients with confirmed COVID-19 infection being treated for schizophrenia in a psychiatric ward. Read More

View Article and Full-Text PDF

Treatment Protocol for COVID-19 Based on T2R Phenotype.

Viruses 2021 03 18;13(3). Epub 2021 Mar 18.

Rhinology and Skull Base Research Group, Baton Rouge General Medical Center, 8585 Picardy Ave., Suite 210, Baton Rouge, LA 70809, USA.

COVID-19 has become a global pandemic of the highest priority. Multiple treatment protocols have been proposed worldwide with no definitive answer for acure. A prior retrospective study showed association between bitter taste receptor 38 (T2R38) phenotypes and the severity of COVID-19. Read More

View Article and Full-Text PDF

Miles and days until medical abortion via TelAbortion versus clinic in Oregon and Washington, USA.

BMJ Sex Reprod Health 2021 Mar 31. Epub 2021 Mar 31.

Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon, USA

Background: Medical abortion provided via telemedicine is becoming more widely available, potentially decreasing travel time for in-person abortion evaluation.

Methods: We conducted a retrospective chart review of all outpatient medical abortions from October 2016 through December 2019 at our academic medical centre in Portland, Oregon, USA. Using mifepristone administration logs, we identified patients who underwent abortion via direct-to-patient telemedicine or in clinic. Read More

View Article and Full-Text PDF

The correlates and extent of prescribing of medications for alcohol relapse prevention in England.

Authors:
Kim Donoghue

Addiction 2021 Mar 31. Epub 2021 Mar 31.

University College London, Research Department of Clinical, Educational and Health Psychology, 1-19 Torrington Place, London, WC1 7HB.

Aims: To determine the pattern and extent of prescribing of medications for alcohol relapse prevention (ARP) in England.

Design: Cross-sectional.

Setting: Specialist drug and alcohol treatment providers in England reporting to the National Drug Treatment Monitoring System. Read More

View Article and Full-Text PDF

Antibody response to SARS-CoV-2 vaccination is extremely vivacious in subjects with previous SARS-CoV-2 infection.

J Med Virol 2021 Mar 31. Epub 2021 Mar 31.

Division of Infectious Diseases, ASST Papa Giovanni XXIII, Bergamo, Italy.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic calls for rapid actions, now principally oriented to a world-wide vaccination campaign. In this study we verified if, in individuals with a previous SARS-CoV-2 infection, a single dose of messenger RNA (mRNA) vaccine would be immunologically equivalent to a full vaccine schedule in naïve individuals. Health care workers (184) with a previous SARS-CoV-2 infection were sampled soon before the second dose of vaccine and between 7 and 10 days after the second dose, the last sampling time was applied to SARS-CoV-2 naïve individuals, too. Read More

View Article and Full-Text PDF

Segesterone Acetate Serum Levels with a Regression Model of Continuous Use of the Segesterone Acetate/Ethinyl Estradiol Contraceptive Vaginal System.

Contraception 2021 Mar 27. Epub 2021 Mar 27.

TherapeuticsMD, Boca Raton, FL.

Objective: To predict serum segesterone (SA) and ethinyl estradiol (EE) levels after 364 days of hypothetical continuous use (without removal) of a cyclic contraceptive vaginal system (CVS) containing 0.15 mg SA and 0.013 mg EE. Read More

View Article and Full-Text PDF

Multicenter Analysis of Clinical Features and Prognosis of COVID-19 Patients with Hepatic Impairment.

Gut Liver 2021 Apr 2. Epub 2021 Apr 2.

Department of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, Korea.

Background/aims: Recent data indicate the presence of liver enzyme abnormalities in patients with coronavirus disease 2019 (COVID-19). We aimed to evaluate the clinical features and treatment outcomes of COVID-19 patients with abnormal liver enzymes.

Methods: We performed a retrospective, multicenter study of 874 COVID-19 patients admitted to five tertiary hospitals from February 20 to April 14, 2020. Read More

View Article and Full-Text PDF

A Novel Anastomosis Technique for Laparoscopic Pancreaticoduodenectomy: Case Series of Our Center's Experience.

Front Surg 2021 12;8:583671. Epub 2021 Mar 12.

Department of Hepatobiliary Surgery, Weihai Central Hospital Affiliated to Qingdao University, Weihai, China.

Laparoscopic pancreaticoduodenectomy has developed rapidly in recent years. Postoperative pancreatic fistula is still the most dangerous complication of laparoscopic pancreaticoduodenectomy. Baumgart pancreaticojejunostomy is considered one of the safest anastomosis procedures, with low rates of pancreatic fistula. Read More

View Article and Full-Text PDF

Acute tubulointerstitial nephritis induced by checkpoint inhibitors versus classical acute tubulointerstitial nephritis: are they the same disease?

Clin Kidney J 2021 Mar 4;14(3):884-890. Epub 2020 May 4.

Nephrology Research Group, Vall d'Hebron Research Institute, Nephrology Department, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

Background: The incidence of acute tubulointerstitial nephritis (ATIN) related to drugs has dramatically increased over recent years. A new subtype of ATIN, apparently different from classical drug-related ATIN, has emerged that has been related to the administration of immune checkpoint inhibitors (ICIs). We investigated these differences between ICI-related ATIN (ICI ATIN) and non-ICI-related ATIN in terms of clinical features, response to treatment with steroids and the evolution of kidney function. Read More

View Article and Full-Text PDF

The McCollough World: Induction of orientation-contingent aftereffects with an altered-reality system.

Vision Res 2021 Mar 24;184:8-13. Epub 2021 Mar 24.

Department of Psychology, University of Minnesota, Twin Cities, United States.

The McCollough Effect is a color aftereffect produced by exposure to colored, oriented patterns. For example, following adaptation to vertical red and horizontal green stripes in alternation, vertical black and white patterns appear greenish, while horizontal black and white patterns appear reddish. The striking aspect of the McCollough Effect is that just a few minutes of adaptation can produce an aftereffect lasting days or weeks. Read More

View Article and Full-Text PDF

Quality of rheumatology care for patients with fibromyalgia and chronic pain syndromes.

BMJ Open Qual 2021 Mar;10(1)

Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Background: One-third of primary care providers (PCPs) refer patients with fibromyalgia or chronic pain (FM/CP) to specialist care, typically rheumatology. Yet, comprehensive data on the quality of rheumatology care for patients with FM/CP are currently lacking.

Methods: Records of patients referred for rheumatology consultation for FM/CP and seen at a single academic centre between 2017 and 2018 were extracted by retrospective chart review. Read More

View Article and Full-Text PDF

[The prognostic value of myoglobin difference in sepsis related chronic critical illness].

Zhonghua Nei Ke Za Zhi 2021 Apr;60(4):350-355

Department of Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.

To investigate the predictive value of myoglobin (Mb) for the prognosis of sepsis related chronic critical illness (CCI). Retrospective study was conducted on septic patients with the length of ICU stay equal or greater than 14 days, and sepsis-related organ failure assessment (SOFA) score equal or greater than 2 on the 14th day in ICU in the First Department of Critical Care Medicine at the First Affiliated Hospital of Sun Yat-sen University from January 2017 to March 2020. Patients' clinical and laboratory data were collected on the 1st and 14th day in ICU. Read More

View Article and Full-Text PDF

Psychosis in a primary hyperparathyroidism patient with mild hypercalcemia: A case report.

Medicine (Baltimore) 2021 Mar;100(12):e25248

Department of Psychiatry, Faculty of Medicine, Shimane University, Izumo.

Introduction: Primary hyperparathyroidism (PHPT) is characterized by hypercalcemia and an elevated level of serum parathyroid hormone (PTH). PHPT presents with a complex set of renal, skeletal, and neuropsychological symptoms. Parathyroidectomy (PTX) is a radical treatment that is recommended for all physically symptomatic patients with PHPT. Read More

View Article and Full-Text PDF

Determination of changes in physicochemical and sensory characteristics of purple passion fruit with the application of different packaging systems, including an ethylene scavenger additive.

J Food Sci 2021 Mar 24. Epub 2021 Mar 24.

Instituto de Ciencia y Tecnología de Alimentos, Universidad Nacional de Colombia, Bogotá, Colombia.

To achieve a suitable packaging configuration, it is important first to determine the physicochemical characteristics related to the packaged product. In this study, the physicochemical characterization of fresh purple passion fruits of three different ripening stages was carried out to determine key variables for the packaging, such as O consumption and CO -ethylene production rates. Subsequently, intermediate-ripe fruits were packaged for 21 days at 6 °C under three packaging conditions: Xtend perforated bags, low-density polyethylene (LDPE) bags, and LDPE bags with a novel ethylene scavenger active additive (ESAA). Read More

View Article and Full-Text PDF

Comparison of Time to Clinical Improvement With vs Without Remdesivir Treatment in Hospitalized Patients With COVID-19.

JAMA Netw Open 2021 03 1;4(3):e213071. Epub 2021 Mar 1.

Department of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, Maryland.

Importance: Clinical effectiveness data on remdesivir are urgently needed, especially among diverse populations and in combination with other therapies.

Objective: To examine whether remdesivir administered with or without corticosteroids for treatment of coronavirus disease 2019 (COVID-19) is associated with more rapid clinical improvement in a racially/ethnically diverse population.

Design, Setting, And Participants: This retrospective comparative effectiveness research study was conducted from March 4 to August 29, 2020, in a 5-hospital health system in the Baltimore, Maryland, and Washington, DC, area. Read More

View Article and Full-Text PDF

Difference in outcome between curative intent vs marginal excision as a first treatment in dogs with oral malignant melanoma and the impact of adjuvant CSPG4-DNA electrovaccination: A retrospective study on 155 cases.

Vet Comp Oncol 2021 Mar 9. Epub 2021 Mar 9.

Department of Veterinary Sciences, University of Torino, Torino, Italy.

Canine oral malignant melanoma is locally invasive and highly metastatic. At present, the best option for local control is en bloc excision followed by radiation if excision margins are incomplete. Adjuvantly, the role of chemotherapy is dubious while immunotherapy appears encouraging. Read More

View Article and Full-Text PDF

Impact of comorbidities on mortality in hospitalized influenza patients with diabetes - Analysis of the Austrian Health Insurance.

Diabetes Res Clin Pract 2021 Mar 17;174:108758. Epub 2021 Mar 17.

Interdisciplinary Metabolic Medicine Trials Unit, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria. Electronic address:

Aims: To assess the impact of characteristics and comorbidities on the hospitalization rate and 30- and 90-days all-cause mortality after hospitalization for influenza-related illness (IRI) in individuals with diabetes.

Methods: Data of 507,184 individuals with diabetes enrolled in the national Austrian Health Insurance database during 2013-2017 were analyzed. Hospitalization for IRI was defined as per International Classification of Disease 10 codes (J09, J10, J11). Read More

View Article and Full-Text PDF