35 results match your criteria 182 sirs


Serum hydroxybutyrate dehydrogenase as an early predictive marker of the severity of acute pancreatitis: a retrospective study.

BMC Gastroenterol 2020 Nov 20;20(1):393. Epub 2020 Nov 20.

Pancreatic Center, Department of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, China.

Background: To investigate the value of serum hydroxybutyrate dehydrogenase (HBDH) level, an isozyme of lactate dehydrogenase, in evaluating the severity of acute pancreatitis (AP).

Methods: Patients diagnosed with AP from January 2013 to December 2018 were included in this retrospective study. Patients were divided into the normal serum HBDH levels group (n-HBDH group) and the high serum HBDH levels group (h-HBDH group) according to the criteria HBDH ≥ 182 U/L after admission. Read More

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November 2020

Liver Dysfunction in Sepsis.

Korean J Gastroenterol 2020 04;75(4):182-187

Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea.

Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. During sepsis, the liver has essential roles, such as immune defense and metabolic adaptation to inflammation. In addition, it is a target for sepsis-related injury, including hypoxic hepatitis, cholestasis, drug-induced liver injury, and secondary sclerosing cholangitis in critically ill patients. Read More

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The role of PSGL-1 in pathogenesis of systemic inflammatory response and coagulopathy in endotoxemic mice.

Thromb Res 2019 Oct 19;182:56-63. Epub 2019 Aug 19.

Key Laboratory of Sepsis Translation Medicine of Hunan, Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, PR China. Electronic address:

Introduction: Endotoxemia often results in systemic inflammatory response syndrome (SIRS), coagulation disturbance and acute lung injury (ALI), and such a condition is associated with the activation of platelets, leukocytes and vascular endothelial cells (VECs). P-selectin glycoprotein ligand 1 (PSGL-1) is a key regulatory molecule in the activation of platelets, leukocytes and VECs. However, it still remains largely unexplored whether PSGL-1 plays an important role in SIRS, coagulation dysfunction and ALI of endotoxemia. Read More

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October 2019

Sepsis Presenting in Hospitals versus Emergency Departments: Demographic, Resuscitation, and Outcome Patterns in a Multicenter Retrospective Cohort.

J Hosp Med 2019 06 8;14(6):340-348. Epub 2019 Apr 8.

Department of Medicine, Hofstra-Northwell School of Medicine, Hempstead, New York.

Background: Differences between hospital-presenting sepsis (HPS) and emergency department-presenting sepsis (EDPS) are not well described.

Objectives: We aimed to (1) quantify the prevalence of HPS versus EDPS cases and outcomes; (2) compare HPS versus EDPS characteristics at presentation; (3) compare HPS versus EDPS in process and patient outcomes; and (4) estimate risk differences in patient outcomes attributable to initial resuscitation disparities.

Design: Retrospective consecutive-sample cohort. Read More

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Significant regional variation in use of implantable cardioverter-defibrillators in Denmark.

Eur Heart J Qual Care Clin Outcomes 2019 10;5(4):352-360

Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, Aarhus N, Denmark.

Aims: Implantable cardioverter-defibrillator (ICD) treatment prevents sudden cardiac death in high-risk patients. This study examined geographical variation in ICD implantation rates in Denmark and potential causes of variation.

Methods And Results: We obtained numbers of ICD implantations in the 5 Danish regions and 98 municipalities during 2007-13 from the Danish Pacemaker and ICD Registry. Read More

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October 2019

Efficacy of Intraoperative Renal Stone Culture in Predicting Postpercutaneous Nephrolithotomy Urosepsis/Systemic Inflammatory Response Syndrome: A Prospective Analytical Study with Review of Literature.

J Endourol 2019 02 31;33(2):84-92. Epub 2019 Jan 31.

2 Department of Microbiology, University College of Medical Sciences (University of Delhi) and GTB Hospital, New Delhi, India.

Aim: To evaluate and study the efficacy of intraoperative renal stone culture (IOSC) in predicting postpercutaneous nephrolithotomy (PCNL) urosepsis (PPS) and systemic inflammatory response syndrome (SIRS). PPS is known to occur in patients despite negative preoperative midstream urine culture (MSUC).

Methods: After obtaining institutional ethics committee approval and informed consent, 78 selected patients undergoing PCNL were evaluated as per protocol for risk factors for SIRS criteria with MSUC, intraoperative renal pelvic urine culture (RPUC), and IOSC. Read More

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February 2019

Steroids in cardiac surgery trial: a substudy of surgical site infections.

Can J Anaesth 2019 02 10;66(2):182-192. Epub 2018 Dec 10.

Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.

Purpose: Postoperative infection, particularly in cardiac surgery, results in significant morbidity, mortality, and healthcare cost. Identification of novel predictors of postoperative infection can target high-risk populations for prophylactic intervention.

Methods: Steroids in cardiac surgery (SIRS) was a multi-centre randomized-controlled trial assessing intraoperative administration of methylprednisone during cardiac surgery, which enrolled 7,507 patients across 80 centres in 18 countries. Read More

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February 2019

Neutrophil-to-lymphocyte ratio and mean platelet volume can be useful markers to predict sepsis in children.

Pak J Med Sci 2018 Jul-Aug;34(4):918-922

Basak Nur Akyildiz, MD. Associate Professor of Paediatrics, Department of Paediatrics, Division of Intensive Care, Erciyes University, Faculty of Medicine, Kayseri, Turkey.

Objectives: Neutrophil-to-Lymphocyte Ratio (NLR) and Mean Platelet Volume (MPV) have been found to be useful indexes for the diagnosis of sepsis in adults. However, the knowledge of their roles and cut-off values in pediatric patients is limited. The primary objective of this study was to assess the ability of NLR and MPV to predict sepsis in children. Read More

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September 2018

Erythrocyte P2X receptor expression is correlated with change in haematocrit in patients admitted to the ICU with blood pathogen-positive sepsis.

Crit Care 2018 08 2;22(1):181. Epub 2018 Aug 2.

Department of Biomedicine, Physiology, Aarhus University, Ole Worms Alle 3, build 1170, 8000, Aarhus C, Denmark.

Background: Pore-forming proteins released from bacteria or formed as result of complement activation are known to produce severe cell damage. Inhibition of purinergic P2X receptors markedly reduces damage inflicted by cytolytic bacterial toxin and after complement activation in both erythrocytes and monocytes. P2X expression generally shows variation throughout the population. Read More

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Increased incidence of cancer in systemic lupus erythematosus: a Finnish cohort study with more than 25 years of follow-up.

Scand J Rheumatol 2018 Nov 10;47(6):461-464. Epub 2018 Jan 10.

c Finnish Cancer Registry , Institute for Statistical and Epidemiological Cancer Research , Helsinki , Finland.

Objective: The aim of this study was to assess the cancer risk in a cohort of Finnish patients with systemic lupus erythematosus (SLE) when followed over the long term.

Method: The cohort consisted of 182 female and 23 male SLE patients treated at the Helsinki University Central Hospital from 1967 to 1987. The cohort was linked to the Finnish Cancer Registry and followed for cancer incidence from 1967 to 2013. Read More

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November 2018

Early sepsis bundle compliance for non-hypotensive patients with intermediate versus severe hyperlactemia.

Am J Emerg Med 2017 Jun 15;35(6):811-818. Epub 2017 Jan 15.

Department of Medicine, Hofstra-Northwell School of Medicine, Hempstead, NY, United States; Department of Science Education, Hofstra-Northwell School of Medicine, Hempstead, NY, United States.

Objective: To compare the association of 3-h sepsis bundle compliance with hospital mortality in non-hypotensive sepsis patients with intermediate versus severe hyperlactemia.

Methods: This was a cohort study of all non-hypotensive, hyperlactemic sepsis patients captured in a prospective quality-improvement database, treated October 2014 to September 2015 at five tertiary-care centers. We defined sepsis as 1) infection, 2) ≥2 SIRS criteria, and 3) ≥1 organ dysfunction criterion. Read More

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Lichen sclerosus and risk of cancer.

Int J Cancer 2017 05 10;140(9):1998-2002. Epub 2017 Feb 10.

Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland.

Malignant potential of lichen sclerosus (LS) has been suspected, but evidence is sparse. We used the population-based Finnish Cancer Registry data to further study this connection. We identified all women with the diagnosis of LS (n = 7,616) listed in the Finnish Hospital Discharge Registry from 1970 to 2012. Read More

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Prognostic Accuracy of the SOFA Score, SIRS Criteria, and qSOFA Score for In-Hospital Mortality Among Adults With Suspected Infection Admitted to the Intensive Care Unit.

JAMA 2017 01;317(3):290-300

Department of Intensive Care and Hyperbaric Medicine, Alfred Hospital, Prahran, Melbourne, Australia3Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Prahran, Melbourne, Australia8Centre for Outcome and Resource Evaluation, Australian and New Zealand Intensive Care Society, Melbourne, Australia.

Importance: The Sepsis-3 Criteria emphasized the value of a change of 2 or more points in the Sequential [Sepsis-related] Organ Failure Assessment (SOFA) score, introduced quick SOFA (qSOFA), and removed the systemic inflammatory response syndrome (SIRS) criteria from the sepsis definition.

Objective: Externally validate and assess the discriminatory capacities of an increase in SOFA score by 2 or more points, 2 or more SIRS criteria, or a qSOFA score of 2 or more points for outcomes among patients who are critically ill with suspected infection.

Design, Setting, And Participants: Retrospective cohort analysis of 184 875 patients with an infection-related primary admission diagnosis in 182 Australian and New Zealand intensive care units (ICUs) from 2000 through 2015. Read More

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January 2017

Systemic Inflammatory Response Syndrome Following Percutaneous Nephrolithotomy: Assessment of Risk Factors and Their Impact on Patient Outcomes.

Urol Int 2016 9;96(2):207-11. Epub 2016 Jan 9.

Department of Urology, All India Institute of Medical Sciences, New Delhi, India.

Objectives: To identify perioperative risk factors for postoperative systemic inflammatory response syndrome (SIRS) and suggest possible modifications to reduce morbidity.

Material And Methods: We prospectively analysed perioperative data such as history of pervious stone surgery, number and configuration of stones, presence of stent or nephrostomy, any previous positive urine culture, intraoperative renal pelvic urine and stone culture, aspiration of turbid urine on initial puncture, number of tracts required and clearance of stones, operative time and intraoperative hypotension and tachycardia of all patients who underwent percutaneous nephrolithotomy over a period of 15 months.

Results: A total of 182 patients were included, average stone size was 2. Read More

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December 2016

High-volume plasma exchange in patients with acute liver failure: An open randomised controlled trial.

J Hepatol 2016 Jan 29;64(1):69-78. Epub 2015 Aug 29.

Institute of Liver Studies, King's College Hospital, London, United Kingdom.

Background & Aims: Acute liver failure (ALF) often results in cardiovascular instability, renal failure, brain oedema and death either due to irreversible shock, cerebral herniation or development of multiple organ failure. High-volume plasma exchange (HVP), defined as exchange of 8-12 or 15% of ideal body weight with fresh frozen plasma in case series improves systemic, cerebral and splanchnic parameters.

Methods: In this prospective, randomised, controlled, multicentre trial we randomly assigned 182 patients with ALF to receive either standard medical therapy (SMT; 90 patients) or SMT plus HVP for three days (92 patients). Read More

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January 2016

Melanoma Risk and Survival among Organ Transplant Recipients.

J Invest Dermatol 2015 Nov 13;135(11):2657-2665. Epub 2015 Aug 13.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA.

Solid organ transplant recipients, who are medically immunosuppressed to prevent graft rejection, have increased melanoma risk, but risk factors and outcomes are incompletely documented. We evaluated melanoma incidence among 139,991 non-Hispanic white transplants using linked US transplant-cancer registry data (1987-2010). We used standardized incidence ratios (SIRs) to compare incidence with the general population and incidence rate ratios (IRRs) from multivariable Poisson models to assess risk factors. Read More

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November 2015

Expression of CD11c and EMR2 on neutrophils: potential diagnostic biomarkers for sepsis and systemic inflammation.

Clin Exp Immunol 2015 Nov 22;182(2):184-94. Epub 2015 Sep 22.

Intensive Care Unit, Guy's and St Thomas' NHS Foundation Trust, London.

There is a need for cellular biomarkers to differentiate patients with sepsis from those with the non-infectious systemic inflammatory response syndrome (SIRS). In this double-blind study we determined whether the expression of known (CD11a/b/c, CD62L) and putative adhesion molecules [CD64, CD97 and epidermal growth factor (EGF)-like molecule containing mucin-like hormone receptor (EMR2)] on blood neutrophils could serve as useful biomarkers of infection and of non-infectious SIRS in critically ill patients. We studied 103 patients with SIRS, 83 of whom had sepsis, and 50 healthy normal subjects, using flow cytometry to characterize neutrophils phenotypically in whole blood samples. Read More

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November 2015

Liver Transplantation-Associated Lung Cancer: Comparison of Clinical Parameters and Outcomes.

Clin Lung Cancer 2015 Sep 17;16(5):e75-81. Epub 2015 Feb 17.

Department of Internal Medicine V (Haematology and Oncology), Innsbruck Medical University, Innsbruck, Austria.

Background: The incidence of lung cancer (LC) is increased in patients with a history of liver transplantation (LT). The purpose of our study was to compare the clinical characteristics and outcomes of patients with postliver transplantation LC (PLTLC) with cohorts of patients with "transplant-naive" LC, and LT patients without LC.

Patients And Methods: All the patients who had undergone LT or had been diagnosed with LC from 1987 to 2012 were included in the present analysis. Read More

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September 2015

Risk of bile duct cancer among printing workers exposed to 1,2-dichloropropane and/or dichloromethane.

J Occup Health 2015 7;57(3):230-6. Epub 2015 Feb 7.

Department of Environmental Medicine and Population Sciences, Graduate School of Medicine, Osaka University.

Objectives: We conducted a retrospective cohort study to examine the risk of bile duct cancer among current and former workers in the offset color proof printing department at a printing company in Osaka, Japan.

Methods: Standardized incidence ratios (SIRs) between January 1, 1985, and December 31, 2012, were estimated for the cumulative years of exposure to two chemicals, dichloromethane (DCM) and 1,2-dichloropropane (1,2-DCP), using the national incidence level as a reference. In addition, we examined risk patterns by the calendar year in which observation started. Read More

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[Phenotype and functions of natural killer cells in septic patients and its clinical significance].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2014 Nov;26(11):827-31

Department of Critical Care Medicine, Anhui Provincial Hospital, Hefei 230001, Anhui, China, Corresponding author: Liu Bao, Email:

Objective: To investigate the possible mechanism of natural killer cells (NK cells) in immune dysfunction in sepsis by monitoring the phenotype and function of periphery NK cells in patients with sepsis.

Methods: A retrospective study was conducted. The patients with systemic inflammatory response syndrome (SIRS, n=59) or sepsis (n=65) admitted to Department of Critical Care Medicine of Anhui Provincial Hospital from August 2011 to August 2013 were enrolled. Read More

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November 2014

Incidence and risk factors of HPV-related and HPV-unrelated Head and Neck Squamous Cell Carcinoma in HIV-infected individuals.

Oral Oncol 2014 Dec 6;50(12):1169-76. Epub 2014 Oct 6.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe St., Baltimore, MD, USA. Electronic address:

Objectives: To examine the risk and trends of HPV-related and HPV-unrelated Head and Neck Squamous Cell Carcinoma (HNSCC) in HIV-infected individuals and assess whether immunosuppression (measured through CD4 cell count) and other risk factors impact HNSCC risk.

Materials And Methods: Incident HNSCCs at HPV-related and HPV-unrelated anatomic sites were detected in HIV-infected participants from pooled data from 17 prospective studies in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) between 1996 and 2009. HNSCC cases were validated using chart review or cancer registry matching. Read More

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December 2014

[Analysis for risk factors of systemic inflammatory response syndrome after one-phase treatment for apyrexic calculous pyonephrosis by percutaneous nephrolithotomy].

Beijing Da Xue Xue Bao Yi Xue Ban 2014 Aug;46(4):566-9

Department of Urology, Peking University People's Hospital, Beijing 100044, China.

Objective: To investigate the risk factors of systemic inflammatory response syndrome (SIRS) after one-phase treatment for apyrexic calculous pyonephrosis by percutaneous nephrolithotomy (PCNL).

Methods: Clinical data of consecutive apyrexic calculous pyonephrosis patients who underwent one-stage PCNL from January 2008 to December 2013 were analyzed retrospectively. The data collected included white blood cells in urine analysis before surgery, midstream urine culture, preoperative renal function, using antibiotics time before surgery, operative time, the number of tracts, intraoperative irrigation peak flow, blood transfusion, and stone composition. Read More

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Invasion and transmission of Salmonella Kentucky in an adult dairy herd using approximate Bayesian computation.

BMC Vet Res 2013 Dec 5;9:245. Epub 2013 Dec 5.

Section of Epidemiology, Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.

Background: An outbreak of Salmonella Kentucky followed by a high level of sustained endemic prevalence was recently observed in a US adult dairy herd enrolled in a longitudinal study involving intensive fecal sampling. To understand the invasion ability and transmission dynamics of Salmonella Kentucky in dairy cattle, accurate estimation of the key epidemiological parameters from longitudinal field data is necessary. The approximate Bayesian computation technique was applied for estimating the transmission rate (β), the recovery rate (γ) and shape (n) parameters of the gamma distribution for the infectious (shedding) period, and the basic reproduction ratio (R0), given a susceptible-infectious-recovered-susceptible (SIRS) compartment model with a gamma distribution for the infectious period. Read More

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December 2013

C-reactive protein predicts short-term mortality in patients with cirrhosis.

J Hepatol 2012 Jun 5;56(6):1299-304. Epub 2012 Feb 5.

Université de Franche Comté et Service d'hépatologie et de soins intensifs digestifs, Besançon, France.

Background & Aims: We aimed at improving prediction of short-term mortality in cirrhotic inpatients by evaluating C-reactive protein (CRP) as a surrogate marker of systemic inflammatory response syndrome (SIRS).

Methods: One-hundred and forty-eight consecutive cirrhotic patients with Child-Pugh score ≥ B8 and without hepatocellular carcinoma were prospectively included and followed for 182 days. The primary end point was 6-month survival. Read More

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Impact of systemic inflammatory response syndrome on vasospasm, cerebral infarction, and outcome after subarachnoid hemorrhage: exploratory analysis of CONSCIOUS-1 database.

Neurocrit Care 2010 Oct;13(2):182-9

Division of Neurosurgery, St. Michael's Hospital, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, 30 Bond Street, Toronto, ON, M5B 1W8, Canada.

Background: Systemic inflammatory response syndrome (SIRS) may develop after aneurysmal subarachnoid hemorrhage (SAH). We investigated factors associated with SIRS after SAH, whether SIRS was associated with complications of SAH such as vasospasm, cerebral infarction, and clinical outcome, and whether SIRS could contribute to a difference in outcome between patients treated by endovascular coiling or neurosurgical clipping of the ruptured aneurysm.

Methods: This was exploratory analysis of 413 patients in the CONSCIOUS-1 study. Read More

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October 2010

Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment.

Am J Respir Crit Care Med 2010 Sep 27;182(6):762-73. Epub 2010 May 27.

Department of Anesthesiology and Critical Care, University of Turin, Ospedale S. Giovanni Battista-Molinette, Turin, Italy.

Rationale: Sepsis is a leading cause of death in the intensive care unit, characterized by a systemic inflammatory response (SIRS) and bacterial infection, which can often induce multiorgan damage and failure. Leukocyte recruitment, required to limit bacterial spread, depends on phosphoinositide-3 kinase γ (PI3Kγ) signaling in vitro; however, the role of this enzyme in polymicrobial sepsis has remained unclear.

Objectives: This study aimed to determine the specific role of the kinase activity of PI3Kγ in the pathogenesis of sepsis and multiorgan damage. Read More

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September 2010

Head injury is not a risk factor for multiple sclerosis: a prospective cohort study.

Mult Scler 2009 Mar 21;15(3):294-8. Epub 2008 Nov 21.

Department of Neurology, Arhus University Hospital, Aalborg, Denmark.

Background: The idea of physical trauma being involved in the causation of multiple sclerosis (MS) had been discussed since the earliest description of the illness. Despite the ongoing debate, the proposed association between physical and especially head trauma and MS failed to be proved or to be refuted conclusively.

Objective: To determine whether head trauma is associated with an increased risk of developing MS. Read More

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Occupational risks for nasal cancer in Sweden.

J Occup Environ Med 2004 Oct;46(10):1033-40

Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden.

An elevated risk of nasal cancer (NC) has been associated with numerous occupations but with contradicting results. We sought to address recent and current risks of NC in a nationwide study. The nationwide Swedish Family-Cancer Database was used to calculate standardized incidence ratios (SIRs) for 52 occupational groups. Read More

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October 2004

Age specific and attributable risks of familial prostate carcinoma from the family-cancer database.

Cancer 2002 Sep;95(6):1346-53

Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden.

Background: Familial risks by proband status and age are useful for clinical counseling, and they can be used to calculate population-attributable fractions (PAFs), which show the proportion of disease that could be prevented if the cause could be removed.

Methods: The authors used the nationwide Swedish Family-Cancer Database on 10.2 million individuals and 182,104 fathers and 3710 sons with medically verified prostate carcinoma to calculate age specific familial standardized incidence ratios (SIRs) with 95% confidence intervals (95%CI) and familial PAFs for prostate carcinoma in sons ages 0-66 years. Read More

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September 2002

[A clinical study on systemic inflammatory response syndrome and multiple organ dysfunction syndrome in patients with abdominal surgical emergency].

Hua Xi Yi Ke Da Xue Xue Bao 1999 Jun;30(2):182-4

Department of General Surgery, First Affiliated Hospital, WCUMS, Chengdu 610041.

In order to analyze the development from systemic inflammatory response syndrome(SIRS) to multiple organ dysfunction syndrome (MODS) and probe the therapeutic strategies, the authors studied retrospectively the clinical data of SIRS and MODS in 1374 patients with abdominal surgical emergency. The results showed that on admission the morbidity of SIRS was 32.5%, afterwards the morbidity of MODS was 6. Read More

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