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Pharmacokinetic and Safety Profile of the Novel HIV Non-Nucleoside Reverse Transcriptase Inhibitor MK-8507 in Adults without HIV.

Antimicrob Agents Chemother 2021 Sep 13:AAC0093521. Epub 2021 Sep 13.

Merck & Co., Inc., Kenilworth, NJ, USA.

MK-8507 is a novel HIV-1 non-nucleoside reverse transcriptase inhibitor in clinical development with potential for once-weekly oral administration for the treatment of HIV-1 infection. Two randomized, double-blind, placebo-controlled phase 1 studies in adults without HIV-1 evaluated the safety, tolerability, and pharmacokinetics of single and multiple doses of MK-8507; drug interaction with midazolam (a cytochrome P450 3A4 substrate) and food effect were also assessed. In Study 1, 16 participants received oral ascending single doses of MK-8507 (2-400 mg) or placebo in an alternating fashion. Read More

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September 2021

Seminal Plasma Does Not Influence Canine Semen Stored at 5°C for Long-Term Conservation.

Biopreserv Biobank 2021 Sep 9. Epub 2021 Sep 9.

Department of Veterinary Surgery and Animal Reproduction, Faculty of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, Brazil.

Seminal plasma has several components that protect the sperm cells and assist in the fertilization process. In contrast, the exact role carried out by seminal plasma during the cooling of canine semen remains controversial. Moreover, concerning the long estrus period, the possibility to store chilled semen at 5C for more than 72 hours and maintain good sperm quality for additional inseminations could increase fertilization rates. Read More

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September 2021

Predicting in-hospital mortality in adult non-traumatic emergency department patients: a retrospective comparison of the Modified Early Warning Score (MEWS) and machine learning approach.

PeerJ 2021 24;9:e11988. Epub 2021 Aug 24.

Department of Computer Science and Engineering, National Sun Yat-Sen University, Kaohsiung, Taiwan (R.O.C.).

Background: A feasible and accurate risk prediction systems for emergency department (ED) patients is urgently required. The Modified Early Warning Score (MEWS) is a wide-used tool to predict clinical outcomes in ED. Literatures showed that machine learning (ML) had better predictability in specific patient population than traditional scoring system. Read More

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A comparative study on the tip position of peripherally inserted central catheter inserted at two forward P-wave amplitudes by intracavitary electrocardiogram in cancer patients.

Ann Palliat Med 2021 Aug 24. Epub 2021 Aug 24.

Vascular Access Center (VAC), Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Bejing), Peking University Cancer Hospital & Institute, Beijing, China; Department of Critical Care Medicine (ICU), Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Bejing), Peking University Cancer Hospital & Institute, Beijing, China.

Background: This study aimed to compare the tip location of peripherally inserted central catheter (PICC) under two forward P-wave amplitudes (P-wave amplitude is the autonomous peak or P-wave amplitude is 50-80% of the QRS main wave) by intracavitary electrocardiogram (IC-EKG) to determine the PICC tip in optimal location thus avoiding catheter-related complications.

Methods: The data of 300 cancer patients with PICC insertion were collected retrospectively. For the observation group, the position of the catheter tip was left at the level when P wave amplitude was its autonomous peak (168 patients catheterized in 2018). Read More

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Cross-sectional association between long working hours and endoscopic gastritis: the Kangbuk Samsung Health Study.

BMJ Open 2021 09 3;11(9):e050037. Epub 2021 Sep 3.

Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

Objectives: This study aimed to determine the cross-sectional association between long working hours and gastritis diagnosed by endoscopy.

Design: Cross-sectional study.

Setting: Large university hospitals in Seoul and Suwon, South Korea. Read More

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September 2021

Applicability of Exposure Reciprocity Law for Fast Polymerization of Restorative Composites Containing Various Photoinitiating Systems.

Authors:
A Tichy P Bradna

Oper Dent 2021 Sep 3. Epub 2021 Sep 3.

Objectives: The exposure reciprocity law (ERL) has been used to calculate the optimal irradiation time of dental composites. This study examined the applicability of ERL for fast polymerization of restorative composites containing various photoinitiating systems using a high-power multi-peak light-emitting diode (LED) lamp.

Methods: Three commercial composites differing in photoinitiating systems were tested: Filtek Ultimate Universal Restorative (FU) with a camphorquinone-amine (CQ-A) photoinitiating system, Tetric EvoCeram (TEC) with CQ-A and (2,4,6-trimethylbenzoyl)phosphine oxide (TPO), and Estelite Σ Quick (ESQ) with CQ and a radical amplified photopolymerization (RAP) initiator. Read More

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September 2021

Cardiac Arrhythmias and Impaired Heart Rate Variability in Older Patients With Ventricular Septal Defects.

J Am Heart Assoc 2021 Sep 1;10(17):e020672. Epub 2021 Sep 1.

Department of Clinical Medicine Aarhus University Aarhus N Denmark.

Background Congenital ventricular septal defects (VSDs) are considered to have benign long-term outcome when treated correctly in childhood. However, abnormal parameters are described in younger adults, including impaired heart rate variability (HRV). It is not known whether such abnormalities will deteriorate with age. Read More

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September 2021

Comparison of skeletal muscle ultrastructural changes between normal and blood flow restricted resistance exercise: A case report.

Exp Physiol 2021 Aug 26. Epub 2021 Aug 26.

School of Exercise and Sport Science, University of Mary Hardin-Baylor, Belton, TX, USA.

New Findings: What is the main observation in this case? The main observation of this case report is that blood flow restriction exercise can cause myofibrils to have an aberrant wave-like appearance that is accompanied by irregular pockets of sarcoplasm in the intermyofibrillar space while traditional forms of damage to the Z-discs and contractile elements are not as apparent. What insights does it reveal? Our finding indicate blood flow restriction mediated fluid pooling may cause alterations in skeletal muscle ultrastructure after exercise that may be directly related to myofiber swelling.

Abstract: The acute effects of blood flow restriction training (BFR) on skeletal muscle ultrastructure are poorly understood due to inconsistent findings and the use of largely imprecise systemic targets for indication. Read More

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24-hour blood pressure variability and treatment effect of intravenous alteplase in acute ischaemic stroke.

Eur Stroke J 2021 Jun 18;6(2):168-175. Epub 2021 Jun 18.

Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Introduction: To assess the association between 24 h blood pressure variability (BPV) on functional outcome and treatment effect of intravenous alteplase in acute ischaemic stroke.

Patients And Methods: In all patients with acute ischaemic stroke of unknown onset randomised in the WAKE-UP (Efficacy and Safety of magnetic resonance imaging [MRI]-based Thrombolysis in Wake-Up Stroke) trial, blood pressure (BP) was measured before randomisation and after initiation of treatment at regular intervals up to 24 hours. Individual BPV was measured by coefficient of variation (CV) of all BP values. Read More

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Efficacy and Safety of an Etofenamate Medicated Plaster for Acute Ankle Sprain: A Randomized Controlled Trial.

Orthop J Sports Med 2021 Aug 12;9(8):23259671211032591. Epub 2021 Aug 12.

Clinsearch, Walchwil, Switzerland.

Background: The favorable benefit-risk profile of topical nonsteroidal anti-inflammatory drugs (NSAIDs) makes them a preferred treatment for pain relief in soft tissue injuries.

Purpose: To assess the efficacy and safety of a novel etofenamate 70-mg medicated plaster in patients with acute uncomplicated ankle sprain.

Study Design: Randomized controlled trial; Level of evidence, 1. Read More

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Acute supplementation with whey protein or collagen does not alter appetite in healthy women: A randomized double-blind and crossover pilot study.

Br J Nutr 2021 Aug 19:1-18. Epub 2021 Aug 19.

Faculty of Nutrition, Federal University of Goiás, Goiânia, Brazil.

Protein quality has an important role in increasing satiety. Evidence suggests that whey protein (WP) provides satiety via gastrointestinal hormone secretion. Hydrolysed collagen supplementation can also stimulate the production of incretins and influence satiety and food intake. Read More

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Impacts of the perioperative fast track surgery concept on the physical and psychological rehabilitation of total hip arthroplasty: A prospective cohort study of 348 patients.

Medicine (Baltimore) 2021 Aug;100(32):e26869

Department of Endocrinology, Minzu Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.

Abstract: Studies have shown that rapid rehabilitation surgery has a positive effect on recovery after major orthopedic surgery. However, very few studies have examined the impact of fast track surgery on physical and psychological rehabilitation in patients who have undergone total hip replacement.This study aimed to investigate the value of the rapid rehabilitation surgical model for patients undergoing total hip arthroplasty during the perioperative period. Read More

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Clinical characteristics and factors relating to poor outcome in patients with aneurysmal subarachnoid hemorrhage in Vietnam: A multicenter prospective cohort study.

PLoS One 2021 13;16(8):e0256150. Epub 2021 Aug 13.

Center for Emergency Medicine, Bach Mai Hospital, Hanoi, Vietnam.

Background: The prevalence of risk factors for poor outcomes from aneurysmal subarachnoid hemorrhage (SAH) varies widely and has not been fully elucidated to date in Vietnam. Understanding the risk and prognosis of aneurysmal SAH is important to reduce poor outcomes in Vietnam. The aim of this study, therefore, was to investigate the rate of poor outcome at 90 days of ictus and associated factors from aneurysmal SAH in the country. Read More

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An Exploratory Analysis of the Association between Hypercapnia and Hospital Mortality in Critically Ill Patients with Sepsis.

Ann Am Thorac Soc 2021 Aug 11. Epub 2021 Aug 11.

Austin Hospital, 96043, Heidelberg, Victoria, Australia.

Rationale: Hypercapnia may affect the outcome of sepsis. Very few clinical studies conducted in non-critically ill patients, have investigated the effects of hypercapnia and hypercapnic acidemia in the context of sepsis. The effect of hypercapnia in critically ill patients with sepsis remains inadequately studied. Read More

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A critical evaluation for validation of composite and unidimensional postoperative pain scales in horses.

PLoS One 2021 5;16(8):e0255618. Epub 2021 Aug 5.

Department of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, São Paulo State University (Unesp), Botucatu, São Paulo, Brazil.

Proper pain therapy requires adequate pain assessment. This study evaluated the reliability and validity of the Unesp-Botucatu horse acute pain scale (UHAPS), the Orthopedic Composite Pain Scale (CPS) and unidimensional scales in horses admitted for orthopedic and soft tissue surgery. Forty-two horses were assessed and videotaped before surgery, up to 4 hours postoperatively, up to 3 hours after analgesic treatment, and 24 hours postoperatively (168 video clips). Read More

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In Vitro Effect of Acidic Solutions and Sodium Fluoride on Surface Roughness of Two Types of CAD-CAM Dental Ceramics.

Int J Dent 2021 23;2021:9977993. Epub 2021 Jul 23.

Dental Research Center, Dentistry Institute, Restorative Dentistry Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

Objectives: This study assessed the effect of immersion in acidic solutions and sodium fluoride on surface roughness of dental ceramics.

Materials And Methods: 40 blocks of Vitablocs Mark II and IPS e.max CAD (5 × 5 × 3) were prepared. Read More

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Comprehensive Physical Activity Assessment During U.S. Army Basic Combat Training.

J Strength Cond Res 2021 Jul 30. Epub 2021 Jul 30.

Injury Prevention Program, Clinical Public Health and Epidemiology Directorate, U.S. Army Public Health Center, Aberdeen Proving Ground, Maryland Department of Exercise Science, The Norman J. Arnold School of Public Health, The University of South Carolina, Columbia, South Carolina Department of Health and Human Performance, The Citadel, the Military College of South Carolina, Charleston, South Carolina South Carolina Rural Health Research Center, Institute for Partnerships to Eliminate Health Disparities, The Norman J. Arnold School of Public Health, The University of South Carolina, Columbia, South Carolina.

Abstract: Alemany, JA, Pierce, JR, Bornstein, DB, Grier, TL, Jones, BH, and Glover, SH. Comprehensive physical activity assessment during U.S. Read More

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Prospective Trial of Near-Infrared Spectroscopy for Continuous Noninvasive Monitoring of Free Fibular Flaps.

Ann Plast Surg 2021 Jul 29. Epub 2021 Jul 29.

From the Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology and National Clinical Research Center for Oral Diseases and National Engineering Laboratory for Digital and Material Technology of Stomatology and Beijing Key Laboratory of Digital Stomatolog, HaiDian District, Beijing, China Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, P.R. China.

Introduction: Some free flaps develop postoperative vessel thrombosis, which influences the flap survival rate. Early discovery and identification of vascular crisis are critical to the success rate of flap salvage. The primary aims of this study were to determine the features of postoperative blood supply changes in fibular flaps with normal and abnormal blood flow, using near-infrared spectroscopy (NIRS), to monitor oxygenation and blood flow, and to characterize the probable risk factors for vascular crisis. Read More

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Comparing JM-105 and MBJ-20 Transcutaneous Bilirubinometers According to the Area Tested in Ethnically Diverse Late-Preterm and Term Neonates.

J Perinat Neonatal Nurs 2021 Jul-Sep 01;35(3):E30-E37

Department of Women's & Newborn Health, Westmead Hospital, Westmead, New South Wales, Australia (Dr Khajehei, Dr Chua, and Mss Gidaszewski and Swain); Westmead Clinical School, The University of Sydney, Sydney, New South Wales, Australia (Dr Khajehei and Ms Gidaszewski); University of New South Wales, Sydney, New South Wales, Australia (Dr Khajehei); and Western Sydney University, Sydney, New South Wales, Australia (Dr Chua).

This study aims to evaluate the correlation between the results of transcutaneous bilirubin (TcB) levels measured by the 2 transcutaneous bilirubinometers according to the area tested and to compare the TcB measurements and the serum bilirubin (SBR) levels. We screened 78 neonates born at more than 35 weeks of gestation and aged less than 168 hours for jaundice. We used JM-105 and MBJ-20 to measure the TcB at the forehead and the chest. Read More

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Laser-Activated Corneal Adhesive: Retinal Safety in Rabbit Model.

Transl Vis Sci Technol 2021 07;10(8):27

The University of Sydney, Save Sight Institute, Discipline of Ophthalmology, Sydney Medical School, Sydney, New South Wales, Australia.

Purpose: The purpose of this study was to investigate whether laser irradiation, used to activate an adhesive for sealing penetrating corneal incisions, causes any ophthalmoscopically or histologically visible retinal changes.

Methods: Baseline fundus assessment was conducted prior to laser irradiation of eyes of pigmented Dutch Belted rabbits. Treatment group was 18 eyes with the corneal adhesive activated in situ by a near infrared laser (125 mW for 45 seconds). Read More

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Population pharmacokinetics of diethylcarbamazine in patients with lymphatic filariasis and healthy individuals.

Antimicrob Agents Chemother 2021 Jul 26:AAC0031721. Epub 2021 Jul 26.

Clinical Pharmacology Laboratory, Dept of Pharmacy Practice and Science, University of Nebraska Medical Center, Omaha, NE 68198, United States.

Diethylcarbamazine (DEC) is a drug of choice to treat lymphatic filariasis (LF) either used alone or in combination as mass drug administration (MDA) preventive strategies. The objective of this study was to develop a population pharmacokinetic model for DEC in subjects infected with lymphatic filariasis (LF) compared to healthy individuals, and to evaluate the effect of covariates on the volume of distribution (V/F) and oral clearance (CL/F) of DEC. This was an open-label cohort study of treatment naïve -infected (n=32) and uninfected (n=24) adults residing in the Agboville district of Côte d'Ivoire. Read More

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A Machine Learning-Based Algorithm for the Prediction of Intensive Care Unit Delirium (PRIDE): Retrospective Study.

JMIR Med Inform 2021 Jul 26;9(7):e23401. Epub 2021 Jul 26.

Department of Critical Care Medicine and Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Delirium frequently occurs among patients admitted to the intensive care unit (ICU). There is limited evidence to support interventions to treat or resolve delirium in patients who have already developed delirium. Therefore, the early recognition and prevention of delirium are important in the management of critically ill patients. Read More

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MRI combined with early clinical variables are excellent outcome predictors for newborn infants undergoing therapeutic hypothermia after perinatal asphyxia.

EClinicalMedicine 2021 Jun 17;36:100885. Epub 2021 May 17.

Neonatal Neuroscience, Translational Health Sciences, University of Bristol, Bristol, United Kingdom.

Background: Binary prediction-models for outcome [death, cognition, presence and severity of cerebral palsy (CP)], using MRI and early clinical data applicable for individual outcome prediction have not been developed.

Methods: From Dec 1 2006 until Dec 31 2013, we recruited 178 infants into a population-based cohort with moderate or severe hypoxic-ischaemic encephalopathy (HIE) including postnatal collapse (PNC,  = 12) and additional diagnoses ( = 12) using CoolCap/TOBY-trial entry-criteria including depressed amplitude-integrated EEG (aEEG). Early clinical/biochemical variables and MRI scans (median day 8) were obtained in 168 infants. Read More

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Cyber-Personality and Expression: A Study From WeChat Users in China.

Authors:
Haojian Li X T Wang

Front Psychol 2021 8;12:626040. Epub 2021 Jul 8.

School of Humanities and Social Science, The Chinese University of Hong Kong, Shenzhen, China.

Clicking the button following a post on social media has become a common means of expressing and gathering social support online. Little is known about how expression is linked and regulated by personality traits and communication motives. Following a preliminary survey ( = 168) about the usage of the function on WeChat, a Chinese social media platform, we conducted an online study ( = 183) to map the Big-Five personality traits and five communication motives to the frequency (likelihood) of expression. Read More

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Stability of Dexmedetomidine in Polyvinyl Chloride Bags Containing 0.9% Sodium Chloride Intended for Subcutaneous Infusions.

Int J Pharm Compd 2021 Jul-Aug;25(4):330-335

Department of Pharmacy, The Ottawa Hospital, The Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Dexmedetomidine is a sedative medication with co-analgesic effects that has been used primarily in critical care and anesthesia as a continuous intravenous infusion. Its utility in the treatment of refractory agitated delirium is being investigated in other settings including palliative care, but continuous intravenous infusions are not always feasible during end-of-life care. Subcutaneous infusions are more commonly used in this setting, but smaller volumes and higher concentrations are typically required. Read More

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The impact of COVID-19 pandemic in stroke code activation and time from symptom onset to hospital arrival in a Portuguese comprehensive stroke centre.

Rev Neurol 2021 08;73(3):89-95

Hospital Garcia de Orta, Almada, Portugal.

Introduction: Coronavirus disease 2019 (COVID-19) impacted emergency services worldwide.

Aim: We aimed to evaluate COVID-19 effect on the number of stroke code activations and timings during the first two months of the pandemic.

Material And Methods: We reviewed the stroke code database of a single comprehensive stroke centre in Portugal for the number of activations through 2019-2020. Read More

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Maternal and Neonatal Outcomes of Placenta Previa with and without Coverage of a Uterine Scar: A Retrospective Cohort Study in a Tertiary Hospital.

Int J Womens Health 2021 6;13:671-681. Epub 2021 Jul 6.

Foshan Fetal Medicine Institute, Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical University (Foshan Maternity & Child Healthcare Hospital), Foshan, Guangdong, 528000, People's Republic of China.

Background: To compare the maternal and neonatal outcomes of placenta previa (PP) with and without coverage of a uterine scar in Foshan, China.

Methods: A retrospective cohort study comparing all singleton pregnancies with PP was conducted at a tertiary, university-affiliated medical center from 1 January 2012 to 31 April 2017 in Foshan, China. Demographic, clinical and laboratory data were extracted from electronic medical records (EMRs). Read More

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Australian Children's Exposure to, and Engagement With, Web-Based Marketing of Food and Drink Brands: Cross-sectional Observational Study.

J Med Internet Res 2021 Jul 12;23(7):e28144. Epub 2021 Jul 12.

Prevention Research Collaboration, School of Public Heath, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.

Background: Food is one of the most frequently promoted commodities, and promoted foods are overwhelmingly unhealthy. Marketing normalizes unhealthy foods, creates a positive brand image, and encourages overconsumption. Limited research is available to describe the extent of food marketing to children on web-based media, and measuring actual exposure is challenging. Read More

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Systemic Immune-Inflammation Index Is a Predictor of Contrast-Induced Nephropathy in Patients With ST-Segment Elevation Myocardial Infarction.

Angiology 2021 Jul 7:33197211029094. Epub 2021 Jul 7.

Department of Cardiology, University of Health Sciences, Dr. Siyami Ersek Training and Research Hospital, Istanbul, Turkey.

We evaluated the predictive value of admission systemic immune-inflammation index (SII) for the risk of contrast-induced nephropathy (CIN) in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and SII (platelet × NLR) levels were calculated in 1621 consecutive patients with STEMI. The relationship of these parameters with CIN development within 72 hours of pPCI was analyzed. Read More

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Clinical Usefulness of a Modified Mohs' Technique and Topical Application of Zinc Oxide Powder for Treating Skin Infiltration Caused by Unresectable Malignant Tumors.

Palliat Med Rep 2021 14;2(1):168-174. Epub 2021 Jun 14.

Department of Dermatology, Fujita Health University School of Medicine, Aichi, Japan.

Infiltrative lesions of the skin caused by unresectable malignant tumors reduce the quality of life of patients significantly due to the presence of bleeding, exudate, pain, and/or malodor. We compared the efficacy of a modified Mohs' technique and topical application of a starch powder containing zinc oxide as palliative treatments for skin lesions caused by unresectable tumors in our hospital. This is a retrospective study. Read More

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