5,911 results match your criteria 1530 [11]

Spontaneous regression of lung metastases after transarterial chemoembolization for hepatocellular carcinoma.

Radiol Case Rep 2021 Jun 18;16(6):1530-1534. Epub 2021 Apr 18.

Department of Gastroenterology and Hepatology, Suita Municipal Hospital, Suita City, Osaka, Japan.

Spontaneous regressions of primary and/or metastatic lesions have been rarely reported in hepatocellular carcinoma (HCC). Herein, we report the case of a 71-year-old man with HCC, focusing on shape changes of lung metastases over time. Lung metastasis of HCC was histologically diagnosed by percutaneous computed tomography (CT)-guided needle biopsy after the treatment of primary HCC lesion. Read More

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Systematic integrated analyses of methylomic and transcriptomic impacts of early combined botanicals on estrogen receptor-negative mammary cancer.

Sci Rep 2021 May 4;11(1):9481. Epub 2021 May 4.

Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard, Birmingham, AL, 35294, USA.

Dietary botanicals such as the cruciferous vegetable broccoli sprouts (BSp) as well as green tea polyphenols (GTPs) have shown exciting potential in preventing or delaying breast cancer (BC). However, little is known about their impact on epigenomic aberrations that are centrally involved in the initiation and progression of estrogen receptor-negative [ER(-)] BC. We have investigated the efficacy of combined BSp and GTPs diets on mammary tumor inhibition in transgenic Her2/neu mice that were administered the diets from prepubescence until adulthood. Read More

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Probing the mineralized tissue-adhesive interface for tensile nature and bond strength.

J Mech Behav Biomed Mater 2021 Apr 29;120:104563. Epub 2021 Apr 29.

Institute for Bioengineering Research (IBER), University of Kansas, 1530 W. 15th St, Lawrence, KS, 66045, USA; Department of Mechanical Engineering, University of Kansas, 1530 W. 15th St, Lawrence, KS, 66045, USA; Civil, Environmental and Architectural Engineering Department, University of Kansas, 1530 W. 15th St, Lawrence, KS, 66045, USA. Electronic address:

The mechanical performance of the dentin-adhesive interface contributes significantly to the failure of dental composite restorations. Rational material design can lead to enhanced mechanical performance, but this requires accurate characterization of the mechanical behavior at the dentin-adhesive interface. The mechanical performance of the interface is typically characterized using bond strength tests, such as the micro-tensile test. Read More

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System Modularity Chip for Analysis of Rare Targets (SMART-Chip): Liquid Biopsy Samples.

ACS Sens 2021 May 3. Epub 2021 May 3.

Department of Chemistry, University of Kansas, 1567 Irving Hill Road, Lawrence, Kansas 66045, United States.

Liquid biopsies are becoming popular for managing a variety of diseases due to the minimally invasive nature of their acquisition, thus potentially providing better outcomes for patients. Circulating tumor cells (CTCs) are among the many different biomarkers secured from a liquid biopsy, and a number of efficient platforms for their isolation and enrichment from blood have been reported. However, many of these platforms require manual sample handling, which can generate difficulties when translating CTC assays into the clinic due to potential sample loss, contamination, and the need for highly specialized operators. Read More

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Experiences of secondary health conditions amongst people with spinal cord injury in South Africa: A qualitative study.

S Afr J Physiother 2021 6;77(1):1530. Epub 2021 Apr 6.

Department of Physiotherapy, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Parktown, South Africa.

Background: Secondary health conditions (SHCs) such as pain, pressure sores, sexual problems, bowel and bladder problems are prevalent throughout the lifespan of people with spinal cord injury (SCI). Studies have reported that SHCs decrease life expectancy and increase health care costs. Studies on the lived experience of SHCs are, however, limited. Read More

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Safeguarding from COVID-19: educating healthcare workers about the available protective equipment.

Z Gesundh Wiss 2021 Apr 25:1-5. Epub 2021 Apr 25.

Department of Pediatric and Neonatal Physiotherapy, Maharishi Markandeshwar Institute of Physiotherapy and Rehabilitation, Maharishi Markandeshwar (Deemed-to-be) University, Mullana, Ambala, Haryana 133207 India.

Aim: Coronavirus disease 2019 (COVID-19) is a viral illness which is transmitted through droplet spread and possibily the aerosol method. Older individuals are at higher risk compared with younger adults and children due to the presence of weaker immune functions. Healthcare workers are also at higher risk due to close proximity with the infected cases. Read More

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Upregulation of ubiquitin-conjugating enzyme E2T (UBE2T) predicts poor prognosis and promotes hepatocellular carcinoma progression.

Bioengineered 2021 Dec;12(1):1530-1542

Department of Radiotherapy, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.

Reportedly, ubiquitin-conjugating enzyme E2T (UBE2T) is closely related to the progression of several malignancies. This work is aimed to probe the role of UBE2T in the progression of hepatocellular carcinoma (HCC) patients. The microarray analysis was executed to screen the differentially expressed genes (DEGs) in HCC tissues. Read More

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December 2021

Thrombocytopenia and Hemostatic Changes in Acute and Chronic Liver Disease: Pathophysiology, Clinical and Laboratory Features, and Management.

J Clin Med 2021 Apr 6;10(7). Epub 2021 Apr 6.

Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Thrombocytopenia, defined as a platelet count <150,000/μL, is the most common complication of advanced liver disease or cirrhosis with an incidence of up to 75%. A decrease in platelet count can be the first presenting sign and tends to be proportionally related to the severity of hepatic failure. The pathophysiology of thrombocytopenia in liver disease is multifactorial, including () splenomegaly and subsequently increased splenic sequestration of circulating platelets, () reduced hepatic synthesis of thrombopoietin with missing stimulation both of megakaryocytopoiesis and thrombocytopoiesis, resulting in diminished platelet production and release from the bone marrow, and () increased platelet destruction or consumption. Read More

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Anxiety does not always affect balance: the predominating role of cognitive engagement in a video gaming task.

Exp Brain Res 2021 Apr 28. Epub 2021 Apr 28.

Department of Health and Kinesiology, College of Health, University of Utah, 250 S 1850 E, Salt Lake City, UT, 84112, USA.

Scientists have predominantly assessed anxiety's impact on postural control when anxiety is created by the need to maintain balance (e.g., standing at heights). Read More

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Glucocorticoids are double-edged sword in the treatment of COVID-19 and cancers.

Int J Biol Sci 2021 10;17(6):1530-1537. Epub 2021 Apr 10.

Department of General Surgery of Ruijin Hospital, Shanghai Institute of Digestive Surgery, and Shanghai Key Laboratory for Gastric Neoplasms, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China.

Glucocorticoids are important steroid hormones. As an outstanding scientific discovery, the scientist who discovered glucocorticoids was awarded the Nobel Prize in Physiology and Medicine in 1950. Cortisone (hydrocortisone) is a natural glucocorticoid, which is secreted with circadian rhythm by the cortical cells of adrenal glands. Read More

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Severe Case of Rickettsiosis Identified by Metagenomic Sequencing, China.

Emerg Infect Dis 2021 May;27(5):1530-1532

A case of Rickettsia sibirica subspecies sibirica BJ-90 infection in China was identified by metagenomic analysis of an eschar biopsy specimen and confirmed by nested PCR. Seroprevalence of spotted fever group Rickettsia was ≈17.4% among the local population. Read More

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The Burden of Reoperations and Timeline of Problems in 1,530 Cases of Mesh-Related Complications.

Urol Int 2021 Apr 22:1-8. Epub 2021 Apr 22.

Division of Pelvic Medicine and Reconstructive Surgery, University of California Los Angeles-UCLA, São Paulo, Brazil.

Background: Mesh-related complications resulting from pelvic organ prolapse (POP) reconstruction operations may be a devastating experience leading to multiple and complex interventions.

Objectives: The aim of the study was to describe the experience and time frame of management of mesh-related complications in women treated for POP or stress urinary incontinence in a tertiary center.

Methods: 1,530 cases of mesh-related complications were accessed regarding their clinical presentation, number of surgeries, and timeline of surgical treatments to treat multiple clinical complaints until the ultimate operation where all the meshes were removed in a single tertiary center. Read More

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Decompression Illness Incidence and Hypoxia Symptoms After Prebreathing in Hypobaric Hypoxia Training.

Aerosp Med Hum Perform 2021 May;92(5):289-293

Hypobaric hypoxia training utilizing the environmental chamber is often preceded by prebreathing of 100% oxygen with the goal of reducing decompression illness (DCI). We aimed to study the impact of prebreathing 100% oxygen for 30 min prior to hypobaria exposure to 7600 m (25,000 ft) on the incidence rate of DCI, as well as the impact of prebreathing on hypoxia symptoms felt during training. Records of participants who underwent hypobaric hypoxia training in the Republic of Singapore Air Force (RSAF) from 2011 to 2014 (before introduction of prebreathing) were compared to those who underwent similar training from 2014 to 2017 (after introduction of prebreathing) to determine the incidences of DCI for both groups. Read More

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[The role of dental medical records in the assessment of the quality of medical care].

Stomatologiia (Mosk) 2021 ;100(2):12-17

Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia.

The influence of the quality of registration of medical records in the provision of dental care to the possibility of objective evaluation of the quality of treatment in forensic examinations. The structure of complaints that became the basis for 432 patients' appeal to the court, the frequency of occurrence and the qualitative composition of questions to expert doctors are determined. It is proved, that the medical record of a dental patient is one of the main proofs in the judicial process when justifying the position of the parties: 81% of legislative examinations contained questions about compliance with clinical recommendations and treatment standards, and 69% about the presence of defects and shortcomings of treatment. Read More

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Narrative review of prostate cancer grading systems: will the Gleason scores be replaced by the Grade Groups?

Transl Androl Urol 2021 Mar;10(3):1530-1540

Department of Surgery, Cordoba University Medical School, Cordoba, Spain.

The Gleason grading system, proposed by Dr. Donald F. Gleason in 1966, is one of the most important prognostic factors in men with prostate cancer (PCa). Read More

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Perianal Crohn's Disease Is Associated With Poor Disease Outcome: A Nationwide Study From the epiIIRN Cohort.

Clin Gastroenterol Hepatol 2021 Apr 9. Epub 2021 Apr 9.

Juliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, Shaare Zedek Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel. Electronic address:

Background & Aims: Limited population-based data have explored perianal involvement in Crohn's disease (CD) and compared the disease course between severe and non-severe perianal CD (PCD). We aimed to explore the disease course of these phenotypes in a population-based study of CD.

Methods: Cases were identified from the epi-IIRN cohort and included 2 Israeli health maintenance organizations covering 78% of the population. Read More

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[Minimal Intervention in Dentistry: An emerging trend during Pandemic?]

Rev Med Chil 2020 10;148(10):1530-1531

Escuela de Odontología, Facultad de Ciencias de la Salud, Universidad de Talca, Chile.

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October 2020

Thrombin generation is associated with ischemic stroke at a young age.

Thromb Res 2021 Mar 29;202:139-144. Epub 2021 Mar 29.

Erasmus MC, University Medical Center Rotterdam, Department of Hematology, the Netherlands. Electronic address:

Introduction: Understanding the underlying mechanisms in ischemic stroke (IS) in young adults remains challenging. Thrombin activates processes that contribute to the development and progression of arterial diseases. We investigated the association between thrombin generation (TG) and a first IS or transient ischemic attack (TIA) in young adults. Read More

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Behavioral and stress responses to feeding time in pregnant sows under limit-fed regime.

J Anim Sci 2021 Apr 9. Epub 2021 Apr 9.

Southern Research and Outreach Center, University of Minnesota, Waseca, MN, USA.

We investigated the effect of feeding time on behavior and stress responses in pregnant sows under isocaloric conditions. Twenty-four sows were balanced for parity and randomly assigned to 1 of 3 feeding times. Corn-soybean meal-based diet was fed once at: 0730 (Control, T1), 1130 (T2), and 1530 h (T3). Read More

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Multifunctional optoelectronic device based on graphene-coupled silicon photonic crystal cavities.

Opt Express 2021 Mar;29(7):11094-11105

We present a hybrid device based on graphene-coupled silicon (Si) photonic crystal (PhC) cavities, featuring triple light detection, modulation, and switching. Through depositing single-layer graphene onto the PhC cavity, the light-graphene interaction can be enhanced greatly, which enables significant detection and modulation of the resonant wavelength. The device is designed to generate a photocurrent directly by the photovoltaic effect and has an external responsivity of ∼14 mA/W at 1530. Read More

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Forecasting major impacts of COVID-19 pandemic on country-driven sectors: challenges, lessons, and future roadmap.

Pers Ubiquitous Comput 2021 Mar 26:1-24. Epub 2021 Mar 26.

Department of Computer Science and Engineering, Faculty of Engineering and Technology, M. S. Ramaiah University of Applied Sciences, Bangalore, Karnataka India.

The pandemic caused by the coronavirus disease 2019 (COVID-19) has produced a global health calamity that has a profound impact on the way of perceiving the world and everyday lives. This has appeared as the greatest threat of the time for the entire world in terms of its impact on human mortality rate and many other societal fronts or driving forces whose estimations are yet to be known. Therefore, this study focuses on the most crucial sectors that are severely impacted due to the COVID-19 pandemic, in particular reference to India. Read More

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Anesthesia screen use may impact operating room communication practices in otolaryngology.

Am J Otolaryngol 2021 Mar 22;42(5):103000. Epub 2021 Mar 22.

Department of Otolaryngology, Boston University School of Medicine, Boston, MA, United States.

Objectives: Failures in communication are a leading contributor to medical error. There is increasing attention on cultivating robust communication practices in the Operating Room (OR) to mitigate against patient injury and optimize efficient patient care. Few studies have evaluated how surgical equipment may introduce barriers to team dynamics. Read More

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Immune Contexture of MMR-Proficient Primary Colorectal Cancer and Matched Liver and Lung Metastases.

Cancers (Basel) 2021 Mar 26;13(7). Epub 2021 Mar 26.

Department of Education and Research, Hospital Nova of Central Finland, 40620 Jyväskylä, Finland.

Purpose: To evaluate immune cell infiltration, the programmed death-1/programmed death ligand-1 (PD-1/PD-L1) expression and their prognostic value in a series of mismatch proficient (pMMR) CRC with matched liver and lung metastases.

Methods: Formalin-fixed paraffin-embedded tissue sections stained for CD3, CD8, PD-L1 and PD-1 from 113 primary CRC tumours with 105 liver and 59 lung metastases were analyzed. The amount of CD3 and CD8 positive lymphocytes were combined as immune cell score (ICS). Read More

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Review: Tissue Engineering of Small-Diameter Vascular Grafts and Their In Vivo Evaluation in Large Animals and Humans.

Cells 2021 Mar 23;10(3). Epub 2021 Mar 23.

Laboratory of Molecular and Cellular Cardiology, Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, J. B. Winsløwsvej 25, 5000 Odense C, Denmark.

To date, a wide range of materials, from synthetic to natural or a mixture of these, has been explored, modified, and examined as small-diameter tissue-engineered vascular grafts (SD-TEVGs) for tissue regeneration either in vitro or in vivo. However, very limited success has been achieved due to mechanical failure, thrombogenicity or intimal hyperplasia, and improvements of the SD-TEVG design are thus required. Here, in vivo studies investigating novel and relative long (10 times of the inner diameter) SD-TEVGs in large animal models and humans are identified and discussed, with emphasis on graft outcome based on model- and graft-related conditions. Read More

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Opiophobia in Emergency Department Healthcare Providers: A Survey in Western Switzerland.

J Clin Med 2021 Mar 25;10(7). Epub 2021 Mar 25.

Emergency Department, University Hospital of Lausanne and Lausanne University, Bugnon 46, 1011 Lausanne, Switzerland.

Opiophobia contributes to oligoanalgesia in the emergency department (ED), but its definition varies, and its association to healthcare providers' personality traits has been scantly explored. Our purpose was to study the different definitions of opiophobia and their association with two personality traits of doctors and nurses working in EDs, namely the stress from uncertainty and risk-taking. We used three online questionnaires: the 'Attitude Towards Morphine Use' Score (ATMS), the Stress From Uncertainty Scale (SUS) and the Risk-Taking Scale (RTS). Read More

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Dynamic ESPI Evaluation of Deformation and Fracture Mechanism of 7075 Aluminum Alloy.

Materials (Basel) 2021 Mar 20;14(6). Epub 2021 Mar 20.

Department of Chemistry and Physics, Southeastern Louisiana University, Hammond, LA 70402, USA.

The deformation and fracture mechanism in 7075 aluminum alloy is discussed based on a field theoretical approach. A pair of peak-aged and overaged plate specimens are prepared under the respective precipitation conditions, and their plastic deformation behaviors are visualized with two-dimensional electronic speckle pattern interferometry (ESPI). The in-plane velocity field caused by monotonic tensile loading is monitored continuously via the contour analysis method of ESPI. Read More

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Study of Cyberbullying among Adolescents in Recent Years: A Bibliometric Analysis.

Int J Environ Res Public Health 2021 03 15;18(6). Epub 2021 Mar 15.

Department of Psychology, Faculty of Psychology, University of Almería, 04120 Almería, Spain.

In recent years, cyberbullying has been recognized as a severe public health problem and is drawing growing interest. The objective of this study was to perform a bibliometric analysis of the scientific production on adolescent cyberbullying in the last decade. A search for publications was made in the Web of Science database, where the 1530 documents identified were analyzed with BibExcel software and visualized using the Pajek and VOSviewer tools. Read More

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Comparison of the Phenolic Compound Profile and Antioxidant Potential of L. and L.

Molecules 2021 Mar 11;26(6). Epub 2021 Mar 11.

WALA Heilmittel GmbH, Department of Analytical Development & Research, Section Phytochemical Research, 73087 Bad Boll, Germany.

In the present study, L. and L. were compared for the first time with regard to their phenolic compound profile and antioxidant activity by applying the 2,2-diphenyl-picryl hydrazyl radical assay. Read More

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Long-term National Trends of Arthroscopic Meniscal Repair and Debridement.

Am J Sports Med 2021 May 2;49(6):1530-1537. Epub 2021 Apr 2.

Department of Orthopaedics & Rehabilitation, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.

Background: Optimal treatment of meniscal pathology continues to evolve in orthopaedic surgery, with a growing understanding of which patients benefit from which procedure and which patients might be best treated nonsurgically. In 2002, Moseley et al found no difference between arthroscopic procedures, including meniscal debridement and sham surgery, in patients with osteoarthritis of the knee. This called into question the role of routine arthroscopic debridement in these patients. Read More

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Diffractive saturable loss mechanism in Kerr-lens mode-locked lasers: direct observation and simulation.

Opt Lett 2021 Apr;46(7):1530-1533

Passive mode-locking relies critically on a saturable loss mechanism to form ultrashort pulses. However, in Kerr-lens mode-locking (KLM), no actual absorption takes place, but rather losses appear due to diffraction, and actual light must escape the cavity. The Kerr-lens effect works to generate through diffraction an effective instantaneous saturable absorber that depends delicately on the interplay between the spatial and temporal profiles of the pulse. Read More

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