35,061 results match your criteria 142 patients

Next- Generation Sequencing Is An Effective Method For Diagnosing Patients With Different Forms Of Monogenic Diabetes.

Diabetes Res Clin Pract 2021 Nov 23:109154. Epub 2021 Nov 23.

Department of Clinical Genetics, Medical University of Lodz, Lodz, Poland.

Aim: Monogenic diabetes (MD) represents 5-7% of antibody-negative diabetes cases and is a heterogeneous group of disorders.

Methods: We used targeted next-generation sequencing (NGS) on Illumina NextSeq 550 platform involving the SureSelect assay to perform genetic and clinical characteristics of a study group of 684 individuals, including 542 patients referred from 12 Polish Diabetes Centers with suspected MD diagnosed between December 2016 and December 2019 and their 142 family members (FM).

Results: In 198 probands (36. Read More

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November 2021

A prospective study on inter-operator variability in semi-robotic software-based MRI/TRUS-fusion targeted prostate biopsies.

World J Urol 2021 Nov 26. Epub 2021 Nov 26.

Department of Urology and Urosurgery, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Purpose: Magnetic resonance imaging (MRI)/ultrasound-fusion prostate biopsy (FB) comprises multiple steps each of which can cause alterations in targeted biopsy (TB) accuracy leading to false-negative results. The aim was to assess the inter-operator variability of software-based fusion TB by targeting the same MRI-lesions by different urologists.

Methods: In this prospective study, 142 patients eligible for analysis underwent software-based FB. Read More

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November 2021

The Implication of Dropping Race from the MDRD Equation to Estimate GFR in an African American-Only Cohort.

Int J Nephrol 2021 16;2021:1880499. Epub 2021 Nov 16.

Department of Medicine, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.

The widely used Modification of Diet in Renal Disease (MDRD) formula adapts a 1.212 multiplier for individuals who are identified as African Americans (AAs) or Blacks, which leads to a higher GFR estimation. As it stands, AAs have a lower prevalence of chronic kidney disease (CKD) but higher incidence of end-stage renal disease (ESRD) compared with Whites. Read More

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November 2021

Reoperation rate and implant survivorship compared between cementless and cemented bipolar hemiarthroplasty in femoral neck fracture patients with chronic kidney disease.

Injury 2021 Nov 14. Epub 2021 Nov 14.

Division of Adult Reconstructive Surgery, Department of Orthopaedic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand. Electronic address:

Background: Chronic kidney disease (CKD) is commonly associated with aging and disorders of mineral and bone metabolism. Femoral neck fracture (FNF) is one of the most common fractures among older adults with coexisting CKD, and bipolar hemiarthroplasty (BHA) is a preferred treatment. However, the optimal method of stem fixation has not been conclusively determined. Read More

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November 2021

Effects of endplate coverage and intervertebral height change on heterotopic ossification following cervical disc replacement.

J Orthop Surg Res 2021 Nov 25;16(1):693. Epub 2021 Nov 25.

Department of Operation Room and Anesthesia Center, West China Hospital, Sichuan University, No. 37 Guo Xue Rd, Chengdu, 610041, China.

Background: Heterotopic ossification (HO) is a common complication after cervical disc replacement (CDR). Biomechanical factors including endplate coverage and intervertebral disc height change may be related to HO formation. However, there is a dearth of quantitative analysis for endplate coverage, intervertebral height change and their combined effects on HO. Read More

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November 2021

The emergence of chloroquine-sensitive Plasmodium falciparum is influenced by selected communities in some parts of the Central Region of Ghana.

Malar J 2021 Nov 25;20(1):447. Epub 2021 Nov 25.

Department of Biology Education, Faculty of Science Education, University of Education, Winneba, Ghana.

Background: The return of chloroquine-sensitive Plasmodium falciparum in sub-Saharan Africa countries offers the opportunity for the reintroduction of chloroquine (CQ) either in combination with other drugs or as a single therapy for the management of malaria. This study assesses the influence of individual study sites on the selection of CQ sensitive P. falciparum markers in the Central region of Ghana. Read More

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November 2021

Low Dose of Direct Oral Anticoagulants after Left Atrial Appendage Occlusion.

J Cardiovasc Dev Dis 2021 Oct 28;8(11). Epub 2021 Oct 28.

Cardiology Department, Cardiovascular Institute (ICCV), Hospital Clinic, IDIBAPS, University of Barcelona, 08036 Barcelona, Spain.

The optimal antithrombotic strategy following left atrial appendage occlusion (LAAO) is not yet clearly established. Low-dose non-vitamin K antagonist oral anticoagulants (NOAC) might represent a valid alternative, but data regarding their usage is scarce. The aim of this study was to examine the efficacy and safety of low-dose NOAC compared to single (SAPT) or dual antiplatelet therapies (DAPT) after LAAO. Read More

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October 2021

[For Which Patients is Web-Based Psychotherapeutic Aftercare after Psychosomatic Rehabilitation Most Suitable?]

Psychother Psychosom Med Psychol 2021 Nov 24. Epub 2021 Nov 24.

Psychology & Methods, Jacobs University Bremen, Bremen, Deutschland.

Objective: In order to maintain the effects achieved during the psychosomatic rehabilitation, according aftercare is indicated for most rehabilitation patients. Due to the current low supply of aftercare psychotherapists (so-called aftercare therapists) licensed by the German Pension Insurance web-based aftercare provides an equivalent alternative to analogue (in person) offers. This study clarifies which characteristics indicate that web-based aftercare is particularly recommended and how web-based formats are evaluated by participants, especially with regard to the therapeutic relationship. Read More

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November 2021

A Study on the Prediction of Reproductive Outcomes in Frozen Embryo Transfer Cycles by Calculating the Volume of Uterine Junctional Zone with Three-Dimensional Ultrasound.

Ultraschall Med 2021 Nov 24. Epub 2021 Nov 24.

Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, China.

Purpose: To prospectively study the influence of the volume of the uterine junctional zone (JZ) as a novel predictor of reproductive outcomes in frozen embryo transfer cycles.

Methods: Among the first 30 patients, intra- and interobserver repeatability was evaluated and expressed as a coefficient of repeatability. The same classification system was used to evaluate the JZ of 142 infertility patients undergoing in vitro fertilization (IVF). Read More

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November 2021

Combined arterial and delayed enhancement patterns of MRI assist in prognostic prediction for intrahepatic mass-forming cholangiocarcinoma (IMCC).

Abdom Radiol (NY) 2021 Nov 25. Epub 2021 Nov 25.

Department of Radiology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Rd, Shanghai, 200032, China.

Objectives: This study valued MR delayed enhancement pattern in predicting postoperative prognosis of intrahepatic mass-forming cholangiocarcinoma (IMCC).

Methods: From 2011 to 2015, 231 patients of IMCC underwent DCE-MRI preoperatively. Enhancement patterns and MRI characteristics were evaluated. Read More

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November 2021

Relationship between potential barriers to early mobilization in adult patients during intensive care stay using the Perme ICU Mobility score.

Can J Respir Ther 2021 22;57:148-153. Epub 2021 Nov 22.

Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo / Brazil.

Background: Identifying barriers to early mobilization is essential for the management of patients in the intensive care unit (ICU). Our objective was to identify the potential barriers to early mobilization in adult patients using the Perme ICU Mobility Score (Perme Score) and its relationship with days of mechanical ventilation (MV) and length of stay in ICU.

Methods: This was a pilot, observational, and prospective study. Read More

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November 2021

Efficacy and Safety of Ergoferon in Children from 6 Months to 6 Years Old with Acute Respiratory Viral Infections in Contemporary Outpatient Practice: A Multicenter, Double-Blind, Placebo-Controlled Randomized Trial.

Can Respir J 2021 15;2021:5570178. Epub 2021 Nov 15.

Department of Pediatrics, Kazakh Medical University of Continuing Education, Almaty 050040, Kazakhstan.

To evaluate the efficacy and safety of Ergoferon in combination with symptomatic therapy in children from 6 months to 6 years old with acute respiratory infections (ARI) in contemporary outpatient practice, an international, multicenter, double-blind, placebo-controlled, randomized, parallel-group clinical trial was performed. Derived by technological treatment of antibodies to interferon gamma, histamine, and CD4, Ergoferon was previously proved to modulate its molecular targets promoting effective antiviral protection. The data of 282 patients with oral temperature ≥38. Read More

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November 2021

Molecular differences of adipose-derived mesenchymal stem cells between non-responders and responders in treatment of  transphincteric perianal fistulas.

Stem Cell Res Ther 2021 Nov 24;12(1):586. Epub 2021 Nov 24.

Molecular Endocrinology and Stem Cell Research Unit, Department of Endocrinology and Metabolism, Odense University Hospital and Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.

Background: Injection of autologous adipose tissue (AT) has recently been demonstrated to be an effective and safe treatment for anal fistulas. AT mesenchymal stem cells (AT-MSCs) mediate the healing process, but the relationship between molecular characteristics of AT-MSCs of the injected AT and fistula healing has not been adequately studied. Thus we aimed to characterize the molecular and functional properties of AT-MSCs isolated from autologous AT injected as a treatment of cryptogenic high transsphincteric perianal fistulas and correlate these findings to the healing process. Read More

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November 2021

Metabolic profile changes in serum of migraine patients detected using H-NMR spectroscopy.

J Headache Pain 2021 Nov 24;22(1):142. Epub 2021 Nov 24.

Departments of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.

Background: Migraine is a common brain disorder but reliable diagnostic biomarkers in blood are still lacking. Our aim was to identify, using proton nuclear magnetic resonance (H-NMR) spectroscopy, metabolites in serum that are associated with lifetime and active migraine by comparing metabolic profiles of patients and controls.

Methods: Fasting serum samples from 313 migraine patients and 1512 controls from the Erasmus Rucphen Family (ERF) study were available for H-NMR spectroscopy. Read More

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November 2021

Publications, by different surgical specialties, on patient-reported outcomes of oncoplastic surgery.

Rev Assoc Med Bras (1992) 2021 Jul;67(7):1069-1074

Universidade Federal de São Paulo, Escola Paulista de Medicina, Translational Surgery Graduate Program - São Paulo (SP), Brazil.

Objective: This study aimed to compare the publications authored by plastic surgeons with those from other specialties' surgeons on patient-reported outcomes of oncoplastic surgery.

Methods: A review was carried out on the Medline database, emcompassing five years (2015-2020). Studies about partial breast reconstruction after conservative treatment, immediate or delayed, by any technique, which presented patient-reported outcomes, were included. Read More

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Slight cartilage damage in weight-bearing area of lateral femoral condyle do not compromise short-term outcomes of medial unicompartmental knee arthroplasty.

Arch Orthop Trauma Surg 2021 Nov 23. Epub 2021 Nov 23.

Department of Orthopedics, Xuanwu Hospital Capital Medical University, 45 Changchun Street, Xicheng District, Beijing, 100053, China.

Introduction: Medial unicompartmental knee arthroplasty (mUKA) requires full-thickness cartilage in the lateral compartment, but slight damage of the cartilage surface can be ignored. However, as this statement lacks literature support, we investigated whether slight cartilage damages in the weight-bearing area of the lateral femoral condyle would affect the outcome of mUKAs.

Materials And Methods: Outerbridge grading was performed on the cartilage in the weight-bearing area of the lateral femoral condyle intraoperatively. Read More

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November 2021

Risk and protective factors of acute kidney injury in decompensated cirrhotic patients with ascites on tolvaptan.

JGH Open 2021 Nov 1;5(11):1298-1305. Epub 2021 Nov 1.

Institute of Gastroenterology, Department of Internal Medicine Tokyo Women's Medical University Shinjuku-ku Tokyo Japan.

Background And Aim: Acute kidney injury (AKI) is a life-threatening complication of liver cirrhosis. Here, we evaluated the risk factors and characteristics of AKI in cirrhosis.

Patients/methods: This was a single-center retrospective study. Read More

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November 2021

One-Year Outcomes of Intracorneal Ring-Segment Insertion Assisted by Femtosecond Laser Simultaneously Performed with Corneal Collagen Cross-Linking for Treatment of Keratoconus.

Clin Ophthalmol 2021 15;15:4447-4453. Epub 2021 Nov 15.

Department of Ophthalmology, Alexandria Faculty of Medicine, Alexandria, Egypt.

Purpose: To assess the results of simultaneously performed femtosecond laser-assisted Keraring intrastromal corneal ring-segment insertion and corneal collagen cross-linking for the treatment of keratoconus.

Patients And Methods: In this retrospective, noncomparative, interventional study, 30 eyes of 24 progressive-keratoconus patients of both sexes aged 18-36 years old with poor best-corrected visual acuity (BCVA) and intolerance to contact lenses were included. All patients had been subjected to complete preoperative and postoperative ophthalmological examinations - unaided VA, BCVA, refraction, Pentacam, and contrast sensitivity examinations at 3-month, 6-month, and 1-year follow-ups. Read More

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November 2021

The effect of persistent anxiety and depressive symptoms on quality of life among patients with heart failure.

Appl Nurs Res 2021 12 24;62:151503. Epub 2021 Sep 24.

University of Sharjah, Po Box 27272 Sharjah, UAE. Electronic address:

Background: Anxiety and depressive symptoms interfere with physical and psychological status, worsening symptoms and quality of life (QoL) among patients with heart failure (HF). This study assesses the impact of persistent anxiety and depressive symptoms on QoL among patients with HF in Jordan.

Methods: This was a prospective observational study of a consecutive sample with a confirmed diagnosis of HF, recruited from four hospitals in Jordan during the period 1-31 March 2020. Read More

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December 2021

[Association between body mass index changes and other risk factors for cardiovascular disease in patients with type 2 diabetes mellitus].

Zhonghua Liu Xing Bing Xue Za Zhi 2021 Jul;42(7):1194-1199

Department of Chronic and Non-communicable Disease Prevention and Control, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.

To investigate the association between body mass index (BMI) changes and other risk factors for cardiovascular disease in patients with type 2 diabetes mellitus (T2DM). Based on the T2DM cohort in rural communities of Zhejiang province, baseline and follow up information of height, weight, blood pressure, glycated hemoglobin (HbA1c), TC, TG, LDL-C and HDL-C of the T2DM patients were collected. After excluding those who died during the follow-up period, lost follow-up or had incomplete information, a total of 8 953 T2DM patients were included in the final analysis. Read More

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Prevalence and determinants of healthcare avoidance during the COVID-19 pandemic: A population-based cross-sectional study.

PLoS Med 2021 Nov 23;18(11):e1003854. Epub 2021 Nov 23.

Department of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, the Netherlands.

Background: During the Coronavirus Disease 2019 (COVID-19) pandemic, the number of consultations and diagnoses in primary care and referrals to specialist care declined substantially compared to prepandemic levels. Beyond deferral of elective non-COVID-19 care by healthcare providers, it is unclear to what extent healthcare avoidance by community-dwelling individuals contributed to this decline in routine healthcare utilisation. Moreover, it is uncertain which specific symptoms were left unheeded by patients and which determinants predispose to healthcare avoidance in the general population. Read More

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November 2021

Adrenal wash-out CT: moderate diagnostic value in distinguishing benign from malignant adrenal masses.

Eur J Endocrinol 2021 Nov 1. Epub 2021 Nov 1.

M Fassnacht, Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital Würzburg, Wuerzburg, 97080, Germany.

Objective: Reliable results of wash-out CT in the diagnostic workup of adrenal incidentalomas are scarce. Thus, we evaluated the diagnostic accuracy of delayed wash-out CT and determined thresholds to accurately differentiate adrenal masses.

Design: Retrospective, single-center cohort study including 216 patients with 252 adrenal lesions who underwent delayed wash-out CT. Read More

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November 2021

Ten months of temporal variation in the clinical journey of hospitalised patients with COVID-19: an observational cohort.

Elife 2021 Nov 23;10. Epub 2021 Nov 23.

ISARIC Global Support Centre, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, London, United Kingdom.

There is potentially considerable variation in the nature and duration of the care provided to hospitalised patients during an infectious disease epidemic or pandemic. Improvements in care and clinician confidence may shorten the time spent as an inpatient, or the need for admission to an intensive care unit (ICU) or high density unit (HDU). On the other hand, limited resources at times of high demand may lead to rationing. Read More

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November 2021

Newly established LC-MS/MS method for measurement of plasma BH4 as a predictive biomarker for kidney injury in diabetes.

Free Radic Biol Med 2021 Nov 19. Epub 2021 Nov 19.

Department of Endocrinology & Metabolism, Renmin Hospital of Wuhan University, China. Electronic address:

Objective: The clinical research on BH4 is limited because of the difficulties on its measurement. In this study, we used our own established LC-MS/MS method to examine the plasma BH4 levels in diabetes to determine whether it could be used as a biomarker for the prediction of kidney injury in those patients.

Methods: Hospitalized diabetes patients in Renmin Hospital of Wuhan University from Jan to Aug 2021 were recruited. Read More

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November 2021

The association of blood urea nitrogen levels upon emergency admission with mortality in acute exacerbation of chronic obstructive pulmonary disease.

Chron Respir Dis 2021 Jan-Dec;18:14799731211060051

Department of Respiratory Medicine Affiliated Jinhua Hospital, RinggoldID:117946Zhejiang University School of Medicine, Jinhua Municipal Central Hospital, Jinhua, China.

Background And Purpose: High blood urea nitrogen (BUN) is associated with an elevated risk of mortality in various diseases, such as heart failure and pneumonia. Heart failure and pneumonia are common comorbidities of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, data on the relationship of BUN levels with mortality in patients with AECOPD are sparse. Read More

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November 2021

Prostate artery embolization for the treatment of urinary retention caused by large (>80 ​mL) benign prostatic hyperplasia: Results of 21 patients.

J Interv Med 2020 Sep 9;3(3):142-145. Epub 2020 Jul 9.

Department of Interventional Radiology, Chinese PLA General Hospital, 28 Fu-xing Rd., Beijing, 100853, PR China.

Objective: A large prostate size (>80 ​mL) of benign prostatic hyperplasia (BPH) is technically challenging to treat surgically. This study aimed to investigate the safety and efficacy of super-selective prostatic artery embolization (PAE) for the treatment of urinary retention caused by large BPH.

Methods: A total of 21 patients with urinary retention, indwelling urinary catheter, or suprapubic cystostomy as a consequence of giant BPH (prostate volume [PV] ​> ​80 ​mL) who sought treatment between January 2013 and December 2017 were enrolled. Read More

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September 2020

Nuclear Morphological Characteristics in Breast Cancer: Correlation with Hormone Receptor and Human Epidermal Growth Factor Receptor 2.

Anal Cell Pathol (Amst) 2021 12;2021:3037993. Epub 2021 Nov 12.

Department of Pathology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Background: Hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) are the common diagnostic/prognostic markers in breast cancer. Few articles have recently reported the correlation between cytology and molecular subtypes. We combined nuclear morphological characteristics with HR and HER2 status to observe the relationship and provide ideas for machine learning. Read More

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November 2021

In-Hospital Mortality Among Critically Ill Patients With Atrial Fibrillation (AF) Versus Patients Without AF.

Cureus 2021 Oct 13;13(10):e18761. Epub 2021 Oct 13.

Department of Medicine, Jinnah Postgraduate Medical Centre, Karachi, PAK.

Introduction Atrial fibrillation (AF) is one of the most frequent arrhythmias observed in the intensive care unit (ICU). The present study assessed AF as an independent risk factor for mortality among patients in the ICU setting. Methodology A prospective cohort study was conducted at the medical ICU in a tertiary academic medical center from September 2020 to January 2021. Read More

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October 2021

Improved Outside-In Suture through the Joint Capsule to Repair the Palmer I-B Triangular Fibrocartilage Complex Superficial Injury.

Comput Math Methods Med 2021 10;2021:8387813. Epub 2021 Nov 10.

Medical College, Soochow University, Suzhou, China.

Background: The treatment of type I-B triangular fibrocartilage complex superficial injury is always a challenge to orthopedists. The traditional outside-in suture method often causes a risk of nervous irritation. We designed a modified outside-in suture through the joint capsule to repair the Palmer I-B triangular fibrocartilage complex superficial injury. Read More

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November 2021

[Single-phase Pulmonary Arteriovenous Separation CT Protocol with Estimated Time of Arrival Method Using 3rd Generation Dual Source CT: Its Success Rate of Pulmonary Arteriovenous Separation in Our Experience of 223 Cases].

Nihon Hoshasen Gijutsu Gakkai Zasshi 2021 ;77(11):1325-1333

Department of Radiology, Mie University Graduate School of Medicine.

We retrospectively investigated the success rate of pulmonary arteriovenous separation in a single-phase computed tomography (CT) protocol using the estimated time of arrival (ETA) method. A total of 223 patients who underwent a single-phase CT protocol using the ETA method for pulmonary arteriovenous separation were included in the analysis. Dual source CT (SOMATOM Force, SIEMENS) was used for imaging. Read More

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November 2021