12 results match your criteria 12months gains

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Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE): Protocol.

Contemp Clin Trials 2019 10 26;85:105832. Epub 2019 Aug 26.

Department of Psychology, University of Pittsburgh, USA.

Despite the ubiquity of normal age-related cognitive decline there is an absence of effective approaches for improving neurocognitive health. Fortunately, moderate intensity exercise is a promising method for improving brain and cognitive health in late life, but its effectiveness remains a matter of skepticism and debate because of the absence of large, comprehensive, Phase III clinical trials. Here we describe the protocol for such a randomized clinical trial called IGNITE (Investigating Gains in Neurocognition in an Intervention Trial of Exercise), a study capable of more definitively addressing whether exercise influences cognitive and brain health in cognitively normal older adults. Read More

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October 2019

Effectiveness of guided internet-delivered cognitive behavior therapy for depression in routine psychiatry: A randomized controlled trial.

Internet Interv 2019 Sep 3;17:100247. Epub 2019 May 3.

Department of Psychology, Lund University, Sweden.

Depression is one of the most common health problems worldwide but is often undertreated. Internet-delivered cognitive behavioral therapy (ICBT) appears to be an effective treatment option, with the potential to reach a larger proportion of individuals suffering from depression. While many studies have examined the efficacy of ICBT for depression in randomized controlled trials, fewer have focused on the effectiveness of ICBT when used as an integral part of routine health care. Read More

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September 2019

Changes in pediatric DXA measures of musculoskeletal outcomes and correlation with quantitative CT following treatment of acute lymphoblastic leukemia.

Bone 2018 07 19;112:128-135. Epub 2018 Apr 19.

Department of Pediatrics, The Children's Hospital of Philadelphia, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, United States.

We previously reported significant gains in pQCT measures of tibia trabecular bone mineral density (BMD) and cortical structure following completion of therapy in children and adolescents with acute lymphoblastic leukemia (ALL). The objective of this study was to examine changes in DXA measures used in clinical practice and expressed as Z-scores using robust national reference data. Children and adolescents, ages 5 to 18 years were enrolled within 2 (median 0. Read More

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Romosozumab increases bone mineral density in postmenopausal Japanese women with osteoporosis: A phase 2 study.

Bone 2017 Oct 5;103:209-215. Epub 2017 Jul 5.

Amgen Inc., Thousand Oaks, CA, USA. Electronic address:

Background: Romosozumab is a monoclonal antibody that inhibits sclerostin and rapidly increases bone mineral density (BMD) through a dual effect on bone by increasing bone formation and decreasing bone resorption, as shown in a global phase 2 study in postmenopausal women with low bone mass. Here, we report the key results of a phase 2, double-blind, placebo-controlled, dose-ranging study to assess the efficacy and safety of romosozumab in postmenopausal Japanese women with osteoporosis.

Methods: Participants were postmenopausal Japanese women with osteoporosis aged 55-85years with a lumbar spine, total hip, or femoral neck dual-energy X-ray absorptiometry T-score≤-2. Read More

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October 2017

Genomic copy number variation associated with clinical outcome in canine cutaneous mast cell tumors.

Res Vet Sci 2017 Apr 17;111:26-30. Epub 2016 Nov 17.

Clinical Veterinary Department, College of Agricultural and Veterinary Sciences, São Paulo State University "Júlio de Mesquita Filho" (UNESP), Jaboticabal, São Paulo, Brazil. Electronic address:

Mast cell tumors are the most common malignant cutaneous tumors in dogs. Although there are several prognostic factors involved, the clinical and biological behavior of this type of tumor varies greatly, making the best choice of treatment challenging. Molecular techniques can be used to evaluate a large number of genes involved in the neoplastic process and aid in the selection of candidate genes related to prognostic and predicting factors. Read More

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One year of abaloparatide, a selective peptide activator of the PTH1 receptor, increased bone mass and strength in ovariectomized rats.

Bone 2017 02 25;95:143-150. Epub 2016 Nov 25.

Radius Health, Waltham, MA, USA. Electronic address:

Abaloparatide is a novel 34 amino acid peptide selected to be a potent and selective activator of the parathyroid hormone receptor 1 (PTHR1) signaling pathway. The effects of 12months of abaloparatide treatment on bone mass, bone strength and bone quality was assessed in osteopenic ovariectomized (OVX) rats. SD rats were subjected to OVX or sham surgery at 6months of age and left untreated for 3months to allow OVX-induced bone loss. Read More

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February 2017

Efficacy of automated telephone continuing care following outpatient therapy for alcohol dependence.

Addict Behav 2015 Feb 30;41:223-31. Epub 2014 Oct 30.

Department of Psychiatry, University of Vermont, Burlington, VT 05401, USA.

Background: Relapse rates following cognitive behavioral therapy (CBT) for alcohol dependence are high. Continuing care programs can prolong therapeutic effects but are underutilized. Thus, there is need to explore options having greater accessibility. Read More

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February 2015

A preliminary investigation of the long-term outcome of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders.

Compr Psychiatry 2014 Nov 22;55(8):1920-7. Epub 2014 Jul 22.

Boston University, 648 Beacon Street, 6th floor, Boston, MA 02215, USA. Electronic address:

Objective: The aim of this study is to conduct a preliminary examination of long-term outcomes on a broad range of affective disorder symptoms treated with a newly developed intervention: The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP).

Method: Maintenance of treatment gains at long-term follow-up (LTFU) were explored in patients (N=15, mean age=32.27; 60% female) who completed a clinical trial of the UP. Read More

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November 2014

Bone mineral density changes following discontinuation of ronacaleret treatment: off-treatment extension of a randomized, dose-finding phase II trial.

Bone 2014 Oct 2;67:104-8. Epub 2014 May 2.

GlaxoSmithKline, King of Prussia, PA 19406, USA.

Context: Parathyroidectomy in patients with hyperparathyroidism can produce subsequent increases in bone mineral density (BMD). Ronacaleret, a selective calcium-sensing receptor antagonist that stimulates endogenous parathyroid hormone release, induced mild hyperparathyroidism.

Objective: The aim of this study is to evaluate whether BMD changes after cessation of ronacaleret treatment. Read More

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October 2014

A meta-analysis of nonrandomized effectiveness studies on outpatient cognitive behavioral therapy for adult anxiety disorders.

Clin Psychol Rev 2013 Dec 20;33(8):954-64. Epub 2013 Jul 20.

Department of Clinical Psychology, Johannes Gutenberg University Mainz, Germany. Electronic address:

Objective: The primary aim of this study was to assess the overall effectiveness of individual and group outpatient cognitive behavioral therapy (CBT) for adults with a primary anxiety disorder in routine clinical practice.

Method: We conducted a random effects meta-analysis of 71 nonrandomized effectiveness studies on outpatient individual and group CBT for adult anxiety disorders. Standardized mean gain effect sizes pre- to posttreatment, and posttreatment to follow-up are reported for disorder-specific symptoms, depression, and general anxiety. Read More

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December 2013

Substantial weight gains are common prior to treatment-seeking in obese patients with binge eating disorder.

Compr Psychiatry 2013 Oct 29;54(7):880-4. Epub 2013 Apr 29.

Department of Psychiatry, Yale University School of Medicine, P.O. Box 208098, New Haven, CT 06520-8098, USA. Electronic address:

This study examined weight trajectories in obese patients with binge eating disorder (BED) during the year prior to treatment initiation and explored potential correlates of these weight changes. One hundred thirty (N=130) consecutive, treatment-seeking, obese patients with BED were assessed with structured interviews and self-report questionnaires. Eighty-three percent (83%; n=108) of treatment seeking obese BED patients gained weight, and 65% (n=84) gained a clinically significant amount of weight (greater than or equal to 5% body weight), in the year preceding treatment. Read More

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October 2013

Effectiveness of a novel community-based early intervention model for children with autistic spectrum disorder.

Am J Intellect Dev Disabil 2010 Nov;115(6):504-23

Dalhousie University, Halifax, NS, Canada.

The Nova Scotia early intensive behavior intervention model -NS EIBI ( Bryson et al., 2007 ) for children with autistic spectrum disorders was designed to be feasible and sustainable in community settings. It combines parent training and naturalistic one-to-one behavior intervention employing Pivotal Response Treatment - PRT (R. Read More

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November 2010
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