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Different threshold levels of circulating total and free 25-hydroxyvitamin D for the diagnosis of vitamin D deficiency in obese adolescents.

Eur J Pediatr 2021 Jun 11. Epub 2021 Jun 11.

Department of Biostatistics, Faculty of Medicine, Erciyes University, Kayseri, Turkey.

The total serum 25-hydroxyvitamin D [25(OH)D] level is lower in obese individuals than in their nonobese peers, despite similar bone turnover markers and bone mineral density. This study aimed to investigate whether the threshold level of 25(OH)D for the diagnosis of vitamin D deficiency (VDD) in obese adolescents was lower than that in controls and to compare 25(OH)D, free [25(OH)D] and bioavailable [25(OH)D] vitamin D with VDBP levels in obese individuals and their controls. A total of 173 adolescents (90 obese individuals and 83 controls) aged 12-18 years were included in the study. Read More

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Anterior chamber angle features in primary congenital glaucoma infants using hand-held anterior segment-oct.

Eye (Lond) 2021 Jun 11. Epub 2021 Jun 11.

Faculty of Medicine, Ophthalmology department, Cairo University, Cairo, Egypt.

Purpose: To describe anterior chamber angle (ACA) structures and parameters in primary congenital glaucoma (PCG) and normal infant eyes, using Hand-held anterior segment optical coherence tomography (HH AS-OCT), as an in-office, non-contact technique.

Methods: Normal and PCG-infants <24 months were examined, using HH AS-OCT (RTVue RT- 100, Optovue Inc., Fremont, CA). Read More

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Modular intervention to improve paternal involvement and support for better infant and young child feeding in a district of coastal South India:  a randomized controlled trial protocol.

F1000Res 2021 17;10:121. Epub 2021 Feb 17.

Department of Community Medicine, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India.

: The major determinant to the well-being of infants and young children (IYC) is their feeding practices. These practices are the responsibility of both parents, meaning that fathers have an equal role to mothers. Fathers' involvement can have an impact on the overall health of the children. Read More

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February 2021

Low preoperative skeletal muscle density is predictive for negative postoperative outcomes in older women with ovarian cancer.

Gynecol Oncol 2021 Jun 7. Epub 2021 Jun 7.

Leiden University Medical Center, Leiden University, Department of Medical Oncology, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands.

Objective: To determine the predictive value of lumbar skeletal muscle mass and density for postoperative outcomes in older women with advanced stage ovarian cancer.

Methods: A multicenter, retrospective cohort study was performed in women ≥ 70 years old receiving surgery for primary, advanced stage ovarian cancer. Skeletal muscle mass and density were assessed in axial CT slices on level L3. Read More

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Attitudes of individuals in Eastern Turkey toward epilepsy and the factors associated with these attitudes.

Epilepsy Behav 2021 Jun 7;121(Pt A):108097. Epub 2021 Jun 7.

Department of Nursing, Faculty of Health Sciences, Istanbul Sabahattin Zaim University, Istanbul, Turkey.

Aim: This study was performed to analyze the attitudes of individuals in eastern Turkey toward epilepsy and the factors associated with these attitudes.

Methods: Designed as a cross-sectional descriptive study, this study was performed from January 28 to February 8, 2021. A snowball sampling technique was used to select the study sample, and a survey was sent online to individuals aged 18 or above. Read More

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Assessment of cube-copying among community-dwelling elderly living in Japan using the vertex criterion and parallelism.

Psychogeriatrics 2021 Jun 9. Epub 2021 Jun 9.

Department of Nursing, Kinjo University, Hakusan, Japan.

Background: The cube-copying test is used to assess cognitive function. It is one of the methods used to distinguish healthy older individuals from those with cognitive impairment based on its 3 mm vertex criterion and parallel line errors. We sought to assess how: (1) precisely elderly community-dwelling individuals draw cubes based on two different vertex criteria; and (2) they keep the parallelism of lines. Read More

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COVID-19 lockdown consequences on body mass index and perceived fragility related to physical activity: A worldwide cohort study.

Health Expect 2021 Jun 9. Epub 2021 Jun 9.

Physiological and Psychosocial Stress, LaPSCo, CNRS, Preventive and Occupational Medicine, WittyFit, University Hospital of Clermont-Ferrand, CHU Clermont-Ferrand, Université Clermont Auvergne, Clermont-Ferrand, France.

Background: This paper is a follow-up study continuing the COVISTRESS network previous research regarding health-related determinants.

Objective: The aim was to identify the main consequences of COVID-19 lockdown on Body Mass Index and Perceived Fragility, related to Physical Activity (PA), for different categories of populations, worldwide.

Design: The study design included an online survey, during the first wave of COVID-19 lockdown, across different world regions. Read More

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Adjuvant Aromatase Inhibitors or Tamoxifen following Chemotherapy for Perimenopausal Breast Cancer Patients.

J Natl Cancer Inst 2021 Jun 8. Epub 2021 Jun 8.

Division of Molecular Pathology, Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.

Background: Benefit of adjuvant aromatase inhibitors (AI) versus tamoxifen has been investigated in randomized clinical trials for premenopausal and postmenopausal patients with early, estrogen receptor positive (ER+) breast cancer. The optimal endocrine treatment for chemotherapy-treated perimenopausal women, who generally develop chemotherapy-induced amenorrhea, is uncertain.

Methods: All Dutch women who received adjuvant chemotherapy and endocrine treatment for stage I-III, ER + (>10% positive cells), invasive breast cancer, diagnosed between 2004-2007, were identified through the Netherlands Cancer Registry. Read More

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Association of the CD14 -260C/T polymorphism with plaque-induced gingivitis depends on the presence of Porphyromonas gingivalis.

Int J Paediatr Dent 2021 Jun 7. Epub 2021 Jun 7.

Department of Stomatology, Institution Shared with St. Anne's Faculty Hospital, Faculty of Medicine, Masaryk University, Pekarska 664/53, 65691, Brno, Czech Republic.

Background: Plaque-induced gingivitis is the most prevalent periodontal disease associated with pathogenic biofilms. The host immune system responds to pathogens through pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) and their co-receptor CD14.

Aim: This study investigated the association between the functional polymorphism in the CD14 gene and the dental plaque microbiota in children with gingivitis. Read More

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Effect of topical applications of sunflower seed oil on systemic fatty acid levels in under-two children under rehabilitation for severe acute malnutrition in Bangladesh: a randomized controlled trial.

Nutr J 2021 Jun 6;20(1):51. Epub 2021 Jun 6.

Department of Pediatrics, Stanford University School of Medicine, 1701 Page Mill Road, Room 121, Palo Alto, Stanford, CA, 94304, USA.

Background: Children with severe acute malnutrition (SAM) have inadequate levels of fatty acids (FAs) and limited capacity for enteral nutritional rehabilitation. We hypothesized that topical high-linoleate sunflower seed oil (SSO) would be effective adjunctive treatment for children with SAM.

Methods: This study tested a prespecified secondary endpoint of a randomized, controlled, unblinded clinical trial with 212 children with SAM aged 2 to 24 months in two strata (2 to < 6 months, 6 to 24 months in a 1:2 ratio) at Dhaka Hospital of icddr,b, Bangladesh between January 2016 and December 2017. Read More

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Information meetings on end-of-life care for older people by the general practitioner to stimulate advance care planning: a pre-post evaluation study.

BMC Fam Pract 2021 Jun 7;22(1):109. Epub 2021 Jun 7.

Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam UMC, Location VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, the Netherlands.

Background: To increase knowledge about options people have concerning end-of-life-care issues, General Practitioners (GPs) can organise meetings to inform their older patients. We evaluated these meetings, using the following research questions: How did the attendees experience the information meeting? Was there a rise in Advance Care Planning (ACP) behaviour after the information meeting? Was there a change in trust people have that physicians will provide good care at the end of life and that they will follow their end-of-life wishes after the information meetings?

Methods: Four GPs invited all patients of 75 years and older registered in their GP practices to the meeting via a written letter. Four meetings of 2 h took place in 2016. Read More

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A children's epilepsy diagnosis aid: Development and early validation using a Bayesian approach.

Epilepsy Behav 2021 Jun 3;121(Pt A):108062. Epub 2021 Jun 3.

Visiting Professor of Neurology at Faculty of Medicine -University Of Khartoum, Sudan.

Introduction: The diagnosis of epilepsy in children is difficult and misdiagnosis rates can be as much as 36%. Diagnosis in all countries is essentially clinical, based on asking a series of questions and interpreting the answers. Doctors experienced enough to do this are either scarce or absent in very many parts of the world so there is a need to develop a diagnostic aid to help less-experienced doctors or non-physician health workers (NPHWs) do this. Read More

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A new modified Gant-Miwa-Thiersch combined with submucosal and perirectal sclerosant injection procedure for full-thickness rectal prolapse in elderly women: clinical analysis of 34 cases.

BMC Surg 2021 Jun 5;21(1):284. Epub 2021 Jun 5.

Shanxi Bethune Hospital, Taiyuan, 030012, People's Republic of China.

Background: Full-thickness rectal prolapse (FTRP) frequently occurs in elderly women, and more than 100 surgical procedures have been proposed to restore FTRP. The Gant-Miwa-Thiersch (GMT) procedure is the most used treatment in China. However, the recurrence rate of FTRP post-GMT, which is as high as 23. Read More

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Efficacy of hook-type locking plate and partially threaded cancellous lag screw in the treatment of displaced medial malleolar fractures in elderly patients.

Arch Orthop Trauma Surg 2021 Jun 5. Epub 2021 Jun 5.

Department of Orthopedic Surgery, Eulji University School of Medicine, Uijeongbu Hospital, 712, Dongil-ro, Uijeongbu-si, Gyeonggi-do, 11759, Republic of Korea.

Introduction: Traditionally, partially threaded cancellous lag screws (PTCS) are used for most medial malleolar fractures but are often challenging to execute in elderly patients because of the high risk of postoperative complications. Limited literature explores whether hook-type locking compression plates (LCPs) reliably offer better outcomes than PTCS in elderly patients. We aimed to compare the midterm radiologic and clinical outcomes between hook-type LCP and PTCS for medial malleolar fractures in an elderly population. Read More

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Changes in cannabis, tobacco, and alcohol use among sexually active female adolescents and young adults over a twelve-year period ending in 2019.

Addict Behav 2021 May 24;121:106994. Epub 2021 May 24.

Department of Cancer Prevention & Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA; Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address:

Background: The United States has experienced an increasing divergence in cannabis, tobacco, and alcohol use among adolescents and young adults (AYA). We assessed the changes in cannabis, tobacco and alcohol use in an inner-city population of predominantly minority AYA females attending a large adolescent-specific health center in New York City.

Methods: This was a longitudinal study of AYA women recruited and followed over a twelve-year period between 2007 and 2019. Read More

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Cannabis and mental health: Prevalence of use and modes of cannabis administration by mental health status.

Addict Behav 2021 May 19;121:106991. Epub 2021 May 19.

School of Public Health & Health Systems, University of Waterloo, ON N2L 3G1, Canada. Electronic address:

Background: Cannabis can have an adverse impact on some mental health conditions, while many consumers report using cannabis to manage or improve mental health. Little data exists on how patterns of cannabis use differ by mental health status. The current study examined the prevalence of cannabis use and modes of cannabis administration among consumers who experienced a mental health condition in the past 12-months. Read More

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Tetrahydrocannabinol (THC)-containing e-cigarette, or vaping, product use behaviors among adults after the onset of the 2019 outbreak of e-cigarette, or vaping, product use-associated lung injury (EVALI).

Addict Behav 2021 May 14;121:106990. Epub 2021 May 14.

National Center for Chronic Disease Prevention and Health Promotion, CDC, United States.

Introduction: During the E-cigarette, or Vaping, Product Use-Associated Lung Injury (EVALI) outbreak, patient data on tetrahydrocannabinol (THC)-containing e-cigarette, or vaping, product (EVP) use was collected, but data on non-affected adult product use after the onset of the EVALI outbreak is limited. This study describes adult THC-EVP use after EVALI began.

Methods: THC-EVP use data came from an 18-state web-based panel survey of adult THC- and nicotine-containing EVP users conducted February 2020. Read More

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Impact of School Closures due to COVID-19 on Children with Neurodevelopmental Disorders in Japan.

J Autism Dev Disord 2021 Jun 3. Epub 2021 Jun 3.

Department of Pediatrics and Neonatology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, 467-8601, Japan.

In March 2020, many schools were closed to prevent the spread of COVID-19 in Japan, and it is predicted that many children, especially those with neurodevelopmental disorders (NDDs), will be affected emotionally and behaviorally. Here, we examined the impact of school closures due to COVID-19 on school-aged children with NDDs using the Child Behavior Checklist. Totally, data on 121 children diagnosed with autism spectrum disorder, attention-deficit hyperactivity disorder, and/or intellectual disorder were analyzed and it was found that externalizing and aggressive behavior increased in all NDDs, regardless of the type of diagnosis. Read More

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Improved sleep efficiency is associated with reduced cardio-metabolic risk: Findings from the MODERN trial.

J Sleep Res 2021 Jun 2:e13389. Epub 2021 Jun 2.

Pre-Clinical Disease and Prevention, Baker Heart and Diabetes Institute, Melbourne, Vic, Australia.

Poor sleep increases cardio-metabolic risk, but limited information on the impact of sleep for the improvement of cardio-metabolic health exists. This analysis examined the impact of sleep on a health and lifestyle modification programme to reduce cardio-metabolic disease risk factors. Secondary analysis of the MODERN randomised controlled trial to reduce cardio-metabolic risk was undertaken at baseline and 24-month follow-up. Read More

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[Sleep apnea syndrome, pregnancy and fetal condition].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(4. Vyp. 2):103-109

Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.

Objective: To assess fetal cardiac activity with simultaneous polysomnographic (PSG) study of pregnancy with obstructive sleep apnea syndrome (OSAS).

Materials And Methods: Forty-nine women, aged 18-30 years, 30-34 weeks pregnant, complaining of snoring, with a positive rating in 2 and/or 3 sections of the Berlin Sleep Questionnaire were included in the study. Sixteen pregnant women with the corresponding gestational age, without complaints of snoring, made up the control group. Read More

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[Self-reported sleep and wake disorders in patients with ostheoarthrosis and end-stage renal disease].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(4. Vyp. 2):80-91

Sechenov Institute of Evolutionary Physiology and Biochemistry of RAS, St. Petersburg, Russia.

Objective: This study aimed to assess subjective sleep and wake disorders (SWD) in patients with osteoarthritis and comorbid end-stage renal disease (ESRD) receiving hemodialysis (ESRD-HD) compared to patients with osteoarthritis and without chronic kidney disease (CKD) as well as to clarify of the association of subjective sleep characteristics with the levels of anxiety and depression and pain, general health score and laboratory parameters in these cohorts.

Material And Methods: This pilot case-control study included the patients with stage III hip osteoarthritis with ESRD-HD (=19) and without CKD (=19) aged 18-85 years. The patients received the consultations of orthopedic surgeon and internal medicine specialist with anthropometry and clinical and biochemical blood tests. Read More

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[Periodic limb movements in sleep and clinicomorphological features of cerebral small vessel disease].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(4. Vyp. 2):75-79

Sechenov First Moscow State Medical University, Moscow, Russia.

Objective: To search for the association between white matter deterioration extend as well as related cognitive dysfunction and periodic limb movements in sleep (PLMS) in patients with cerebral small vessel disease (cSVD).

Material And Methods: Thirty-four subjects with cSVD were enrolled (12 men, 22 women, average age 66.9 y. Read More

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[COVID-19 effect on mental health and sleep disorders].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(4. Vyp. 2):49-54

Central State Medical Academy of Department of Presidential Affairs, Moscow, Russia.

Purpose Of The Study: To study the prevalence of anxiety-depressive disorders and sleep disorders in their structure among patients hospitalized in connection with COVID-19, as well as to develop differentiated recommendations for their therapy in patients with new coronavirus infection.

Material And Methods: In this publication, the authors present preliminary results of their own observations of psychoemotional disorders and sleep disorders in their structure in patients with a new coronavirus infection. We analyzed the data of 119 patients (aged 47 to 69 years, male and female), conducted a detailed interview, including using telemedicine technologies, and assessed the scales: The hospital Anxiety and Depression Scale (HADS), subjective the asthenia rating scale (MFI-20, Multidimensional Fatigue Inventory) and the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Read More

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[Psychological factors of sleep and daytime complaints during the COVID-19 Lockdown: the role of anxiety, well-being, autonomy, and coping].

Authors:
E I Rasskazova

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(4. Vyp. 2):24-30

Lomonosov Moscow State University, Moscow, Russia.

Objective: To reveal psychological (anxiety, coping with pandemic stress, autonomy) and behavioral (compliance with recommendations, monitoring information) factors associated with complaints of sleep and daytime functioning disturbances during the lockdown period in the spring of 2020.

Material And Methods: Two hundred and three adults (106 men and 97 women), aged 18 to 59 years, participated in the study. Participants filled the questionnaires 1-2 weeks after the start of the lockdown and 3-4 weeks after the first measurement. Read More

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[Eating behavior, sleep self-assessment and personality traits of students with extreme chronotypes].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(4. Vyp. 2):19-23

North Caucasus Federal University, Stavropol, Russia.

Objective: To identify the differences in eating behavior, sleep self-assessment and personality traits in students with extreme chronotypes.

Material And Methods: Students (=350), aged 17 to 23 years, with extreme chronotypes (owls/larks) were studied. Eating behavior was assessed with the Three-Factor Eating Questionnaire (TFEQ-R18). Read More

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Effects of a short eight Tai Chi-forms for the pre-frail elderly people in senior living communities.

Physiother Theory Pract 2021 Jun 2:1-9. Epub 2021 Jun 2.

Rehabilitation Department, North China University of Science and Technology, Tangshan City, Hebei Province, China.

: To investigate effects of a short 8-form Tai Chi exercise on physical function, fear of falling, and depression in pre-frail elderly people living in senior communities. : This 8-week randomized controlled trial was conducted in senior living communities with qualified pre-frail elderly subjects in a Tai Chi group (TCG, n= 32) and a control group (CG, n = 33). The TCG received TC intervention: three times/week, 60 min each; while the CG did usual care only. Read More

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Is it safe to perform elective orthopaedic surgery with high community rates of COVID-19? An observational cohort study.

Ann R Coll Surg Engl 2021 Jun;103(6):415-419

University Hospitals Birmingham NHS Foundation Trust, UK.

Introduction: During the first wave of the COVID-19 pandemic, University Hospitals Birmingham NHS Foundation trust was able to recommence elective orthopaedic surgery using private hospitals procured by the NHS as COVID-19 free 'green' sites. We report on the safety of elective orthopaedic surgery with high rates of community transmission.

Methods: We conducted an observational cohort study on consecutive NHS patients attending three private hospitals between 4 May 2020 and 16 June 2020. Read More

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High flow nasal cannula oxygenation in COVID-19 related acute respiratory distress syndrome: a safe way to avoid endotracheal intubation?

Ther Adv Respir Dis 2021 Jan-Dec;15:17534666211019555

Service de médecine interne, maladie infectieuse et hématologie, Centre Hospitalier Bretagne Atlantique, Vannes, France.

Backgrounds: High flow nasal cannula (HFNC) is an alternative therapy for acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19). This study aimed first to describe outcomes of patients suffering from COVID-19-related ARDS treated with HFNC; secondly to evaluate safety of HFNC (patients and healthcare workers) and compare patients according to respiratory outcome.

Methods: A retrospective cohort was conducted in French general hospital intensive care unit (ICU). Read More

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Effect of Moderately but Persistently Elevated Lipid Levels on Risks of Stroke and Myocardial Infarction in Young Korean Adults.

J Am Heart Assoc 2021 May 31:e020050. Epub 2021 May 31.

Department of Internal Medicine Seoul National University College of Medicine Seoul Republic of Korea.

Background Identifying predictive markers for future atherosclerotic cardiovascular diseases may be helpful to motivate young adults to promote healthy lifestyle. We sought to determine the association between persistently elevated low-density lipoprotein-cholesterol (LDL-C) and/or triglyceride levels and the atherosclerotic cardiovascular diseases risks in young adults. Methods and Results We conducted a nationwide population-based cohort study of 1 887 853 statin-naive adults aged 20 to 39 years, with LDL-C <190 mg/dL, using the Korean National Health Insurance Service database. Read More

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Patient satisfaction following total knee arthroplasty using restricted kinematic alignment.

Bone Joint J 2021 Jun;103-B(6 Supple A):59-66

Department of Orthopaedic Surgery, University of Louisville, Louisville, Kentucky, USA.

Aims: Alternative alignment concepts, including kinematic and restricted kinematic, have been introduced to help improve clinical outcomes following total knee arthroplasty (TKA). The purpose of this study was to evaluate the clinical results, along with patient satisfaction, following TKA using the concept of restricted kinematic alignment.

Methods: A total of 121 consecutive TKAs performed between 11 February 2018 to 11 June 2019 with preoperative varus deformity were reviewed at minimum one-year follow-up. Read More

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