4,176 results match your criteria 111 glucose


Effect of selenium supplementation on musculoskeletal health in older women: a randomised, double-blind, placebo-controlled trial.

Lancet Healthy Longev 2021 Apr;2(4):e212-e221

Mellanby Centre for Musculoskeletal Research, University of Sheffield, Northern General Hospital, Sheffield, UK.

Background: Observational and preclinical studies show associations between selenium status, bone health, and physical function. Most adults in Europe have serum selenium below the optimum range. We hypothesised that selenium supplementation could reduce pro-resorptive actions of reactive oxygen species on osteoclasts and improve physical function. Read More

View Article and Full-Text PDF

The Relationship between the Concentration of Magnesium and the Presence of Depressive Symptoms and Selected Metabolic Disorders among Men over 50 Years of Age.

Life (Basel) 2021 Mar 3;11(3). Epub 2021 Mar 3.

Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University, 70-210 Szczecin, Poland.

Background: changes in the concentration of magnesium influence numerous processes in the body, such as hormone and lipid metabolism, nerve conduction, a number of biochemical pathways in the brain, and metabolic cycles. As a result, changes in magnesium concentration may contribute to the emergence of such pathologies as depressive and metabolic disorders, including hypertension, diabetes, and dyslipidemia.

Methods: blood samples were taken from 342 men whose mean age was 61. Read More

View Article and Full-Text PDF

The Influence of Biologically Active Substances Secreted by the Adipose Tissue on Endometrial Cancer.

Diagnostics (Basel) 2021 Mar 11;11(3). Epub 2021 Mar 11.

Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.

Endometrial cancer is one of the most frequently diagnosed gynecological neoplasms in developed countries and its incidence is rising. Usually, it is diagnosed in the early stages of the disease and has a good prognosis; however, in later stages, the rate of recurrence reaches up to 60%. The discrepancy in relapse rates is due to the heterogeneity of the group related to the presence of prognostic factors affecting survival parameters. Read More

View Article and Full-Text PDF

Ginsenoside derivatives inhibit advanced glycation end-product formation and glucose-fructose mediated protein glycation in vitro via a specific structure-activity relationship.

Bioorg Chem 2021 Mar 22;111:104844. Epub 2021 Mar 22.

Department of Biotechnology and Genetic Engineering, Islamic University, Kushtia 7003, Bangladesh.

Ginseng (Panax ginseng and red ginseng) extract has been reported to inhibit the formation of advanced glycation end-products (AGEs); however, the potential inhibitory activity of its major constituents (ginsenosides) against AGE formation is still unknown. In the present study, we investigated the inhibitory effect of ginsenoside derivatives on AGE formation. Herein, we assessed the activity of 22 ginsenosides, most of which significantly inhibited fluorescent AGE formation. Read More

View Article and Full-Text PDF

Common biomarkers of physiologic stress and associations with delirium in patients with intracerebral hemorrhage.

J Crit Care 2021 Mar 23;64:62-67. Epub 2021 Mar 23.

Department of Neurology, Brown University, Alpert Medical School, Providence, RI, USA.

Purpose: To examine associations between physiologic stress and delirium in the setting of a direct neurologic injury.

Materials And Methods: We obtained initial neutrophil-to-lymphocyte ratio (NLR), glucose, and troponin in consecutive non-comatose patients with non-traumatic intracerebral hemorrhage (ICH) over 1 year, then used multivariable regression models to determine associations between each biomarker and incident delirium. Delirium diagnoses were established using DSM-5-based methods, with exploratory analyses further categorizing delirium as first occurring <24 h ("early-onset") or > 24 h after presentation ("later-onset"). Read More

View Article and Full-Text PDF

Modulations of obesity-related microRNAs after exercise intervention: a systematic review and bioinformatics analysis.

Mol Biol Rep 2021 Mar 27. Epub 2021 Mar 27.

Departments of Molecular Genetics, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran.

Obesity is one of the prevalent health-threatening conditions; however, it is preventable by lifestyle interventions such as exercise. The molecular mechanisms underlying physiological adaptation to physical activity are not fully understood. It has been documented that both intracellular and extracellular (circulating) microRNAs (miRNAs) are involved in both obesogenic and exercise adaptation mechanisms. Read More

View Article and Full-Text PDF

In vitro fermentation characteristics of polysaccharide from Sargassum fusiforme and its modulation effects on gut microbiota.

Food Chem Toxicol 2021 Mar 23;151:112145. Epub 2021 Mar 23.

Faculty of Food Technology & Biotechnology, University of Zagreb, Prolaz Kasandrića 6, 23000 Zadar, Croatia.

In this study, polysaccharides from Sargassum fusiforme (SFP) were obtained by cellulase assisted hot water extraction. The chemical composition, structural characteristics, and in vitro fermentation properties of SFP were investigated. Results showed that the contents of total carbohydrate, protein, uronic acid and sulfate in SFP were 83. Read More

View Article and Full-Text PDF

Outcome Goals and Health Care Preferences of Older Adults With Multiple Chronic Conditions.

JAMA Netw Open 2021 Mar 1;4(3):e211271. Epub 2021 Mar 1.

Center for Innovations in Quality, Effectiveness and Safety (CIN 13-413), Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas.

Importance: Older adults with multiple chronic conditions (MCCs) vary in their health outcome goals and the health care that they prefer to receive to achieve these goals.

Objective: To describe the outcome goals and health care preferences of this population with MCCs.

Design, Setting, And Participants: This cross-sectional study included participants in the Patient Priorities Care study who underwent health priorities identification from February 1, 2017, to August 31, 2018, in a primary care practice. Read More

View Article and Full-Text PDF

Inhibitory Effect of Paeonol on Apoptosis, Oxidative Stress, and Inflammatory Response in Human Umbilical Vein Endothelial Cells Induced by High Glucose and Palmitic Acid Induced Through Regulating SIRT1/FOXO3a/NF-κB Pathway.

J Interferon Cytokine Res 2021 Mar;41(3):111-124

Department of Research, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.

Reactive oxygen species (ROS) induced by high glucose and high fat of diabetes mellitus (DM) finally caused the occurrence and progression of atherosclerosis and other macrovascular complications. Paeonol (Pae) exhibits anti-inflammation, antioxidation, and antiatherosclerosis activities. However, the role of Pae in diabetic cardiopathy has not been fully understood. Read More

View Article and Full-Text PDF

Metabolic Effects of Growth Hormone Treatment in Short Prepubertal Children: A Double-Blinded Randomized Clinical Trial.

Horm Res Paediatr 2021 Mar 8:1-10. Epub 2021 Mar 8.

Department of Women's and Children's Health, Division of Pediatric Endocrinology, Karolinska Institutet, Stockholm, Sweden.

Introduction: Growth hormone (GH) is a central hormone for regulating linear growth during childhood and also highly involved in the metabolism of lipids, carbohydrates, and protein. However, few studies report on how treatment with GH during childhood influences metabolic parameters. Our aim was to investigate metabolic effects of different doses of GH in short children with GH peak levels in the low to normal range. Read More

View Article and Full-Text PDF

Body composition in term offspring after maternal gestational diabetes does not predict postnatal hypoglycemia.

BMC Pediatr 2021 Mar 6;21(1):111. Epub 2021 Mar 6.

Department of Neonatology, University Children's Hospital, Eberhard Karls University, Calwerstr. 7, 72076, Tuebingen, Germany.

Background: Offspring of mothers with gestational diabetes mellitus (GDM) have an increased risk of neonatal complications like birth trauma due to macrosomia or postnatal hypoglycemia, as well as long-term metabolic sequelae. Neonatal body composition may be a sensitive marker of metabolic effects on the fetus caused by suboptimal glycemic control during pregnancy.

Objective: To determine body composition in offspring of mothers with GDM compared to a reference cohort of healthy term neonates and to assess whether increased body fat would be associated with postnatal hypoglycemia. Read More

View Article and Full-Text PDF

Monitoring the Impact of Aggressive Glycemic Intervention during Critical Care after Cardiac Surgery with a Glycemic Expert System for Nurse-Implemented Euglycemia: The MAGIC GENIE Project.

J Diabetes Sci Technol 2021 Mar;15(2):251-264

Division of Endocrinology, Medicine Service Line, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA.

A novel, multi-dimensional protocol named GENIE has been in use for intensive insulin therapy (IIT, target glucose <140 mg/dL) in the surgical intensive care unit (SICU) after open heart surgery (OHS) at VA Pittsburgh since 2005. Despite concerns over increased mortality from IIT after the publication of the NICE-SUGAR Trial, it remains in use, with ongoing monitoring under the MAGIC GENIE Project showing that GENIE performance over 12 years (2005-2016) aligns with the current consensus that IIT with target blood glucose (BG) <140 mg/dL is advisable only if it does not provoke severe hypoglycemia (SH). Two studies have been conducted to monitor glucometrics and outcomes during GENIE use in the SICU. Read More

View Article and Full-Text PDF

A beneficial cardiometabolic health profile associated with dietary supplement use: A cross-sectional study.

Int J Vitam Nutr Res 2021 Mar 1:1-11. Epub 2021 Mar 1.

Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.

As a follow-up to an earlier study demonstrating healthier cardiometabolic profiles among long-term multiple dietary supplement (LTMDS) users, we examined if cardiometabolic health benefits associated with LTMDS use persisted with aging. The study is based on LTMDS users from North America and 2007-2010 NHANES participants who were used for comparison to the LTMDS users. NHANES subjects were classified as non-dietary supplement (NS) users, single supplement/single purpose supplement (SS) users, multivitamin/mineral supplement (MVMS) users, and multiple dietary supplement (MDS) users. Read More

View Article and Full-Text PDF

Clinical and metabolomic predictors of regression to normoglycemia in a population at intermediate cardiometabolic risk.

Cardiovasc Diabetol 2021 Feb 27;20(1):56. Epub 2021 Feb 27.

Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, 100 Cambridge, Boston, MA, USA.

Background: Impaired fasting glucose (IFG) is a prevalent and potentially reversible intermediate stage leading to type 2 diabetes that increases risk for cardiometabolic complications. The identification of clinical and molecular factors associated with the reversal, or regression, from IFG to a normoglycemia state would enable more efficient cardiovascular risk reduction strategies. The aim of this study was to identify clinical and biological predictors of regression to normoglycemia in a non-European population characterized by high rates of type 2 diabetes. Read More

View Article and Full-Text PDF
February 2021

Is the NHS Diabetes Prevention Programme Intervention Delivered as Planned? An Observational Study of Fidelity of Intervention Delivery.

Ann Behav Med 2021 Feb 13. Epub 2021 Feb 13.

Manchester Centre of Health Psychology, Division of Psychology and Mental Health, University of Manchester, Manchester, UK.

Background: The NHS Diabetes Prevention Programme (NHS-DPP) has been delivered by four commercial organizations across England, to prevent people with impaired glucose tolerance developing Type 2 diabetes. Evidence reviews underpinning the NHS-DPP design specification identified 19 Behavior Change Techniques (BCTs) that are the intervention "active ingredients." It is important to understand the discrepancies between BCTs specified in design and BCTs actually delivered. Read More

View Article and Full-Text PDF
February 2021

Identifying Risk Factors for Diabetic Ketoacidosis Associated with SGLT2 Inhibitors: a Nationwide Cohort Study in the USA.

J Gen Intern Med 2021 Feb 9. Epub 2021 Feb 9.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Suite 3030, Boston, MA, 02120, USA.

Introduction: Sodium glucose co-transporter-2 inhibitors (SGLT2) are commonly prescribed to patients with type 2 diabetes mellitus, but can increase the risk of diabetic ketoacidosis. Identifying patients prone to diabetic ketoacidosis may help mitigate this risk.

Methods: We conducted a population-based cohort study of adults initiating SGLT2 inhibitor use from 2013 through 2017. Read More

View Article and Full-Text PDF
February 2021

The potential of the oleaginous yeast Rhodotorula paludigena CM33 to produce biolipids.

J Biotechnol 2021 Mar 4;329:56-64. Epub 2021 Feb 4.

School of Biotechnology, Institute of Agricultural Technology, Suranaree University of Technology, 111 University Avenue, Suranaree Sub-district, Muang District, Nakhon Ratchasima, 30000, Thailand. Electronic address:

Sixty-seven yeast strains were isolated from castor beans then their endogenous lipids were stained by Nile Red (NR) fluorescence dye, and flow cytometry was used to obtain a strain with a high relative mean fluorescence intensity (MFI) value. The highest MFI value was obtained for strain CM33, which produced a maximum lipid content of 20.8 % dry cell weight (DCW). Read More

View Article and Full-Text PDF

Maternal obesity influences Birth Weight more than gestational Diabetes author.

Authors:
Eman M Alfadhli

BMC Pregnancy Childbirth 2021 Feb 6;21(1):111. Epub 2021 Feb 6.

Medicine department, Taibah University Medical College, PO Box 344, Girls section. Universities Road, T 0966555305170, Medina, Saudi Arabia.

Background: Maternal obesity and gestational diabetes (GDM) are commonly encountered during pregnancy. Both conditions are independently associated with unfavorable pregnancy consequences. The objective of this study was to compare the effects of obesity and GDM on birth weight, macrosomia, and other adverse pregnancy outcomes. Read More

View Article and Full-Text PDF
February 2021

Exosomal microRNA-22-3p alleviates cerebral ischemic injury by modulating KDM6B/BMP2/BMF axis.

Stem Cell Res Ther 2021 Feb 5;12(1):111. Epub 2021 Feb 5.

Department of Neurology, Affiliated Hospital of Chengdu University, Chengdu, 610081, People's Republic of China.

Background: Cerebral ischemia-reperfusion (I/R) injury, the most common form of stroke, has high mortality and often brings persistent and serious brain dysfunction among survivors. Administration of adipose-derived mesenchymal stem cells (ASCs) has been suggested to alleviate the I/R brain injury, but the mechanism remains uncharacterized. Here, we aimed at investigating the mechanism of ASCs and their extracellular vesicles (EVs) in the repair of or protection from I/R injury. Read More

View Article and Full-Text PDF
February 2021

Glucose-6-Phosphate Isomerase FgGPI, a β Tubulin-Interacting Protein, Is Indispensable for Fungal Development and Deoxynivalenol Biosynthesis in .

Phytopathology 2021 Mar 4;111(3):531-540. Epub 2021 Feb 4.

College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China.

Glucose-6-phosphate isomerase (GPI) is ubiquitous in most organisms, catalyzing the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. In this study, we investigated biological and genetic functions of in the phytopathogen . We found that hyphal growth, conidial germination, and septa formation were significantly inhibited in deletion mutant ∆FgGPI. Read More

View Article and Full-Text PDF

[Clinical characteristics of viral pneumonia in patients with chronic obstructive pulmonary disease].

Zhonghua Jie He He Hu Xi Za Zhi 2021 Feb;44(2):88-95

Department of Laboratory Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing 100730,China.

To study the clinical and etiological characteristics of viral pneumonia in patients with chronic obstructive pulmonary disease(VP-COPD), and to identify the risk factors associated with poor prognosis. From August 1, 2017 to August 1, 2019, totally 235 patients in a general hospital in Beijing were prospectively enrolled in this research, and all patients were diagnosed with viral pneumonia by imaging and etiology. The patients were divided into VP-COPD group(=60) and VP-nCOPD(viral pneumonia in non-COPD patients) group(=175). Read More

View Article and Full-Text PDF
February 2021

Glucose, lipid and oxidative stress lowering activity of the aqueous extract from leafy stems of Gilg & Brandt in dexamethasone-induced hyperglycemia in rats.

J Diabetes Metab Disord 2020 Dec 9;19(2):1527-1535. Epub 2020 Nov 9.

Department of Animal Biology, Faculty of Sciences, University of Dschang, Dschang, Cameroon.

Background: Diabetes mellitus is a metabolic disorder characterised by chronic hyperglycemia. The present research work aimed to evaluate the hypoglycaemic, hypolipidemic and antioxidant effects of leafy stems of Gilg & Brandt in insulin resistant rats.

Methods: The oral glucose tolerance test (OGTT) was performed in normal rats. Read More

View Article and Full-Text PDF
December 2020

The Postnatal Offspring of Finasteride-Treated Male Rats Shows Hyperglycaemia, Elevated Hepatic Glycogen Storage and Altered GLUT2, IR, and AR Expression in the Liver.

Int J Mol Sci 2021 Jan 27;22(3). Epub 2021 Jan 27.

Department of Histology and Embryology, Pomeranian Medical University (PMU), Powstańców Wlkp. 72 Avene, 70-111 Szczecin, Poland.

Background: A growing body of data indicates that the physiology of the liver is sex-hormone dependent, with some types of liver failure occurring more frequently in males, and some in females. In males, in physiological conditions, testosterone acts via androgen receptors (AR) to increase insulin receptor (IR) expression and glycogen synthesis, and to decrease glucose uptake controlled by liver-specific glucose transporter 2 (GLUT-2). Our previous study indicated that this mechanism may be impaired by finasteride, a popular drug used in urology and dermatology, inhibiting 5α-reductase 2, which converts testosterone (T) into dihydrotestosterone (DHT). Read More

View Article and Full-Text PDF
January 2021

Evaluation of oral dextrose gel for prevention of neonatal hypoglycemia (hPOD): A multicenter, double-blind randomized controlled trial.

PLoS Med 2021 Jan 28;18(1):e1003411. Epub 2021 Jan 28.

Newborn Services, Auckland City Hospital, Auckland, New Zealand.

Background: Neonatal hypoglycemia is common and can cause brain injury. Buccal dextrose gel is effective for treatment of neonatal hypoglycemia, and when used for prevention may reduce the incidence of hypoglycemia in babies at risk, but its clinical utility remains uncertain.

Methods And Findings: We conducted a multicenter, double-blinded, placebo-controlled randomized trial in 18 New Zealand and Australian maternity hospitals from January 2015 to May 2019. Read More

View Article and Full-Text PDF
January 2021

Leptin ameliorates testicular injury by altering expression of nitric oxide synthases in diabetic rats.

Bratisl Lek Listy 2021 ;122(2):111-115

Objectives: We aimed to evaluate the effects of leptin and nitro-L-arginine methyl ester hydrochloride (L-NAME) on testicular damage and expression of nitric oxide synthase (NOS) types (neuronal, endothelial and inducible NOS) in streptozotocin (STZ) -induced diabetic and non-diabetic rats.

Methods: Testicular damage was evaluated histologically and expression of NOSs was evaluated immunohistochemically in testis. Plasma leptin level and blood glucose level were assessed. Read More

View Article and Full-Text PDF
February 2021

Preoperatively Treated Diffuse-Type Gastric Adenocarcinoma: Glucose vs. Other Energy Sources Substantially Influence Prognosis and Therapy Response.

Cancers (Basel) 2021 Jan 23;13(3). Epub 2021 Jan 23.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Diffuse type of gastric adenocarcinoma (dGAC) generally confers a poor prognosis compared to intestinal type. Some dGACs are not avid on fluorine-18 fluoro-2-deoxy-D-glucose PET (FDG-PET) while others seem to consume glucose avidly. We analyzed the outcomes based on the avidity (high with standardized uptake value (SUV) > 3. Read More

View Article and Full-Text PDF
January 2021

The triglycerides and glucose index is strongly associated with hepatic steatosis in children with overweight or obesity.

Eur J Pediatr 2021 Jan 25. Epub 2021 Jan 25.

Unidad de Investigación Biomédica, Delegación Durango, Instituto Mexicano del Seguro Social, Durango, Mexico.

Given the worldwide increase prevalence of overweight, obesity, and nonalcoholic fatty liver disease (NAFLD), the objective of this study was to evaluate whether the triglycerides and glucose (TyG) index is associated with hepatic steatosis in children with overweight or obesity. Apparently healthy children aged 5‑17 years were included and allocated into the groups with and without hepatic steatosis. The TyG index was calculated as Ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)]/2. Read More

View Article and Full-Text PDF
January 2021

Study on a novel spherical polysaccharide from Fructus Mori with good antioxidant activity.

Carbohydr Polym 2021 Mar 16;256:117516. Epub 2020 Dec 16.

School of Food Science and Engineering, South China University of Technology, 381 Wushan Road, Guangzhou, 510640, China; SCUT-Zhuhai Institute of Modern Industrial Innovation, Zhuhai, 519715, China; Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, Guangzhou, 510640, China; Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center), Guangzhou, 510640, China. Electronic address:

A novel polysaccharide (MFP1P) was isolated from Fructus Mori, followed by purification via DEAE-52 cellulose and 27 % ethanol fraction. The MFP1P had the molecular weight of 56.78 kDa and the total sugar content of 93. Read More

View Article and Full-Text PDF

Antioxidant, Anti-Inflammatory and Antidiabetic Proprieties of LC-MS/MS Identified Polyphenols from Coriander Seeds.

Molecules 2021 Jan 18;26(2). Epub 2021 Jan 18.

Laboratory of Biotechnology, Environment, Agrifood, and Health, University of Sidi Mohamed Ben Abdellah, FSDM-Fez 47963, Morocco.

L. seeds are traditionally used to treat diabetes and its complications (inflammation and formation of reactive oxygen species) around the world. The present study investigates the antidiabetic, anti-inflammatory, and antioxidant effects of the polyphenol fraction of seeds (PCS). Read More

View Article and Full-Text PDF
January 2021