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A rapid UPLC-MS/MS method for the quantification of daidzein, its valine carbamate prodrug, and glucuronide in rat plasma samples: Comparison of the pharmacokinetic behavior of daidzine valine carbamate prodrugs.

J Sep Sci 2021 Aug 4. Epub 2021 Aug 4.

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.

Two valine carbamate prodrugs of daidzein were designed to improve its bioavailability. To compare the pharmacokinetic behavior of these prodrugs with different protected phenolic hydroxyl groups of daidzein, a rapid and sensitive method for simultaneous quantification of daidzein, its valine carbamate prodrug, and daidzein-7-O-glucuronide in rat plasma was developed and validated in this study. The samples were processed using a fast one-step protein precipitation method with methanol added to 50 μL of plasma and were analyzed by ultra-high performance liquid chromatography with tandem mass spectrometry. Read More

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Monitoring geographical differences in illicit drugs, alcohol, and tobacco consumption via wastewater-based epidemiology: Six major cities in Turkey.

Sci Total Environ 2021 Jul 20;797:149156. Epub 2021 Jul 20.

Istanbul University-Cerrahpaşa, Institute of Forensic Sciences and Legal Medicine, Department of Medicine, Buyukcekmece, 34500 Istanbul, Turkey.

A national wastewater-based epidemiology (WBE) monitoring campaign has been initiated to determine the trends in drug consumption in Turkey since 2019. This study aimed to present the wastewater monitoring results for four periods in 2019 for six major cities with 17 wastewater treatment plants. The study investigated heroin (HER), amphetamine (AMP), methamphetamine (METH), cocaine (COC), 3,4-methylenedioxymethamphetamine (MDMA), cannabis, alcohol, and tobacco to understand the temporal and geographical drug consumption trends. Read More

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Changes in Invasiveness and Latent Infection Rate Associated with Switching the Approach in Total Hip Replacement.

Clin Med Insights Arthritis Musculoskelet Disord 2021 13;14:11795441211031340. Epub 2021 Jul 13.

Department of Orthopedic Surgery, Akita University Graduate School of Medicine, Akita, Japan.

Purpose: Muscle-sparing approaches for total hip replacement (THR) involve learning curves. This study aimed to clarify changes in invasiveness and infection rate with changes in approach.

Methods: One surgeon changed the approach of THR from Dall's approach (Dall) to anterolateral modified Watson-Jones approach (OCM). Read More

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A 13-Year-Old With Fever and Chest Pain.

Pediatrics 2021 Aug 3. Epub 2021 Aug 3.


A 13-year-old boy with a recent diagnosis of ulcerative colitis presented with fever and chest pain to the emergency department. The sharp pain had begun 2 days previous and radiated to his shoulders. It was constant, although it improved with sitting up and leaning forward. Read More

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Early recovery of basic mobility under femoral nerve block after hip fracture surgery - A propensity score matched pilot study.

Injury 2021 Jul 23. Epub 2021 Jul 23.

Department of Orthopedic Surgery, Suwa Central Hospital, 4300 Tamagawa, Chino, Nagano 391-8503, Japan. Electronic address:

Background: Previous studies have shown better pain reduction utilizing femoral nerve block (FNB) in patients who underwent hip fracture surgery. However, few studies have focused on the recovery of physical function after FNB, and most studies excluded patients with dementia. We investigated the association between FNB performed in the operating room and the recovery of physical function after hip fracture surgery, including patients with dementia. Read More

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Ambit-SLN: an Open Source Software Library for Processing of Chemical Objects via SLN Linear Notation.

Mol Inform 2021 Aug 3. Epub 2021 Aug 3.

University of Plovdiv, Faculty of Chemistry, Department of Analytical Chemistry and Computer Chemistry, 24 Tsar Assen Str., 4000, Plovdiv, Bulgaria.

SLN (SYBYL Line Notation) is the most comprehensive and rich linear notation for representation of chemical objects of various kinds facilitating a wide range of cheminformatics algorithms. Though, it is not the most popular linear notation nowadays, SLN has capabilities for supporting the most challenging tasks of the present day cheminformatics research. We present Ambit-SLN, a new software library for cheminformatics processing of chemical objects via linear notation SLN. Read More

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Incremental Prognostic Value of Coronary Artery Calcium Score for Predicting All-Cause Mortality after Transcatheter Aortic Valve Replacement.

Radiology 2021 Aug 3:204623. Epub 2021 Aug 3.

From the Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland (M.E., R.H., A.L.N.S., A.E., R.M., H.A.); Department of Cardiology, University Heart Center Zurich (N.K., B.E.S., A.M.K., R.M., F.C.T.), and Epidemiology, Biostatistics and Prevention Institute (K.R.), University of Zurich, Zurich, Switzerland; and Institute for Biomedical Engineering, Swiss Federal Institute of Technology in Zurich (ETH), Zurich, Switzerland (R.M.).

Background Current risk models show limited performances for predicting all-cause mortality after transcatheter aortic valve replacement (TAVR). Purpose To determine the prognostic value of coronary artery calcium (CAC) scoring for predicting 30-day and 1-year mortality in patients undergoing TAVR. Materials and Methods In this single-center institutional review board-approved secondary analysis of prospectively collected data (SwissTAVI Registry), the authors evaluated participants who, before TAVR, underwent CT that included a nonenhanced electrocardiography-gated cardiac scan between May 2008 and September 2019 and who had not undergone previous coronary revascularization. Read More

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Chief Resident Indirect Supervision in Training Safety Study: Is a Chief Resident General Surgery Service Safe for Patients?

J Surg Educ 2021 Jul 30. Epub 2021 Jul 30.

Department of Surgery, University of Kansas School of Medicine-Wichita, Wichita, Kansas. Electronic address:

Objective: There has been concern expressed amongst the medical educational community regarding the readiness of general surgery residents in the United States to be competent practicing attendings upon graduation and that limited autonomy may be a contributing factor to this unpreparedness. The purpose of this study was to evaluate an RRC-accredited general surgery residency chief resident acute care surgery service with indirect supervision of cases in terms of safety and outcomes compared to traditional general surgeon cases with direct supervision. The study focused on common general surgical procedures, specifically cholecystectomies, appendectomies, and inguinal and ventral hernia repairs. Read More

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Prevalence, risk factors, and complications associated with hyponatraemia following elective primary hip and knee arthroplasty.

Perioper Med (Lond) 2021 Aug 3;10(1):25. Epub 2021 Aug 3.

Outcomes Unit, Musgrave Park Hospital, Belfast Health and Social Care Trust, Stockman's Lane, Belfast, BT9 7JB, Northern Ireland.

Background: Hyponatraemia, defined as a serum sodium [Na] concentration below 135 mmol/L, is common following surgery. As inpatient peri-operative stays shorten, there is a need to recognise pre-operative risk factors for post-operative hyponatraemia and complications associated with a peri-operative drop in Na. This audit aimed to investigate the prevalence of, risk factors for, and complications associated with hyponatraemia following elective primary hip and knee arthroplasty. Read More

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Evidence Of Respiratory Infection Transmission Within Physician Offices Could Inform Outpatient Infection Control.

Health Aff (Millwood) 2021 08;40(8):1321-1327

Michael Lawrence Barnett is an assistant professor in the Department of Health Policy and Management, Harvard T. H. Chan School of Public Health, and an assistant professor of medicine at Harvard Medical School.

Early in the COVID-19 pandemic, outpatient clinics throughout the US shifted toward virtual care to limit viral transmission in the office. However, as health care facilities have reopened, evidence about the risk of acquiring respiratory viral infections in medical office settings remains limited. To inform policy for reopening outpatient care settings, we analyzed rates of potential airborne disease transmission in medical office settings, focusing on influenza-like illness. Read More

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Excessive supraventricular ectopic activity and risk of incident atrial fibrillation in a consecutive population referred to ambulatory cardiac monitoring.

Heart Rhythm O2 2021 Jun 22;2(3):231-238. Epub 2021 Apr 22.

Department of Cardiology, Copenhagen University Hospital of Bispebjerg, Copenhagen, Denmark.

Background: Excessive supraventricular ectopic activity (ESVEA), defined as ≥720 premature atrial contractions (PAC) per day or any runs of ≥20 PACs, has been proposed as a surrogate marker for paroxysmal atrial fibrillation (PAF).

Objective: We aimed to estimate the prognostic impact of ESVEA on the future development of PAF in consecutive patients referred to ambulatory cardiac monitoring.

Methods: The cohort consists of a population with comorbidities referred to 48-hour ambulatory electrocardiogram aged 30-98 (n = 1316) between 2009 and 2011. Read More

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Safety Evaluation of Standardized Extract of (NR-INF-02): A 90-Day Subchronic Oral Toxicity Study in Rats.

Biomed Res Int 2021 14;2021:6671853. Epub 2021 Jul 14.

R&D Center, Natural Remedies Private Limited, Bengaluru, Karnataka, India.

NR-INF-02 is a standardized extract containing turmerosaccharides from that has anti-inflammatory, analgesic, and chondroprotective potential. In view of its potential uses, NR-INF-02 was evaluated for its safety in Wistar rats at an oral dose of 250, 500, and 1000 mg/kg in a 90-day repeated dose subchronic toxicity study. NR-INF-02 administered at 250, 500, and 1000 mg/kg for 90 days did not show any mortality or clinical signs of toxicity. Read More

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Effectiveness of Steroid Pulse Therapy for Systemic Side Effects after Bacillus Calmette-Guérin Intravesical Instillation Therapy: A Series of Five Cases.

Case Rep Urol 2021 9;2021:5548054. Epub 2021 Jul 9.

Department of Urology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.

Introduction: Bacillus Calmette-Guérin (BCG) instillation is an established therapy for the treatment of carcinoma in situ (CIS) of the bladder and prevention of recurrence after transurethral resection of bladder tumor noninvasive bladder cancer. However, serious systemic side effects may occur in less than 5% of patients with BCG intravesical instillation. Systemic side effects can sometimes be fatal and require early and accurate treatment. Read More

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Intraoperative parathormone increase after focused parathyroidectomy in a patient with sarcoidosis - Case report.

Ann Med Surg (Lond) 2021 Aug 17;68:102577. Epub 2021 Jul 17.

Department of Surgical Oncology, Institute of Oncology Ljubljana, Zaloska Cesta 2, 1000, Ljubljana, Slovenia.

Introduction: Hypercalcaemia is most commonly a sign of primary hyperparathyroidism but can also be a sign of an active granulomatous disease. Standard treatment for primary hyperparathyroidism caused by a solitary parathyroid gland adenoma identified by localisation studies is minimally invasive focused parathyroidectomy. If unsuccessful, bilateral neck exploration is recommended. Read More

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Toxicological Assessment of Bromochlorophene: Single and Repeated-Dose 28-Day Oral Toxicity, Genotoxicity, and Dermal Application in Sprague-Dawley Rats.

Front Pharmacol 2021 14;12:690141. Epub 2021 Jul 14.

Division of Toxicological Research, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Osong, South Korea.

Bromochlorophene (BCP) has shown good properties in sterilization and antibacterial activity and is widely used as a household chemical. We evaluated the genotoxicity, single and repeated-dose 28-day oral toxicity, and dermal application of a BCP suspension in Sprague-Dawley (SD) rats. For the single-dose toxicity study, a dose of 25-1,000 mg per kg of bodyweight (mg/kg b. Read More

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Seroconversion among COVID-19 patients admitted in a dedicated COVID hospital: A longitudinal prospective study of 1000 patients.

Med J Armed Forces India 2021 Jul 26;77:S379-S384. Epub 2021 Jul 26.

Assistant Professor, Department of Community Medicine, Armed Forces Medical College, Pune, India.

Background: The immune response after SARS-CoV-2 is complex and may be affected by severity of the disease, race, etc. The present study was conducted to assess the serial antibody response among the COVID-19 patients admitted in the hospital.

Methods: The study was conducted between July and October 2020 in a dedicated COVID-19 hospital. Read More

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Apparent temperature and heat-related illnesses during international athletic championships: A prospective cohort study.

Scand J Med Sci Sports 2021 Aug 1. Epub 2021 Aug 1.

European Athletics Medical & Anti-Doping Commission, European Athletics Association (EAA), Lausanne, Switzerland.

International outdoor athletics championships are typically hosted during the summer season, frequently in hot and humid climatic conditions. Therefore, we analysed the association between apparent temperature and heat-related illnesses occurrence during international outdoor athletics championships and compared its incidence rates between athletics disciplines. Heat-related illnesses were selected from illness data prospectively collected at seven international outdoor athletics championships between 2009 and 2018 using a standardised methodology. Read More

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Evaluation of a subunit vaccine candidate (Biotech Vac Cox) against Eimeria spp. in broiler chickens.

Poult Sci 2021 Jun 11;100(9):101329. Epub 2021 Jun 11.

Vetanco SA, Villa Martelli B1603, Province of Buenos Aires, Argentina; Vetanco USA, Saint Paul, MN 55114, USA; BV Science, Lenexa, KS 66219, USA. Electronic address:

This study evaluated growth performance and cross-protection against Eimeria spp. using a subunit coccidia vaccine in 2 independent challenge experiments. In both trials, chickens were challenged with E. Read More

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Development of a method based on dispersive liquid-liquid microextraction followed by partial vaporization of the extract for ultra-preconcentration of some pesticide residues in fruit juices.

J Chromatogr A 2021 Jul 21;1653:462427. Epub 2021 Jul 21.

Department of Analytical Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran; Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

A new simple and efficient method has been developed for the ultra-preconcentration of multiclass pesticide residues including penconazole, chlorpyrifos, ametryn, clodinafop-propargyl, diniconazole, oxadiazon, and fenpropathrin from some fruit juice samples based on evaporation of the sedimented organic phase obtained from dispersive liquid-liquid microextraction. The enriched target analytes were analyzed by gas chromatography-flame ionization detection. In the microextraction procedure, a mixture of iso-propanol as a disperser and 1,2-dibromoethane as an extraction solvent is quickly injected into an aqueous phase containing the analytes and centrifuged. Read More

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Bioanalysis of niclosamide in plasma using liquid chromatography-tandem mass and application to pharmacokinetics in rats and dogs.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Jul 18;1179:122862. Epub 2021 Jul 18.

Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon 34134, Republic of Korea. Electronic address:

Niclosamide, which is an anti-tapeworm drug, was developed in 1958. However, recent studies have demonstrated the antiviral effects of niclosamide against the SARS-CoV-2 virus, which causes COVID-19. In this study, we developed and validated a quantitative analysis method for the determination of niclosamide in rat and dog plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS), and used this method for pharmacokinetic studies. Read More

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Active smokers show ameliorated delayed gastric emptying after pancreatoduodenectomy.

BMC Surg 2021 Jul 31;21(1):316. Epub 2021 Jul 31.

Department of Surgery, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.

Background: Delayed gastric emptying (DGE) is the most common complication following pancreatoduodenectomy (PD). The data about active smoking in relation to gastric motility have been inconsistent and specifically the effect of smoking on gastric emptying after PD has not yet been investigated in detail.

Methods: 295 patients at our department underwent PD between January 2009 and December 2019. Read More

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Routine postoperative fluid restriction to prevent syndrome of inappropriate antidiuretic hormone secretion after transsphenoidal resection of pituitary adenoma.

J Neurosurg 2021 Jul 30:1-8. Epub 2021 Jul 30.

1Department of Neurological Surgery and.

Objective: Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a common problem during the postoperative course after pituitary surgery. Although treatment of this condition is well characterized, prevention strategies are less studied and reported. The authors sought to characterize outcomes and predictive factors of SIADH after implementation of routine postoperative fluid restriction for patients undergoing endoscopic transsphenoidal surgery for pituitary adenoma. Read More

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Dietary sugar intake and risk of Alzheimer's disease in older women.

Nutr Neurosci 2021 Jul 30:1-12. Epub 2021 Jul 30.

Division of Cardiology, Heart and Vascular Institute, Pennsylvania State University, Hershey, PA, USA.

Background: Despite some reports of cardiometabolic disorders associated with the risk of Alzheimer's disease (AD), limited studies have been conducted to examine the association between excessive sugar intake (a risk factor for cardiometabolic disorders) and AD risk.

Aim: The purpose of our study was to evaluate if excessive sugar intake has a significant long-term effect on the risk of AD.

Methods: A population sample of 37,689 participants, who enrolled in the United States (US) Women's Health Initiative - Dietary Modification Trial (WHI-DM) in 1993-2005 and its extended observational follow-up study through 1 March 2019, were analyzed. Read More

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The effect of omega-3 fatty acid supplementation on seizure frequency in individuals with epilepsy: a systematic review and meta-analysis.

Nutr Neurosci 2021 Jul 30:1-10. Epub 2021 Jul 30.

Non-Invasive Brain Stimulation and Neuroplasticity Laboratory, Department of Physiotherapy, School of Primary and Allied Health Care, Faculty of Medicine, Nursing and Health Science, Monash University, Melbourne, Australia.

Background: Although there is ample evidence for the effect of omega-3 supplementation on seizure frequency in individuals with epilepsy, the results are inconsistent. Therefore, we conducted this systematic review and meta-analysis to elucidate the potential effect of omega-3 supplementation in the adult and pediatric population.

Methods: Clinical trials articles were searched in electronic databases (Web of Science, Scopus, PubMed/Medline, Embase, and Google Scholar database up to October 2020). Read More

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Evidence for Systemic Reactive Oxygen Species in UVB-mediated Microvesicle Formation.

Photochem Photobiol 2021 Jul 29. Epub 2021 Jul 29.

Departments of Pharmacology and Toxicology, Boonshoft School of Medicine at Wright State University, Dayton, OH, 45435, USA.

Recent studies have implicated subcellular microvesicle particles (MVP) in the ability of Ultraviolet B radiation to exert both local and systemic effects. Indeed, UVB generates MVP (UVB-MVP) in human skin and systemically following phototherapy. The current studies were designed to test the hypothesis that the ability of UVB to generate MVP was dependent upon reactive oxygen species (ROS). Read More

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Days away from work injury and associated factors among waste collectors in Mekelle city, Northern Ethiopia.

J Prev Med Hyg 2021 Mar 29;62(1):E141-E147. Epub 2021 Apr 29.

Department of Environmental Health, College of Health Sciences, Mekelle University, Mekelle, Ethiopia.

Introduction: In most cities of low-income countries, waste management is a labour intensive task, which exposes workers to numerous occupational hazards. This study was aimed to investigate the magnitude of days away from work-related injury and associated factors among organized waste collectors in Mekelle city, Northern Ethiopia.

Method: A pre-tested questionnaire and observation checklist based cross-sectional study design was employed from June 1 to 30, 2017. Read More

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Simultaneous trace-level monitoring of seven opioid analgesic drugs in biological samples by pipette-tip micro solid phase extraction based on PVA-PAA/CNT-CNC composite nanofibers followed by  HPLC-UV analysis.

Mikrochim Acta 2021 Jul 27;188(8):275. Epub 2021 Jul 27.

Department of Analytical Chemistry and Pollutants, Faculty of Chemistry and Petroleum Sciences, Shahid Beheshti University, Tehran, Iran.

Electrospun poly(vinyl alcohol)-(PVA)-poly(acrylic acid) (PAA)/carbon nanotubes(CNTs)-cellulose nanocrystal (CNC) (PVA-PAA/CNT-CNC) composite nanofibers were prepared and characterized using Fourier transform-infrared spectroscopy and field emission scanning electron microscopy. The resultant composite was used as an effective and novel sorbent for pipette-tip micro-solid phase extraction (PT-μSPE) of seven opioid analgesics (OAs) in biological samples followed by HPLC-UV analysis. Addition of CNT-CNC with the high specific surface area and plenty of OH-functional groups endows the nanofibers with considerable extraction efficiency. Read More

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Virus Induced Lymphocytes (VIL) as a novel viral antigen-specific T cell therapy for COVID-19 and potential future pandemics.

Sci Rep 2021 07 27;11(1):15295. Epub 2021 Jul 27.

Intima Bioscience, Inc., New York, NY, USA.

The a priori T cell repertoire and immune response against SARS-CoV-2 viral antigens may explain the varying clinical course and prognosis of patients having a mild COVID-19 infection as opposed to those developing more fulminant multisystem organ failure and associated mortality. Using a novel SARS-Cov-2-specific artificial antigen presenting cell (aAPC), coupled with a rapid expansion protocol (REP) as practiced in tumor infiltrating lymphocytes (TIL) therapy, we generate an immune catalytic quantity of Virus Induced Lymphocytes (VIL). Using T cell receptor (TCR)-specific aAPCs carrying co-stimulatory molecules and major histocompatibility complex (MHC) class-I immunodominant SARS-CoV-2 peptide-pentamer complexes, we expand virus-specific VIL derived from peripheral blood mononuclear cells (PBMC) of convalescent COVID-19 patients up to 1000-fold. Read More

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SARS-CoV-2 spike glycoprotein-reactive T cells can be readily expanded from COVID-19 vaccinated donors.

Immun Inflamm Dis 2021 Jul 27. Epub 2021 Jul 27.

Department of Immunology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.

Introduction: The COVID-19 vaccine was designed to provide protection against infection by the severe respiratory coronavirus 2 (SARS-CoV-2) and coronavirus disease 2019 (COVID-19). However, the vaccine's efficacy can be compromised in patients with immunodeficiencies or the vaccine-induced immunoprotection suppressed by other comorbidity treatments, such as chemotherapy or immunotherapy. To enhance the protective role of the COVID-19 vaccine, we have investigated a combination of the COVID-19 vaccination with ex vivo enrichment and large-scale expansion of SARS-CoV-2 spike glycoprotein-reactive CD4 and CD8 T cells. Read More

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Consumption of tetracyclines, sulphonamides and trimethoprim, and other antibacterials in the community, European Union/European Economic Area, 1997-2017.

J Antimicrob Chemother 2021 Jul;76(Supplement_2):ii45-ii59

Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium.

Objectives: Data on consumption of tetracyclines, sulphonamides and trimethoprim, and other antibacterials were collected from 30 EU/European Economic Area (EEA) countries over two decades. This article reviews temporal trends, seasonal variation, presence of change-points and changes in the composition of main subgroups of tetracyclines, sulphonamides and trimethoprim and other antibacterials.

Methods: For the period 1997-2017, data on consumption of tetracyclines (ATC group J01A), sulphonamides and trimethoprim (ATC group J01E), and other antibacterials (ATC group J01X) in the community and aggregated at the level of the active substance, were collected using the WHO ATC/DDD methodology (ATC/DDD index 2019). Read More

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