153,392 results match your criteria 100 cases

PLS-DA and data fusion of visible Reflectance, XRF and FTIR spectroscopy in the classification of mixed historical pigments.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Sep 10;265:120384. Epub 2021 Sep 10.

Laboratório de Instrumentação e Simulação Computacional. LISCOMP/IFRJ-CPAR, 26600-000, Paracambi, Brazil. Electronic address:

In this work samples of historical pigments of green hue were brushed on a canvas and studied by Visible Reflectance, X-Ray Fluorescence and Fourier Transform Infrared Spectroscopy. One hundred samples were investigated, all with green hue, these prepared from pigments themselves green, such as chromium oxide (CrO) or from a mixture of pigments that result in green, for example, chrome yellow (PbCrO) and Prussian blue (Fe[Fe(CN)]). Because every sample investigated through the spectroscopic techniques were of green hue, the characterization of the pigments present in the mixtures through the visual inspection of spectra has become a complex task in some cases, also, due the large number of recorded spectra. Read More

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September 2021

Cytokine profile in Egyptian children and adolescents with COVID-19 pneumonia: a multicenter study.

Pediatr Pulmonol 2021 Sep 18. Epub 2021 Sep 18.

Department of Radiology, Texas Tech University Health Sciences Center El Paso, Texas, USA.

Background: To date, the cytokine profile in children and adolescent with novel coronavirus disease 2019 (COVID-19) has not been reported.

Objectives: we investigated serum levels of a panel of key cytokines in children and adolescent with COVID-19 pneumonia with a primary focus on "cytokine storm" cytokines such as IL-1β, IL-6, IL-17, IL-2, IL-4, IL-10, interferon (IFN-γ), tumor necrosis factor (TNF)-α and two chemokines interferon inducible protein-10 (IP-10) and IL-8]. We also studied whether these cytokines could be potential markers for illness severity in COVID-19 pneumonia. Read More

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September 2021

Risk Stratification of Breast Fine-Needle Aspiration Biopsy Specimens Performed without Radiologic Guidance by Application of the International Academy of Cytology Yokohama System for Reporting Breast Fine-Needle Aspiration Cytopathology.

Acta Cytol 2021 Sep 14:1-11. Epub 2021 Sep 14.

Department of Radiation Oncology, All India Institute of Medical Sciences (AIIMS), Jodhpur, India.

Background And Objective: The International Academy of Cytology (IAC) Yokohama system for reporting breast fine-needle aspiration biopsy (FNAB) cytopathology has been proposed to standardize breast FNAB reporting. The aim of this study was to categorize breast FNAB cases performed by palpation without radiological guidance according to the IAC system, establish the risk of malignancy (ROM) for the categories and assess the system's utility, pitfalls, and implications in low-resource/financial constraint settings.

Methods: A retrospective analysis of palpation-guided FNAB of breast lesions performed without radiological guidance between January 2016 and December 2019 was carried out and was correlated with follow-up biopsies wherever available. Read More

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September 2021

Native joint infections in Iceland 2003-2017: an increase in postarthroscopic infections.

Ann Rheum Dis 2021 Sep 17. Epub 2021 Sep 17.

Infectious Diseases, Landspitali, Reykjavik, Iceland

Objectives: Nationwide study on the epidemiology, clinical characteristics and outcomes among patients with native joint infection (NJI) in Iceland, 2003-2017.

Methods: All positive synovial fluid culture results in Iceland were identified and medical records reviewed.

Results: A total of 299 NJI (40 children and 259 adults) were diagnosed in Iceland in 2003-2017, with a stable incidence of 6. Read More

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September 2021

Myocarditis following COVID-19 vaccination - A case series.

Vaccine 2021 Sep 4. Epub 2021 Sep 4.

Medical Corps, Israeli Defense Forces, Israel; The Faculty of Medicine, Hebrew University, Jerusalem, Israel.

There have been reports of myocarditis following COVID-19 vaccination. We surveyed all hospitalized military personnel in the Isareli Defense Forces during the period of the COVID-19 vaccination operation (12/28/2021-3/7/2021) for diagnosed myocarditis. We identified 7 cases of myocarditis with symptoms starting in the first week after the second dose of COVID-19 Pfizer-BioNTech vaccine. Read More

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September 2021

Accuracy of SD Malaria Ag P.f/Pan® as a rapid diagnostic test in French Amazonia.

Malar J 2021 Sep 17;20(1):369. Epub 2021 Sep 17.

Academic Laboratory of Parasitology-Mycology, Cayenne General Hospital, Cayenne, French Guiana.

Background: French Guiana (FG) is a French overseas territory where malaria is endemic. The current incidence rate is 0.74‰ inhabitants, and Plasmodium vivax is widely predominating even though Plasmodium falciparum is still present due to imported cases mainly from Africa. Read More

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September 2021

Evolution and Transformation of Uterine Transplantation: A Systematic Review of Surgical Techniques and Outcomes.

J Reconstr Microsurg 2021 Sep 17. Epub 2021 Sep 17.

Division of Plastic and Reconstructive Surgery, Strong Memorial Hospital, University of Rochester Medical Center, New York.

Background:  Uterine transplantation (UTx) is acknowledged to be on the second (2A) of five steps of development in accordance with the staging system for the evaluation of surgical innovations. Accordingly, we aimed to systematically review the available evidence of the surgical techniques and outcomes of UTx in terms of graft survival.

Methods:  A comprehensive search was conducted across PubMed Medline, Cochrane-EBMR, Scopus, Web of Science, and CENTRAL through November 2020. Read More

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September 2021

Estimates of Cases and Hospitalizations Averted by COVID-19 Case Investigation and Contact Tracing in 14 Health Jurisdictions in the United States.

J Public Health Manag Pract 2021 Sep 15. Epub 2021 Sep 15.

CDC COVID-19 Response Team.

Context: The implementation of case investigation and contact tracing (CICT) for controlling COVID-19 (caused by SARS-CoV-2 virus) has proven challenging due to varying levels of public acceptance and initially constrained resources, especially enough trained staff. Evaluating the impacts of CICT will aid efforts to improve such programs.

Objectives: Estimate the number of COVID-19 cases and hospitalizations averted by CICT and identify CICT processes that could improve overall effectiveness. Read More

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September 2021

Histologic and Molecular Characterization of Non-Small Cell Lung Carcinoma With Discordant ROS1 Immunohistochemistry and Fluorescence In Situ Hybridization.

Appl Immunohistochem Mol Morphol 2021 Sep 16. Epub 2021 Sep 16.

University of Utah and ARUP Laboratories, Salt Lake City, UT St. Jude Childrens' Research Hospital, Memphis, TN.

Introduction: ROS1 immunohistochemical (IHC) positivity requires follow-up with confirmatory testing such as fluorescence in situ hybridization (FISH). Identifying predictive characteristics of false positive ROS1 IHC cases could aid in optimizing testing algorithms, decrease testing costs and preserve tissue.

Materials And Methods: Retrospective results were retrieved for 2054 patients with non-small cell lung carcinoma submitted to our laboratory for molecular testing. Read More

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September 2021

Interleukin-37 is down-regulated in serum of patients with severe coronavirus disease 2019 (COVID-19).

Cytokine 2021 Sep 9;148:155702. Epub 2021 Sep 9.

Tropical-Biological Research Unit, College of Science, University of Baghdad, Baghdad, Iraq. Electronic address:

Pro-inflammatory and anti-inflammatory cytokines are indicated to play a prominent role in mediating the immunopathogenesis of coronavirus disease 19 (COVID-19). Interleukin (IL-37) is one of the anti-inflammatory cytokines that has been proposed to be involved in disease progression but the data are not overwhelming. Therefore, a case-control study was performed to analyze IL-37 levels in serum of 100 patients with severe COVID-19 and 100 blood donors (control group). Read More

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September 2021

Arthroscopic evaluation of the synovial membrane and its relationship with histological changes and biomarkers in equine joint disease.

Res Vet Sci 2021 Sep 8;140:212-220. Epub 2021 Sep 8.

Department of Internal Medicine, University of São Paulo, School of Veterinary Medicine and Animal Science, Av. Prof. Dr. Orlando Marques de Paiva, 87, Cidade Universitária, 05508270 São Paulo, Brazil. Electronic address:

The synovial membrane (SM) presents itself with distinctive characteristics during arthroscopic procedures in cases of osteoarthritis (OA) as well as osteochondritis dissecans (OCD) in horses. Most of the arthroscopic findings of the SM are limited to a description of a nonspecific inflammation state. In the present study, the macroscopic and histological aspects of the SM in OA and OCD horses were compared to those of healthy horses. Read More

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September 2021

The level of urbanization influences acute ischemic stroke care: A nationwide ecological study from Germany.

J Neurol Sci 2021 Sep 13;430:119983. Epub 2021 Sep 13.

Department of Neurology, St. Josef-Hospital Bochum, Ruhr University Bochum, Germany; Medical Faculty, Ruhr University Bochum, Germany. Electronic address:

Background And Purpose: Regional differences in acute ischemic stroke (AIS) care are still reported for Germany but not fully understood. We aimed to analyze the impact of the level of urbanization on the application of proved treatment procedures and the incidence of hospitalized AIS cases in Germany.

Methods: The level of urbanization of the 401 districts and district-free cities in Germany was defined according to the Federal Institute for Building, Urban Affairs and Spatial Research classification. Read More

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September 2021

The opening size of the laminoplasty is dependent on the groove size: A numerical study.

Clin Biomech (Bristol, Avon) 2021 Sep 11;89:105479. Epub 2021 Sep 11.

Technical University of Liberec, Studentska 2, Liberec 46117, Czech Republic. Electronic address:

Background: The expansion of the cervical vertebrae lamina appears to be crucial to related surgical procedures. The dimensions of the groove influence the strain concentration within the lamina of the vertebra and, thus, the potential success or failure of respective surgical procedure. The aim of this computational study is to clarify both the role of the size of the groove with concern to both the open door and the double door laminoplasty techniques. Read More

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September 2021

Similar Ferroportin Q248H polymorphism prevalence in patients with Plasmodium falciparum malaria and control subjects in the low-endemic setting of Botswana.

Clin Chim Acta 2021 Sep 14. Epub 2021 Sep 14.

School of Allied Health Professions, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana. Electronic address:

Introduction: Recent evidence suggests that ferroportin (FPN) Q248H may confer a survival advantage against malaria by reducing erythrocytic intracellular iron in Africans. We investigated if FPN Q248H mutation, that is prevalent in Batswana, is a factor in limiting the susceptibility to Plasmodium falciparum malaria.

Methods: 264 archived dried blood spot samples (183 P. Read More

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September 2021

Phenotype and genotype of 197 British patients with McArdle disease: an observational single-centre study.

J Inherit Metab Dis 2021 Sep 17. Epub 2021 Sep 17.

Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK.

Objective: McArdle disease is caused by recessive mutations in PYGM gene. The condition is considered to cause a 'pure' muscle phenotype with symptoms including exercise intolerance, inability to perform isometric activities, contracture, acute rhabdomyolysis leading to acute renal failure.

Methods: This is a retrospective observational study aiming to describe phenotypic and genotypic features of a large cohort of patients with McArdle disease between 2011-2019. Read More

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September 2021

Pupillary fluctuation amplitude before target presentation reflects short-term vigilance level in Psychomotor Vigilance Tasks.

PLoS One 2021 17;16(9):e0256953. Epub 2021 Sep 17.

Department of Intelligence Science and Technology, Graduate School of Informatics, Kyoto University, Kyoto, Kyoto, Japan.

Our daily activities require vigilance. Therefore, it is useful to externally monitor and predict our vigilance level using a straightforward method. It is known that the vigilance level is linked to pupillary fluctuations via Locus Coeruleus and Norepinephrine (LC-NE) system. Read More

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September 2021

The increased presence of repetitive motifs in the KDDR-plus recombinant protein, a kinesin-derived antigen from Leishmania infantum, improves the diagnostic performance of serological tests for human and canine visceral leishmaniasis.

PLoS Negl Trop Dis 2021 Sep 17;15(9):e0009759. Epub 2021 Sep 17.

Programa de Pós-graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Visceral leishmaniasis (VL) is caused by protozoa belonging to the Leishmania donovani complex and is considered the most serious and fatal form among the different types of leishmaniasis, if not early diagnosed and treated. Among the measures of disease control stand out the management of infected dogs and the early diagnosis and appropriate treatment of human cases. Several antigens have been characterized for use in the VL diagnosis, among them are the recombinant kinesin-derived antigens from L. Read More

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September 2021

Incidence of Newly Registered Blindness From Age-Related Macular Degeneration in Australia Over a 21-Year Period: 1996-2016.

Asia Pac J Ophthalmol (Phila) 2021 Sep 16. Epub 2021 Sep 16.

Centre for Ophthalmology and Visual Science (Incorporating Lions Eye Institute), The University of Western Australia, Nedlands, Western Australia, Australia Department of Ophthalmology, Royal Perth Hospital, Perth, Western Australia, Australia School of Population and Global Health, The University of Western Australia, Crawley, Western Australia, Australia Department of Ophthalmology, Perth Children's Hospital, Nedlands, Western Australia, Australia.

Purpose: Report the age-standardized annual incidence of blindness registration due to age-related macular degeneration (AMD) in Australia in patients aged 50 years and older. Frequencies of photodynamic therapy (PDT) and intravitreal therapy (IVT) were examined.

Design: Retrospective observational study. Read More

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September 2021

Accurate Distinction of Ovarian Clear Cell From Endometrioid Carcinoma Requires Integration of Phenotype, Immunohistochemical Predictions, and Genotype: Implications for Lynch Syndrome Screening.

Am J Surg Pathol 2021 Sep 16. Epub 2021 Sep 16.

Department of Pathology, University of Calgary Division of Gynecologic Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB Cancer Control Research, BC Cancer Agency Department of Pathology and Laboratory Medicine, BC Cancer, Vancouver, BC, Canada Division of Epidemiology, Biostatistics and Preventative Medicine, Department of Internal Medicine, University of New Mexico, Albuquerque, NM Department of Pathology and Laboratory Medicine, University of California Davis, Davis, CA.

Ovarian clear cell carcinoma (OCCC) and ovarian endometrioid carcinoma (OEC) are both associated with endometriosis but differ in histologic phenotype, biomarker profile, and survival. Our objectives were to refine immunohistochemical (IHC) panels that help distinguish the histotypes and reassess the prevalence of mismatch repair deficiency (MMRd) in immunohistochemically confirmed OCCC. We selected 8 candidate IHC markers to develop first-line and second-line panels in a training set of 344 OCCC/OEC cases. Read More

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September 2021

Risk factors, epidemiology and prognosis of cholangiocarcinoma in Finland.

United European Gastroenterol J 2021 Sep 17. Epub 2021 Sep 17.

Department of Gastroenterology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Background: Cholangiocarcinoma (CCA) is a cancer arising from the intra- and extrahepatic bile ducts. The early stages are often asymptomatic, CCA is frequently diagnosed in an advanced stage and the prognosis of CCA is often dismal.

Objective: Our objective was to estimate the incidence of CCA in Finland and to identify risk factors for CCA, with a special interest in primary sclerosing cholangitis (PSC). Read More

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September 2021

Performance of IOTA Simple Rules, Simple Rules Risk assessment, ADNEX model and O-RADS in discriminating between benign and malignant adnexal lesions in North American population.

Ultrasound Obstet Gynecol 2021 Sep 17. Epub 2021 Sep 17.

Department of Obstetrics and Gynecology, Division of Oncology and Advanced Pelvic Surgery, University of Cincinnati, Cincinnati, OH, 45267.

Objective: To apply the International Ovarian Tumor Analysis (IOTA) Simple Rules (SR), IOTA Simple Rules Risk assessment (SRR), IOTA Assessment of Different NEoplasias in the adneXa (ADNEX) model, and the Ovarian-Adnexal Reporting and Data System (O-RADS) in the same cohort of patients and to compare their performance in the preoperative discrimination between benign and malignant adnexal lesions.

Methods: This is a single-center diagnostic accuracy study performed between March 2018 and February 2021, which includes 150 women with adnexal lesions. The lesions were classified prospectively using the ADNEX model; whereas, SR, SRR assessment, and O-RADS were applied retrospectively. Read More

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September 2021

Assessment of Allergic and Anaphylactic Reactions to mRNA COVID-19 Vaccines With Confirmatory Testing in a US Regional Health System.

JAMA Netw Open 2021 Sep 1;4(9):e2125524. Epub 2021 Sep 1.

Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford, California.

Importance: As of May 2021, more than 32 million cases of COVID-19 have been confirmed in the United States, resulting in more than 615 000 deaths. Anaphylactic reactions associated with the Food and Drug Administration (FDA)-authorized mRNA COVID-19 vaccines have been reported.

Objective: To characterize the immunologic mechanisms underlying allergic reactions to these vaccines. Read More

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September 2021

Hepatitis A Outbreaks and Environmental Circulation of Genotype IA Strains in the São Paulo City, 2017-2018.

Food Environ Virol 2021 Sep 17. Epub 2021 Sep 17.

Division of Microbiology and Parasitology, Department of Environmental Analysis, Environmental Company of the São Paulo State (CETESB), Av. Prof. Frederico Hermann Jr., 345, São Paulo, CEP 05459-900, Brazil.

Hepatitis A virus (HAV) is the major cause of enterically transmitted infectious hepatitis. Between 2016 and 2017, the number of confirmed cases of hepatitis A virus (HAV) increased from 64 to 786 in São Paulo affecting mainly adults aged between 18 and 39 years (80%) and males (88%). To support epidemiological surveillance, the present study monitored the presence of HAV in urban sewage samples collected bimonthly for 1 year (November 2017-November 2018) in the central region of the city, where most of cases were detected. Read More

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September 2021

Mycoplasma Pneumoniae-Induced Rash and Mucositis: A Systematic Review of the Literature.

Spartan Med Res J 2021 30;6(2):25284. Epub 2021 Aug 30.

McLaren Oakland Hospital, Pontiac, MI, USA.

Introduction: (MP) is a common respiratory pathogen that can result in community-acquired pneumonia (CAP). Approximately 25% of patients diagnosed with MP experience extrapulmonary manifestations. -induced rash and mucositis (MIRM) was coined as a unique disease process in 2014. Read More

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Causes and outcome of rhabdomyolysis in patients admitted to medical wards in the Prince of Wales Hospital.

Ann Transl Med 2021 Aug;9(16):1329

Faculty of Medicine, Macau University of Science and Technology, Macau, China.

Background: Rhabdomyolysis with a marked elevation of serum creatine kinase (CK) can be caused by various conditions. Acute kidney injury (AKI) is a potential complication of severe rhabdomyolysis and leads to a rapid increase in serum creatinine.

Methods: This study was performed to identify medical cases diagnosed with rhabdomyolysis and to examine the likely causes. Read More

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Case selection and implementation of tubeless percutaneous nephrolithotomy.

Transl Androl Urol 2021 Aug;10(8):3415-3422

Department of Urology, Lingnan Hospital, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Background: The tubeless percutaneous nephrolithotomy (PCNL) was proposed to eliminate the side effects of the nephrostomy tube in recent years, such as pain, channel infection, postoperative bleeding, and longer hospital stay. But there is neither clinical guidelines nor consensus about tubeless PCNL in clinical practice. The study is aimed to how to implement the tubeless PCNL step by step, including case selection preoperatively, improving the technique of the surgeon, making the correct decisions at the end of the procedure, which had not been previously examined. Read More

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Cambodia malaria indicator survey 2020: Implications for malaria elimination.

Malariaworld J 2021 1;12. Epub 2021 Jul 1.

Health and Social Development (HSD), Cambodia.

Background: Cambodia has made significant progress in controlling malaria in the past decade. It now aims to eliminate malaria from the country by 2025. It launched the Malaria Elimination Action Framework (MEAF 2016-2020) in 2015 with strong political commitment targeting appropriate interventions on high-risk populations, particularly mobile and migrant groups. Read More

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Natural selection contributes to the myopia epidemic.

Natl Sci Rev 2021 Jun 17;8(6). Epub 2020 Aug 17.

Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA.

The prevalence of myopia, or nearsightedness, has skyrocketed in the past few decades, creating a public health crisis that is commonly attributed to lifestyle changes. Here we report an overall increase in the frequencies of myopia-associated mutant alleles over 25 years among participants of the UK Biobank. Although myopia itself appears to be selected against, many of the mutant alleles are associated with reproductive benefits, suggesting that reproduction-related selection inadvertently contributes to the myopia epidemic. Read More

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Proton stereotactic body radiation therapy for liver metastases-results of 5-year experience for 81 hepatic lesions.

J Gastrointest Oncol 2021 Aug;12(4):1753-1760

Department of Radiation Oncology, Loma Linda University Medical Center, Loma Linda, CA, USA.

Background: To report on our institutional experience using Proton stereotactic body radiation therapy (SBRT) for patients with liver metastases.

Methods: All patients with liver metastases treated with Proton SBRT between September 2012 and December 2017 were retrospectively analyzed. Local control (LC) and overall survival (OS) were estimated using the Kaplan-Meier method calculated from the time of completion of Proton SBRT. Read More

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Reducing the Toxicity of Designer Aminoglycosides as Nonsense Mutation Readthrough Agents for Therapeutic Targets.

ACS Med Chem Lett 2021 Sep 9;12(9):1486-1492. Epub 2021 Aug 9.

Inception Sciences Canada, 210-887 Great Northern Way, Vancouver, British Columbia, V5T 4T5, Canada.

A significant proportion of genetic disease cases arise from truncation of proteins caused by premature termination codons. In eukaryotic cells some aminoglycosides cause readthrough of premature termination codons during protein translation. Inducing readthrough of these codons can potentially be of therapeutic value in the treatment of numerous genetic diseases. Read More

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September 2021