Am J Surg Pathol 2021 Sep 16. Epub 2021 Sep 16.
Department of Pathology, University of Calgary Division of Gynecologic Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB Cancer Control Research, BC Cancer Agency Department of Pathology and Laboratory Medicine, BC Cancer, Vancouver, BC, Canada Division of Epidemiology, Biostatistics and Preventative Medicine, Department of Internal Medicine, University of New Mexico, Albuquerque, NM Department of Pathology and Laboratory Medicine, University of California Davis, Davis, CA.
Ovarian clear cell carcinoma (OCCC) and ovarian endometrioid carcinoma (OEC) are both associated with endometriosis but differ in histologic phenotype, biomarker profile, and survival. Our objectives were to refine immunohistochemical (IHC) panels that help distinguish the histotypes and reassess the prevalence of mismatch repair deficiency (MMRd) in immunohistochemically confirmed OCCC. We selected 8 candidate IHC markers to develop first-line and second-line panels in a training set of 344 OCCC/OEC cases. Read More