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Modified Superior Capsule Reconstruction Using the Long Head of the Biceps Tendon as Reinforcement to Rotator Cuff Repair Lowers Retear Rate in Large to Massive Reparable Rotator Cuff Tears.

Arthroscopy 2021 Apr 14. Epub 2021 Apr 14.

Department of Orthopaedics, National Cheng Kung University Hospital, Tainan, Taiwan, R.O.C.

Purpose: To retrospectively assess the clinical outcomes of the patients with large to massive reparable rotator cuff tears (RCTs) treated by arthroscopic rotator cuff repair (ARCR) combined with modified superior capsule reconstruction (mSCR) using the long head of biceps tendon (LHBT) as reinforcement with a minimum of 2 years of follow-up.

Methods: We retrospectively evaluated 40 patients with large to massive reparable RCTs who underwent ARCR and mSCR (Group I) between February 2017 and June 2018 (18 patients) or underwent ARCR and tenotomy of LHBT performed at the insertion site (Group II) between January 2015 and January 2017 (22 patients). The pain visual analog score (VAS) was assessed preoperatively and 1, 3, 6, 12, 24 months postoperatively. Read More

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Impact of obstructive sleep apnea and intermittent hypoxia on blood rheology - a translational study.

Eur Respir J 2021 Apr 16. Epub 2021 Apr 16.

Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

Rationale: Hemorheological alterations are reported in obstructive sleep apnea (OSA) and reversed with continuous positive airway pressure (CPAP), observations potentially explained by intermittent hypoxia (IH)-induced oxidative stress.

Objective: To investigate whether IH causes hemorheological alterations oxidative stress.

Methods: Wistar rats were exposed to normoxia (n=7) or IH (n=8) for 14 days. Read More

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Does number of autotransplanted parathyroid glands affects postoperative hypoparathyroidism and serum parathyroid hormone levels?

Asian J Surg 2021 Apr 13. Epub 2021 Apr 13.

Center of Thyroid & Parathyroid Surgery, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan Province, PR China. Electronic address:

Background: To investigate how number of autotransplanted parathyroid glands (PGs) affects the incidence of postoperative hypoparathyroidism and the recovery of parathyroid function.

Methods: A systematic search was performed in the MEDLINE, Embase, and Cochrane Central Register of Controlled Trials databases. The evaluated indices included the incidence of postoperative transient and permanent hypoparathyroidism and parathyroid hormone (PTH) levels during follow-up. Read More

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Pilot study on the effects of low intensity focused ultrasound in a swine model of neuropathic pain.

J Neurosurg 2021 Apr 16:1-8. Epub 2021 Apr 16.

Departments of1Neurosurgery.

Objective: The authors' laboratory has previously demonstrated beneficial effects of noninvasive low intensity focused ultrasound (liFUS), targeted at the dorsal root ganglion (DRG), for reducing allodynia in rodent neuropathic pain models. However, in rats the DRG is 5 mm below the skin when approached laterally, while in humans the DRG is typically 5-8 cm deep. Here, using a modified liFUS probe, the authors demonstrated the feasibility of using external liFUS for modulation of antinociceptive responses in neuropathic swine. Read More

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Complications and outcomes following open laryngotracheal reconstruction: A 15 year experience at an Australian paediatric tertiary referral centre.

Int J Pediatr Otorhinolaryngol 2021 Mar 29;145:110687. Epub 2021 Mar 29.

Department of Paediatric Otolaryngology, The Children's Hospital at Westmead, The University of Sydney, Westmead, NSW, Australia; Discipline of Child and Adolescent Health, Faculty of Medicine and Health, University of Sydney, NSW, Australia. Electronic address:

Objective: To report on our experience with open pediatric laryngotracheal reconstruction (LTR) with cartilage interposition grafts over the past 15 years and document setbacks and factors that affect postoperative outcomes.

Method: A retrospective chart review was performed on all pediatric patients who underwent single and double-stage LTR at The Children's Hospital in Westmead between August 2004 and July 2019. The outcomes measured include the overall decannulation rate, rates of postoperative complications, need for subsequent procedures and postoperative functional results (dyspnea, stridor, voice impairment). Read More

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"Prospective, Randomized, Controlled Trial of Ultra-modified Internal Sphincterotomy vs Closed Lateral Internal Sphincterotomy for Chronic Fissure-in-Ano".

Am Surg 2021 Apr 16:31348211011104. Epub 2021 Apr 16.

Department of Anesthesiology & Critical Care, 64052Pamukkale University School of Medicine, Denizli, Turkey.

Background: Currently, the lateral internal sphincterotomy is the treatment of choice for a chronic anal fissure (CAF). However, the length of the internal sphincter incision varies, due to lack of standardization. Insufficient length increases the risk of recurrence. Read More

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Effect of Curcumin on Severity of Functional Dyspepsia: a Triple Blinded Clinical Trial.

Adv Exp Med Biol 2021 ;1308:119-126

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

BackgroundFunctional dyspepsia is the main cause of upper abdominal discomfort affecting 5-10% of the world population. Despite various therapeutic approaches, up to 50% of patients with functional dyspepsia seek alternative treatments. In the present study we evaluated the effect of curcumin supplementation along with famotidine therapy on severity of functional dyspepsia. Read More

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January 2021

Promoting Motivational Interviewing in Primary Care: More Than Intention.

PRiMER 2021 4;5. Epub 2021 Feb 4.

Department of Internal Medicine, Boonshoft School of Medicine, Wright State University, Dayton, OH.

Introduction: Interacting with patients in a manner that furthers self-responsibility for health is an important skill for primary care clinicians. Motivational interviewing (MI) is such an approach to patient engagement, but it remains to be more widely implemented. In a program training health professionals and health professions students in MI, we examined posttraining attitudes and intentions regarding the utilization of MI. Read More

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February 2021

Impact of idiopathic pulmonary fibrosis on clinical outcomes of lung cancer patients.

Sci Rep 2021 Apr 15;11(1):8312. Epub 2021 Apr 15.

Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.

The clinical characteristics of lung cancer in patients with idiopathic pulmonary fibrosis (IPF) differ from those of lung cancer in patients without IPF. Thus, we aimed to evaluate the impact of IPF on the clinical course of patients with lung cancer. Clinical data of IPF patients with lung cancer (n = 122) were compared with those of patients with lung cancer without IPF (n = 488) matched by age, sex, histopathology, stage, and date of diagnosis of lung cancer. Read More

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Aggressive progression of a facial super giant basal cell carcinoma.

BMJ Case Rep 2021 Apr 15;14(4). Epub 2021 Apr 15.

Internal Medicine, Jackson Memorial Hospital, Miami, Florida, USA

Super giant basal cell carcinoma (BCC) is a rare oncological entity. A 52-year-old man with a history of a left upper facial lesion for 11 years was transferred to our facility seeking an evaluation. He frequented multiple hospitals where he was treated with antibiotics for this condition. Read More

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Clinical evaluation of direct anterior approach total hip arthroplasty for severe developmental dysplasia of the hip.

Sci Rep 2021 Apr 14;11(1):8105. Epub 2021 Apr 14.

Department of Orthopedics, Joint Disease and Sport Medicine Center, Xinqiao Hospital, Army Medical University, 183# Xinqiao Street, Shapingba District, Chongqing, 400037, China.

It is challenging to treat developmental dysplasia of the hip (DDH) classified Crowe III-IV using direct anterior approach (DAA) total hip arthroplasty (THA), and very little is known on its outcome. This study aimed to investigate the clinical result in this defined disorder with DAA versus posterolateral approach. Twenty-three consecutive hips with Crowe III-IV DDH who underwent DAA were retrospectively evaluated from 2016 through 2018. Read More

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Dysosmia and drug tolerance with use of venlafaxine.

BMJ Case Rep 2021 Apr 14;14(4). Epub 2021 Apr 14.

Community Health and Family Medicine, University of Florida Health, Gainesville, Florida, USA

A 57-year-old woman presented with a 1-year history of major depressive disorder. She was started on venlafaxine XR 75 mg orally daily and a few days later developed severe dysosmia to foods she used to enjoy. She never had previous problems with smell or taste. Read More

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Repetitive deep TMS for the reduction of body weight: Bimodal effect on the functional brain connectivity in "diabesity".

Nutr Metab Cardiovasc Dis 2021 Feb 25. Epub 2021 Feb 25.

Department of Biomedical Sciences for Health, Università Degli Studi di Milano, Milan, Italy; Department of Endocrinology, Nutrition and Metabolic Diseases, IRCCS MultiMedica, Sesto San Giovanni, MI, Italy. Electronic address:

Background And Aims: Deep repetitive Transcranial Magnetic Stimulation (deep rTMS) over the bilateral insula and prefrontal cortex (PFC) can promote weight-loss in obesity, preventing cardiometabolic complications as Type 2 Diabetes (T2D). To investigate the changes in the functional brain integration after dTMS, we conducted a resting-state functional connectivity (rsFC) study in obesity.

Methods And Results: This preliminary study was designed as a randomized, double-blind, sham-controlled study: 9 participants were treated with high-frequency stimulation (realTMS group), 8 were sham-treated (shamTMS group). Read More

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February 2021

Robotic-Assisted Unicompartmental Knee Arthroplasty Reduces Components' Positioning Differences among High- and Low-Volume Surgeons.

J Knee Surg 2021 Apr 14. Epub 2021 Apr 14.

Orthopaedic Clinic CTO, University of Florence, Florence, Italy.

Robotic-assisted medial unicompartmental knee arthroplasty (mUKA) has been introduced to improve accuracy in implant positioning and limb alignment, overcoming the reported high failure rates of conventional UKA. Indeed, mUKA is a technically challenging procedure strongly related to surgeons' skills and expertise. The purpose of this study was to evaluate the likelihood of robotic-assisted surgery in reducing the variability of coronal and sagittal component positioning between high- and low-volume surgeons. Read More

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Clinical features and follow-up of pediatric patients hospitalized for COVID-19.

Pediatr Pulmonol 2021 Apr 14. Epub 2021 Apr 14.

Medicine Research Center, Ningbo City First Hospital, Ningbo, Zhejiang Province, China.

Objective: This report summarizes the clinical features and 1-month follow-up observations for pediatric patients who were hospitalized with coronavirus disease 2019 (COVID-19) in Wuhan Women and Children's Hospital.

Methods: The 1-month follow-up data included clinical manifestations and results from serum severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG and IgM tests, reverse-transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2, lung computed tomography (CT) scans, and laboratory tests.

Results: Between January 20 and March 15, 2020, 127 patients aged 0-15 years were hospitalized for COVID-19 treatment, including 3 severe cases and 124 mild or moderate cases. Read More

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Vigilance for carcinoid heart disease is still required in the era of somatostatin analogues: Lessons from a case series.

Asia Pac J Clin Oncol 2021 Apr 14. Epub 2021 Apr 14.

Department of Endocrine Oncology, University Hospital, Uppsala, Sweden.

Aim: Carcinoid heart disease (CHD) is a well-documented complication of neuroendocrine tumors (NETs) due to secreted hormones causing fibrosis. Somatostatin analogues (SSAs) can decrease hormonal secretion and inhibit tumor growth. The reported incidence of CHD has decreased as SSA use has increased. Read More

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Early Improvement in Clinical Status Following Ventricular Assist Device Implantation in Children: A Marker for Survival.

ASAIO J 2021 Apr 7. Epub 2021 Apr 7.

From the Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada The Johns Hopkins Hospital, Baltimore, Maryland Nationwide Children's Hospital, Columbus, Ohio Kirklin Institute for Research in Surgical Outcomes (KIRSO), The University of Alabama at Birmingham, Birmingham, Alabama Abbott Northwestern Hospital, Minneapolis, Minnesota Mayo Clinic College of Medicine, Rochester, Minnesota The Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York.

While clinical status at the time of ventricular assist device (VAD) implant can negatively affect outcomes, it is unclear if early improvement after implant can have a positive effect. Therefore, the objectives of this study were to describe the clinical status of pediatric patients supported with a VAD and determine the impact of clinical status on the 1-month follow-up form on survival and ability to discharge. This was a retrospective analysis of data collected prospectively by the Pediatric Interagency Registry for Mechanical Circulatory Support Registry (Pedimacs) Registry. Read More

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Suctioning semirigid ureteroscopic lithotomy versus minimally invasive percutaneous nephrolithotomy for large upper ureteral stones: a retrospective study.

Transl Androl Urol 2021 Mar;10(3):1056-1063

Department of Urology, Xiangya Hospital, Central South University, Changsha, China.

Background: To compare the safety and validity of a suctioning semirigid ureteroscopic lithotomy (Sotn-URSL) and minimally percutaneous nephrolithotomy (mPCNL) in treating upper ureteral stone larger than 15 mm.

Methods: Between February 2018 and December 2019, 97 patients who had upper ureteral stone >15 mm were consecutively included in this study. Forty-six patients underwent Sotn-URSL and 51 underwent mPCNL by the same surgeon. Read More

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Severe stridor and profound weakness after cerebral malaria.

BMJ Case Rep 2021 Apr 13;14(4). Epub 2021 Apr 13.

Department of Neurosciences, Alder Hey Children's Hospital, Liverpool, UK.

Cerebral malaria (CM) is defined by WHO as coma (Blantyre Coma Score 2 or less) in a patient with parasitaemia and no alternative cause of coma identified. Mortality is approximately 15%-30% in African children and up to one-third of survivors have neurological sequelae. We present a patient with severe stridor and prolonged profound weakness during an intensive care admission with CM. Read More

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Pembrolizumab with or without enzalutamide in selected populations of men with previously untreated metastatic castration-resistant prostate cancer harbouring programmed cell death ligand-1 staining: a retrospective study.

BMC Cancer 2021 Apr 13;21(1):399. Epub 2021 Apr 13.

Department of Neurosurgery, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Yuexiu District, Guangzhou, 510080, China.

Background: The purpose of this retrospective study was to evaluate the survival outcomes of pembrolizumab (PEM) plus enzalutamide (ENZ) versus PEM alone in selected populations of men with previously untreated metastatic castration-resistant prostate cancer (mCRPC) harbouring programmed cell death ligand-1 (PD-L1) staining.

Methods: Consecutive men with previously untreated mCRPC harbouring PD-L1 staining who underwent treatment with PEM plus ENZ (PE) or PEM alone (PA) at our medical centre from January 1, 2017, to January 31, 2021, were retrospectively identified. Follow-up was conducted monthly during the first year and then every 1 month thereafter. Read More

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Laparoscopic uterovaginal anastomosis in patients with congenital cervicovaginal atresia: An institutional experience with 23 patients.

Eur J Obstet Gynecol Reprod Biol 2021 Mar 31;260:218-224. Epub 2021 Mar 31.

Department of Obstetrics and Gynecology, The 3rd Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, 518000, PR China.

Objective: To introduce our experience of laparoscopic uterovaginal anastomosis and operative outcomes following this technique and update the clinical management of congenital cervicovaginal atresia.

Study Design: Between March 2015 and January 2019, twenty-three patients with congenital cervicovaginal atresia underwent laparoscopic uterovaginal anastomosis and Luohu procedure. Their clinical characteristics, surgical outcomes and follow-up data were retrospectively reviewed. Read More

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Particulate air pollution and survival after stroke in older adults: A retrospective cohort study in Korea.

Environ Res 2021 Apr 10:111139. Epub 2021 Apr 10.

Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen Denmark. Electronic address:

Although many studies have evaluated the effects of ambient particulate matter with diameters of less than 2.5 μm (PM) on stroke mortality in the general population, little is known about the mortality effects of PM in post-stroke populations. Therefore, a retrospective cohort was constructed using information from the health insurance database to evaluate whether exposure to PM is associated with increased mortality in aged stroke survivors residing in seven Korean metropolitan cities. Read More

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Evaluation of the participation of hyaluronic acid with platelet-rich plasma in the treatment of temporomandibular joint disorders.

Dent Med Probl 2021 Jan-Mar;58(1):81-88

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Damascus University, Syria.

Background: Temporomandibular joint disorders (TMDs) are widely researched diseases in medical literature. They are associated with many symptoms, such as pain, limited mouth opening and joint sounds, resulting in decreased quality of life for the patient. Both the hyaluronic acid (HA) injection and the plateletrich plasma (PRP) injection have a remarkable efficacy in the treatment of TMDs. Read More

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Pressure adjustment is the most useful intervention for improving compliance in telemonitored patients treated with CPAP in the first 6 months of treatment.

Sleep Breath 2021 Apr 13. Epub 2021 Apr 13.

Department of Pulmonary Medicine, CHU Saint-Pierre, Brussels, Belgium.

Purpose: Telemonitoring (TMg) for patients treated with continuous positive airway pressure (CPAP) is now routine care in some sleep labs. The purpose of the present study was to identify technical interventions associated with improved CPAP compliance in a real-life cohort of newly telemonitored patients with obstructive sleep apnea (OSA) during the first 6 months of treatment.

Methods: All patients with moderate-to-severe OSA (apnea-hypopnea index (AHI) ≥ 15/h) who were newly treated with CPAP were included in the study and telemonitored. Read More

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Characterization of myocardial injury in a cohort of patients with SARS-CoV-2 infection.

Med Clin (Barc) 2021 Mar 24. Epub 2021 Mar 24.

Cardiology Department, Hospital Universitario La Paz, Madrid, Spain.

Background: Myocardial injury has been identified as a common complication in patients with COVID-19. However, recent research has serious limitations, such as non-guideline definition of myocardial injury, heterogenicity of troponin sampling or very short-term follow-up. Using data from a large European cohort, we aimed to overcome these pitfalls and adequately characterize myocardial damage in COVID-19. Read More

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Laminectomy versus Unilateral Hemilaminectomy for the Removal of Intraspinal Schwannoma: Experience of a Single Institution and Review of Literature.

J Neurol Surg A Cent Eur Neurosurg 2021 Apr 12. Epub 2021 Apr 12.

Department of Neurosurgery, Università Politecnica delle Marche, Ancona, Italy.

Background And Study Aims:  Spinal schwannomas are benign slow-growing tumors, and gross total resection is the gold standard of treatment. The conventional surgical approach is laminectomy, which provides a wide working area. Today minimally invasive surgery (MIS) is popular because it is associated with shorter hospital stay, less operative blood loss, minimized tissue traumas and relative postoperative pain, and, and spine surgery, avoidance of spinal instability. Read More

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Short- and Mid-Term Impact of Tobacco Smoking on Donor Renal Function Following Living Kidney Donation at a Tertiary Referral Hospital.

Rev Invest Clin 2021 Apr 12. Epub 2021 Apr 12.

Department of Urology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Background: The negative impact of tobacco smoking on renal function has been widely studied. However, there is limited knowledge about the effect of smoking on pre-operative and post-operative renal function in living kidney donors.

Objective: The objective of the study was to evaluate the short- and mid-term impact of smoking on donor renal function. Read More

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Multipass low fluence, high-frequency 755-nm alexandrite laser versus high fluence, low-frequency 1064-nm long-pulsed Nd: YAG laser in axillary hair reduction of dark skin phototypes: an intra-individual randomized comparative study.

J Dermatolog Treat 2021 Apr 12:1-13. Epub 2021 Apr 12.

Assistant Professor of Dermatology & Venereology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Background: Laser hair removal has become popular means of achieving hair reduction with improved quality of life.

Objective: This study aimed to assess the safety and efficacy of Multipass low fluence, high-frequency 755-nm Alexandrite laser versus the high fluence, low-frequency 1064-nm long-pulsed Nd: YAG laser on axillary hair reduction in women with dark skin phototypes.

Patients And Methods: This study was carried out on 30 adult women [skin type, IV-VI)] who seek axillary hair reduction. Read More

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Safety of video-based telemedicine compared to in-person triage in emergency ophthalmology during COVID-19.

EClinicalMedicine 2021 Apr 5:100818. Epub 2021 Apr 5.

Department of Digital Medicine, Moorfields Eye Hospital NHS Foundation Trust, 162 City Road, London EC1V 2PD, United Kingdom.

Background: the need for social distancing midst the COVID-19 pandemic has forced ophthalmologists to innovate with telemedicine. The novel process of triaging emergency ophthalmology patients via videoconsultations should reduce hospital attendances. However, the safety profile of such services were unknown. Read More

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Comparison of posterior corneal elevation after SMILE and FS-LASIK in correcting myopia over -9.0 diopters.

Ann Transl Med 2021 Mar;9(5):373

Department of Ophthalmology and Optometry, Eye and ENT Hospital of Fudan University, Shanghai, China.

Background: To compare the changes in posterior corneal elevation after small incision lenticule extraction (SMILE) and femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK) in correcting myopia over -9 diopters (D).

Methods: In this prospective comparative study, 82 eyes of 82 patients scheduled for refractive correction were recruited. Eyes were randomly assigned to the SMILE group (45 eyes, -10. Read More

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