114 results match your criteria 1-163 months

Factors affecting in-stent restenosis after angioplasty with the Enterprise stent for intracranial atherosclerotic diseases.

Sci Rep 2021 May 18;11(1):10479. Epub 2021 May 18.

Henan Provincial Cerebrovascular Hospital, Henan Provincial People's Hospital, Zhengzhou University, 7 Weiwu Road, Zhengzhou, 450003, Henan Province, China.

This study investigated factors affecting the safety and in-stent restenosis after intracranial stent angioplasty using the Enterprise stent for symptomatic intracranial atherosclerotic stenosis. Between January 2017 and March 2019, patients with intracranial atherosclerotic stenosis treated with Enterprise stent angioplasty were enrolled, including 400 patients in the modeling group and 89 patients in the validation group. The clinical factors affecting in-stent restenosis after Enterprise stent angioplasty in the modeling group were analyzed, and a logistic regression model of these factors was established and validated in the validation group. Read More

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Absolute Neutrophil Count in the Peripheral Blood Predicts Prognosis in Lung Cancer Patients Treated with Anlotinib.

Cancer Manag Res 2021 3;13:3619-3627. Epub 2021 May 3.

Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Purpose: Anlotinib is a multi-targeted tyrosine kinase inhibitor that inhibits tumor angiogenesis and cell proliferation. It is widely used as a third-line therapy for lung cancer. However, reliable prognostic biomarkers for predicting the efficacy of anlotinib are lacking. Read More

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Estimating the Period Prevalence of Publicly Funded Abortion to Space Live Births, 1999 to 2014.

J Prim Care Community Health 2021 Jan-Dec;12:21501327211012182

American Association of Pro-Life Obstetricians and Gynecologists, Eau Claire, MI, USA.

Introduction/objectives: Although a majority of women who have an abortion report having 1 or more children, there is no published research on the number of abortions which occur between live births, after a first child but before the last. The objectives of this research, therefore, were to estimate the period prevalence of an induced abortion separating live births in a population of Medicaid eligible enrollees and to identify the characteristics of enrollees significantly associated with the use of abortion to enable child spacing.

Methods: A retrospective, cross-sectional, longitudinal analysis of the pregnancy outcome sequences of eligible enrollees over age 13 from the 17 states where Medicaid included coverage of all abortions, with at least one identifiable pregnancy outcome between 1999 and 2014. Read More

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Tenofovir disoproxil fumarate on the risk of hepatocellular carcinoma in chronic hepatitis B patients with failure to preceding treatments: A nationwide cohort study.

J Viral Hepat 2021 May 1. Epub 2021 May 1.

Division for Healthcare Technology Assessment Research, National Evidence-based Healthcare Collaborating Agency, Seoul, Korea.

Tenofovir disoproxil fumarate (TDF) monotherapy is recommended for the treatment of chronic hepatitis B (CHB) patients who are refractory to other drugs. Yet, little data are available for the effectiveness of TDF monotherapy compared with TDF-based combination therapy on the risk of hepatocellular carcinoma (HCC) and death/transplantation. This nationwide population-based cohort study included 11,289 CHB patients who initiated TDF rescue therapy after failure of preceding treatments between 2012 and 2014 in Korea. Read More

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Is quantitative ultrasound a measure for metabolic bone disease in preterm-born infants? A prospective subcohort study.

Eur J Pediatr 2021 Apr 22. Epub 2021 Apr 22.

Division of Neonatology, Department of Pediatrics, Amsterdam UMC, Location VU University Medical Center, De Boelelaan 1117, 1081, HV, Amsterdam, The Netherlands.

In this study, we aimed to (a) evaluate postnatal changes in bone development in relation to growth and (b) to determine factors associated with bone development, from birth to 24 months of corrected age. The metacarpal speed of sound (mcSOS) and metacarpal bone transmission time (mcBTT) were used to evaluate bone development in 98 preterm infants, during hospitalization and follow-up. The mcSOS and mcBTT values not only declined in the first 6 weeks of hospitalization but also during follow-up. Read More

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Myocardial Fibrosis and Inflammation by CMR Predict Cardiovascular Outcome in People Living With HIV.

JACC Cardiovasc Imaging 2021 Apr 7. Epub 2021 Apr 7.

Institute of Experimental and Translational Cardiac Imaging, DZHK (German Centre for Cardiovascular Research) Centre for Cardiovascular Imaging, University Hospital Frankfurt, Frankfurt am Main, Germany; Department of Cardiology, University Hospital Warsaw, Warsaw, Poland. Electronic address:

Objectives: The goal of this study was to examine prognostic relationships between cardiac imaging measures and cardiovascular outcome in people living with human immunodeficiency virus (HIV) (PLWH) on highly active antiretroviral therapy (HAART).

Background: PLWH have a higher prevalence of cardiovascular disease and heart failure (HF) compared with the noninfected population. The pathophysiological drivers of myocardial dysfunction and worse cardiovascular outcome in HIV remain poorly understood. Read More

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An 8-Week Self-Administered At-Home Behavioral Skills-Based Virtual Reality Program for Chronic Low Back Pain: Double-Blind, Randomized, Placebo-Controlled Trial Conducted During COVID-19.

J Med Internet Res 2021 02 22;23(2):e26292. Epub 2021 Feb 22.

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, CA, United States.

Background: Chronic low back pain is the most prevalent chronic pain condition worldwide and access to behavioral pain treatment is limited. Virtual reality (VR) is an immersive technology that may provide effective behavioral therapeutics for chronic pain.

Objective: We aimed to conduct a double-blind, parallel-arm, single-cohort, remote, randomized placebo-controlled trial for a self-administered behavioral skills-based VR program in community-based individuals with self-reported chronic low back pain during the COVID-19 pandemic. Read More

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February 2021

Association between the severity of liver fibrosis and cardiovascular outcomes in patients with type 2 diabetes.

J Gastroenterol Hepatol 2021 Jun 15;36(6):1703-1713. Epub 2021 Jan 15.

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Background And Aim: Cardiovascular disease (CVD) is the principal cause of death in patients with type 2 diabetes (T2D). In this study, we assessed whether liver fibrosis predicted the risk of CVD in patients with T2D.

Methods: A total of 1481 patients who had commenced oral antidiabetic drugs to treat newly diagnosed T2D between 2006 and 2010 were recruited. Read More

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Infarct site and prognosis in small subcortical infarction: Role of the corticospinal tract and lentiform.

J Neurol Sci 2020 Nov 7;418:117130. Epub 2020 Sep 7.

Department of Neurology, the Jikei University School of Medicine, Tokyo, Japan.

Objective: To determine the impact of infarct site combinations on prognosis of small subcortical infarction (SSI) by classifying the infarcted perforator area in relation to the anatomical structures that surround and/or involve the corticospinal tract.

Methods: Consecutive patients with SSI ≤24 h from onset to initial magnetic resonance imaging (MRI) and ≤ 14 days from onset to second MRI were included. Infarct sites were defined as follows: caudate head, lentiform (L), corona radiata (CR), posterior limb and genu of the internal capsule (IC), thalamus, and brainstem with or without involvement of the corticospinal tract. Read More

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November 2020

Feasibility of neoadjuvant and adjuvant intraperitoneal chemotherapy in patients with advanced epithelial ovarian cancer: A single-center experience.

Medicine (Baltimore) 2020 Sep;99(36):e22100

Department of Obstetrics and Gynecology of the First Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, China.

Intraperitoneal (IP) chemotherapy is believed to prolong the survival of patients with advanced ovarian cancer after primary debulking surgery. However, there is little knowledge about IP chemotherapy in the setting of neoadjuvant chemotherapy, and there are contradictory conclusions about adjuvant IP chemotherapy. Here, we evaluated the feasibility of neoadjuvant and adjuvant IP chemotherapy in patients with advanced epithelial ovarian cancer (AEOC). Read More

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September 2020

Intravenous Glucocorticoid Treatment for Korean Graves' Ophthalmopathy Patients.

J Korean Med Sci 2020 Jun 15;35(23):e177. Epub 2020 Jun 15.

Department of Ophthalmology, Chung-Ang University College of Medicine, Seoul, Korea.

Background: High-dose intravenous steroids are the first-line treatment for patients with moderate-to-severe and active Graves' ophthalmopathy (GO). We aimed to investigate the response rate of methylprednisolone (MPD) treatment among Korean patients with active moderate-to-severe GO and to identify predictive factors of treatment response.

Methods: This is a retrospective observational study. Read More

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Amide Proton Transfer-Weighted (APTw) Imaging of Intracranial Infection in Children: Initial Experience and Comparison with Gadolinium-Enhanced T1-Weighted Imaging.

Biomed Res Int 2020 16;2020:6418343. Epub 2020 May 16.

Department of Radiology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Purpose: To evaluate the performance of amide proton transfer-weighted (APTw) imaging against the reference standard of gadolinium-enhanced T1-weighted imaging (Gd-T1w) in children with intracranial infection.

Materials And Methods: Twenty-eight pediatric patients (15 males and 13 females; age range 1-163 months) with intracranial infection were recruited in this study. 2D APTw imaging and conventional MR sequences were conducted using a 3 T MRI scanner. Read More

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Self-evaluation of negative symptoms in adolescent and young adult first psychiatric episodes.

Prog Neuropsychopharmacol Biol Psychiatry 2020 12 29;103:109988. Epub 2020 May 29.

AP-HP Greater Paris University Hospital, Psychiatry Department, University Hospital Louis Mourier, France; University of Paris, INSERM UMR1266, Institute of Psychiatry and Neurosciences of Paris (IPNP), Paris, France.

Background: Negative Symptoms (blunted affect, alogia, anhedonia, avolition, and asociality) are usually described in schizophrenia but they are also present in other psychiatric disorders. The diagnosis and prognosis relevance of negative symptoms (NS) self-assessment during a first psychiatric episode is still unknown.

Aims: To determine (i) the rate of self-assessed NS in a first psychiatric episode among adolescents and young adults compared to control subjects; and (ii), whether there is a difference in the prevalence of NS between schizophrenia and major depressive disorder first episodes. Read More

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December 2020

Pharmacodynamic, pharmacokinetic and physical characterization of cilnidipine loaded solid lipid nanoparticles for oral delivery optimized using the principles of design of experiments.

Colloids Surf B Biointerfaces 2020 Sep 24;193:111073. Epub 2020 Apr 24.

Department of Pharmacy, BITS-Pilani Hyderabad Campus, Hyderabad 500078, Telangana, India.

Cilnidipine (CND), an anti-hypertensive drug, is known to have low oral bioavailability due to its poor aqueous solubility, low dissolution rate and high gut wall metabolism. In the present study, CND loaded compritol based nanoparticles (CND-CMP-NPs) were prepared by emulsification-solvent evaporation method applying the concepts of design of experiments. Critical factors affecting particle size and loading efficiency (LE%) were assessed by hybrid design approach, comprising of Mini Run Resolution IV design followed by Box-Behnken design. Read More

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September 2020

Photodynamic therapy for squamous cell carcinoma of the index finger: A case report.

Junhong Ma Xin Wang

Photodiagnosis Photodyn Ther 2020 Mar 13;29:101661. Epub 2020 Jan 13.

Department of Dermatology, The First Affiliated Hospital of Tsinghua University, Beijing, China.

Skin squamous cell carcinoma (SCC) is the second most common skin cancer, and surgical resection is the first choice of treatment. However, some special sites such as lips, eyelids, distal fingers and genital areas are not suitable for operation. We report a case of SCC on his left index for three years. Read More

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Risk factors of cage subsidence after removal of localized heterotopic ossification by anterior cervical discectomy and fusion: A retrospective multivariable analysis.

Medicine (Baltimore) 2019 Oct;98(42):e17505

Department of Orthopedic Surgery, the Orthopedics Hospital of XingTai, XingTai.

The purpose of the study was to identify risk factors of cage subsidence and evaluate surgical outcome by at least 12 months postoperative follow-up.We retrospectively investigated 113 consecutive patients who underwent anterior surgery to relieve spine cord compression resulted from localized heterotopic ossification, from July, 2011 to February, 2016. We divided the patients into 2 groups: cage subsidence <2 mm group and ≥2 mm group. Read More

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October 2019

Effect of default order set settings on telemetry ordering.

J Am Med Inform Assoc 2019 12;26(12):1488-1492

Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Objective: To investigate the effects of adjusting the default order set settings on telemetry usage.

Materials And Methods: We performed a retrospective, controlled, before-after study of patients admitted to a house staff medicine service at an academic medical center examining the effect of changing whether the admission telemetry order was pre-selected or not. Telemetry orders on admission and subsequent orders for telemetry were monitored pre- and post-change. Read More

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December 2019

[Clinical analysis of a modified LMB89 Group C regimen in the treatment of pediatric high-risk Burkitt lymphoma].

Zhonghua Xue Ye Xue Za Zhi 2019 Aug;40(8):633-638

Beijing Key Laboratory of Pediatric Hematology Oncology; National Discipline of Pediatrics, Ministry of Education; MOE Key Laboratory of Major Diseases in Children; Hematology Oncology Center, Beijing 100045, China.

To analyze the therapeutic effect of a modified LMB89 Group C regimen in the treatment of pediatric high-risk Burkitt lymphoma. The clinical data of 172 children with newly diagnosed high-risk Burkitt lymphoma from January 2007 to April 2017 were retrospectively analyzed. All the cases were treated with the modified LMB89 Group C regimen. Read More

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Genetic diversity and epidemiology of Genogroup II noroviruses in children with acute sporadic gastroenteritis in Shanghai, China, 2012-2017.

BMC Infect Dis 2019 Aug 22;19(1):736. Epub 2019 Aug 22.

Department of Clinical Laboratory, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.

Background: Noroviruses (NoVs) are considered an important cause of acute gastroenteritis (AGE) across all age groups, especially in children under 5 years of age. We investigated the epidemiology of noroviruses in outpatient children from the Children's Hospital of Fudan University in Shanghai, China.

Methods: Stool specimens were collected between January 2012 and December 2017 from 1433 children under 5 years of age with acute gastroenteritis. Read More

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Survey of U.S. adults with spina bifida.

Disabil Health J 2020 04 1;13(2):100833. Epub 2019 Aug 1.

Department of Physical Medicine & Rehabilitation, Upstate Medical University, Syracuse, NY, USA; Department of Public Health & Preventive Medicine, Upstate Medical University, 750 E Adams St, Syracuse, NY, USA. Electronic address:

Background: Spina Bifida (SB) is one of the most common birth defects and causes of permanent disability in the United States (US), with approximately 3.5 cases per 10,000 live births.

Objective: To identify complications associated with SB related to skin breakdown, pain, and urinary tract infections (UTIs), and to examine socio-demographic differences related to these complications. Read More

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Radiotherapy After Skin-Sparing Mastectomy and Implant-Based Breast Reconstruction.

Clin Breast Cancer 2019 10 11;19(5):e611-e616. Epub 2019 Apr 11.

Department of Radiation Oncology, Hacettepe University Medical School, Ankara, Turkey. Electronic address:

Introduction: We evaluated the cosmetic results of radiotherapy (RT) after implant-based reconstruction (IBR).

Patients And Methods: We retrospectively evaluated 170 patients with 171 breast cancers treated between December 2004 and January 2016 in 2 university hospitals. RT fields were reconstructed breast (RB) only in 24 (14%), and RB and regional lymphatics in 147 (86%) breasts, respectively. Read More

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October 2019

[Analysis on prognosis and influencing factors of postoperative low anterior resection syndrome for rectal cancer patients undergoing laparoscopic anus-preserving radical resection].

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Jun;22(6):573-578

Department of Gastrointestinal Surgery, the First Affiliated Hospital, Bengbu Medical College, Anhui Bengbu 233004, China.

To investigate the prognosis and influencing factors of postoperative low anterior resection syndrome (LARS) for rectal cancer patients undergoing laparoscopic sphincter-preserving radical resection. A retrospective case-control study was used in this study. Clinical data of 268 rectal cancer patients undergoing laparoscopic sphincter-preserving radical resection at Department of Gastrointestinal Surgery of The First Affiliated Hospital of Bengbu Medical College from January 2016 to January 2018 were retrospectively collected. Read More

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Parent-directed intervention in promoting knowledge of pediatric nutrition and healthy lifestyle among low-SES families with toddlers: A randomized controlled trial.

Child Care Health Dev 2019 07 27;45(4):518-522. Epub 2019 May 27.

TMW Center for Early Learning and Public Health, Department of Surgery, The University of Chicago Medicine, Chicago, Illinois.

Objective: The objective of this study is to determine the efficacy of an interactive, home visiting curriculum tailored to low socio-economic status families in improving parental knowledge of paediatric nutrition and healthy lifestyle.

Methods: Parents of toddlers aged 13-16 months living with a household income below 200% of the federal poverty line were randomized into healthy lifestyle intervention and control home visiting curriculum groups. Each curriculum consisted of 12 one-on-one educational sessions with parents facilitated by a trained home-visitor that were administered over a 6-month intervention period. Read More

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Association between Pretreatment Serum Uric Acid Levels and Progression of Newly Diagnosed Primary Angle-Closure Glaucoma: A Prospective Cohort Study.

Oxid Med Cell Longev 2019 7;2019:7919836. Epub 2019 Feb 7.

Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China.

Purpose: Increased evidence reveals that uric acid (UA) may have an important neuroprotective effect through its antioxidant properties. The aim of the present study was to investigate the relationship between pretreatment serum UA levels and the progression of newly diagnosed primary angle-closure glaucoma (PACG).

Methods: This prospective observational cohort study included 64 patients with newly diagnosed PACG who were followed up for a mean period of 12. Read More

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Leukocytosis and neutrophilia as independent prognostic immunological biomarkers for clinical outcome in the CAO/ARO/AIO-04 randomized phase 3 rectal cancer trial.

Int J Cancer 2019 10 2;145(8):2282-2291. Epub 2019 Apr 2.

Department of Radiotherapy and Oncology, University of Frankfurt, Frankfurt, Germany.

Peripheral blood leukocytosis and neutrophilia reflect cancer inflammation and have been proposed as prognostic immunological biomarkers in various malignancies. However, previous studies were limited by their retrospective nature and small patient numbers. Baseline peripheral blood leukocytes, neutrophils, hemoglobin, platelets, lactate dehydrogenase and carcinoembryonic antigen (CEA) were correlated with clinicopathologic characteristics, and clinical outcome in 1236 patients with rectal cancer treated with 5-FU-based preoperative chemoradiotherapy (CRT) alone or with oxaliplatin followed by surgery and adjuvant chemotherapy within the CAO/ARO/AIO-04 randomized phase 3 trial. Read More

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October 2019

Lentiviral vector-mediated overexpression of Klotho in the brain improves Alzheimer's disease-like pathology and cognitive deficits in mice.

Neurobiol Aging 2019 06 13;78:18-28. Epub 2019 Feb 13.

Department of Pharmacology, Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, China. Electronic address:

Alzheimer's disease (AD) is the most common type of senile dementia. The antiaging gene Klotho is reported to decline in the brain of patients and animals with AD. However, the role of Klotho in the progression of AD remains elusive. Read More

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Glioblastoma Treatment with Temozolomide and Bevacizumab and Overall Survival in a Rural Tertiary Healthcare Practice.

Biomed Res Int 2018 31;2018:6204676. Epub 2018 Dec 31.

Department of Neurology (Neuro-oncology), Marshfield Clinic, 1000 North Oak Avenue, Marshfield, WI 54449, USA.

Background: The efficacy of temozolomide (TMZ) chemotherapy for treating newly diagnosed glioblastoma (GBM), a primary brain tumor with short survival, was demonstrated in a clinical trial in 2005, and since then, the standard-of-care for newly diagnosed GBM has been maximal safe surgery followed by 60 Gray of radiation with concomitant and adjuvant TMZ (standard radiotherapy and TMZ). In 2009, clinical trials also reported on the efficacy of bevacizumab for treating recurrent GBM. We performed a retrospective cohort study to evaluate the impact of treatment regimens on overall survival for patients with GBM at a rural tertiary healthcare practice. Read More

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Massive transfusion in the pediatric population: A systematic review and summary of best-evidence practice strategies.

J Trauma Acute Care Surg 2019 04;86(4):744-754

From the School of Medicine (R.W.K.) and Departments of Surgery (H.J.L., C.R., U.P.N., E.T.T.), Pediatrics (C.M.R.), and Pathology (J.L.P.), Duke University, Durham, North Carolina.

Background: Pediatric patients require massive transfusion (MT) in a variety of settings. Multiple studies of adult MT support balanced ratio transfusion to improve outcomes; however, it is unclear if these findings can be extrapolated to pediatric populations. The use of balanced transfusion ratios, MT protocols, hemostatic adjuncts, and even the definition of a MT in children are all open questions. Read More

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Renal Venous Pattern: A New Parameter for Predicting Prognosis in Heart Failure Outpatients.

J Cardiovasc Dev Dis 2018 Nov 3;5(4). Epub 2018 Nov 3.

University Cardiology Unit, Cardiothoracic Department, Policlinic University Hospital, Piazza Giulio Cesare 11, 70124 Bari, Italy.

Aim Of The Study: In chronic heart failure (CHF) patients, renal congestion plays a key role in determining the progression of renal dysfunction and a worse prognosis. The aim of this study was to define the role of Doppler venous patterns reflecting renal congestion that predict heart failure progression.

Methods: We enrolled outpatients affected by CHF, in stable clinical conditions and in conventional therapy. Read More

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November 2018

Community delivery of antiretroviral drugs: A non-inferiority cluster-randomized pragmatic trial in Dar es Salaam, Tanzania.

PLoS Med 2018 09 19;15(9):e1002659. Epub 2018 Sep 19.

Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, United States of America.

Background: With the increase in people living with HIV in sub-Saharan Africa and expanding eligibility criteria for antiretroviral therapy (ART), there is intense interest in the use of novel delivery models that allow understaffed health systems to successfully deal with an increasing demand for antiretroviral drugs (ARVs). This pragmatic randomized controlled trial in Dar es Salaam, Tanzania, evaluated a novel model of ARV community delivery: lay health workers (home-based carers [HBCs]) deliver ARVs to the homes of patients who are clinically stable on ART, while nurses and physicians deliver standard facility-based care for patients who are clinically unstable. Specifically, the trial aimed to assess whether the ARV community delivery model performed at least equally well in averting virological failure as the standard of care (facility-based care for all ART patients). Read More

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September 2018