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Impact of renin-angiotensin system inhibitors on long-term clinical outcomes of patients with rheumatic heart disease.

ESC Heart Fail 2021 Sep 20. Epub 2021 Sep 20.

Department of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.

Aims: Rheumatic heart disease (RHD) remains a major global health problem. Renin-angiotensin-aldosterone system inhibitors (RAASi) are commonly administered in the treatment of cardiovascular disease, but its role in RHD patients is still limited. We performed a retrospective study to determine the effect of RAASi on long-term outcomes for RHD patients. Read More

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September 2021

A trauma-related survival predictive model of acute respiratory distress syndrome.

J Clin Lab Anal 2021 Sep 20:e24006. Epub 2021 Sep 20.

Department of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Purpose: The purpose of this study was to construct and validate a simple model for the prediction of survival in patients with trauma-related ARDS.

Methods: This is a single-center, retrospective cohort study using MIMIC-III Clinical Database.

Results: 842 patients were included in this study. Read More

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September 2021

Culprit-Plaque Morphology and Residual SYNTAX Score Predict Cardiovascular Risk in Acute Myocardial Infarction: An Optical Coherence Tomography Study.

J Atheroscler Thromb 2021 Sep 19. Epub 2021 Sep 19.

Department of Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences.

Aims: Culprit-plaque morphology [plaque rupture (PR) and plaque erosion (PE)] and high-risk plaques (HRP) identified by optical coherence tomography (OCT) and residual SYNTAX score (rSS) have been reported to influence clinical outcomes. Thus, in this study, we aimed to investigate the prognostic implication of culprit-plaque morphology and rSS for major adverse cardiovascular events (MACE) in patients with ST-segment elevation myocardial infarction (STEMI).

Methods: Based on plaque morphology and rSS, 274 STEMI patients were divided into 4 groups: PE/low-rSS (n=61), PE/high-rSS (n=58), PR/low-rSS (n=55), and PR/high-rSS (n=100). Read More

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September 2021

Predictive value of a reduction in the level of high-density lipoprotein-cholesterol in patients with non-small-cell lung cancer undergoing radical resection and adjuvant chemotherapy: a retrospective observational study.

Lipids Health Dis 2021 Sep 20;20(1):109. Epub 2021 Sep 20.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Medical Oncology, Guangdong Esophageal Cancer Institute, Sun Yat- sen University Cancer Center, 510060, Guangzhou, People's Republic of China.

Background: Cancer patients often exhibit chemotherapy-associated changes in serum lipid profiles, however, their prognostic value before and after adjuvant chemotherapy on survival among non-small-cell lung cancer (NSCLC) patients is unknown.

Methods: NSCLC patients undergoing radical resection and subsequent adjuvant chemotherapy from 2013 to 2017 at Sun Yat-sen University Cancer Center were retrospectively reviewed. Fasted serum lipid levels were measured before and after chemotherapy. Read More

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September 2021

Acute effects of acupuncture in balance and gait of Parkinson disease patients - A preliminary study.

Complement Ther Clin Pract 2021 Sep 8;45:101479. Epub 2021 Sep 8.

ICBAS-Abel Salazar Institute for Biomedical Sciences, University of Porto, Portugal; Escola Superior de Saúde, Piaget Institute, Vila Nova de Gaia, Portugal.

Introduction: Balance and gait disorders are relevant symptoms in the quality of life of Parkinson's patients. Currently, there is no therapy to reverse or treat this condition. Acupuncture treatment is believed to improve motor ability through the cortico-basal-thalamus-cortical-ganglia. Read More

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September 2021

Gentamicin-Containing Collagen Implant May Reduce Surgical Site Infections After Open Infrainguinal Arterial Revascularisation.

Ann Vasc Surg 2021 Sep 17. Epub 2021 Sep 17.

School of Medicine, Faculty of Health and Medical Sciences, The University of Western Australia, Mailbox Drop Point 509, 35 Stirling Hwy, Nedlands, 6009, Western Australia, Australia; Department of Vascular and Endovascular Surgery, Sir Charles Gairdner Hospital, Level 6, G Block, QEII Medical Centre, Hospital Avenue, Nedlands, 6009 Western Australia, Australia; Curtin Medical School, Faculty of Health Sciences, Curtin University Level 4 Building 400, GPO Box U1987, Perth, Western Australia 6845 Australia; Heart and Vascular Research Institute, Level 2 Harry Perkins Institute of Medical Research, 6 Verdun Street, Nedlands, Western Australia, Australia 6009. Electronic address:

Objectives: Deep-space surgical site infections carry significant morbidity and mortality. The evidence for gentamicin-containing collagen implants at reducing surgical site infections in open infrainguinal arterial surgery is limited. This study examined whether gentamicin-containing collagen implants reduces 30-day surgical site infections and their severity following open infrainguinal arterial surgery. Read More

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September 2021

Effects of Sevoflurane-Propofol-Balanced Anesthesia on Flash Visual Evoked Potential Monitoring in Spine Surgery: A Randomized Noninferiority Trial.

Anesth Analg 2021 Sep 20. Epub 2021 Sep 20.

From the Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.

Background: Intraoperative flash visual evoked potential (FVEP) can be used to monitor visual function during spine surgery. However, it is limited due to the previous perception of its sensitivity to inhalation anesthesia. We conducted this trial to test the noninferiority of sevoflurane-propofol-balanced anesthesia (BA) versus popular propofol-based total intravenous anesthesia (TIVA) on the amplitude of FVEP during spine surgery. Read More

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September 2021

Characteristics and Outcomes of the Idiopathic Intracranial Hypertension Treatment in Intrinsic and Extrinsic Stenosis: A Single-Center Experience in China.

Neurol Ther 2021 Sep 20. Epub 2021 Sep 20.

Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, No. 119, the South Fourth Ring West Road, Fengtai district, Beijing, 100070, China.

Introduction: This study aimed to explore the precipitating factors and evaluate the impact of different stenosis types on treatment outcomes in patients with idiopathic intracranial hypertension (IIH) and venous sinus stenosis (VSS).

Methods: We recruited patients with IIH who presented with VSS, either intrinsic or extrinsic. We observed the clinical and laboratory findings, and we then compared the outcomes of stenting and medical treatment in different stenosis types. Read More

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September 2021

Prevalence and prognosis of isolated posterior ST-segment elevation acute myocardial infarction using synthesized-V lead.

Cardiovasc Interv Ther 2021 Sep 20. Epub 2021 Sep 20.

Department of Cardiology, Ogaki Municipal Hospital, 4-86 Minaminokawa-cho, Ogaki, Gifu, Japan.

Limited data exist on the prevalence and prognosis of isolated posterior ST-segment elevation acute myocardial infarction (STEMI), revealed with a posterior chest lead. Furthermore, the utility of a synthesized-V lead in the diagnosis of STEMI is unclear; therefore, we aimed to evaluate its usefulness. We enrolled 142 consecutive patients with STEMI with the culprit lesion on the left circumflex artery (STEMI-LCx) undergoing percutaneous coronary intervention (PCI) between January 2009 and December 2019. Read More

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September 2021

Monitoring postoperative lung recovery using electrical impedance tomography in post anesthesia care unit: an observational study.

J Clin Monit Comput 2021 Sep 20. Epub 2021 Sep 20.

Department of Anesthesiology, Medical Faculty, RWTH Aachen University, Aachen, Germany.

With electrical impedance tomography (EIT) recruitment and de-recruitment phenomena can be quantified and monitored at bedside. The aim was to examine the feasibility of EIT with respect to monitor atelectasis formation and resolution in the post anesthesia care unit (PACU). In this observational study, 107 postoperative patients were investigated regarding the presence and recovery of atelectasis described by the EIT-derived parameters Global Inhomogeneity Index (GI Index), tidal impedance variation (TIV), and the changes in end-expiratory lung impedance (ΔEELI). Read More

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September 2021

Circulating tumor DNA harboring the V600E mutation may predict poor outcomes of primary papillary thyroid cancer patients.

Thyroid 2021 Sep 19. Epub 2021 Sep 19.

The University of Tokyo Institute of Medical Science, 26430, Division of Molecular Pathology, Minato-ku, Tokyo, Japan;

Background: The significance of circulating tumor DNA (ctDNA) in primary papillary thyroid cancer (PTC) has yet to be well established. This study aimed to clarify whether ctDNA carrying the V600E mutation in plasma from primary PTC patients before and after surgery can predict outcomes.

Methods: Twenty-two primary PTC patients without distant metastasis, who underwent surgical resection at the University of Tokyo Hospital, were eligible for this study. Read More

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September 2021

Re-evaluation of the prognostic significance of retropharyngeal node metastasis in nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy.

Asia Pac J Clin Oncol 2021 Sep 19. Epub 2021 Sep 19.

Department of Radiotherapy, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, China.

Background And Purpose: To investigate the prognostic value of retropharyngeal lymphadenopathy in nasopharyngeal carcinoma (NPC) after intensity-modulated radiotherapy.

Materials And Methods: Retrospective studies were performed in a total of 1197 patients. We evaluated the incidence of the retropharyngeal node (RPN) metastasis and the characteristics of the metastatic RPN including laterality, size, necrosis, and extranodal neoplastic spread. Read More

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September 2021

Distribution and risk factors of cleft lip and palate on patients from a sample of Damascus hospitals - A case-control study.

Heliyon 2021 Sep 7;7(9):e07957. Epub 2021 Sep 7.

Faculty of Medicine, Syrian Private University, Damascus, Syria.

Objective: This case-control study was conducted to determine the distribution of cleft lip and/or palate, its association with family history, syndromes and serous otitis media (SOM), and its relation with several risk factors.

Methods: The case group comprised of 133 children born with cleft lip and/or palate, and the control was 133 non-cleft children born full-term. Data was collected including age, gender, origin and risk factors for cleft lip and palate from patients' files, interviewing supervising doctors, and the patient. Read More

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September 2021

Athletes With Anterior Shoulder Instability: A Prospective Study on Player Perceptions of Injury and Treatment.

Orthop J Sports Med 2021 Sep 15;9(9):23259671211032239. Epub 2021 Sep 15.

Columbia University Center for Shoulder, Elbow and Sports Medicine, New York, New York, USA.

Background: Many in-season athletes choose to delay or avoid surgery in order to continue playing and avoid downtime such as missed games or seasons.

Purpose: To learn about the attitudes toward the injury and treatment of in-season shoulder instability in competitive athletes who have suffered a shoulder dislocation.

Study Design: Cross-sectional study; Level of evidence, 3. Read More

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September 2021

Shear wave elastography in optic neuritis: diagnostic accuracy of the optic nerve and adjacent fat tissue values.

J Ultrason 2021 Aug 9;21(86):e194-e199. Epub 2021 Sep 9.

Radiology Department, Mehmet Akif Ersoy Training and Research Hospital, Turkey.

In this study, we attempt to determine the diagnostic performance of shear wave elastography of the optic nerve and adjacent fat tissue in patients with optic neuritis. The study included a patient group consisting of 72 eyes of 36 patients who were diagnosed with unilateral optic neuritis, and an age-matched control group of 36 eyes of 18 healthy subjects. The patient group consisted of 25 multiple sclerosis patients and 11 recurrent isolated optic neuritis patients. Read More

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Expression of miR-192-5p in colon cancer serum and its relationship with clinicopathologic features.

Am J Transl Res 2021 15;13(8):9371-9376. Epub 2021 Aug 15.

Department of Pharmacy, Suzhou Xiangcheng People's Hospital Suzhou 215006, People's Republic of China.

Colon cancer has a poor prognosis due to a lack of biomarkers for early diagnosis and prognosis. The present study analyzed serum miR-192-5p expression levels in colon cancer patients and their correlations with clinicopathologic features. Relative mRNA expression was assessed by real-time fluorescence-based quantitative PCR in the serum of 164 colon cancer patients and 60 healthy controls. Read More

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Evaluation of Risk Factors for Bleeding After Ultrasound-Guided Liver Biopsy.

Int J Gen Med 2021 11;14:5563-5571. Epub 2021 Sep 11.

Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People's Republic of China.

Purpose: This study was performed to analyze the risk factors for hemorrhagic complications after ultrasound-guided liver biopsies.

Patients And Methods: In this retrospective study, we reviewed 1193 ultrasound-guided percutaneous liver biopsies performed in our hospital from January 2018 to December 2020. Relevant patient characteristics, indications for biopsy, laboratory findings, biopsy technique, hemorrhagic complications, and pathologic outcomes were collected. Read More

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September 2021

Factors Associated with Reoperation after Pyrocarbon Proximal Interphalangeal Joint Arthroplasty for the Arthritic Joint: A Retrospective Cohort Study.

J Hand Microsurg 2021 Jul 9;13(3):132-137. Epub 2020 Apr 9.

Department of Orthopaedic Surgery, Hand and Upper Extremity Service, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States.

 The rate of reoperation after pyrocarbon proximal interphalangeal (PIP) joint arthroplasty ranges from 5.9 to 37% and complications such as radiographic loosening, deformity, dislocation, and stiffness are common. Because of the limited amount of knowledge around these problems, we evaluated factors associated with reoperation after pyrocarbon PIP arthroplasty. Read More

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Subpathologies and genomic classifier for treatment individualization of post-prostatectomy radiotherapy.

Urol Oncol 2021 Sep 16. Epub 2021 Sep 16.

Department of Radiation Oncology, University of Toronto; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Techna Institute, University Health Network, Toronto, Ontario, Canada. Electronic address:

Purpose/objective: Risk-stratification for post-prostatectomy radiotherapy (PORT) using conventional clinicopathologic indexes leads to substantial over- and under-treatment. Better patient selection could spare unnecessary toxicities and improve outcomes. We investigated the prognostic utility of unfavorable subpathologies intraductal carcinoma and cribriform architecture (IDC/CA), and a 22-gene Decipher genomic classifier (GC) in prostate cancer (PCa) patients receiving PORT. Read More

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September 2021

Voice changes after surgically assisted rapid maxillary expansion.

Am J Orthod Dentofacial Orthop 2021 Sep 16. Epub 2021 Sep 16.

Faculty of Dentistry, Department of Orthodontics, Bezmialem Vakif University, Istanbul, Turkey. Electronic address:

Introduction: This study aimed to investigate voice changes in patients who had surgically assisted rapid maxillary expansion (SARME).

Methods: Nineteen adult patients with maxillary transverse deficiency were asked to pronounce the sounds "[a], [ϵ], [ɯ], [i], [ɔ], [œ] [u], [y]" for 3 seconds. Voice records were taken before the expansion appliance was placed (T0) and 5. Read More

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September 2021

Preoperative nutritional status assessed using the CONUT tool and its relationship with the appearance of major postoperative complications.

Rev Esp Anestesiol Reanim 2021 Sep 16. Epub 2021 Sep 16.

Servicio de Anestesiología y Reanimación, Hospital Universitario de la Princesa, Madrid, España.

Introduction: Malnutrition is a risk factor for the appearance of major postoperative complications; therefore, early identification and perioperative optimization of surgical patients may improve postoperative outcomes. The objective of our study was to determine the prevalence of moderate or high under nutrition alerts in patients undergoing major non-cardiac surgery, and their relationship with the appearance of major postoperative complications. Nutritional status was calculated using the CONUT tool. Read More

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September 2021

Hospitalization and mortality from COVID-19 of patients with rheumatic inflammatory diseases in Andalusia.

Reumatol Clin (Engl Ed) 2021 Sep 9. Epub 2021 Sep 9.

Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain; UGC de Reumatología, Hospital Regional Universitario de Málaga, Málaga, Spain; Departamento de Medicina, Universidad de Málaga, Málaga, Spain.

Objective: To describe whether rheumatic inflammatory diseases (RID) are associated with a higher risk of hospitalization and/or mortality from COVID-19 and identify the factors associated with hospitalization and mortality in RID and COVID-19 in different Hospitals in Andalusia.

Methods: Design: Multicentre observational case-COntrol study.

Patients: RID and COVID-19 from different centres in Andalusia. Read More

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September 2021

Inhibition of WEE1 Is Effective in - and -Mutant Metastatic Colorectal Cancer: A Randomized Trial (FOCUS4-C) Comparing Adavosertib (AZD1775) With Active Monitoring.

J Clin Oncol 2021 Sep 18:JCO2101435. Epub 2021 Sep 18.

MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.

Purpose: Outcomes in -mutant metastatic colorectal cancer (mCRC) remain poor and patients have limited therapeutic options. Adavosertib is the first small-molecule inhibitor of WEE1 kinase. We hypothesized that aberrations in DNA replication seen in mCRC with both and mutations would sensitize tumors to WEE1 inhibition. Read More

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September 2021

Contact activated kallikrein generation is reduced six months after gastric bypass.

Thromb Res 2021 Sep 14;207:50-54. Epub 2021 Sep 14.

Unit for Thrombosis Research, Department of Clinical Biochemistry, University Hospital of Southern Denmark, Esbjerg, Denmark; Department of Regional Health Research, University of Southern Denmark, Denmark.

Background: Prothrombotic and inflammatory variables decrease after obesity surgery. The contact activation system may be a common denominator of these changes.

Objective: To characterize the contact system before and 6 months after Roux-en-Y gastric bypass (RYGB) and to evaluate associations with changes (post-surgery minus pre-surgery) in metabolic variables. Read More

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September 2021

Validating a nodal regression system for gastric cancer: An ancillary cohort study of the GASTRODOC trial.

Int J Surg 2021 Sep 15;94:106112. Epub 2021 Sep 15.

General and Oncologic Surgery, Department of Surgery, Morgagni-Pierantoni Hospital, Forlì, Italy.

Background: To validate a nodal regression system for gastric cancer and to verify its impact on prognosis.

Methods: This is an ancillary study which included 47 patients of the GASTRODOC trial. The dedicated pathologists of each Institute were invited to revise all the lymph nodes included in the surgical specimens in order to classify the regression according to the grading system proposed by Tsekrekos et al. Read More

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September 2021

Surgical site infections in early onset scoliosis: what are long-term outcomes in patients with traditional growing rods?

Spine Deform 2021 Sep 18. Epub 2021 Sep 18.

Division of Pediatric Orthopaedic Surgery, Rainbow Babies and Children's Hospital, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH, 44106, USA.

Purpose: Deep surgical site infections (SSIs) are a common and potentially severe complication in early onset scoliosis (EOS) patients. We sought to identify the long-term outcomes following SSI, specific risk factors associated with recurrent infections, and if instrument retention is a prudent SSI management strategy in EOS.

Methods: We performed a retrospective review of all EOS patients who underwent traditional growing rod spine procedures from 2003 to 2017. Read More

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September 2021

Comparison of FORTA, PRISCUS and EU(7)-PIM lists on identifying potentially inappropriate medication and its impact on cognitive function in multimorbid elderly German people in primary care: a multicentre observational study.

BMJ Open 2021 Sep 17;11(9):e050344. Epub 2021 Sep 17.

Department of Primary Medical Care, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Objectives: Our study aimed to assess the frequency of potentially inappropriate medication (PIM) use (according to three PIM lists) and to examine the association between PIM use and cognitive function among participants in the MultiCare cohort.

Design: MultiCare is conducted as a longitudinal, multicentre, observational cohort study.

Setting: The MultiCare study is located in eight different study centres in Germany. Read More

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September 2021

Associations between obesity, weight change and decreased renal function in Korean type 2 diabetic patients: a longitudinal follow-up study.

BMC Endocr Disord 2021 Sep 17;21(1):188. Epub 2021 Sep 17.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, 170 Jomaru-ro, Wonmi-gu, Bucheon, 14584, Republic of Korea.

Background: We aimed to examine the associations between the risk of decreased renal function, obesity, and weight changes in Korean type 2 diabetic patients with normal renal function.

Methods: Type 2 diabetic patients (n = 1060) who visited the diabetic clinic at Soonchunhyang University Bucheon Hospital between 2001 and 2007 with follow up surveys completed in 2016 to 2017 were recruited into the study. Decreased renal function was defined as an estimated glomerular filtration rate < 60 mL/min/1. Read More

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September 2021

Extended Anticoagulant Treatment with Full- or Reduced-Dose Apixaban in Patients with Cancer-Associated Venous Thromboembolism: the API-CAT Study.

Thromb Haemost 2021 Sep 17. Epub 2021 Sep 17.

Unité de Recherche Clinique Innovation et Pharmacologie, Centre Hospitalier Universitaire de Saint-Etienne, Saint-Etienne, France.

Cancer-associated thrombosis (CAT) is associated with a high risk of recurrent venous thromboembolic events (VTE) that require extended anticoagulation in patients with active cancer, putting them at risk of bleeding.The aim of the API-CAT study (NCT03692065) is to assess whether a reduced-dose regimen of apixaban (2.5 mg twice daily [bid]) is non-inferior to a full-dose regimen of apixaban (5 mg bid) for the prevention of recurrent VTE in patients with active cancer who have completed ≥6 months of anticoagulant therapy for a documented index event of proximal deep-vein thrombosis and/or pulmonary embolism. Read More

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September 2021