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Maternal genetic diversity, differentiation and phylogeny of three white yak breeds/populations in China.

Anim Biotechnol 2021 Sep 17:1-6. Epub 2021 Sep 17.

Qinghai Academy of Animal Science and Veterinary Medicine, Qinghai University, Xining, Qinghai, China.

White yak is a unique economic livestock animal on the Qilian Mountains of Qinghai-Tibet Plateau (QTP). Here, 369 mitochondrial D-loop sequences from three Chinese white yak breeds/populations (Tianzhu, Menyuan and Huzhu) were comprehensively analyzed to indicate their maternal genetic diversity, differentiation and phylogenetic relationship. Our results showed that the haplotype diversity (Hd) was found to be highest in Tianzhu white yak (Hd ± SD = 0. Read More

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September 2021

Diversity of Epithelial-Mesenchymal Phenotypes in Circulating Tumour Cells from Prostate Cancer Patient-Derived Xenograft Models.

Cancers (Basel) 2021 Jun 1;13(11). Epub 2021 Jun 1.

Faculty of Health and Institute of Health & Biomedical Innovation (IHBI), School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane City, QLD 4000, Australia.

Metastasis is the leading cause of cancer-related deaths worldwide. The epithelial-mesenchymal plasticity (EMP) status of primary tumours has relevance to metastatic potential and therapy resistance. Circulating tumour cells (CTCs) provide a window into the metastatic process, and molecular characterisation of CTCs in comparison to their primary tumours could lead to a better understanding of the mechanisms involved in the metastatic cascade. Read More

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Prognostic value of C-reactive protein to albumin ratio for long-term outcomes of patients with peripheral arterial disease underwent endovascular treatment.

Vascular 2021 Jun 10:17085381211025172. Epub 2021 Jun 10.

Department of Cardiology, Medical Faculty, M.D. Kafkas University, Kars, Turkey.

Background: Peripheral artery disease (PAD) is part of the systemic atherosclerotic process that is highly associated with cardiovascular diseases. Despite successful endovascular treatment (EVT) strategies, mortality and morbidity rates still remain higher in PAD patients. C-reactive protein (CRP) and albumin are biomarkers of inflammation and malnutrition that play key roles in the progression of peripheral arterial disease. Read More

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Skin and sepsis: contribution of dermatology to a rapid diagnosis.

Infection 2021 Aug 15;49(4):617-629. Epub 2021 Apr 15.

CIBER de Enfermedades Respiratorias (CIBERES CB06/06/0058), Madrid, Spain.

In patients who develop sepsis, whether due to primary, secondary or metastatic lesions, the skin is frequently affected. However, there are unresolved aspects regarding the general clinical manifestations in the skin or the prognosis and/or therapeutic implications. The main challenge in the approach to sepsis is its early diagnosis and management. Read More

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Modern femoral component design in total knee arthroplasty shows a lower patellar contact force during knee flexion compared with its predecessor.

Knee 2021 Jun 27;30:1-8. Epub 2021 Mar 27.

Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: The relationship between the femoral component design in total knee arthroplasty (TKA) and the patellofemoral contact force, as well as the soft tissue balance, has not been well reported thus far.

Methods: Twenty-eight mobile-bearing posterior-stabilized (PS) TKAs using the traditional model (PFC Sigma) and 27 mobile-bearing PS TKAs using the latest model (Attune) were included. Surgeries were performed using the measured resection technique assisted with the computed tomography (CT)-based free-hand navigation system. Read More

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Oropharyngeal Dysphagia in Older People is Associated with Reduced Pharyngeal Sensitivity and Low Substance P and CGRP Concentration in Saliva.

Dysphagia 2021 Mar 12. Epub 2021 Mar 12.

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas Y Digestivas (Ciberehd), Instituto de Salud Carlos III, Barcelona, Spain.

Substance P (SP) and Calcitonine gene-related peptide (CGRP) are released by sensory nerve fibers in the oropharynx. Patients with oropharyngeal dysphagia (OD) present reduced oropharyngeal sensitivity and low SP concentration in saliva. We aimed to assess the concentration of salivary SP and CGRP in healthy volunteers, and older people without and with OD, and the relationship with pharyngeal sensory threshold. Read More

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In vitro activity of ibrexafungerp and comparators against Candida albicans genotypes from vaginal samples and blood cultures.

Clin Microbiol Infect 2021 Jun 16;27(6):915.e5-915.e8. Epub 2021 Feb 16.

Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.

Objectives: Emergence of azole resistance may contribute to recurrences of vulvovaginal candidiasis. Thus, new drugs are needed to improve the therapeutic options. We studied the in vitro activity of ibrexafungerp and comparators against Candida albicans isolates from vaginal samples and blood cultures. Read More

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Ibrutinib in combination with nab-paclitaxel and gemcitabine for first-line treatment of patients with metastatic pancreatic adenocarcinoma: phase III RESOLVE study.

Ann Oncol 2021 05 1;32(5):600-608. Epub 2021 Feb 1.

Department of Medical Oncology, Vall d'Hebron University Hospital and Institute of Oncology (VHIO), IOB-Quiron, UVic-UICC, CIBERONC, Barcelona, Spain.

Background: First-line treatment of metastatic pancreatic ductal adenocarcinoma (PDAC) includes nab-paclitaxel/gemcitabine. Ibrutinib, a Bruton's tyrosine kinase inhibitor, exhibits antitumor activity through tumor microenvironment modulation. The safety and efficacy of first-line ibrutinib plus nab-paclitaxel/gemcitabine treatment in patients with PDAC were evaluated. Read More

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Lack of relationship between genotype and virulence in Candida species.

Rev Iberoam Micol 2021 Jan-Mar;38(1):9-11. Epub 2021 Jan 7.

Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.

Background: The virulence of isolates among different Candida species causing candidemia may play a role in the prognosis of the patients. Furthermore, the potential relationship between genotype and virulence is still unclear and need to be further studied.

Aims: We aim to assess the relationship between genotype and virulence in Candida species using a Galleria mellonella larvae infection model. Read More

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January 2021

GJA1 Expression and Its Prognostic Value in Cervical Cancer.

Biomed Res Int 2020 24;2020:8827920. Epub 2020 Nov 24.

Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

Gap Junction Protein Alpha 1 (GJA1) belongs to the gap junction family and has been widely studied in cancers. We evaluated the role of GJA1 in cervical cancer (CC) using public data from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) database. The difference of GJA1 expression level between CC and normal tissues was analyzed by the Gene Expression Profiling Interactive Analysis (GEPIA), six GEO datasets, and the Human Protein Atlas (HPA). Read More

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POFUT1 mRNA expression as an independent prognostic parameter in muscle-invasive bladder cancer.

Transl Oncol 2021 Jan 21;14(1):100900. Epub 2020 Oct 21.

Department of Urology and Urosurgery, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.

Muscle-invasive bladder cancer (MIBC) is characterized by high recurrence and rapid progression. Progression is linked to changes in glycan structures and altered levels of glycosyltransferases. The relationship of mRNA expression by glycosyltransferase genes B4GALT1, EXT1, MGAT5B, and POFUT1 to the probability of surviving MIBC after radical cystectomy has not yet been investigated. Read More

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January 2021

Renal Manifestations of Tuberous Sclerosis Complex: Key Findings From the Final Analysis of the TOSCA Study Focussing Mainly on Renal Angiomyolipomas.

Front Neurol 2020 16;11:972. Epub 2020 Sep 16.

Klinikverbund Allgäu gGmbH, Kempten, Germany.

Renal angiomyolipomas are one of the most common renal manifestations in patients with tuberous sclerosis complex (TSC), with potentially life-threatening complications and a poor prognosis. Despite the considerable progress in understanding TSC-associated renal angiomyolipomas, there are no large scale real-world data. The aim of our present study was to describe in detail the prevalence and outcome of renal angiomyolipomas in patients with TSC, enrolled into the TuberOus SClerosis registry to increase disease Awareness (TOSCA) from 170 sites across 31 countries worldwide. Read More

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September 2020

Marcus Relationship Maintained During Ultrafast Electron Transfer Across a Supramolecular Capsular Wall.

J Phys Chem A 2020 Jul 23;124(26):5297-5305. Epub 2020 Jun 23.

Department of Chemistry, University of Miami, Coral Gables, Florida 33146, United States.

Photoinduced electron transfer across an organic capsular wall between excited donors and ground-state acceptors is established to occur with rate constants varying in the range 0.32-4.0 × 10 s in aqueous buffer solution. Read More

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Dual-Modal FeCuSe and Upconversion Nanoparticle Assemblies for Intracellular MicroRNA-21 Detection.

ACS Appl Mater Interfaces 2021 Sep 19;13(35):41405-41413. Epub 2020 Mar 19.

In situ quantification and imaging of low-level intracellular microRNAs (miRs) are important areas in biosensor research. Herein, DNA-driven [email protected] nanoparticle (UCNP) [email protected] nanostructures were developed to probe microRNA-21 (miR-21). [email protected] probes displayed dual signals: upconversion luminescence (UCL) and magnetic resonance imaging (MRI). Read More

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September 2021

Therapeutic Drug Monitoring of Antifungal Drugs: Another Tool to Improve Patient Outcome?

Infect Dis Ther 2020 Mar 5;9(1):137-149. Epub 2020 Feb 5.

Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Introduction: This study aimed to examine the relationship among adequate dose, serum concentration and clinical outcome in a non-selected group of hospitalized patients receiving antifungals.

Methods: Prospective cross-sectional study performed between March 2015 and June 2015. Dosage of antifungals was considered adequate according to the IDSA guidelines, whereas trough serum concentrations (determined with HPLC) were considered adequate as follows: fluconazole > 11 µg/ml, echinocandins > 1 µg/ml, voriconazole 1-5. Read More

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Determination and Modeling on Ultraviolet Light Degradation of Pyridaben Based on Fluorescence Spectrum.

Comb Chem High Throughput Screen 2020 ;23(2):141-147

Jiangsu Laboratory of Lake Environment Remote Sensing Technologies, School of Electronic Information Engineering, Huaiyin Institute of Technology, Huaian, China.

Aims And Objective: Pesticide residues seriously affect human health, so it is very important to study the degradation of pesticide residues for food safety. The degradation of pyridaben by ultraviolet (UV) irradiation was studied, the degradation characteristics and modeling were analyzed in this paper. This study was undertaken to fully reveal the degradation mechanism of UV irradiation for pyridaben residue and provided the evaluation method of degradation effect. Read More

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Gut microbiota differences in elderly subjects between rural city Kyotango and urban city Kyoto: an age-gender-matched study.

J Clin Biochem Nutr 2019 Sep 9;65(2):125-131. Epub 2019 Aug 9.

Department of Longevity and Regional Epidemiology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan.

Several outcomes have been reported on the role of gut microbiota in health promotion and disease prevention. Kyotango, one of the longevity areas with various centenarians, is a provincial city located in the northern part of Kyoto Prefecture in Japan. To understand the relationship between gut microbiota and urbanization, we compared the diversity, abundance, and function of gut microbiota in older healthy subjects between Kyotango and Kyoto cities; Kyoto is an urban city located in the southern part of Kyoto Prefecture. Read More

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September 2019

Rasburicase versus intravenous allopurinol for non-malignancy-associated acute hyperuricemia in paediatric cardiology patients.

Cardiol Young 2019 Sep;29(9):1160-1164

Division of Cardiology, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, USA.

Objectives: Limited data exist for management of hyperuricemia in non-oncologic patients, particularly in paediatric cardiac patients. Hyperuricemia is a risk factor for acute kidney injury and may prompt treatment in critically ill patients. The primary objective was to determine if rasburicase use was associated with greater probability normalisation of serum uric acid compared to allopurinol. Read More

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September 2019

Utility of novel serum biomarkers to predict subclinical atherosclerosis: A sub-analysis of the EISNER study.

Atherosclerosis 2019 03 24;282:80-84. Epub 2019 Jan 24.

Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, USA.

Background And Aims: Certain novel biomarkers may predict atherosclerotic cardiovascular disease (ASCVD) events; however, data on their relationship to coronary atherosclerosis and its progression as measured by coronary artery calcium (CAC) scanning is lacking. We evaluated the association between novel biomarkers and presence or progression of CAC.

Methods: The EISNER study was a prospective trial of patients without known ASCVD. Read More

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Inadequate fat or carbohydrate intake was associated with an increased incidence of type 2 diabetes mellitus in Korean adults: A 12-year community-based prospective cohort study.

Diabetes Res Clin Pract 2019 Feb 28;148:254-261. Epub 2019 Jan 28.

Major of Food and Nutrition, School of Human Ecology, The Catholic University of Korea, Gyeonggi, Republic of Korea. Electronic address:

Aims: Few studies have focused on the relationship between long-term fat intake and type 2 diabetes mellitus (T2D) risk in Asia where fat intake is relatively lower than the Western countries. We examined association of dietary fat and carbohydrate intake with incidence of T2D among Korean adults.

Methods: Based on the data from the Korean Genome and Epidemiology Study, a total of 5595 adults aged 40-69 years without diabetes, cardiovascular diseases or any cancer at baseline were included. Read More

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February 2019

Gene Point Mutations Are Not Antifungal Resistance Markers in .

Antimicrob Agents Chemother 2019 01 21;63(1). Epub 2018 Dec 21.

Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain

The high rates of antifungal resistance in may be facilitated by the presence of alterations in the gene. We aimed to study the sequence of the gene in 124 invasive isolates causing incident episodes of candidemia ( = 81), subsequent candidemia episodes ( = 9), endocarditis ( = 2), and -generated echinocandin-resistant isolates ( = 32) and assessed its relationship with genotypes, acquisition of antifungal resistance and , and patient prognosis. The gene was sequenced, and isolates were genotyped using six microsatellite markers and multilocus sequence typing (MLST) based on six housekeeping genes. Read More

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January 2019

Expression of the Vesicular Monoamine Transporter Gene Solute Carrier Family 18 Member 1 () in Lung Cancer.

Cancer Genomics Proteomics 2018 Sep-Oct;15(5):387-393

Severn Health Solutions, Severna Park, MD, U.S.A.

Background: One aspect of smoking and lung cancer that has not been closely examined, is that regarding genes that may predispose to tobacco dependence. Smoking and mental illness are tightly linked, apparently the result of smokers using cigarettes to self-medicate for mental problems. The gene for solute carrier family 18 member A1 (vesicular monoamine transporter; SLC18A1) is of particular interest in this regard because of its association with schizophrenia, autism and bipolar illness as well as with cancer. Read More

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November 2018

Relationship between Xanthine Oxidoreductase Redox and Oxidative Stress among Chronic Kidney Disease Patients.

Oxid Med Cell Longev 2018 8;2018:9714710. Epub 2018 Jul 8.

Department of Nephrology and Hypertension, Fukushima Medical University, Fukushima, Japan.

Xanthine oxidase (XO), an isoform of xanthine oxidoreductase (XOR), is thought to increase the cardiovascular burden among chronic kidney disease (CKD) patients via oxidative radical production. Plasma XOR redox, which is characterized by the ratio of XO to total XOR, changes under different oxidative conditions associated with kidney dysfunction. However, the relationship between plasma XOR redox and oxidative stress (OS) is unclear. Read More

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December 2018

The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models.

Sci Adv 2018 06 20;4(6):eaat1719. Epub 2018 Jun 20.

Department of Radiation Oncology, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298-0058, USA.

Poor survival rates of patients with tumors arising from or disseminating into the brain are attributed to an inability to excise all tumor tissue (if operable), a lack of blood-brain barrier (BBB) penetration of chemotherapies/targeted agents, and an intrinsic tumor radio-/chemo-resistance. Ataxia-telangiectasia mutated (ATM) protein orchestrates the cellular DNA damage response (DDR) to cytotoxic DNA double-strand breaks induced by ionizing radiation (IR). ATM genetic ablation or pharmacological inhibition results in tumor cell hypersensitivity to IR. Read More

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Retrospective analysis of factors associated with the success of stepwise excavation procedure in deep carious lesions.

J Am Dent Assoc 2018 Jun 6;149(6):442-450. Epub 2018 Apr 6.

Background: Recent scientific evidence regarding the stepwise excavation procedure (SWP) has not addressed the consideration of patient factors when selecting SWP as treatment for deep carious lesions (DCLs). This study assessed patient factors predicting a successful SWP defined as a tooth restored with SWP and did not result in root canal treatment or a dental extraction.

Methods: SWPs completed in 626 patients without symptomatic irreversible pulpitis at the University of Iowa College of Dentistry from January 2004 through December 2012 were evaluated. Read More

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Facile synthesis of simple 2-oxindole-based compounds with promising antiproliferative activity.

Authors:
Riham F George

Future Med Chem 2018 02 15;10(3):269-282. Epub 2018 Jan 15.

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.

Aim: Discovery of novel potent anticancer agents with lower side effects is a challenge to overcome cancer, the second leading cause of death.

Methodology: 2-oxindole-based hydrazides (6a-g) and benzenesulfonyl hydrazides (9a-d) were synthesized by simple condensation reactions of the appropriate hydrazides (2a-g) or (8a-d) with 1-ethyl-2,3-oxindolinedione (4). They were screened for their cytotoxicity against HepG2 (liver), MCF-7 (breast), HCT116 (colon) and A549 (lung) cancer cell lines. Read More

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February 2018

Eradication of P. aeruginosa biofilm in endotracheal tubes based on lock therapy: results from an in vitro study.

BMC Infect Dis 2017 12 4;17(1):746. Epub 2017 Dec 4.

Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.

Background: Despite the several strategies available for the management of biofilm-associated ventilator-associated pneumonia, data regarding the efficacy of applying antibiotics to the subglottic space (SS) are scarce. We created an in vitro model to assess the efficacy of antibiotic lock therapy (ALT) applied in the SS for eradication of Pseudomonas aeruginosa biofilm in endotracheal tubes (ETTs).

Methods: We applied 2 h of ALT to a P. Read More

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December 2017

Tracking the Genetic Stability of a Honey Bee (Hymenoptera: Apidae) Breeding Program With Genetic Markers.

J Econ Entomol 2017 08;110(4):1419-1423

USDA-ARS, Honey Bee Breeding, Genetics, and Physiology Laboratory, 1157 Ben Hur Rd., Baton Rouge, LA 70820.

A genetic stock identification (GSI) assay was developed in 2008 to distinguish Russian honey bees from other honey bee stocks that are commercially produced in the United States. Probability of assignment (POA) values have been collected and maintained since the stock release in 2008 to the Russian Honey Bee Breeders Association. These data were used to assess stability of the breeding program and the diversity levels of the contemporary breeding stock through comparison of POA values and genetic diversity parameters from the initial release to current values. Read More

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Initial Experience With Real-Time Continuous Physical Activity Monitoring in Patients Undergoing Spine Surgery.

Clin Spine Surg 2017 Dec;30(10):E1434-E1443

Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA.

Study Design: Multicenter prospective pilot study.

Objective: To evaluate if continuous physical activity monitoring by a personal electronic 3-dimensional accelerometer device is feasible and can provide objective data that correlates with patient-reported outcomes following spine surgery.

Summary Of Background Data: Self-reported health-related quality-of-life (HRQOL) metrics are inherently limited by being very subjective, having a low frequency of data collection, and inconsistent follow-up. Read More

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December 2017

Diffusion tensor tractography of pyramidal tracts in patients with brainstem and intramedullary spinal cord tumors: Relationship with motor deficits and intraoperative MEP changes.

J Magn Reson Imaging 2017 09 24;46(3):715-723. Epub 2017 Jan 24.

Department of Neurosurgery, Medical University of Warsaw, Warsaw, Poland.

Purpose: To evaluate whether pyramidal tracts course alterations observed in diffusion tensor tractography (DTT) in cases of brainstem and intramedullary spinal cord tumors reflect patient clinical status and prognosis.

Materials And Methods: For this purpose, we assessed in 17 patients relationships between pyramidal tracts course alterations observed in DTT (classified into four categories: unaffected; displaced or interspaced; partially disintegrated and completely disintegrated) performed on a 1.5 Tesla scanner and the presence of preoperative motor deficits, changes observed in motor evoked potentials (MEPs) records at the beginning of the operation, deterioration of the MEPs records during the operation, and perioperative deterioration of muscle strength. Read More

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September 2017