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Comparing Different Techniques in Children With or Without a Simultaneous Fundoplication: Does the Gastrostomy Technique Matter?

J Laparoendosc Adv Surg Tech A 2021 Sep 12;31(9):1067-1072. Epub 2021 Jul 12.

Department of Pediatric Gastroenterology, Hepatology and Nutrition, Ondokuz Mayıs University Medical School, Samsun, Turkey.

To evaluate the results of different gastrostomy techniques and the impact of simultaneous fundoplication. The patients who underwent a gastrostomy procedure between 2009 and 2019 in a single tertiary center were evaluated retrospectively. The patients are divided into groups depending on the gastrostomy techniques as open gastrostomy (OG), laparoscopic gastrostomy (LG), percutaneous endoscopic gastrostomy (PEG), and laparoscopy-assisted PEG (LAPEG). Read More

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September 2021

Management and Survival Analysis of Gastrointestinal Neuroendocrine Tumors by Different Tumor Characteristics: Tertiary Center Experience.

J Gastrointest Cancer 2021 Sep 15. Epub 2021 Sep 15.

Department of Pathology, Faculty of Medicine, Inonu University, Malatya, 44280, Turkey.

Background: Gastrointestinal neuroendocrine tumor (GI-NET) is a group of neoplasia consisting of amine and acid producing cells with different hormonal profiles. Although the entire GIS accounts for about 2% of tumors, recent research reveals that the incidence rate has increased. Given the increasing incidence in GI-NETs, more and more extensive research is needed on this subject. Read More

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September 2021

Sirolimus (Rapamycin) for Slow-Flow Malformations in Children: The Observational-Phase Randomized Clinical PERFORMUS Trial.

JAMA Dermatol 2021 Sep 15. Epub 2021 Sep 15.

University of Tours, Centre Hospitalier Régional Universitaire Tours, Department of Pediatric Radiology, Tours, France.

Importance: Sirolimus is increasingly being used to treat various vascular anomalies, although evidence of its efficacy is lacking.

Objective: To assess the efficacy and safety of sirolimus for children with slow-flow vascular malformations to better delineate the indications for treatment.

Design, Setting And Participants: This multicenter, open-label, observational-phase randomized clinical trial included 59 children aged 6 to 18 years with a slow-flow vascular malformation who were recruited between September 28, 2015, and March 22, 2018, in 11 French tertiary hospital centers. Read More

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September 2021

The effect of transverse fascia inversion on postoperative seroma in direct hernias treated with laparoscopic TAPP procedure.

Ann Ital Chir 2021 ;92:384-389

Aim: This study aims to reveal the results of the transverse fascia inversion technique applied in laparoscopic transabdominal preperitoneal (TAPP) procedure to reduce the risk of seroma in direct hernias.

Marial And Methods: Patients who underwent elective inguinal hernia repair with the laparoscopic TAPP procedure were retrospectively evaluated. Indirect inguinal or femoral hernias and emergency operations were excluded, and only patients with direct or indirect + direct inguinal hernia were included in the study. Read More

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January 2021

Prehospital Evaluation of the FAST-ED as a Secondary Stroke Screen to Identify Large Vessel Occlusion Strokes.

Prehosp Emerg Care 2021 Sep 15:1-8. Epub 2021 Sep 15.

Mecklenburg EMS Agency, Charlotte, North Carolina, USA.

Introduction: The Field Assessment Stroke Triage for Emergency Destination (FAST-ED) was developed to identify Large Vessel Occlusion Strokes (LVOS) presenting out of hospital, although there is limited prospective research validating its use in this setting. This study evaluated the test characteristics of the FAST-ED to identify LVOS when used as a secondary stroke screen in the prehospital environment. Secondary analysis compared the performance of the CPSS and the FAST-ED in identifying an LVOS. Read More

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September 2021

Correlation of fetal ventricular size and need for postnatal cerebrospinal fluid diversion surgery in open spina bifida.

Ultrasound Obstet Gynecol 2021 Sep 15. Epub 2021 Sep 15.

Fetal Medicine Unit, Dept. of Obstetrics & Gynaecology, Mount Sinai Hospital, Toronto, ON, Canada.

Objectives: Open spina bifida is a common cause of hydrocephalus in the postnatal period. However, in-utero closure of the fetal spinal defect has decreased the need for cerebrospinal fluid (CSF) diversion surgery postnatally. Good prenatal predictors of the need for postnatal CSF diversion surgery are currently lacking. Read More

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September 2021

Derangement of protein S and C4b-binding protein levels as acquired thrombophilia in HIV-infected adult Nigerians.

South Afr J HIV Med 2021 23;22(1):1253. Epub 2021 Aug 23.

Harvard School of Public Health, Boston, Massachusetts, United States of America.

Background: HIV is a chronic inflammatory state with the production of many acute-phase-reactant proteins. Some of these proteins have procoagulant activities that predispose HIV-infected patients to thrombosis.

Objectives: The aim of the study was to evaluate the effects of HIV infection on the serum levels of C4b-binding protein (C4BP) and protein S as markers of predisposition to thrombosis in HIV-infected adults. Read More

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Efficiency of complete omentectomy in patients with resectable gastric cancer: a meta‑analysis and systematic review.

BMC Gastroenterol 2021 Sep 14;21(1):346. Epub 2021 Sep 14.

Department of Gastrointestinal Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 31006, China.

Background: We performed a meta-analysis to investigate the efficacy of complete omentectomy (CO) in patients undergoing radical gastrectomy for gastric cancer.

Methods: We conducted a literature search in PubMed, Web of Science, and the Cochrane Library databases for clinical research that compared CO with non-complete omentectomy (NCO). These articles were published prior to April 2021. Read More

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September 2021

Magnetic resonance imaging with intravenous gadoteridol injection based on 3D-real IR sequence of the inner ear in Meniere's disease patient: feasibility in 3.5-h time interval.

Acta Otolaryngol 2021 Sep 14:1-8. Epub 2021 Sep 14.

Department of Radiology, Eye & ENT Hospital of Fudan University, Shanghai, PR China.

Background: Intravenous gadoteridol injection can be applied to visualize endolymphatic hydrops (EH).

Aims/objectives: To explore whether 3.5-h time interval was feasible for clinical practice. Read More

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September 2021

Coronary revascularization in acute coronary syndrome: does the choice of the conduit matter?

J Cardiovasc Surg (Torino) 2021 Sep 14. Epub 2021 Sep 14.

Department of Cardiovascular Surgery, University Heart Center Freiburg, Bad Krozingen, Germany.

Background: Our retrospective study evaluates the impact on short - and long-term outcome according to the graft selection during emergency coronary revascularization surgery.

Methods: 339 Patients with acute coronary syndrome undergoing emergency coronary bypass surgery at our institution from 2008 until 2018 were analyzed using propensity score analysis. The primary endpoint was in-hospital survival. Read More

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September 2021

All cause hepatocellular carcinoma survival in the era of direct-acting antiviral therapy.

J Gastroenterol Hepatol 2021 Sep 14. Epub 2021 Sep 14.

St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, New South Wales, Australia.

Background And Aims: Hepatitis C virus (HCV) cure with direct-acting antiviral (DAA) therapy improves survival in patients with HCV-related hepatocellular carcinoma (HCC). We hypothesised that HCV-HCC survival has increased in the DAA-era, more than other aetiologies of HCC. We aimed to evaluate survival following HCC diagnosis in the pre-DAA and DAA eras, across each aetiology of HCC. Read More

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September 2021

Changes in COVID-19 measures in the workplace: 8-month follow-up in a cohort study of full-time employees in Japan.

J Occup Health 2021 Jan;63(1):e12273

Department of Mental Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Objectives: It is unclear how many workplace COVID-19 preventive measures were maintained during repeated outbreaks. The aim of this study was to investigate a longitudinal change of implementation of workplace preventive measures responding to COVID-19 in Japan.

Methods: An online longitudinal study was conducted using a cohort of full-time employees in Japan, starting in March 2020 (T1), with follow-up surveys in May (T2), August (T3), and November (T4) 2020. Read More

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January 2021

Segmental transverse colectomy. Minimally invasive versus open approach: results from a multicenter collaborative study.

Updates Surg 2021 Sep 14. Epub 2021 Sep 14.

Department of Clinical Medicine and Surgery, Federico II University of Naples, Via Sergio Pansini, 5, 80131, Naples, Italy.

The role of minimally invasive surgery in the treatment of transverse colon cancer is still controversial. The aim of this study is to investigate the advantages of a totally laparoscopic technique comparing open versus laparoscopic/robotic approach. Three hundred and eighty-eight patients with transverse colon cancer, treated with a segmental colon resection, were retrospectively analyzed. Read More

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September 2021

Clinical and immunological allergy assessment in cancer patients.

Sci Rep 2021 Sep 13;11(1):18110. Epub 2021 Sep 13.

Surgery Department of the School of Medicine of the Federal University of Minas Gerais, Belo Horizonte, Brazil.

Cancer is associated with immunodeficiency, while allergies result from immune system hyperactivity mediated by cytokines and immunoglobulins. The purpose of this study was to determine the relationship between immune environment of specific cancers and allergies, emphasizing cytokines related to Th1 and Th2 responses associated with IgE. 80 adults were distributed into two groups: control (n = 20) and cancer (n = 60), distributed in three subgroups (n = 20), head and neck, stomach, and prostate cancers. Read More

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September 2021

The Montelukast Therapy in Asthmatic Children with and without Food Allergy: Does It Make Any Difference?

Int Arch Allergy Immunol 2021 Sep 9:1-10. Epub 2021 Sep 9.

Division of Pediatric Allergy, Hacettepe University School of Medicine, Ankara, Turkey.

Introduction: Children with food allergy are at increased risk for asthma and asthma morbidity. Since leukotrienes are implicated in the pathogenesis of both asthma and probably in food allergies, we hypothesized that asthmatic children with concomitant food allergy may have a favorable response to antileukotriene treatment.

Methods: Asthmatic children aged 6-18 years with and without food allergy were treated with montelukast and placebo in a double-blind, placebo-controlled cross-over parallel-group study. Read More

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September 2021

The association between BMI, smoking, drinking and thyroid disease: a cross-sectional study in Wuhan, China.

BMC Endocr Disord 2021 Sep 13;21(1):184. Epub 2021 Sep 13.

Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 JieFang Avenue, 430022, Wuhan, Hubei, China.

Background: There is no clear conclusion on the relationship between thyroid disease and obesity and lifestyle factors such as smoking and drinking. In this study, we analysed the association of body mass index (BMI), smoking and drinking with subclinical hypothyroidism (SHO) and thyroid nodules (TNs) with the results of a cross-sectional survey of urban residents in central China and discussed the potential mechanism linking these predictive factors and the two diseases.

Methods: This study included 1279 participants who were recruited from a Chinese community in 2011 and 2012. Read More

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September 2021

Mitral Annular Disjunction of Degenerative Mitral Regurgitation: 3D Evaluation and Implications for Mitral Repair.

J Am Soc Echocardiogr 2021 Sep 10. Epub 2021 Sep 10.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota. Electronic address:

Background: Mitral annular disjunction (MAD) dynamic consequences on the mitral apparatus and the left ventricle (LV) remain unclear and are crucial in the context of mitral surgery. Thus, we aimed to assess mitral valvular/annular/ventricular dynamics in mitral valve prolapse (MVP) stratified by MAD presence.

Methods: In 61 patients (62±11 years; 25% women) with MVP and severe mitral-regurgitation undergoing mitral-surgery between 2009 and 2016, valvular/annular dimensions/dynamics by 2D transthoracic and 3D-transesophageal-echocardiography, and LV dimensions/dynamics were analyzed stratified by MAD presence, pre and post-surgery. Read More

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September 2021

Genetic association between bone mineral density and the fracture of distal radius: A case-control study.

Medicine (Baltimore) 2021 Sep;100(36):e27116

Department of Orthopedics, Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong, China.

Abstract: Low bone mineral density (BMD) was significantly related to the fracture of distal radius. Serum brain-derived neurotrophic factor (BDNF) level was closely related to BMD in spine and osteoporotic fractures. In this study, we aimed to explore the association of BDNF polymorphisms (rs6265 and rs7124442) with BMD and the fracture of distal radius. Read More

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September 2021

Balanced Binocular Inputs Support Superior Stereopsis.

Invest Ophthalmol Vis Sci 2021 Sep;62(12):10

McGill Vision Research Unit, Department of Ophthalmology & Visual Sciences, McGill University, Montreal, Quebec, Canada.

Purpose: Our visual system compares the inputs received from the two eyes to estimate the relative depths of features in the retinal image. We investigated how an imbalance in the strength of the input received from the two eyes affects stereopsis. We also explored the level of agreement between different measurements of sensory eye imbalance. Read More

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September 2021

Hematological Indices Predicting the Severity of Acute Pancreatitis Presenting to the Emergency Department: A Retrospective Analysis.

Cureus 2021 Jul 30;13(7):e16752. Epub 2021 Jul 30.

General Surgery, Civil Hospital Karachi, Karachi, PAK.

Introduction Acute pancreatitis is defined as inflammation of the pancreas. The body responds to inflammation by producing excessive neutrophils and causing programmed cell death of lymphocytes. This leads to immunological instability, which increases the severity of the disease and mortality rate. Read More

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A randomised controlled trial of effectiveness and safety of Niclosamide as add on therapy to the standard of care measures in COVID-19 management.

Ann Med Surg (Lond) 2021 Sep 4;69:102779. Epub 2021 Sep 4.

College of Medicine, University of Baghdad, Bab Al-Muadham, Baghdad, Iraq.

Background: COVID-19 pandemic has ignited the urge for repurposing old drugs as candidate antiviral medicines to treat novel challenges of viral infections. Niclosamide (NCS) is an anti-parasitic drug of known antiviral potential. Therefore, this study attempts to investigate the antiviral effect and safety of NCS on SARS-CoV-2 caused COVID-19 patients. Read More

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September 2021

The Level of vWF Antigen and Coagulation Markers in Hospitalized Patients with Covid-19.

J Blood Med 2021 30;12:809-817. Epub 2021 Aug 30.

College of Medicine, King Saud University, King Saud University, Riyadh, Saudi Arabia.

Background: The coagulopathy of COVID-19 still awaits more clarification, and one approach that has not been investigated is to compare the hemostatic changes between COVID-19 and non-COVID-19 infected patients.

Objective: This study aims to study COVID-19 coagulopathy by measuring markers of endothelial injury and coagulation, including anticoagulants (TFPI, protein C, protein S, and AT) in COVID-19 patients and compare them with non-COVID-19 patients early in the course of the disease.

Methodology: This is an observational, prospective cross-sectional study comparing the levels of protein C, protein S, antithrombin (AT) III, clotting factor (F) VIII, von Willebrand factor (vWF) and coagulation screening tests (PT and a PTT), fibrinogen, D-dimer in COVID-19 patients admitted during the same time with non-COVID-19 infections. Read More

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The Relationship Between Carotid Intima Media Thickness, Inflammation and GLA Rich Protein Levels in Chronic Kidney Disease.

Int J Gen Med 2021 1;14:5119-5126. Epub 2021 Sep 1.

Department of Nephrology, Ataturk University Faculty of Medicine, Erzurum, Turkey.

Aim: Vascular calcification is a common complication in CKD. Studies conducted in patients with end-stage renal disease (ESRD) showed that calcification in vascular structures is an important component of the atherosclerosis process. GLA rich protein (GRP) has been suggested as a potential marker for vascular calcification. Read More

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September 2021

Use of labour neuraxial analgesia according to maternal immigration status: a national cross-sectional retrospective population-based study in France.

Br J Anaesth 2021 Sep 9. Epub 2021 Sep 9.

Paris University, Centre for Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Obstetric Perinatal and Paediatric Epidemiology Research Team, EPOPé, INSERM, INRA, Paris, France; Maternity Unit, Notre Dame de Bon Secours - Groupe Hospitalier Paris-Saint-Joseph Hospital, Paris University, Paris, France.

Background: Disparities in neuraxial analgesia use for childbirth by maternal origin have been reported in high-resource countries. We explored the association between maternal immigrant status (characterised separately by geographic continental origin and Human Development Index [HDI] of maternal country of birth) and neuraxial analgesia use. We hypothesised that immigrant women from low-resource countries may have more limited access to neuraxial analgesia than native French women. Read More

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September 2021

Longer-term soy nut consumption improves cerebral blood flow and psychomotor speed: results of a randomized, controlled crossover trial in older men and women.

Am J Clin Nutr 2021 Sep 12. Epub 2021 Sep 12.

Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.

Background: Effects of soy foods on cerebral blood flow (CBF)-a marker of cerebrovascular function-may contribute to the beneficial effects of plant-based diets on cognitive performance.

Objectives: We aimed to investigate longer-term effects of soy nut consumption on CBF in older adults. Changes in 3 different domains of cognitive performance were also studied. Read More

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September 2021

Herbs and spices at a relatively high culinary dosage improves 24-hour ambulatory blood pressure in adults at risk of cardiometabolic diseases: a randomized, crossover, controlled-feeding study.

Am J Clin Nutr 2021 Sep 12. Epub 2021 Sep 12.

Department of Nutritional Sciences, Pennsylvania State University, University Park, PA, USA.

Background: Intake of a single meal containing herbs and spices attenuates postprandial lipemia, hyperglycemia, and oxidative stress, and improves endothelial function. There has been limited investigation of the effect of longer-term intake of mixed herbs and spices on risk factors for cardiometabolic diseases.

Objectives: The objective was to assess the effect of an average American diet containing herbs and spices at 0. Read More

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September 2021

Impact of Low Humidity on Damage Associated Molecular Patterns at the Ocular Surface during Dry Eye Disease.

Optom Vis Sci 2021 Sep 9. Epub 2021 Sep 9.

The Ocular Surface Institute, College of Optometry, University of Houston, Houston, Texas.

Significance: Dry eye is one of the leading causes for individuals to seek eye care, while the pathogenesis is poorly understood. One mechanism in which dry eye inflammation may ensue is by the release of damage associated molecular patterns (DAMPs) by damaged cells to stimulate the production of cytokines and matrix metalloproteinases. Examining DAMPs levels on the ocular surface during dry eye disease (DED) will increase our understanding of their potential involvement in the pathogenesis of DED. Read More

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September 2021

Exploring Factors Associated With Depressive Symptoms Among Patients With Chronic Pain: A Cross-Sectional Multicenter Study.

J Nerv Ment Dis 2021 Sep 10. Epub 2021 Sep 10.

Psychiatry Residency Program, Oman Medical Speciality Board Department of Behavioural Medicine, Sultan Qaboos University Hospital Department of Orthopaedics, Khoula Hospital, Ministry of Health Department of Pain Medicine, Royal Hospital, Ministry of Health Department of Pain Medicine, Sultan Qaboos University Hospital Sultan Qaboos Comprehensive Cancer Care and Research Centre Studies and Research Section, Oman Medical Speciality Board, Muscat, Oman School of Social Sciences, Department of Psychology, London Metropolitan University, London, United Kingdom.

Abstract: This cross-sectional study examined the factors associated with depression among people with chronic pain (PwCP) attending specialized pain clinics in Muscat, Oman. Two-hundred eighty-seven participants were recruited for the study, and univariate analyses were used to investigate the difference between individuals who scored above/below the cutoff points for depressive symptoms. A multiple regression analysis was used to detect the independent predictors. Read More

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September 2021

Work loss in patients with celiac disease: A population-based longitudinal study.

Clin Gastroenterol Hepatol 2021 Sep 9. Epub 2021 Sep 9.

Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg, Sweden; Department of Pediatric Gastroenterology, Queen Silvia Children's Hospital, Gothenburg, Sweden.

Background: Celiac disease (CD) affects around 1% of the population worldwide. Data on work disability in celiac patients remain scarce. We estimated work loss in celiac patients including its temporal relationship to diagnosis. Read More

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September 2021

Conservative treatment for lumbar spondylolysis in children of elementary school age.

J Clin Neurosci 2021 Oct 24;92:197-202. Epub 2021 Aug 24.

Department of Orthopaedic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

Purpose: Lumbar spondylolysis in children of elementary school age has different characteristics from those of junior or senior high school patients. The purpose of the present study was to investigate the outcomes of conservative treatment for lumbar spondylolysis in patients of elementary school age.

Methods: We included 46 lesions in 32 consecutive patients of elementary school age with fresh cases of lumbar spondylolysis (5 girls and 27 boys; mean age, 11. Read More

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October 2021