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Detection of anti-mitochondrial 2-oxoacid dehydrogenase complex subunit's antibodies for the diagnosis of primary biliary cholangitis.

Clin Immunol 2021 May 1:108749. Epub 2021 May 1.

Department of Immunology, Hospital Universitari de Bellvitge, Catalonia, Spain.

Anti-mitochondrial antibodies (AMA), directed against the E2 subunits of the 2-oxo acid dehydrogenase complexes, are markers of Primary Biliary Cholangitis (PBC), a chronic autoimmune liver disease. However, the clinical significance of subunits-specific AMA type PDC-E2 -E2 subunit of the pyruvate dehydrogenase complex-, BCOADC-E2 -E2 subunit of the branched-chain 2-oxo acid dehydrogenase complex-, OGDC-E2 -E2 subunit of the 2-oxo-glutarate dehydrogenase complex- and nPDC -native pyruvate dehydrogenase complex (M2-AMA) . Is not well known, and not all AMA specificities are associated with PBC. Read More

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Prevalence of COVID-19 in children, adolescents, and adults in remote education situation in the city of Fortaleza - Brazil.

Int J Infect Dis 2021 May 1. Epub 2021 May 1.

Biotechnology and Molecular Biology Laboratory, State University of Ceará, Campus do Itaperi, 60714-903 Fortaleza, CE, Brazil.

Objectives: A retrospective study was conducted on a database of the COVID-19 Tracking Program in schoolchildren to identify the prevalence of COVID-19 through serology and RT-PCR in children, adolescents, and adults.

Methods: The data was composed of sociodemographic and clinical variables, results of serological tests (IgM and IgG), and RT-PCR results of IgM-positive individuals. The statistical analysis was performed with a 5% significance level. Read More

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The Association between QuantiFERON-TB Gold Test and Clinical Manifestations of Uveitis in the United States.

Am J Ophthalmol 2021 May 1. Epub 2021 May 1.

National Eye Institute, National Institutes of Health, Bethesda, MD. Electronic address:

Purpose: To report the prevalence of QuantiFERON-TB Gold (QFT-G) positivity among uveitis patients compared to general population and to evaluate the differences in clinical features of uveitis.

Design: Retrospective cohort study.

Methods: SETTING: Institutional. Read More

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Chitosan-based hydrogels supplemented with gelatine and Link N enhance extracellular matrix deposition by encapsulated cells in a degenerative intervertebral disc environment.

Eur Cell Mater 2021 May 4;41:471-484. Epub 2021 May 4.

Laboratory for endovascular biomaterials (LBeV), CHUM research centre (CRCHUM), 900 St Denis St, Montreal, QC H2X 3H8,

Injectable therapies for intervertebral disc (IVD) repair are gaining much interest. Recently, a chitosan (CH)-based injectable scaffold has been developed that has similar mechanical properties to human nucleus pulposus (NP) and provides a suitable environment for encapsulated NP cell survival and proteoglycan production. The hypothesis of the study was that the biological response of the encapsulated cells can be further increased by adding gelatine and Link N (LN, a naturally occurring peptide present in cartilage and IVD extracellular matrix), known to increase cell adhesion and proteoglycan production, respectively. Read More

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The Demography and Characteristic of SARS-CoV-2 Sero-positive Residents and Staff of Nursing Homes for Older Adults in the Community of Madrid: the SeroSOS Study.

Age Ageing 2021 May 4. Epub 2021 May 4.

Vice-counselor of Public Health, Community of Madrid.

Background: Nursing homes for older adults have concentrated large numbers of severe cases and deaths for COVID-19.

Methods: Point seroprevalence study of nursing homes to describe the demography and characteristic of SARS-CoV-2 IgG-positive residents and staff.

Results: Clinical information and blood samples were available for 9,332 residents (mean age 86. Read More

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Reaching underserved South Africans with integrated chronic disease screening and mobile HIV counselling and testing: A retrospective, longitudinal study conducted in Cape Town.

PLoS One 2021 4;16(5):e0249600. Epub 2021 May 4.

Faculty of Health Sciences, The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

Background: Community-based, mobile HIV counselling and testing (HCT) and screening for non-communicable diseases (NCDs) may improve early diagnosis and referral for care in underserved populations. We evaluated HCT/NCD data and described population characteristics of those visiting a mobile clinic in high HIV disease burden settings in Cape Town, South Africa, between 2008 and 2016.

Methods: Trained counsellors registered patients ≥12 years old at a mobile clinic, which offered HCT and blood pressure, diabetes (glucose testing) and obesity (body mass index) screening. Read More

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genetic testing in melanoma-prone families in Sweden in the years 2015-2020: implications for novel national recommendations.

Acta Oncol 2021 May 4:1-9. Epub 2021 May 4.

Department of Oncology and Pathology, Karolinska Institutet and Theme Cancer, Karolinska University Hospital, Stockholm, Sweden.

Inherited pathogenic variants (PVs) in the gene are among the strongest known risk factors for cutaneous melanoma. Carriers are at high risks to develop multiple primary melanomas and other cancers, in particular pancreatic cancer. In this study, the testing, carried out in Sweden in the years 2015-2020, was evaluated. Read More

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The Association Between Obesity and Peak Antibody Titer Response in COVID-19 Infection.

Obesity (Silver Spring) 2021 May 4. Epub 2021 May 4.

Sheba Talpiot Medical Leadership Program, Tel Hashomer, Israel.

Objective: Obesity is associated with severe COVID-19 infection. Disease severity is associated with a higher COVID-19 antibody titer. We compared the COVID-19 antibody titer response of patients with obesity versus patients without obesity. Read More

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Rheumatoid factor and falsely elevated results in commercial immunoassays: data from an early arthritis cohort.

Rheumatol Int 2021 May 4. Epub 2021 May 4.

Department of Medical Biochemistry, Oslo University Hospital-Radiumhospitalet, Box 4953 Nydalen, 0424, Oslo, Norway.

The aim of the study was to  assess RF cross-reactivity to animal antibodies used in immunoassays, and to test if selected commercial immunoassays are vulnerable to interference from RF, causing false test results. Our study included samples from patients with RF-positive rheumatoid arthritis (RA) and controls (patients with RF-negative RA and psoriatic arthritis), included in an early arthritis-cohort. Reactivity to mouse IgG1, mouse IgG2a, rabbit IgG, bovine IgG, sheep/goat IgG and human IgG was analysed using in-house interference assays. Read More

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Synovial Cell Count Before Reimplantation Can Predict the Outcome of Patients with Periprosthetic Knee Infections Undergoing Two-stage Exchange.

Clin Orthop Relat Res 2021 May 3. Epub 2021 May 3.

T. Ascione, Service of Infectious Diseases, Cardarelli Hospital, Naples, Italy.

Background: Although synovial fluid can be used to diagnose periprosthetic joint infections (PJI) effectively, only the cutoff values adopted at the time of PJI diagnosis have been standardized, and few data are currently available about effectiveness of synovial fluid examination before definitive reimplantation.

Questions/purposes: We asked: (1) What are the most appropriate thresholds for synovial fluid leukocyte counts (WBC) and neutrophil percentage (PMN percentage) in a patient group undergoing definitive reimplantation after an uninterrupted course of antibiotic therapy for chronic PJI? (2) What is the predictive value of our synovial WBC and PMN percentage threshold compared with previously proposed thresholds?

Methods: In all, 101 patients with PJI were evaluated for inclusion from January 2016 to December 2018. Nineteen percent (19 of 101) of patients were excluded because of the presence of a chronic inflammatory disease, acute/late hematogenous infection, low amount of synovial fluid for laboratory investigations or infection persistence after spacer placement, and adequate antibiotic therapy. Read More

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Experiences of workplace bullying among academics in a health sciences faculty at a South African university.

S Afr Med J 2021 Mar 31;111(4):315-320. Epub 2021 Mar 31.

School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: Workplace bullying and other negative workplace behaviours are problems that need to be addressed across many work settings, including at universities.

Objectives: To examine the prevalence of bullying among academics, and factors associated with bullying, in a faculty of health sciences (FHS) of a South African university.

Methods: All academic staff, except senior managers, were invited to participate by completing a self-administered, web-based questionnaire hosted on REDCap. Read More

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The burden of hypertension in KwaZulu-Natal Province, South Africa: A 6-year perspective.

S Afr Med J 2021 Feb 1;111(2):159-165. Epub 2021 Feb 1.

Department of Internal Medicine, King Edward VIII Hospital and Nelson R Mandela School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa.

Background: Hypertension (HPT) and its complications continue to pose a global threat and contribute to premature mortality worldwide. The adverse interactions between HPT, obesity and COVID-19 are currently being witnessed globally and represent a collision of pandemics. Understanding the burden that this non-communicable disease (NCD) poses in KwaZulu-Natal (KZN) Province, South Africa (SA), would help in developing improved public healthcare strategies. Read More

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February 2021

Clinical characteristics and outcomes of hospitalized COVID-19 patients with COPD.

Expert Rev Respir Med 2021 May 4. Epub 2021 May 4.

Chest Diseases Department, Canakkale 18 Mart University, Canakkale, Turkey.

Background: Although COPD is not one of the most common comorbidities in COVID-19 patients, it can be more fatal in this group. This study aimed to investigate the characteristics and prognosis of COPD patients among the population with COVID-19.

Research Design And Methods: Patients diagnosed with positive PCR test were included in our multicentered, retrospective study. Read More

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Assessment of an AI Aid in Detection of Adult Appendicular Skeletal Fractures by Emergency Physicians and Radiologists: A Multicenter Cross-sectional Diagnostic Study.

Radiology 2021 May 4:203886. Epub 2021 May 4.

From the Department of Radiology, Hôpital Fondation A. de Rothschild, 25 rue Manin, 75019 Paris, France (L.D.); Faculty of Medicine, Université de Paris, Paris, France (L.D., A. Feydy); Gleamer, Paris, France (A.D., C.A., N.C., Z.Z., N.N., E.L., A.P., N.E.R.); Department of Biostatistics, CHU Rouen, Rouen, France (A.G.); Department of Radiology, Hôpital Hôtel-Dieu, Assistance Publique-Hôpitaux de Paris, Paris, France (J.L.); Department of Radiology, Hôpital Ambroise-Paré, Assistance Publique-Hôpitaux de Paris, Boulogne-Billancourt, France (A. Felter); Department of Radiology, Hôpital Raymond-Poincaré, Assistance Publique-Hôpitaux de Paris, Garches, France (A. Felter); and Department of Radiology B, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France (L.L., N.E.R., A. Feydy).

Background The interpretation of radiographs suffers from an ever-increasing workload in emergency and radiology departments, while missed fractures represent up to 80% of diagnostic errors in the emergency department. Purpose To assess the performance of an artificial intelligence (AI) system designed to aid radiologists and emergency physicians in the detection and localization of appendicular skeletal fractures. Materials and Methods The AI system was previously trained on 60 170 radiographs obtained in patients with trauma. Read More

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AI-based Strategies to Reduce Workload in Breast Cancer Screening with Mammography and Tomosynthesis: A Retrospective Evaluation.

Radiology 2021 May 4:203555. Epub 2021 May 4.

From the Breast Cancer Unit, Department of Radiology, Hospital Universitario Reina Sofía, Av Menéndez Pidal s/n, Córdoba 14004, Spain (J.L.R.P., S.R.M., E.E.C., M.Á.B.); Maimonides Institute for Biomedical Research of Córdoba, Córdoba, Spain (J.L.R.P., S.R.M., E.E.C., M.Á.B.); and Department of Clinical Science, ScreenPoint Medical, Nijmegen, the Netherlands (A.G.M., A.R.R.).

Background The workflow of breast cancer screening programs could be improved given the high workload and the high number of false-positive and false-negative assessments. Purpose To evaluate if using an artificial intelligence (AI) system could reduce workload without reducing cancer detection in breast cancer screening with digital mammography (DM) or digital breast tomosynthesis (DBT). Materials and Methods Consecutive screening-paired and independently read DM and DBT images acquired from January 2015 to December 2016 were retrospectively collected from the Córdoba Tomosynthesis Screening Trial. Read More

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Red cell index: A novel biomarker for 3-month mortality in acute ischemic stroke patients treated with intravenous thrombolysis.

Brain Behav 2021 May 4:e02170. Epub 2021 May 4.

Department of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Background: The red cell index (RCI) was described as a biomarker for evaluating respiratory function in previous studies, but the relationship between RCI and stroke, remained a mystery. The present study aimed to probe the association between RCI at 24-hr and 3-month mortality and functional outcomes among acute ischemic stroke (AIS) patients treated with recombinant tissue plasminogen activator (r-tPA).

Methods: A total of 217 AIS patients between January 2016 and January 2019 were recruited in this retrospective study. Read More

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Role of chemotherapy after curative esophagectomy in squamous cell carcinoma of the thoracic esophagus: A propensity score-matched analysis.

Thorac Cancer 2021 May 4. Epub 2021 May 4.

Department of Esophageal Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.

Background: The efficacy of postoperative treatment of squamous cell carcinoma of the esophagus has not yet been determined. In this retrospective study, we investigated whether postoperative adjuvant chemotherapy (POCT) confers a survival benefit on patients who undergo curative esophagectomy.

Methods: A total of 782 patients were enrolled in our study. Read More

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Selecting and imagining rewarding activities during the COVID-19 lockdown: Effects on mood and what moderates them.

Int J Psychol 2021 May 4. Epub 2021 May 4.

Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Germany.

The COVID-19 outbreak strongly restricted daily activities, creating a risk factor for negative affect and depression. This study assessed the immediate effects of a behavioural activation (BA) intervention on positive (PA) and negative (NA) state affect. We expected depression and anxiety to function as moderators reducing the intervention effects. Read More

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Evaluation of the Roche MagNA Pure 96 nucleic acid extraction platform for the Seegene Anyplex II HPV28 detection assay.

J Appl Microbiol 2021 May 3. Epub 2021 May 3.

Centre for Women's Infectious Diseases, The Royal Women's Hospital, Melbourne, Victoria, Australia.

Aim: Validate the Roche, MagNAPure96 (MP96) nucleic acid extraction platform for Seegene Anyplex II HPV28 (Anyplex28) detection of Human Papillomavirus.

Methods And Results: Comparisons were made for Anyplex28 genotyping from 115 cervical samples extracted on the Hamilton, STARlet and the MP96. Two DNA concentrations were used for the MP96, one matched for sample input to the STARlet, and another 5x concentration (laboratory standard). Read More

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Pembrolizumab-caused polyradiculoneuropathy as an immune-related adverse event.

Neuropathology 2021 May 3. Epub 2021 May 3.

Department of Neurology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Hiroshima, Japan.

Immune-related adverse events (irAEs) commonly involve the gastrointestinal tract, endocrine glands, skin, and liver, and rarely the nervous system. The pathomechanism of irAEs in the nervous system is unclear, and so characterizing these severe toxic effects is a priority, even if irAEs are uncommon in the nervous system. Our patient presented subacute muscle weakness and dysesthesia with colitis as irAEs caused by pembrolizumab, one of the anti-programmed death-1 (PD-1) antibodies. Read More

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Elevated levels of interleukin-35 and interleukin-37 in adult patients with obstructive sleep apnea.

J Clin Lab Anal 2021 May 4:e23790. Epub 2021 May 4.

Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Background: Systemic inflammation has a critical role in the pathogenesis of obstructive sleep apnea (OSA). Interleukin (IL)-35 and IL-37 have been identified as novel immune-modulating cytokines with anti-inflammatory activities in numerous types of inflammatory disease. The present study aimed to examine the serum levels of IL-35 and IL-37 in patients with OSA, and to investigate their associations with the severity of OSA. Read More

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Mycoplasma hyopneumoniae in free-living wild boars in Paraná, Brazil.

Braz J Microbiol 2021 May 3. Epub 2021 May 3.

Laboratory of Animal Virology, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Londrina, Paraná, Brazil.

This is the first study conducted in Paraná, Brazil, to investigate Mycoplasma hyopneumoniae (Mhyo) infection in free-living wild boars. Eighty-eight wild boars were managed by authorized controllers between 2017 and 2019 in the state of Paraná in southern Brazil. Management georeferencing, sex, and weight were recorded for each animal. Read More

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Effectiveness of fast-track pathway for diabetic foot ulcerations.

Acta Diabetol 2021 May 3. Epub 2021 May 3.

Diabetic Foot Unit, University of Rome Tor Vergata, Viale Oxford 81, 00133, Rome, Italy.

Aim: To investigate the effectiveness of fast-track pathway (FTP) in the management of diabetic foot ulceration (DFU) after 2 years of implementation.

Methods: The study group was composed of patients who referred to a specialized DF centre due to DFUs. Those were divided in two groups: early referral (ER) and late referral (LR) patients. Read More

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Automatic prediction of left cardiac chamber enlargement from chest radiographs using convolutional neural network.

Eur Radiol 2021 May 3. Epub 2021 May 3.

Radiology, Seoul National University Hospital, Seoul, Republic of Korea.

Objective: To develop deep learning-based cardiac chamber enlargement-detection algorithms for left atrial (DLCE-LAE) and ventricular enlargement (DLCE-LVE), on chest radiographs METHODS: For training and internal validation of DLCE-LAE and -LVE, 5,045 chest radiographs (CRs; 2,463 normal and 2,393 LAE) and 1,012 CRs (456 normal and 456 LVE) matched with the same-day echocardiography were collected, respectively. External validation was performed using 107 temporally independent CRs. Reader performance test was conducted using the external validation dataset by five cardiothoracic radiologists without and with the results of DLCE. Read More

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Family cohesion and depression in adolescents: A mediating role of self-confidence.

J Pak Med Assoc 2021 Feb;71(2(B)):677-680

Institute of Clinical Psychology, University of Management and Technology, Lahore, Pakistan.

Objective: To identify the mediating role of self-confidence in family cohesion and depression in adolescents.

Methods: The cross-sectional study was conducted at five mainstream government boys and girls schools in Lahore, Pakistan, from March 1 to November 30, 2019, and comprised adolescents aged 12-19 years. Data was collected using Family Cohesion Scale, Self-confidence Scale and Depression Scale for Adolescents. Read More

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February 2021

Self-reported and Documented Substance Use Among Adolescents in the Pediatric Hospital.

Pediatrics 2021 May 3. Epub 2021 May 3.

Department of Pediatrics, Children's Mercy Hospital, Kansas City, Missouri.

Background And Objectives: Adolescent substance use is associated with numerous adverse health outcomes. A hospitalization represents an opportunity to identify and address substance use. We sought to describe self-reported and documented substance use among hospitalized adolescents. Read More

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Usefulness of hematopoietic progenitor cell monitoring to predict autologous peripheral blood stem cell harvest timing: A single-center retrospective study.

Transfus Apher Sci 2021 Apr 24:103150. Epub 2021 Apr 24.

Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Japan.

Introduction: In autologous peripheral blood stem cell harvest (APBSCH), CD34-positive cells have been measured to assess the numbers of hematopoietic stem cells, but measurement requires specialized equipment. Recently, there was a report that peripheral blood hematopoietic progenitor cells (HPCs) are useful indicators of the presence of hematopoietic stem cells. We examined the usefulness of HPC monitoring to predict APBSCH timing. Read More

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[Impact of positive surgical margins on prostate cancer prognosis].

Prog Urol 2021 Apr 30. Epub 2021 Apr 30.

Service d'urologie, CHU de Reims, 51100 Reims, France.

Objective: To examine the impact of positive surgical margins (PSM) after radical prostatectomy (RP) for prostate cancer on oncological results.

Patients And Methods: We performed a study where all patients who underwent radical prostatectomy between January 2004 and December 2018 for prostate cancer were included. The preoperative, postoperative data and the carcinological results collected were analyzed. Read More

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Prognostic impact of lymph node metastasis along the left gastric artery in esophageal squamous cell carcinoma.

J Cardiothorac Surg 2021 May 3;16(1):124. Epub 2021 May 3.

Department of thoracic surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangdong Esophageal Cancer Institute, 651 Dongfengdong Road, Guangzhou, 510060, China.

Background: Although the incidence of lymph node (LN) metastasis (LNM) along the left gastric artery is high, its relationship with the prognosis in postoperative patients with esophageal squamous cell carcinoma (ESCC) is rarely reported. This study clarified the prognostic impact of LNM along the left gastric artery in postoperative patients with ESCC.

Methods: This study assessed data of 1521 patients with ESCC who underwent esophagectomy at the Sun Yat-sen University Cancer Center between March 1992 and March 2012. Read More

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Knowledge, health beliefs and attitudes towards dementia and dementia risk reduction among the Dutch general population: a cross-sectional study.

BMC Public Health 2021 May 3;21(1):857. Epub 2021 May 3.

Department of Epidemiology, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, PO Box 30 001, FA40, 9700, RB, Groningen, the Netherlands.

Background: Positive health beliefs and attitudes towards dementia and dementia risk reduction may encourage adopting a healthy behaviour. Therefore, we aimed to investigate the knowledge, health beliefs and attitudes towards dementia and dementia risk reduction among the Dutch general population and its association with the intention to change health behaviours.

Methods: A random sample of Dutch residents (30 to 80 years) was invited to complete an online survey. Read More

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