2,004 results match your criteria -rhamnopyranosyl -->


Triterpenoid saponins and others glycosides from the stem barks of Pancovia turbinata Radlk.

Carbohydr Res 2021 Jul 10;508:108393. Epub 2021 Jul 10.

Laboratoire de Pharmacochimie des Substances Naturelles, Département de Chimie Organique, Faculté de Sciences, Université de Yaoundé I, BP 812, Yaoundé, Cameroon; UMR 152 Pharma Dev, Université de Toulouse, IRD, UPS, France. Electronic address:

In our continuing search of saponins from the plant of Sapindaceae family, phytochemical investigation of the stem barks of Pancovia turbinata Radlk., led to the isolation and structural characterization of two new triterpenoid saponins, named turbinatosides A-B (1-2), one new farnesyl glycoside, named turbinoside A (3), one new coumarin glucoside, named panturboside A (4), together with a known saponin (5). The structures of the new compounds were established, using extensive analysis of NMR techniques, mainly 1D NMR (H, C, and DEPT) and 2D NMR (COSY, NOESY, HSQC, HSQC-TOCSY and HMBC) experiments, HRESIMS and by comparison with the literature data, as 3-O-β-d-xylopyranosyl-(1 → 3)-α-l-arabinopyranosyl-(1 → 4)-β-d-glucopyranosyl-(1 → 3)-α-l-rhamnopyranosyl-(1 → 2)-α-l-arabinopyranosylhederagenin 28-O-β-d-glucopyranosyl ester (1), 3-O-α-l-arabinopyranosyl-(1 → 4)-β-d-glucopyranosyl-(1 → 3)-α-l-rhamnopyranosyl-(1 → 2)-α-l-arabinopyranosylhederagenin 28-O-β-d-xylopyranosyl-(1 → 4)-β-d-glucopyranosyl ester (2), 1-O-{β-d-glucopyranosyl-(1 → 3)-α-l-rhamnopyranosyl-(1 → 2)-[α-l-rhamnopyranosyl-(1 → 6)]-β-d-glucopyranosyl}-(2E,6E)-farnes-1,12-diol (3), and 5-O-β-d-glucopyranosyl-5,6,7-trihydroxy-8-methoxycoumarin (4), respectively. Read More

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Studies on isolation and structural identification of saponins from the herb Hylomecon japonica and their bioactivities.

Carbohydr Res 2021 Jul 7;507:108391. Epub 2021 Jul 7.

School of Pharmaceutical Sciences, Jilin University, Changchun, 130021, PR China. Electronic address:

Three undescribed oleanane type triterpenoid saponins (1-3), along with one known saponin (4) were isolated from the whole herb of Hylomecon japonica. Their structures were elucidated by analysis of 1D and 2D-NMR (H-H COSY, HSQC, and HMBC) spectroscopic data, mass spectrometry (HR-ESI-MS) and chromatographic date (GC and LC) as 3-O-β-d-glucopyranosyl-(1 → 2)-β-d-glucuronopyranosyl gypsogenin 28-O-β-d-galactopyranosyl-(1 → 3)-[β-d-xylopyranosyl-(1 → 4)]-α-l-rhamnopyranosyl-(1 → 2)-β-l-arabinopyranosyl ester (1), 3-O-β-d-galactopyranosyl-(1 → 2)-β-d-glucuronopyranosyl gypsogenin 28-O-α-l-arabinopyranosyl-(1 → 3)-[β-d-xylopyranosyl-(1 → 4)]-α-l-rhamnopyranosyl-(1 → 2)-β-l-arabinopyranosyl ester (2), 3-O-β-d-galactopyranosyl-(1 → 2)-β-d-glucuronopyranosyl gypsogenin 28-O-β-d-galactopyranosyl-(1 → 3)-[β-d-xylopyranosyl-(1 → 4)]-α-l-rhamnopyranosyl-(1 → 2)-β-d-galactopyranosyl ester (3), 3-O-β-d-galactopyranosyl-(1 → 2)-[α-l-arabinopyranosyl-(1 → 3)]-β-d-glucuronopyranosyl gypsogenin 28-O-β-d-glucopyranosyl-(1 → 3)-[β-d-xylopyranosyl-(1 → 4)]-α-l-rhamnopyranosyl-(1 → 2)-β-d-fucopyranosyl ester (4). All saponins possess a partial sequence β-d-galactopyranosyl-(1 → 2)-β-d-glucuronopyranosyl at C-3 of the aglycon. Read More

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Bioactive oleanane-type saponins from Hylomecon Japonica.

Phytochemistry 2021 Jul 14;190:112870. Epub 2021 Jul 14.

School of Pharmaceutical Sciences, Jilin University, Changchun, 130021, People's Republic of China. Electronic address:

Six undescribed oleanane-type saponins, named as Hylomeconosides L-Q, were isolated from the whole herb of Hylomecon Japonica, their structures were determined by analysis of 1D and 2D-NMR (H-H COSY, HSQC, and HMBC) spectroscopic data, mass spectrometry (HRESI-MS) and chromatographic data (GC and LC). Their structures were identified as 3-O-β-D-galactopyranosyl-(1 → 2)-β-D-glucuronopyranosyl gypsogenin 28-O-β-D-galactopyranosyl-(1 → 3)-α-L-rhamnopyranosyl-(1 → 2)-β-L-arabinopyranoside; 3-O-β-D-galactopyranosyl-(1 → 2)-β-D-glucuronopyranosyl gypsogenin 28-O-β-D-xylopyranosyl-(1 → 4)-α-L-rhamnopyranosyl-(1 → 2)-β-D-quinovopyranoside; 3-O-β-D-glucuronopyranosyl gypsogenin 28-O-β-D-xylopyranosyl-(1 → 3)-β-D-xylopyranosyl-(1 → 4)-α-L-rhamnopyranosyl-(1 → 2)-β-D-quinovopyranoside; 3-O-β-D-xylopyranosyl-(1 → 3)-β-D-glucuronopyranosyl gypsogenin 28-O-β-D-xylopyranosyl-(1 → 4)-α-L-rhamnopyranosyl-(1 → 2)-β-D-quinovopyranoside; 3-O-β-D-galactopyranosyl-(1 → 2)-[α-L-rhamnopyranosyl-(1 → 3)]-β-D-glucuronopyranosyl quillaic acid 28-O-β-D-xylopyranosyl-(1 → 3)-β-D-xylopyranosyl-(1 → 4)-α-L-rhamnopyranosyl-(1 → 2)-β-D-quinovopyranoside; 3-O-β-D-galactopyranosyl-(1 → 2)-[α-L-rhamnopyranosyl-(1 → 3)]-β-D-glucuronopyranosyl quillaic acid 28-O-β-D-xylopyranosyl-(1 → 3)-β-D-xylopyranosyl-(1 → 4)-α-L-rhamnopyranosyl-(1 → 2)-β-D-galactopyranoside. Hylomeconosides L-Q showed selective cytotoxicities against human cancer cell lines A549, AGS, HeLa, Huh 7, HT29 and K562. Read More

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Anticholinesterase Activity of Eight Medicinal Plant Species: and Studies in the Search for Therapeutic Agents against Alzheimer's Disease.

Evid Based Complement Alternat Med 2021 25;2021:9995614. Epub 2021 Jun 25.

Department of Science, University of Basilicata, Viale Dell'Ateneo Lucano 10, Potenza 85100, Italy.

Many Bangladeshi medicinal plants have been used to treat Alzheimer's disease and other neurodegenerative diseases. In the present study, the anticholinesterase effects of eight selected Bangladeshi medicinal plant species were investigated. Species were selected based on the traditional uses against CNS-related diseases. Read More

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Acetylcholinesterase and monoamine oxidase-B inhibitory activities by ellagic acid derivatives isolated from Castanopsis cuspidata var. sieboldii.

Sci Rep 2021 Jul 6;11(1):13953. Epub 2021 Jul 6.

Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon, 57922, Republic of Korea.

Among 276 herbal extracts, a methanol extract of Castanopsis cuspidata var. sieboldii stems was selected as an experimental source for novel acetylcholinesterase (AChE) inhibitors. Five compounds were isolated from the extract by activity-guided screening, and their inhibitory activities against butyrylcholinesterase (BChE), monoamine oxidases (MAOs), and β-site amyloid precursor protein cleaving enzyme 1 (BACE-1) were also evaluated. Read More

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Surface Plasmon Resonance Monitoring of Mono-Rhamnolipid Interaction with Phospholipid-Based Liposomes.

Langmuir 2021 07 25;37(26):7975-7985. Epub 2021 Jun 25.

CNRS, Claude Bernard Lyon 1 University, Institute of Analytical Sciences, University of Lyon, 5 rue de la Doua, F-69100 Villeurbanne, France.

The interactions of mono-rhamnolipids (mono-RLs) with model membranes were investigated through a biomimetic approach using phospholipid-based liposomes immobilized on a gold substrate and also by the multiparametric surface plasmon resonance (MP-SPR) technique. Biotinylated liposomes were bound onto an SPR gold chip surface coated with a streptavidin layer. The resulting MP-SPR signal proved the efficient binding of the liposomes. Read More

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Glycosides of polygalacic acid from the stem barks of Piper guineense Schum and Thonn.

Carbohydr Res 2021 Jun 16;507:108374. Epub 2021 Jun 16.

Department of Chemistry, University of the Free State, 205 Nelson Mandela Avenue, Bloemfontein, 9301, South Africa.

In a continuation of our study on constituents of P. guineense now focusing on the search for saponins, phytochemical investigation of the n-BuOH fraction of P. guineense stem bark led to the isolation of three previously undescribed triterpenoid saponins, named guineenosides A─C (1─3). Read More

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Clerodane-type Diterpene Glycosides from Dicranopteris pedata.

Nat Prod Bioprospect 2021 Jun 5. Epub 2021 Jun 5.

State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.

Three new clerodane-type diterpene glycosides, (5R,6S,8R,9S,10R)-6-O-[β-D-glucopyranosyl-(1 → 4)-α-L-rhamnopyranosyl]cleroda-3,13(16),14-diene (1), (5R,6S,8R,9S,10R,13S)-6-O-[β-D-glucopyranosyl-(1 → 4)-α-L-rhamnopyranosyl]-2-ox-oneocleroda-3,13-dien-15-ol (2), (5R,6S,8R,9S,10R)-6-O-[β-D-glucopyranosyl-(1 → 4)-α-L-rhamnopyranosyl]-(13E)-2-oxoneocleroda-3,14-dien-13-ol (3), together with two known compounds 4 and 5 were isolated from Dicranopteris pedata. The structures of these compounds were elucidated by detailed spectroscopic analysis, and the absolute configuration of compound 2 was determined by ECD calculations. In addition, compound 1 exhibited weak inhibitory activities against SMMC-7721, MCF-7 and SW480. Read More

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Anti-phytopathogen terpenoid glycosides from the root bark of Chytranthus macrobotrys and Radlkofera calodendron.

Phytochemistry 2021 Aug 20;188:112797. Epub 2021 May 20.

PEPITE EA 4267, Laboratoire de Pharmacognosie, UFR des Sciences de Santé, Université de Bourgogne Franche-Comté, BP 87900, 21079, Dijon, Cedex, France.

Chytranthus macrobotrys and Radlkofera calodendron are two Sapindaceae characterized by a lack of phytochemical data. Both root barks from the two Sapindaceae species were processed by ethanol extraction followed by the isolation of their primary constituents by liquid chromatography. This process yielded four previously undescribed terpenoid glycosides together with eight known analogues. Read More

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Steroidal alkaloids isolated from Veratrum grandiflorum Loes. as novel Smoothened inhibitors with anti-proliferation effects on DAOY medulloblastoma cells.

Bioorg Med Chem 2021 Jun 21;39:116166. Epub 2021 Apr 21.

Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Institute of Materia Medica, Hangzhou Medical College, Hangzhou, Zhejiang 310013, China. Electronic address:

Constitutive activation of Hedgehog (Hh) pathway is intimately related with the occurrence and development of several malignancies, such as medulloblastoma (MB) and other tumors. Therefore, small molecular inhibitors of Hh pathway are urgently needed. In this study, three new steroidal alkaloids, ⊿ (20R, 24R) 23-oxo-24-methylsolacongetidine, ⊿ (20S, 24R) 23-oxo-24-methylsolacongetidine and veralinine 3-O-α-l-rhamnopyranosyl-(1 → 2)-β-D-glucopyranoside, together with six known alkaloids, 20-epi-verazine, verazine, protoverine 15-(l)-2'-methylbutyrate, jervine, veramarine and β1-chaconine, were isolated and determined from Veratrum grandiflorum Loes. Read More

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The flavonoid, kaempferol-3-O-apiofuranosyl-7-O-rhamnopyranosyl, as a potential therapeutic agent for breast cancer with a promoting effect on ovarian function.

Phytother Res 2021 Apr 28. Epub 2021 Apr 28.

Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.

It is widely known that breast cancer cells eventually develop resistance to hormonal drugs and chemotherapies, which often compromise fertility. This study aimed to investigate the effect of the flavonoid, kaempferol-3-O-apiofuranosyl-7-O-rhamnopyranosyl (KARP), on 1) the viability of MCF-7 breast cancer cells and 2) ovarian function in rats. A dose-dependent decrease in MCF-7 cell survival was observed, and the IC50 value was found to be 48 μg/ml. Read More

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A novel acylated flavonol tetraglycoside and rare oleanane saponins with a unique acetal-linked dicarboxylic acid substituent from the xero-halophyte Bassia indica.

Fitoterapia 2021 Jul 20;152:104907. Epub 2021 Apr 20.

Department of Agro-environmental Sciences, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Fukuoka 819-0395, Japan. Electronic address:

In recent years, the scientific interest and particularly the economic significance of halophytic plants has been highly demanding due to the medicinal and nutraceutical potential of its bioactive compounds. A xero-halophyte Bassia indica is deemed to be a very cheap source of natural entities without chemical or biological investigation. In this context, a new acylated flavonol tetraglycoside, kaempferol-3-O-β-d-glucopyranosyl-(1→6)-O-[β-D-galactopyranosyl-(1→3)-2-O-trans-feruloyl-α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside (14), together with rare occurring flavonol triglycoside, isorhamnetin-3-O-β-d-glucopyranosyl-(1→6)-O-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside (15), were isolated from the aqueous methanol extract of the aerial parts of B. Read More

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HPLC-ESI/MS profiling, phytoconstituent isolation and evaluation of renal function, oxidative stress and inflammation in gentamicin-induced nephrotoxicity in rats of Ficus spragueana Mildbr. & Burret.

Biomed Chromatogr 2021 Apr 5:e5135. Epub 2021 Apr 5.

Medicinal and Pharmaceutical Chemistry Department (Pharmacology Group), Pharmaceutical and Drug Industries Research Division, National Research Centre (ID 60014618), Giza, Egypt.

Ficus spragueana Mildbr. & Burret (family Moraceae) was reported to have various biological activities. However, its activity in treatment of renal injury has not been investigated yet. Read More

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Suppression of cytokine production by newly isolated flavonoids from pepper.

Authors:
Ahmed E Allam

Fitoterapia 2021 Jun 2;151:104903. Epub 2021 Apr 2.

Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt. Electronic address:

New flavonoid glycoside, kaempferol 3-O-α-[(6-P-coumaroyl galactopyranosyl-O-β-(→4)-O-α-rhamnopyranosyl-(1→4)]-O-α-rhamnopyranoside 1, in addition to five known flavonoid glycosides (2-6) kaempferol 3-O-[α-rhamnopyranosyl-(1→4)-O-α-rhamnopyranosyl-(1→6)-O]-β-galactopyranoside (kaempferol 3-O-β-isorhamninoside) 2, quercetin 3-O-[(2,3,4-triacetyl-α-rhamnopyranosyl)-(1 → 6)-β-galactopyranoside 3, quercetin 3-O-[(2,4-diacetyl-α-rhamnopyranosyl)-(1 → 6)]-3,4-diacetyl-β-galactopyranoside 4, quercetin 3-O-[(2,4-diacetyl-α-rhamnopyranosyl)-(1→6)]-2,4-diacetyl-β-galactopyranoside 5, quercetin 3-O-[(2,3,4-triacetyl-α-rhamnopyranosyl)-(1 → 6)-3-acetyl-β-galactopyranoside 6 were isolated from bell pepper (Capsicum annum L.) fruits and tested for both anti-inflammatory activity through cytokine production (TNF-α and IL-1β) and antioxidant activity through scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Compounds 1-3 significantly suppressed production of TNF-α / IL-1β in cultured THP-1 cells previously co-stimulated by LPS in a dose-dependent manner (10. Read More

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Laboratory and Field Evaluation of the Phytotoxic Activity of Gaertn Pulp Extract and Identification of a Phytotoxic Substance.

Molecules 2021 Mar 2;26(5). Epub 2021 Mar 2.

SFA Key Laboratory of Bamboo and Rattan Science and Technology, International Centre for Bamboo and Rattan, No. 8 Futong Dongdajie, Wangjing, Chaoyang District, Beijing 100102, China.

Interest in finding plant-based herbicides to supplement synthesized herbicides is increasing. Although the extract of Gaertn has been reported to have herbicidal activity, little is known about phytotoxic substances and their efficacy of weed control in the field. To identify phytotoxic substances, the bioassay-guided fractionation by column chromatography and high-speed counter-current chromatography (HSCCC) was carried out. Read More

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Preparative separation of five polyphenols from the fruits of Sorbus pohuashanensis Hedl. by high-speed counter-current chromatography.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 May 5;1172:122620. Epub 2021 Mar 5.

School of Pharmaceutical Sciences, Liaoning University, Shenyang 110036, PR China; Natural Products Pharmaceutical Engineering Technology Research Center of Liaoning Province, Shenyang 110036, PR China. Electronic address:

The fruits of Sorbus pohuashanensis Hedl. (S. pohuashanensis) are rich in polyphenols with many beneficial effects such as anti-inflammatory, anti-tussive, anti-asthmatic and anti-cancer. Read More

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Compounds DRG and DAG, Two Phenol Glycosides, Inhibit TNF-α-stimulated Inflammatory Response through Blocking NF-kB/AKT/JNK Signaling Pathways in MH7A Cells.

Inflammation 2021 Mar 25. Epub 2021 Mar 25.

Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, People's Republic of China.

Fourteen constituents were recently isolated from the roots of Dendropanax dentiger with cyclooxygenase-2 (COX-2) inhibitory effects. However, the effect of 14 constituents on rheumatoid arthritis (RA) and their action mechanism remain unclear. The study aimed to explore the anti-RA effect and potential mechanism of these constituents in tumor necrosis factor α (TNF-α)-stimulated human RA fibroblast-like synoviocytes (MH7A cells). Read More

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Manniosides B-F, five new triterpenoid saponins from the leaves of Schefflera mannii (Hook.f.) Harms.

Carbohydr Res 2021 Apr 1;502:108279. Epub 2021 Mar 1.

Department of Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812-8582, Japan. Electronic address:

Fifteen triterpenoid saponins including five new compounds (Mannioside B: 3β-[(β-d-glucopyranosyl)oxy]urs-12-en-28-oic acid α-l-rhamnopyranosyl-(1 → 4)-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranosyl ester (1), mannioside C: 3β-[(β-d-glucopyranosyl)23-dioxy]urs-12-en-28-oic acid α-l-rhamnopyranosyl-(1 → 4)-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranosyl ester (2), mannioside D: 3β,23-dihydroxyurs-12-en-28-oic acid β-d-glucopyranosyl-(1 → 6)- β-d-glucopyranosyl ester (3), mannioside E: 3β-hydroxy-23-oxolup-20(29)-en-28-oic acid α-l-rhamnopyranosyl-(1 → 4)-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranosyl ester (4) and mannioside F: (22S)-27β-[(β-d-glucopyranosyl)oxy]-22-hydroxyprotosta-12,24-dien-3β-yl β-d-glucopyranoside (5)) were isolated from the leaves of Schefflera mannii (Hook.f.) Harms. Read More

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In Vivo Hepatoprotective and Nephroprotective Activity of Acylated Iridoid Glycosides from .

Biology (Basel) 2021 Feb 12;10(2). Epub 2021 Feb 12.

Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.

Phytochemical investigation of the chloroform fraction obtained from aerial parts led to the isolation of nine acylated iridoid glycosides. The new compounds were identified as 6-O-α-L(2″-acetyl, 3″,4″-di-O--cinnamoyl) rhamnopyranosyl-6'-acetyl catalpol (6'-acetyl hypericifolin A) (), 6-O-α-L(2″, 4″-diacetyl, 3″-O--cinnamoyl) rhamnopyranosyl-6'-acetyl catalpol (6'-acetyl hypericifolin B) (), 6-O-α-L(2″-acetyl, 3″,4″-di-O--cinnamoyl) rhamnopyranosyl catalpol (hypericifolin A) () and 6-O-α-L(2″, 4″-diacetyl, 3″-O--cinnamoyl) rhamnopyranosyl catalpol (hypericifolin B) (). Previously reported compounds were identified as laterioside (), 8-O-acetylharpagide (), 6-O-α-L(4'-O--cinnamoyl) rhamnopyranosyl catalpol (), lagotisoside D () and harpagoside (). Read More

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February 2021

New Phenylpropanoid Glycosides from Illicium majus and Their Radical Scavenging Activities.

Chem Biodivers 2021 Apr 24;18(4):e2001012. Epub 2021 Mar 24.

School of Pharmaceutical Science, Zhengzhou University, Ke Xue Da Dao 100, Zhengzhou, 450001, P. R. China.

Chemical investigation of the ethanol extract of the branch and leaves of Illicium majus resulted in the isolation of four new phenylpropanoid glycosides (1-4) and one new phenolic glycoside (9), along with 13 known ones. Spectroscopic techniques were used to elucidate the structures of the new isolates such as 3-[(2R,3S)-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1-benzofuran-5-yl]propyl β-D-glucopyranoside (1), [(2R,3S)-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-5-(3-hydroxypropyl)-2,3-dihydro-1-benzofuran-3-yl]methyl 2-O-α-L-rhamnopyranosyl-β-D-glucopyranoside (2), [(2R,3S)-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-5-(3-hydroxypropyl)-2,3-dihydro-1-benzofuran-3-yl]methyl 2-O-α-L-rhamnopyranosyl-β-D-xylopyranoside (3), 3-[(2R,3S)-3-({[2-O-(4-O-acetyl-α-L-rhamnopyranosyl)-β-D-xylopyranosyl]oxy}methyl)-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-2,3-dihydro-1-benzofuran-5-yl]propyl acetate (4), and 4-(2-hydroxyethyl)phenyl 3-O-β-D-glucopyranosyl-β-D-glucopyranoside (9). Free radical scavenging activities of the isolates were elucidated through the DPPH assay method. Read More

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Induction of stress resistance and extension of lifespan in Chaenorhabditis elegans serotonin-receptor knockout strains by withanolide A.

Phytomedicine 2021 Apr 28;84:153482. Epub 2021 Jan 28.

Department of Pharmaceutical Biology, Institute of Biochemistry and Pharmacy, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany. Electronic address:

Introduction: Approximately 300 million people worldwide suffer from depression. The COVID-19 crisis may dramatically increase these numbers. Severe side effects and resistance development limit the use of standard antidepressants. Read More

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A new flavonoid, a new phenylethanoid glycoside and related compounds isolated from the inflorescences of L.

Nat Prod Res 2021 Feb 18:1-12. Epub 2021 Feb 18.

Department of Pharmaceutical Botany and Plant Biotechnology, Poznań University of Medical Sciences, Poznań, Poland.

For the first time inflorescences of a plant species from the genus (Pantaginaceae)- L. (Ribwort Plantain), a known medicinal plant, were subjected to studies of phenolic compounds, which resulted in an isolation of two new compounds: a flavonoid-isorhamnetin 3--α-L-C-arabinopyranosyl-(1→2)-β-D-C-glucopyranoside) () and a phenylethanoid glycoside-2-(3,4-dihydroxyphenyl)ethyl -α-L-arabinofuranosyl-(1→2)-[α-L-C-rhamnopyranosyl-(1→3)][-caffeoyl-1→4]-β-D-C-glucopyranoside (), along with fourteen known compounds-eight flavonoids () and six phenylethanoid glycosides (, ). The chemical structures were established by 1 D and 2 D NMR and HRESIMS spectral methods. Read More

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February 2021

Phenolic Acid Derivatives, Flavonoids and Other Bioactive Compounds from the Leaves of (Thunb.) Makino (Liliaceae).

Plants (Basel) 2021 Feb 7;10(2). Epub 2021 Feb 7.

Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.

(Thunb.) Makino (Family: Liliaceae), commonly known as 'Ubayuri', is native to Japan and some islands in the Russian Far East. It has high value as food, medicinal, and ornamental species. Read More

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February 2021

Improving the inhibition of β-amyloid aggregation by withanolide and withanoside derivatives.

Int J Biol Macromol 2021 Mar 16;173:56-65. Epub 2021 Jan 16.

Department of Plant Sciences, School of Life Sciences, University of Hyderabad, Gachibowli, Telangana 500046, India. Electronic address:

Here, we have studied the ameliorative effects of Withania somnifera derivatives (Withanolide A, Withanolide B, Withanoside IV, and Withanoside V) on the fibril formation of amyloid-β for Alzheimer's disease. We analyzed reduction in the aggregation of β amyloid protein with these Ashwagandha derivatives by Thioflavin T assay in the oligomeric and fibrillar state. We have tested the cytotoxic activity of these compounds against human SK-N-SH cell line for 48 h, and the IC value found to be 28. Read More

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Phytochemistry and Biological Activities of Iris Species Growing in Iraqi Kurdistan and Phenolic Constituents of the Traditional Plant .

Molecules 2021 Jan 7;26(2). Epub 2021 Jan 7.

Medical Analysis Department, Faculty of Science, Tishk International University, Erbil 44001, Kurdistan Region, Iraq.

A dozen species (Iridaceae) are considered traditional remedies in Kurdistan, especially for treating inflammations. Phytochemical studies are still scarce. The information reported in the literature about species growing in Kurdistan has been summarized in the first part of this paper, although, except for , investigations have been performed on vegetal samples collected in countries different from Kurdistan. Read More

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January 2021

β-Selective Glycosylation Using Axial-Rich and 2-O-Rhamnosylated Glucosyl Donors Controlled by the Protecting Pattern of the Second Sugar.

Chem Pharm Bull (Tokyo) 2021 ;69(1):124-140

School of Science and Technology, Kwansei Gakuin University.

Herein, we describe two counterexamples of the previously reported β/α-selectivity of 96/4 for glycosylation using ethyl 2-O-[2,3,4-tris-O-tert-butyldimethylsilyl (TBS)-α-L-rhamnopyranosyl]-3,4,6-tris-O-TBS-thio-β-D-glucopyranoside as the glycosyl donor. Furthermore, we investigated the effects of protecting group on the rhamnose moieties in the glycosylation with cholestanol and revealed that β-selectivity originated from the two TBS groups at the 3-O and 4-O positions of rhamnose. In contrast, the TBS group at the 2-O position of rhamnose hampered the β-selectivity. Read More

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Enhanced production of mono-rhamnolipid in Pseudomonas aeruginosa and application potential in agriculture and petroleum industry.

Bioresour Technol 2021 Mar 31;323:124605. Epub 2020 Dec 31.

School of Life Sciences, Qufu Normal University, Qufu, Shandong Province 273165, China.

Differences in the rhamnolipid structures must result in its different activities, thus affecting its application effect. The rhlC gene in Pseudomonas aeruginosa SG was knocked out to construct strain P. aeruginosa SGΔrhlC. Read More

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Infraspecific Chemical Variability and Biological Activity of Casearia sylvestris from Different Brazilian Biomes.

Planta Med 2021 Feb 21;87(1-02):148-159. Epub 2020 Dec 21.

Institute of Chemistry, Department of Biochemistry and Organic Chemistry, São Paulo State University (UNESP), Araraquara/SP, Brazil.

is an outstanding representative of the genus. This representability comes from its distinctive chemical profile and pharmacological properties. This species is widespread from North to South America, occurring in all Brazilian biomes. Read More

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February 2021

Isolation, structural features, in vitro antioxidant activity and assessment of complexation ability with β-lactoglobulin of a polysaccharide from fruit.

Heliyon 2020 Nov 13;6(11):e05499. Epub 2020 Nov 13.

Natural Products Laboratory, Department of Chemistry, The University of Burdwan, Golapbag, Burdwan, West Bengal 713 104, India.

This research was intended to investigate the structural feature, antioxidative activity and interaction with β-lactoglobulin (β-lg) of a polysaccharide () isolated from fruit thru aqueous extraction, protein elimination and chromatographic techniques. Polysaccharide (molecular weight: 21,000 g mol) was constituted of arabinose, galactose, glucose, and rhamnose in a 50:24:20:6 M ratio alongside 9% (w/w) galacturonic acid. It encompassed a petite backbone entailing galacturonopyranosyl and rhamnopyranosyl units substituted with sizable side chains comprising of arabinofuranosyl, galactopyranosyl and esterified coumaric acid (CA) residues. Read More

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November 2020

Identification of anthocyanin and other flavonoids from the green-blue petals of Puya alpestris (Bromeliaceae) and a clarification of their coloration mechanism.

Phytochemistry 2021 Jan 24;181:112581. Epub 2020 Nov 24.

Department of Botany, National Museum of Nature and Science, Tsukuba, Ibaraki, 305-0005, Japan.

To understand the unique green-blue color of Puya alpestris (Bromeliaceae) flowers, we investigated their constituent anthocyanin and related compounds. An anthocyanin, two undescribed flavonols, and two flavones were isolated and identified as delphinidin 3,3',5'-tri-O-β-glucopyranoside, myricetin 3-O-[α-rhamnopyranosyl-(1 → 6)-β-glucopyranoside]-3',5'-di-O-β-glucopyranoside, myricetin 3,3',5'-tri-O-β-glucopyranoside, luteolin 4'-O-glucoside, and apigenin 4'-O-glucoside. Furthermore, the presence of chlorophyll has also been revealed. Read More

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January 2021