408,504 results match your criteria -negative patients


Development of a nomogram for predicting clinical outcome in patients with angiogram-negative subarachnoid hemorrhage.

CNS Neurosci Ther 2021 Jul 28. Epub 2021 Jul 28.

Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China.

To the best of our knowledge, this is the largest clinical retrospective study in AN-SAH patients, and is the first time to establish accurate predictive models paired with bleeding pattern.

Background: Angiogram-negative subarachnoid hemorrhage (AN-SAH) has a definite incidence of delayed cerebral ischemia (DCI) and poor clinical outcomes. The purpose is to screen independent factors and establish a nomogram to guide the clinical therapy and assess post-discharge prognosis. Read More

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The Effect of Septoplasty on Endothelial Function in Patients With Marked Nasal Septal Deviation.

J Craniofac Surg 2021 Jul 27. Epub 2021 Jul 27.

Department of Otolaryngology Department of Cardiology, School of Medicine, Yozgat Bozok University, Yozgat, Turkey.

Background: It is known that nasal septal deviation (NSD) has negative effects on the cardiovascular system, but the possible pathophysiological mechanisms of these effects still need to be explained. The aim of this study was to investigate the endothelial dysfunction (ED) caused by NSD and the effects of septoplasty on it.

Methods: The study included 40 patients between the ages of 18 to 50 years with a marked NSD indication for septoplasty and 40 healthy age-and gender-matched individuals. Read More

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Comparative effectiveness and safety of 32 pharmacological interventions recommended by guidelines for coronavirus disease 2019: a systematic review and network meta-analysis combining 66 trials.

Chin Med J (Engl) 2021 Jul 27. Epub 2021 Jul 27.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing 100191, China Department of Clinical Epidemiology and EBM, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China Primary Care Unit, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge CB18RN, UK Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton L8S4K1, Canada Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China.

Background: The global pandemic coronavirus disease 2019 (COVID-19) has become a major public health problem and presents an unprecedented challenge. However, no specific drugs were currently proven. This study aimed to evaluate the comparative efficacy and safety of pharmacological interventions in patients with COVID-19. Read More

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Relationship between Chronic Kidney Disease, Time-in-Therapeutic Range, and Adverse Outcomes in Atrial Fibrillation: A post hoc Analysis from the AMADEUS Trial.

Cerebrovasc Dis 2021 Jul 28:1-7. Epub 2021 Jul 28.

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom.

Background: The benefit of anticoagulation therapy in atrial fibrillation (AF) and chronic kidney disease (CKD) remains controversial. We aimed to evaluate the impact of renal function on the quality of anticoagulation control, and the effects of both these factors on outcomes in AF.

Methods: Post hoc analysis of the AMADEUS trial. Read More

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Objective and Subjective Outcomes in Patients with Hearing Aids: A Cross-Sectional, Comparative, Associational Study.

Audiol Neurootol 2021 Jul 28:1-9. Epub 2021 Jul 28.

Hearing Center/Hearing and Speech Laboratory, Department of Otorhinolaryngology Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.

Introduction: Outcome assessment for hearing aids (HAs) is an essential part of HA fitting and validation. There is no consensus about the best or standard approach for evaluating HA outcomes. And, the relationship between objective and subjective measures is ambiguous. Read More

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Desmoplastic Small Round Cell Tumor of the Submandibular Gland: A Case Report and Literature Review.

ORL J Otorhinolaryngol Relat Spec 2021 Jul 28:1-6. Epub 2021 Jul 28.

Department of Pathology, Maoming People's Hospital, Maoming, China.

Desmoplastic small round cell tumor (DSRCT) is a rare and aggressively malignant tumor mostly occurring in the abdominal and pelvic cavity of young patients. However, few cases had been reported concerning DSRCT occurring in the head and neck region. We presented a rare case of DSRCT of the right submandibular in a 25-year-old man. Read More

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Associations of increased interstitial fluid with vascular and neurodegenerative abnormalities in a memory clinic sample.

Neurobiol Aging 2021 Jul 5;106:257-267. Epub 2021 Jul 5.

Department of Radiology & Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands; School for Mental Health & Neuroscience, Alzheimer Center Limburg, Maastricht, the Netherlands; Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands. Electronic address:

The vascular and neurodegenerative processes related to clinical dementia cause cell loss which induces, amongst others, an increase in interstitial fluid (ISF). We assessed microvascular, parenchymal integrity, and a proxy of ISF volume alterations with intravoxel incoherent motion imaging in 21 healthy controls and 53 memory clinic patients - mainly affected by neurodegeneration (mild cognitive impairment, Alzheimer's disease dementia), vascular pathology (vascular cognitive impairment), and presumed to be without significant pathology (subjective cognitive decline). The microstructural components were quantified with spectral analysis using a non-negative least squares method. Read More

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Familial resemblance in mental health symptoms, social and cognitive vulnerability, and personality: A study of patients with depressive and anxiety disorders and their siblings.

J Affect Disord 2021 Jul 1;294:420-429. Epub 2021 Jul 1.

Amsterdam UMC, Vrije Universiteit, Psychiatry, Amsterdam Public Health research institute, Amsterdam, The Netherlands.

Background: Investigating siblings of probands with affective disorders enables the identification of psychopathology-related risk features. Leveraging data from an older adult sample, as compared to most previous sibling studies, enabled us to study more definitive clinical profiling across the lifespan. We examined prevalence of depressive/anxiety disorders in siblings, proband-sibling resemblance in psychopathology-related features, and whether unaffected siblings showed higher levels of these features than healthy controls. Read More

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Italian translation and psychometric validation of the ABILHAND-26 and its correlation with upper limb objective and subjective measures in multiple sclerosis subjects.

Mult Scler Relat Disord 2021 Jul 21;55:103160. Epub 2021 Jul 21.

Dept. of Rehabilitation, CRRF "Mons. Luigi Novarese", Moncrivello, VC, Italy.

Background: Upper limb (UL) function is affected in about 50% of people with Multiple Sclerosis (PwMS). In the last decade, Patient Reported Outcome Measures (PROM) are playing an important role in clinical trial and practice. ABILIHAND-26 is a PROM that assess self-perceived manual ability defined as the capacity to manage daily activities using the upper limbs. Read More

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Application of the Bethesda system for reporting thyroid cytopathology for classification of thyroid nodules: A clinical and cytopathological characteristics in Bhutanese population.

Diagn Cytopathol 2021 Jul 28. Epub 2021 Jul 28.

Department of Pathology and Laboratory Medicine, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan.

Introduction: The existence of baseline data on the spectrum of thyroid nodules in Bhutanese patients is unknown. Fine-needle aspiration cytology (FNAC) is regarded as the gold standard diagnostic test for pre-op assessment of thyroid lesions.

Materials And Methods: We conducted a retrospective study, involving 765 patients who underwent FNAC of the thyroid gland, at Jigme Dorji Wangchuck National Referral Hospital, Thimphu, between January-2018 to December-2020. Read More

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External valıdatıon of a prostate cancer nomogram on magnetıc resonance/transrectal ultrasound fusıon bıopsy ın men wıth prıor negatıve systematıc bıopsy.

Int J Clin Pract 2021 Jul 28:e14654. Epub 2021 Jul 28.

Department of Urology, School of Medicine, Gazi University, Ankara, Turkey.

Objective: To observe how the nomogram, which was created by Truong et al., works in an independent patient group by performing external validation.

Patients And Methods: One hundred eighty-one patients who had at least one prior negative 12-core standard systematic biopsy and lesions with PI-RADS scores of 3 or higher that were detected as a result of mpMRI were included in the study. Read More

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Expression and prognostic significance of vascular endothelial growth factor-A (VEGF-A) and its receptor in canine prostate cancer.

Prostate 2021 Jul 28. Epub 2021 Jul 28.

Department of Veterinary Surgery and Anesthesiology, School of Veterinary Medicine and Animal Science, São Paulo State University-UNESP, Botucatu, Sao Paulo, Brazil.

Background: Vascular endothelial growth factor-A (VEGF-A) and its receptor, VEGF receptor-2 (VEGFR-2), represent a complex family of angiogenic molecules consisting of different ligands and receptors. Due to the importance of VEGF-A/VEGFR-2 signaling in tumor proliferation and angiogenesis, this study aimed to evaluate the protein and gene expression levels of VEGF-A and VEGFR-2 in canine prostate cancer (PC).

Methods: We analyzed VEGF-A and VEGFR-2 expression in 87 PC samples by immunohistochemistry and quantitative-polymerase chain reaction. Read More

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Low mortality in SARS-CoV-2 infected heart transplant recipients at a single center.

Clin Transplant 2021 Jul 28. Epub 2021 Jul 28.

Division of Infectious Diseases and Global Public Health, Department of Internal Medicine, University of California San Diego Sulpizio Cardiovascular Center, La Jolla, California, USA.

Immunosuppressed heart transplant (HT) recipients are thought to be at higher risk of infection and mortality from SARS-CoV-2 infection coronavirus disease 2019 (COVID-19), however evidence guiding management of HT patients are limited. Retrospective search of electronic health records from February 2020 - February 2021, identified 28 HT recipients out of 400 followed by UC San Diego who tested positive for SARS-CoV-2. Patient demographics, COVID-19 directed therapies, hospital course and outcomes were compared to control HT recipients who tested negative for SARS-CoV-2 during the same period (n = 80). Read More

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HER2 activation and endocrine treatment resistance in HER2-negative breast cancer.

Endocrinology 2021 Jul 28. Epub 2021 Jul 28.

Aging and Cancer Immunology, Sanford Burnham Prebys Medical Discovery Institute.

The lethality of estrogen receptor alpha positive (ER+) breast cancer, which is often considered to have better prognosis than other subtypes, is defined by resistance to the standard of care endocrine treatment. Relapse and metastasis are inevitable in almost every patient whose cancer is resistant to endocrine treatment. Therefore, understanding the underlying causes of treatment resistance remains an important biological and clinical focus of research in this area. Read More

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High-dose AraC is Essential for the Treatment of ML-DS Independent of Post-Induction MRD: Results of COG AAML1531.

Blood 2021 Jul 28. Epub 2021 Jul 28.

University of Ottawa, Canada.

Myeloid leukemia in children with Down syndrome (ML-DS) is associated with young age and somatic GATA1 mutations. Due to high event-free survival (EFS) and hypersensitivity of the leukemic blasts to chemotherapy, the prior Children's Oncology Group protocol ML-DS protocol (AAML0431), reduced overall treatment intensity but lacking risk stratification, retained the high-dose cytarabine course (HD-AraC), which was highly associated with infectious morbidity. Despite high EFS of ML-DS, survival for those who relapse is rare. Read More

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Impact of the coronavirus disease 2019 on the diagnoses of Hansen's disease in Brazil.

Rev Soc Bras Med Trop 2021 23;54:e02512021. Epub 2021 Jul 23.

Universidade José do Rosário Vellano, Centro de Reabilitação de Anomalias Craniofaciais, Alfenas, MG, Brasil.

Introduction: Coronavirus disease 2019 (COVID-19) has limited the access of patients with Hansen's disease (HD) to care due to changes in routine health services.

Methods: To ascertain this, we compared the number of HD cases diagnosed before and after the COVID-19 pandemic.

Results: The decrease in HD cases in Brazil reached 18,223 (-48. Read More

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Patient needs four years after first psychiatric hospitalization in a Brazilian cohort.

Braz J Med Biol Res 2021 23;54(8):e11447. Epub 2021 Jul 23.

Departamento de Neurociências e Ciências do Comportamento, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.

Knowledge about the needs of psychiatric patients is essential for mental health care planning. However, research on met and unmet needs is still scarce, particularly in low- and middle-income countries. This study aimed to describe the patients' needs (met and unmet) at least four years after their first psychiatric hospitalization and to verify the role of demographic and clinical features as possible predictors of these needs. Read More

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Clinical validation of a smartphone-based handheld fundus camera for the evaluation of optic nerve head.

Arq Bras Oftalmol 2021 Jul 14. Epub 2021 Jul 14.

Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.

Purpose: To compare the quality of retinal images captured with a smartphone-based, handheld fundus camera with that of retinal images captured with a commercial fundus camera and to analyze their agreement in determining the cup-to-disc ratio for a cohort of ophthalmological patients.

Methods: A total of 50 patients from a secondary ophthalmic outpatient service center underwent a bilateral fundus examination under mydriasis with a smartphone-based, handheld fundus camera and with a commercial fundus camera (4 images/patient by each). Two experienced ophthalmologists evaluated all the fundus images and graded them on the Likert 1-5 scale for quality. Read More

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Three Decades of Contact Lens-associated Microbial Keratitis in a Referral Hospital in São Paulo, Brazil.

Arq Bras Oftalmol 2021 Jul 14. Epub 2021 Jul 14.

Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Hospital São Paulo, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Purpose: The aim of this study was to analyze patient data and the laboratory results of corneal samples collected from patients followed at the Ophthalmology Department, Hospital São Paulo, Brazil over a 30-year period, and correlate the analize with contact lens wearing.

Methods: Corneal samples from patients diagnosed clinically with microbial keratitis between January 1987 and December 2016 were included in this study. Cultures that were positive for bacteria, fungi, and Acanthamoeba spp. Read More

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Accuracy of Post-thrombolysis ST-segment Reduction as an Adequate Reperfusion Predictor in the Pharmaco-Invasive Approach.

Arq Bras Cardiol 2021 Jul;117(1):15-25

Universidade Federal de Sao Paulo, São Paulo, SP - Brasil.

Background: Primary percutaneous coronary intervention is considered the "gold standard" for coronary reperfusion. However, when not available, the drug-invasive strategy is an alternative method and the electrocardiogram (ECG) has been used to identify reperfusion success.

Objectives: Our study aimed to assess ST-Segment changes in post-thrombolysis and their power to predict recanalization and using the angiographic scores TIMI-flow and Myocardial Blush Grade (MBG) as an ideal reperfusion criterion. Read More

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Type I collagen promotes tumor progression of integrin β1 positive gastric cancer through a BCL9L/β-catenin signaling pathway.

Aging (Albany NY) 2021 Jul 28;13(undefined). Epub 2021 Jul 28.

Department of Immunology and Rheumatology, The Fourth Hospital of Hebei Medical University, Hebei, China.

The mechanism of extracellular matrix induced tumor progression is poorly understood. Based on the TCGA database and clinical tumor tissues analysis, we observed abundant type I collagen expression in tumor tissues and poor overall survival in gastric patients with high integrin β1 (ITGB1) expression. , our study found that 3D collagen culture promoted the capability of colony formation and growth in ITGB1 positive gastric cancer, whereas limited colony growth was observed in ITGB1 negative gastric cancer, suggesting the role of ITGB1 in type I collagen associated tumor progression. Read More

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Lower sexual satisfaction in women with polycystic ovary syndrome with metabolic syndrome.

Endocr Connect 2021 Jul 1. Epub 2021 Jul 1.

M Ruchala, Endocrinology, Poznan University of Medical Sciences, Poznan, Poland.

Background: Polycystic ovary syndrome (PCOS) is a multi-symptom disorder linked with a range of metabolic and hormonal disturbances. Psychological and sexual aspects of PCOS also need to be considered.

Objective Of The Study: This study aimed to assess sexual satisfaction(SS) in PCOS patients and eumenorrheic controls (CON). Read More

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The impact of face masks on the communication of adults with hearing loss during COVID-19 in a clinical setting.

Int J Audiol 2021 Jul 28:1-6. Epub 2021 Jul 28.

Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC, Rotterdam, The Netherlands.

Objective: The aim of the study was to investigate the effect of surgical masks and face shields on speech intelligibility of adults with moderate to severe hearing loss.

Design: This study measured speech tracking scores in quiet for life speech in three different conditions: without a mask, with a surgical mask and with a face shield. Acoustic effects of the masks and face shields on the speech signal were also investigated. Read More

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Predictive value of contrast-enhanced ultrasound combined with conventional ultrasound in solid renal parenchymal lesions.

Br J Radiol 2021 Jul 28:20210518. Epub 2021 Jul 28.

Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objective: This study aimed to develop a model to predict the risk of malignancy in solid renal parenchymal lesions based on the imaging features of combined conventional and contrast-enhanced ultrasound (CEUS).

Methods: A retrospective review was performed among patients with focal solid renal parenchymal lesions on ultrasound images. Ultrasound features were characterized by two experienced radiologists independently. Read More

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A comparison among gamma distribution, intravoxel incoherent motion, and mono-exponential models with turbo spin-echo diffusion-weighted MR imaging in the differential diagnosis of orofacial lesions.

Dentomaxillofac Radiol 2021 Jul 28:20200609. Epub 2021 Jul 28.

Department of Oral and Maxillofacial Radiology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.

Objectives: To compare the gamma distribution (GD), intravoxel incoherent motion (IVIM), and monoexponential (ME) models in terms of their goodness-of-fit, correlations among the parameters, and the effectiveness in the differential diagnosis of various orofacial lesions.

Methods: A total of 85 patients underwent turbo spin-echo diffusion-weighted imaging with six b-values. The goodness-of-fit of three models was assessed using Akaike Information Criterion. Read More

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Analytical and Clinical Performance of Droplet Digital PCR in the Detection and Quantification of SARS-CoV-2.

Mol Diagn Ther 2021 Jul 28. Epub 2021 Jul 28.

Catholic Genetic Laboratory Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Background And Objective: Since the initial coronavirus disease outbreak in late 2019 (COVID-19), reverse-transcription real-time polymerase chain reaction (RT-qPCR) has become the gold standard test to detect severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). However, a more sensitive and accurate diagnostic tool was required. Therefore, droplet digital polymerase chain reaction (ddPCR) was suggested as an alternative method. Read More

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Effect of the base-out recovery point as the surgical target for acute acquired comitant esotropia.

Graefes Arch Clin Exp Ophthalmol 2021 Jul 28. Epub 2021 Jul 28.

The Eye Hospital of Wenzhou Medical University, No. 270, West Xueyuan Rd., Wenzhou, 325027, Zhejiang, China.

Purpose: To evaluate the treatment efficacy of the preoperative base-out recovery point as the surgical target angle for acute acquired comitant esotropia.

Methods: Prospective study. Twenty-two patients with acute acquired comitant esotropia (AACE) underwent strabismus surgery based on the target angle of the preoperative base-out recovery point. Read More

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Original Article: Clinical Research.

Sarcoidosis Vasc Diffuse Lung Dis 2021 28;38(2):e2021020. Epub 2021 Jun 28.

Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Turkey.

Aim: In this study, we aimed to investigate the possible role of endotrophin, a profibrotic byproduct of collagen VI, in the complex process of fibrosis development in the disease group with pulmonary fibrosis among interstitial lung diseases.

Material And Method: When the patients' participation in the study were completed, smoking or alcohol drinking conditions, and family history were recorded. Their weights and heights were recorded and body mass index (BMI) was calculated. Read More

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The organizational and environmental characteristics associated with hospitals' use of intensivists.

Health Care Manage Rev 2021 Jul 23. Epub 2021 Jul 23.

Bart Liddle, PhD, MBA, Associate Dean, Department of Management, Entrepreneurship and Marketing, College of Business, Lipscomb University, Nashville, Tennessee. Robert Weech-Maldonado, PhD, MBA, Professor, Department of Health Services Administration, School of Health Professions, University of Alabama at Birmingham. E-mail: Ganisher Davlyatov, PhD, MD, Assistant Professor, Department of Health Administration and Policy, Hudson School of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City. Stephen J. O'Connor, PhD, FACHE, Professor, Department of Health Services Administration, School of Health Professions, University of Alabama at Birmingham. Patricia Patrician, PhD, RN, FAAN, Professor, Department of Nursing Science, School of Nursing, University of Alabama at Birmingham. Larry R. Hearld, PhD, Associate Professor, Department of Health Services Administration, School of Health Professions, University of Alabama at Birmingham.

Background: As large numbers of coronavirus disease 2019 (COVID-19) patients were admitted to intensive care units (ICUs) in 2020 and 2021, the United States faced a shortage of critical care providers. Intensivists are physicians specializing in providing care in the ICU. Although studies have explored the clinical and financial benefits associated with the use of intensivists, little is known about the organizational and market factors associated with a hospital administrator's strategic decision to use intensivists. Read More

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Changes in telomere length and serum neurofilament light chain levels in female patients with chronic insomnia disorder.

J Clin Sleep Med 2021 Jul 28. Epub 2021 Jul 28.

Department of Neurology, The First Affiliated Hospital of Anhui University of Science and Technology (The First People's Hospital of Huainan City), Huainan, 2P. R. China.

Study Objectives: The aims of this study were to explore changes in the telomere length (relative telomere repeat copy/single-copy gene, T/S ratio) and serum neurofilament light chain (sNfL) levels in female patients with chronic insomnia disorder (CID), examine their relationships with emotional abnormalities and cognitive impairment, and determine whether these 2 indicators were independently associated with sleep quality.

Methods: The CID group contained 80 patients diagnosed with CID, and 51 individuals constituted a healthy control group (HC). Participants completed sleep, emotion, and cognition assessments. Read More

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