4,307,171 results match your criteria -control n=40


Treatment of Short Stature with Aromatase Inhibitors: A Systematic Review and Meta-Analysis.

Horm Metab Res 2021 Jun 21;53(6):391-401. Epub 2021 Jun 21.

Department of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, China.

The objective of the study is to determine the risks and benefits of treating idiopathic short stature (ISS) with aromatase inhibitors (AIs). We comprehensively searched PubMed, Embase, and the China National Knowledge Infrastructure between establishment year and January 31, 2020. Mean difference (MD)/Standardized mean differences (SMD) with 95% confidence intervals (CI) of individual studies were pooled using fixed or random effects models. Read More

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Primary Hyperparathyroidism Masquerading as Acute Pancreatitis.

Horm Metab Res 2021 Jun 21;53(6):377-381. Epub 2021 Jun 21.

Dayanand Medical College and Hospital, Tagore Nagar, Ludhiana, Punjab, India.

Acute pancreatitis as an initial manifestation of primary hyperparathyroidism (PHPT) is a rare occurrence and timely diagnosis of PHPT is crucial in preventing repeat attack of pancreatitis. The study aimed at evaluating the clinico-radiological profile of patients admitted with acute pancreatitis as the index presentation of PHPT and to determine the factors associated with development of severe pancreatitis. This series included retrospective analysis of medical records of 30 patients admitted with acute pancreatitis as initial manifestation of PHPT. Read More

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Connecting Across Competencies: Leveraging Best Practices for Processing.

Biomed Instrum Technol 2021 Mar;55(s3):6-11

The AAMI working group ST/WG 93 is finalizing a standard (AAMI ST98) for the cleaning validation of reusable medical devices based on guidance from the technical information report AAMI TIR30:2011/(R)2016. A number of analytical best practices are being considered for this new standard. Test method suitability for processing cleaning validations historically has been established using one positive control and performing an extraction efficiency. Read More

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Testing the feasibility and acceptability of a culturally adapted physical activity intervention for adult Somali women.

Transl Behav Med 2021 Jun 21. Epub 2021 Jun 21.

Center for Health Promotion and Health Equity, School of Public Health, Brown University, Providence, Rhode Island, USA.

Despite growing numbers in the USA, immigrant populations are underrepresented in existing physical activity (PA) research, in particular Muslim immigrant women. The current study is a pilot evaluation of a culturally adapted evidence-based PA intervention for adult Somali women. Stratified randomization was used to assign participants from a sample of 27 Somali women, aged 18 to 65, to a PA group or a waitlist control group. Read More

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Dysregulation of brain and choroid plexus cell types in severe COVID-19.

Nature 2021 Jun 21. Epub 2021 Jun 21.

ChEM-H, Stanford University, Stanford, CA, USA.

Though SARS-CoV-2 primarily targets the respiratory system, patients and survivors can suffer neurological symptoms. Yet, an unbiased understanding of the cellular and molecular processes affected in the brains of COVID-19 patients is still missing. Here, we profile 65,309 single-nucleus transcriptomes from 30 frontal cortex and choroid plexus samples across 14 control (including 1 terminal influenza) and 8 COVID-19 patients. Read More

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Control Beliefs among People with Dementia: A Systematic Review.

Dement Geriatr Cogn Disord 2021 Jun 21:1-19. Epub 2021 Jun 21.

Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.

Introduction: Dementia diseases are still incurable, and in order to assist in living well with the disease, researchers are increasing their attention to the value of control beliefs. Control beliefs are associated with coping and psychological well-being; however, knowledge on how they relate to well-being outcomes in people with dementia is limited. This review aimed to synthesize knowledge about control beliefs in this group to guide future interventions and research. Read More

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Disparities between Asian and Non-Asian Thrombolyzed Acute Ischemic Stroke Patients in the Enhanced Control of Hypertension and Thrombolysis Stroke Trial.

Cerebrovasc Dis 2021 Jun 21:1-7. Epub 2021 Jun 21.

The George Institute for Global Health, Faculty of Medicine, UNSW, Sydney, New South Wales, Australia.

Background And Purpose: As outcomes for acute ischemic stroke (AIS) vary according to clinical profile and management approaches, we aimed to determine disparities in clinical outcomes between Asian and non-Asian participants of the international, Enhanced Control of Hypertension and Thrombolysis Stroke study (ENCHANTED).

Methods: ENCHANTED was a multicenter, prospective, partial-factorial, randomized, open trial of low-dose (0.6 mg/kg) versus standard-dose (0. Read More

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Weak Hip Strength Increases Dynamic Knee Valgus in Single-Leg Tasks of Collegiate Female Athletes.

J Sport Rehabil 2021 Jun 20:1-4. Epub 2021 Jun 20.

Clinical Scenario: Dynamic knee valgus (DKV) is a mechanical alteration in the knee that leads to increased risk of injury. Weakness of hip musculature in hip abduction (HABD), extension (HEXT), and external rotation (HER) may contribute to increased DKV in single-leg landing tasks. Focused Clinical Question: Is decreased hip strength associated with an increase in DKV during a single-leg landing task in collegiate female athletes? Summary of Key Findings: Three studies were included: One randomized control trial (RCT), one cohort study, and one case-control. Read More

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Salvia officinalis and Lippia triphylla: Chemical characterization and evaluation of antidepressant-like activity.

J Pharm Biomed Anal 2021 Jun 12;203:114207. Epub 2021 Jun 12.

Laboratory of Health and Environment, Department of Biology, Moulay Ismail University, Meknes, Morocco.

Salvia officinalis (Lamiaceae) and Lippia triphylla (Verbenaceae) are two plants known for their therapeutic effects in conventional medicine for the treatment of a wide extent of diseases, including the ones on the central nervous system. In the present study, the impact of aqueous extract from the leaves of these two herbs for the treatment of depression was examined. The phytochemical profile highlighted the presence of eighteen and ten polyphenolic compounds in Salvia officinalis and Lippia triphylla, respectively. Read More

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Development and validation of a nomogram to predict in-hospital cardiac arrest among patients admitted with acute coronary syndrome.

Am J Emerg Med 2021 Jun 6;49:240-248. Epub 2021 Jun 6.

Department of Cardiovascular Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fujian, China.

Aim: This study aimed to develop and validate a nomogram to recognize in-hospital cardiac arrest (CA) in patients with acute coronary syndrome (ACS).

Methods: This multicenter case-control study reviewed 164 ACS patients who had in-hospital CA and randomly selected 521 ACS patients with no CA experience. We randomly assigned 80% of the participants to a development cohort, 20% of those to an independent validation cohort. Read More

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Evening the playing field: microenvironmental control over stem cell competition during fate programming.

Curr Opin Genet Dev 2021 Jun 18;70:66-75. Epub 2021 Jun 18.

School of Biomedical Engineering, Faculty of Applied Science and Faculty of Medicine, University of British Columbia, Biomedical Research Centre, 2222 Health Sciences Mall, V6T 1Z3, Vancouver, Canada. Electronic address:

Recent advancements in cellular engineering, including reprogramming of somatic cells into pluripotent stem cells, have opened the door to a new era of regenerative medicine. Given that cellular decisions are guided by microenvironmental cues, such as secreted factors and interactions with neighbouring cells, reproducible cell manufacturing requires robust control over cell-cell interactions. Cell competition has recently emerged as a previously unknown interaction that plays a significant role in shaping the growth and death dynamics of multicellular stem cell populations, both in vivo and in vitro. Read More

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Effect of biochar amendment on compost quality, gaseous emissions and pathogen reduction during in-vessel composting of chicken manure.

Chemosphere 2021 Jun 11;283:131129. Epub 2021 Jun 11.

Department of Environmental Energy and Engineering, Kyonggi University Youngtong-Gu, Suwon, Gyeonggi-Do, 16227, Republic of Korea. Electronic address:

Because of rapid development in the livestock industry, the production of chicken manure has subsequently increased, which may contribute to environmental pollution. In this regard, in-vessel composting of biochar amended chicken manure and sawdust mixtures was investigated to find out the effect of biochar at the ratios of 0% (control), 3% (T1), 5% (T2), and 10% (T3) on ammonia and greenhouse gases (GHGs) emission, compost quality, pathogenic contaminants and phytotoxicity. The composting process was performed in 100-L, pilot-scale, plastic, cylindrical vessels for 50 days. Read More

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Construction of visible light driven silver sulfide/graphitic carbon nitride p-n heterojunction for improving photocatalytic disinfection.

Chemosphere 2021 Jun 15;283:131167. Epub 2021 Jun 15.

State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmaceutical Science of Guangxi Normal University, Guilin, 541004, PR China.

Compared with the Z-scheme and type-II heterojunctions, p-n type heterojunctions are more favorable for the migration of photo-induced carriers owing to the advantage of built-in electric fields. In addition, it is still of great significance to understand the carrier migration properties of the p-n heterojunction. Therefore, the development of new p-n heterojunctions and the development of high-efficiency catalysts with effective modulation of light responsiveness and rapid transfer of charge to achieve photocatalytic inactivation have attracted much attention. Read More

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Metagenomic profiles and health risks of pathogens and antibiotic resistance genes in various industrial wastewaters and the associated receiving surface water.

Chemosphere 2021 Jun 16;283:131224. Epub 2021 Jun 16.

Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Guangdong Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou, 510006, China; Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control, Key Laboratory of City Cluster Environmental Safety and Green Development, School of Environmental Science and Engineering, Guangdong University of Technology, Guangzhou, 510006, China. Electronic address:

The aquatic environment may represent an essential route for transmission of antibiotic resistance to opportunistic human pathogens. Since industrial wastewater is discharged into the river after treatment, understanding the distribution of antibiotic resistance genes (ARGs) in river systems and the possibility of pathogens acquiring antibiotic resistance are challenges with far-reaching significance. This work mainly studied distribution profiles of pathogens and ARGs, and compared their health risk in various industrial wastewater with that of river water. Read More

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Effects and mechanisms of modified biochars on microbial iron reduction of Geobacter sulfurreducens.

Chemosphere 2021 Jun 3;283:130983. Epub 2021 Jun 3.

College of Environmental Science and Engineering, Hunan University, Changsha, 410082, Hunan, China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha, 410082, Hunan, China.

Biochar was proved as an electron shuttle to facilitate extracellular electron transfer (EET) of electrochemically active bacteria (EAB); however, its underlying mechanism was not fully understood. In this study, we aimed to further explore how the regulation of surface functional groups of biochar would affect the microbial iron reduction process of Geobacter sulfurreducens as a typical EAB. Two modified biochars were achieved after HNO (NBC) and NaBH (RBC) pretreatments, and a control biochar was produced after deionized water (WBC) washing. Read More

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Removal of chlorophenols in the aquatic environment by activation of peroxymonosulfate with [email protected] hybrid composites: Performance and mechanism.

Chemosphere 2021 Jun 14;283:131188. Epub 2021 Jun 14.

School of Resources and Environmental Engineering, Hefei University of Technology, Hefei, 230009, PR China; Key Laboratory of Nanominerals and Pollution Control of Higher Education Institutes, Hefei University of Technology, Hefei, 230009, PR China.

Functional [email protected] composites were synthesized via a simple co-precipitation method. The nanomaterials have efficient activity in activating peroxymonosulfate (PMS) for removal of chlorophenols (CPs). Rice husk biochar (RBC) could support nMnOx, and acted as an electron shuttle to mediate electron transfer reaction. Read More

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Iodine-125 radioactive seed brachytherapy as a treatment for spine and bone metastases: A systematic review and meta-analysis.

Surg Oncol 2021 Jun 10;38:101618. Epub 2021 Jun 10.

Department of Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

Aim: To evaluate the analgesic efficacy, safety, and local tumor control of iodine-125 (I) seed brachytherapy (BT) for the management of spine and bone metastases.

Methods: A systematic literature search was conducted using PubMed, the Cochrane Library, and Scopus databases. Data regarding patient demographics, tumor characteristics, procedural parameters, and clinical outcomes were extracted and analyzed. Read More

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Antagonistic interaction between perfluorobutanesulfonate and probiotic on lipid and glucose metabolisms in the liver of zebrafish.

Aquat Toxicol 2021 Jun 10;237:105897. Epub 2021 Jun 10.

State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China. Electronic address:

Perfluorobutanesulfonate (PFBS) and probiotic bacteria can interact to induce hepatic hypertrophy. However, the molecular events occurring in the hypertrophic liver are still unknown. Therefore, we performed this follow-up study using adult zebrafish that were exposed for 40 days to 0 and 10 μg/L PFBS, with or without dietary supplementation of probiotic Lactobacillus rhamnosus. Read More

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The effect of body fatness on regional brain imaging markers and cognitive function in healthy elderly mediated by impaired glucose metabolism.

J Psychiatr Res 2021 Jun 11;140:488-495. Epub 2021 Jun 11.

Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea; Department of Public Health, Yonsei University Graduate School, Seoul, 03722, Republic of Korea; Institute of Human Complexity and Systems Science, Yonsei University, Incheon, 21983, Republic of Korea. Electronic address:

Brain atrophy is related to vascular risk factors and can increase cognitive dysfunction risk. This community-based, cross-sectional study investigated whether glucose metabolic disorders due to body fatness are linked to regional changes in brain structure and a decline in neuropsychological function in cognitively healthy older adults. From 2016 to 2019, 429 participants underwent measurements for cortical thickness and subcortical volume using 3 T magnetic resonance imaging and for cognitive function using the neuropsychological screening battery. Read More

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The use of computational models in the management and prognosis of refractory epilepsy: A critical evaluation.

Seizure 2021 Jun 10;91:132-140. Epub 2021 Jun 10.

Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, United Kingdom. Electronic address:

Purpose: Drug resistant epilepsy (DRE) affects approximately 30 percent of individuals with epilepsy worldwide. Surgery remains the most effective treatment for individuals with DRE, but referral to surgery is low and only about 60 percent of individuals who undergo surgery experience seizure control postoperatively. The present paper evaluates the evidence for using computational models in the prediction of surgical resection sites and surgical outcomes for patients with DRE. Read More

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Microplastic residues in wetland ecosystems: Do they truly threaten the plant-microbe-soil system?

Environ Int 2021 Jun 18;156:106708. Epub 2021 Jun 18.

Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; Center for Water and Ecology, State Key Joint Laboratory of Environment Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China.

The ecological stress of microplastic contamination to ecosystem functioning and biota raises concerns worldwide, but the impacts of microplastics on wetland ecosystems (e.g., plants, microbes, and soil) have not been fully elucidated. Read More

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Exploring personal chemical exposures in China with wearable air pollutant monitors: A repeated-measure study in healthy older adults in Jinan, China.

Environ Int 2021 Jun 18;156:106709. Epub 2021 Jun 18.

Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT 06520, USA. Electronic address:

The health impact of airborne contaminants has been challenging to assess due to current limitations in measurement technologies. The emergence of wearable passive samplers coupled with high resolution mass spectrometry (HR-MS) chemical analysis has enabled comprehensive characterization of personal exposures. We conducted a repeated-measure study among 84 older adults in Jinan, China, as part of the Biomarkers for Air Pollutants Exposure (China BAPE) study. Read More

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Human biomonitoring of toxic and essential metals in younger elderly, octogenarians, nonagenarians and centenarians: Analysis of the Healthy Ageing and Biomarkers Cohort Study (HABCS) in China.

Environ Int 2021 Jun 18;156:106717. Epub 2021 Jun 18.

China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China; School of Public Health, Anhui Medical University, Hefei, Anhui, China. Electronic address:

Background: Metals can be either toxic or essential to health, as they play different role in oxidative stress and metabolic homeostasis during the ageing process. Population-based biomonitoring have documented levels and ranges in concentrations among general population of 0-79 years of age. In people aged 80 and above, toxic metals and essential metals may have different risk profiles, and thus need to be better studied. Read More

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Identification and functional characterization of Gh_D01G0514 (GhNAC072) transcription factor in response to drought stress tolerance in cotton.

Plant Physiol Biochem 2021 Jun 9;166:361-375. Epub 2021 Jun 9.

State Key Laboratory of Cotton Biology/Institute of Cotton Research, Chinese Academy of Agricultural Science (ICR, CAAS), Anyang, Henan, 455000, China; School of Agricultural Sciences, Zhengzhou University, Zhengzhou, Henan, 450001, PR China. Electronic address:

Cotton encounters long-term drought stress problems resulting in major yield losses. Transcription factors (TFs) plays an important role in response to biotic and abiotic stresses. The coexpression patterns of gene networks associated with drought stress tolerance were investigated using transcriptome profiles. Read More

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Immunomodulatory activity of brown algae Turbinaria ornata derived sulfated polysaccharide on LPS induced systemic inflammation.

Phytomedicine 2021 May 29;89:153615. Epub 2021 May 29.

Natural Products Research Laboratory, Department of Biotechnology, School of Life Sciences, Pondicherry University, Puducherry 605014, India. Electronic address:

Background: Inflammation and oxidative stress are common pathologies in a wide range of chronic diseases. Polysaccharides are known to exhibit antioxidant and anti-inflammatory potential and are suggested to possess immunomodulatory potential.

Purpose: Herein, the immunomodulatory activity of a sulfated polysaccharide (PS) separated from a brown marine algae Turbinaria ornata is studied in LPS instigated systemic inflammation in experimental rats. Read More

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Characterization of liver injury induced by a pyrrolizidine alkaloid in rats.

Phytomedicine 2021 May 16;89:153595. Epub 2021 May 16.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. Electronic address:

Background: Pyrrolizidine alkaloids (PAs) are common phytotoxins. PA intoxication is reported to cause severe acute liver damage, typically known as hepatic sinusoidal obstruction syndrome (HSOS), but it remains obscure whether the acute liver damage may progress into chronic liver disease characterized by hepatic fibrosis.

Purpose: This study aims to characterize the biochemical markers of liver injury and histological features of regressive and progressive liver fibrosis, and to examine changes in hepatic gene expression that may underpin mechanisms of fibrogenesis in rats induced by retrorsine (RTS), a representative toxic PA. Read More

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The KAG motif of HLA-DRB1 (β71, β74, β86) predicts seroconversion and development of type 1 diabetes.

EBioMedicine 2021 Jun 18;69:103431. Epub 2021 Jun 18.

Department of Clinical Sciences, Lund University CRC, Skåne University Hospital, Jan Waldenströms gata 35, Skåne University Hospital SUS, Malmö SE-205 02, Sweden. Electronic address:

Background: HLA-DR4, a common antigen of HLA-DRB1, has multiple subtypes that are strongly associated with risk of type 1 diabetes (T1D); however, some are risk neutral or resistant. The pathobiological mechanism of HLA-DR4 subtypes remains to be elucidated.

Methods: We used a population-based case-control study of T1D (962 patients and 636 controls) to decipher genetic associations of HLA-DR4 subtypes and specific residues with susceptibility to T1D. Read More

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Cognitive and neurological outcome of patients in the Dutch pyridoxine-dependent epilepsy (PDE-ALDH7A1) cohort, a cross-sectional study.

Eur J Paediatr Neurol 2021 Jun 7;33:112-120. Epub 2021 Jun 7.

Department of Paediatric Neurology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Electronic address:

Background: Pyridoxine monotherapy in PDE-ALDH7A1 often results in adequate seizure control, but neurodevelopmental outcome varies. Detailed long-term neurological outcome is unknown. Here we present the cognitive and neurological features of the Dutch PDE-ALDH7A1 cohort. Read More

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Climatic requirements of the southern paralysis tick, Ixodes cornuatus, with a consideration of its host, Vombatus ursinus, and the possible geographic range of the tick up to 2090.

Ticks Tick Borne Dis 2021 Jun 4;12(5):101758. Epub 2021 Jun 4.

Department of Parasitology, School of Chemistry & Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia. Electronic address:

The southern paralysis tick, Ixodes cornuatus, is a tick of veterinary and medical importance in Australia. We use two methods, CLIMEX, and an envelope-model approach which we name the 'climatic-range method' to study the climatic requirements of I. cornuatus and thus to attempt to account for the geographic distribution of I. Read More

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