59 results match your criteria -1082g>a tnf


No Major Effect of Innate Immune Genetics on Acute Kidney Rejection in the First 2 Weeks Post-Transplantation.

Front Pharmacol 2019 20;10:1686. Epub 2020 Feb 20.

Discipline of Pharmacology, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.

Background: Innate immunity contributes to acute rejection after kidney transplantation. Genetic polymorphisms affecting innate immunity may therefore influence patients' risk of rejection. -330T > G, -1082G > A, -819C > T, and -592C > A, and -308G > A are not associated with acute rejection incidence in Caucasian kidney transplant recipients receiving a calcineurin inhibitor, ciclosporin or tacrolimus (TAC). Read More

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February 2020

Genetic variation of TNF-α and IL-10, IL-12, IL-17 genes and association with torque teno virus infection post hematopoietic stem cell transplantation.

Acta Virol 2019 ;63(2):186-194

Little is known about the role of genetic variation in the genes for cytokines and susceptibility to viral infection especially torque teno virus (TTV) following allogeneic hematopoietic stem cell transplantation. In this study, the association between interleukin-12, interleukin-17, interleukin-10 (IL-12,-17,-10) and tumor necrosis factor-α (TNF-α) polymorphisms was evaluated in patients with TTV infection who underwent allogeneic hematopoietic stem cell transplantation from South of Iran. The single nucleotide polymorphisms in the cytokine genes including IL-12 (-1188A/C), IL-17 (-197G/A), IL-10 (-1082G/A, -819C/T and -592C/A) and TNF-α (-308 G/A) were analyzed by PCR-RFLP methods. Read More

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Prediction of features of the course of chronic hepatitis C using Bayesian networks.

Ter Arkh 2019 Mar;91(2):32-39

M.V. Lomonosov Moscow State University, Moscow, Russia.

Materials And Methods: 253 patients with chronic hepatitis C (CHC) and liver cirrhosis were included in the study. Assessment of gene polymorphisms of genes involved in inflammatory reactions and antiviral immunity (IL-1β-511C/T, IL-10 -1082G/A, IL28B C/T, IL28B T/G, TNF-α -238G/A, TGF-β -915G/C, IL-6 -174G/C), activators of local hepatic fibrosis (AGT G-6A, AGT 235 M/T, ATR1 1166 A/C), hemochromatosis (HFE C282Y, HFE H63D), platelet receptors (ITGA2 807 C/T, ITGB3 1565 T/C), coagulation proteins and endothelial dysfunction (FII 20210 G/A, FV 1691G/A, FVII 10976 G/A, FXIII 103 G/T, eNOS 894 G/T, CYBA 242 C/T, FBG -455 G/A, PAI-675 5G/4G, MTHFR 677 C/T) was carried. Using Bayesian networks we studied the predictor value of clinical and laboratory factors for the following conditions - end points (EP): development of cirrhosis (EP1), fibrosis rate (EP2), presence of portal hypertension (EP3) and cryoglobulins (EP4). Read More

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IL-10 polymorphisms +434T/C, +504G/T, and -2849C/T may predispose to tubulointersititial nephritis and uveitis in pediatric population.

PLoS One 2019 19;14(2):e0211915. Epub 2019 Feb 19.

Timo Jahnukainen, Department of Pediatric Nephrology and Transplantation, New Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background: Tubulointerstitial nephritis (TIN) and uveitis syndrome (TINU) are likely to be autoimmune diseases. Based on previous studies, adults with isolated idiopathic uveitis have polymorphisms in interleukin 10 (IL-10) and tumor necrosis factor α (TNF-α) genes. We aimed to evaluate the presence of IL-10 and TNF-α polymorphisms in a nationwide cohort of pediatric TIN/TINU patients. Read More

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November 2019

Genetic modifications of cytokine genes and Toxoplasma gondii infections in pregnant women.

Microb Pathog 2018 Aug 31;121:283-292. Epub 2018 May 31.

Department of Foeto-Maternal Medicine and Obstetrics, University of Warmia and Mazury in Olsztyn, Municipal Polyclinical Hospital in Olsztyn, Poland. Electronic address:

Purpose: Toxoplasma gondii causes one of the most common intrauterine infections worldwide, thus being a severe threat during pregnancy. IL1, IL6, IL10, IL12, and TNF-α cytokines were reported to be involved in immune responses to infections with T. gondii. Read More

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Cytokine Gene Polymorphism Profiles in Kidney Transplant Patients - Association of +1188A/C RS3212227 SNP in the IL12B Gene Prevents Delayed Graft Function.

Arch Med Res 2018 02 10;49(2):101-108. Epub 2018 May 10.

Clinic of Nephrology, Clinical Center of Serbia, Belgrade, Serbia; Department of Internal Medicine, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Background And Aims: Transplantation is the best treatment option for end stage kidney disease. The most common early complications in post-transplant period are acute rejection (AR) of the graft and delayed graft function (DGF). The underlying mechanisms in these events are heterogeneous and at least in part involve cytokine genes which regulate immune response to allograft. Read More

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February 2018

Gene polymorphisms of TNF-238G/A, TNF-308G/A, IL10-1082G/A, TNFAIP3, and MC4R and comorbidity occurrence in a Romanian population with psoriasis.

J Med Life 2018 Jan-Mar;11(1):69-74

Department of Dermatology, MEDAS Medical Center, Bucharest.

Psoriasis is a prevalent chronic inflammatory disease with worldwide distribution affecting approximately 2% of the Caucasian population. There have been many population- and family-based studies that agree on the strong genetic component of this disease. Several studies have investigated the relationship between cytokine gene polymorphisms, psoriasis, and the occurrence of comorbidities but their data are conflicting. Read More

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Genetic Polymorphisms in Cytokine Genes in Colombian Patients with Ocular Toxoplasmosis.

Infect Immun 2018 04 22;86(4). Epub 2018 Mar 22.

Grupo Infección e Inmunidad, Facultad de Ciencias de la Salud, Universidad Tecnológica de Pereira, Pereira, Colombia

Toxoplasmosis is caused by infection with the protozoan parasite , which has the capacity to infect all warm-blooded animals worldwide. Toxoplasmosis is a major cause of visual defects in the Colombian population; however, the association between genetic polymorphisms in cytokine genes and susceptibility to ocular toxoplasmosis has not been studied in this population. This work evaluates the associations between polymorphisms in genes coding for the cytokines tumor necrosis factor alpha (TNF-α) (rs1799964, rs1800629, rs1799724, rs1800630, and rs361525), interleukin 1β (IL-1β) (rs16944, rs1143634, and rs1143627), IL-1α (rs1800587), gamma interferon (IFN-γ) (rs2430561), and IL-10 (rs1800896 and rs1800871) and the presence of ocular toxoplasmosis (OT) in a sample of a Colombian population (61 patients with OT and 116 healthy controls). Read More

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Association of TNF-α, IL-10 and IL-6 promoter polymorphisms in pulmonary tuberculosis patients and their household contacts of younger age group.

Comp Immunol Microbiol Infect Dis 2018 Feb 26;56:20-26. Epub 2017 Dec 26.

Bhagwan Mahavir Medical hospital and Research Centre, Hyderabad, Andhra Pradesh, India; Department of Genetics, Osmania University, Hyderabad, Andhra Pradesh, India. Electronic address:

Single nucleotide polymorphisms (SNPs) of cytokine genes have been found to be involved in the clinical outcome of Tuberculosis. The present study was aimed to identify the high risk genotypes in Tuberculosis patients and their household contacts. A total of 490 subjects were studied which includes 150 active pulmonary tuberculosis patients (APTB), 190 household contacts (HHC) and 150 healthy controls (HC). Read More

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February 2018

The Synergistic Effect of TNFA and IL10 Promoter Polymorphisms on Genetic Predisposition to Systemic Lupus Erythematosus.

Genet Test Mol Biomarkers 2018 Feb 3;22(2):135-140. Epub 2018 Jan 3.

1 Department of Molecular Biology, Immunology and Medical Genetics, Medical Faculty, Trakia University , Stara Zagora, Bulgaria .

Aims: We investigated the individual and combined effect of functional TNFA -308G/A and IL10 -1082G/A single nucleotide polymorphisms (SNPs) and their genotypes on the susceptibility to systemic lupus erythematosus (SLE) in a Bulgarian population.

Materials And Methods: Genotyping for -1082A/G IL10 (rs1800896) and -308G/A TNFA (rs1800629) polymorphisms was performed for 154 SLE patients and 224 healthy controls.

Results: An association between SLE and the rs1800629 polymorphism was established under the allelic model (allele A vs. Read More

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February 2018

Tumour necrosis factor-alpha (-308G/A) promoter polymorphism is associated with ulcerative colitis in Brazilian patients.

Int J Immunogenet 2016 Dec 16;43(6):376-382. Epub 2016 Aug 16.

Department of Pathology, Federal University of Pernambuco, Recife, Brazil.

Inflammatory bowel disease consists of multifactorial diseases whose common manifestation is inflammation of the gastrointestinal tract and their pathogenesis remains unknown. This study aimed to analyse the gene polymorphisms in Brazilian patients with inflammatory bowel disease. A total of 101 patients diagnosed with inflammatory bowel disease were analysed for the tumour necrosis factor-alpha (-308 G/A; rs1800629) and interleukin-10 (-1082 G/A; rs1800896) gene polymorphisms. Read More

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December 2016

Evaluation of cytokine genetic polymorphisms in adult patients with common variable immunodeficiency: A single-center study.

Immunol Lett 2016 08 8;176:97-104. Epub 2016 Jun 8.

Institute of Human Genetics, School of Medicine University of Belgrade, Visegradska 26, 11000 Belgrade, Serbia.

Common variable immunodeficiency (CVID) is a heterogeneous disease characterized by impaired B-cell differentiation and maturation accompanied with the defective antibody production. Several investigators addressed the possibility that disturbed cytokine production of TNF, IL-6, IFN-γ and IL-10, among a variety of others, may be implicated in CVID. The aim of this study was to test the hypothesis that genetic polymorphisms involving TNF (-308G/A), IFNG (+874 T/A), IL10 (-1082G/A, -819T/C and -592A/C), and IL6 (-174G/C) cytokine genes might contribute to susceptibility to CVID. Read More

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The association between pro- and anti-inflammatory cytokine polymorphisms and periventricular leukomalacia in newborns with hypoxic-ischemic encephalopathy.

J Inflamm Res 2016 5;9:59-67. Epub 2016 May 5.

Radiology Department, São José do Rio Preto Medical School, FAMERP, São Paulo, Brazil.

Background: Periventricular leukomalacia (PVL) is a frequent consequence of hypoxic-ischemic injury. Functional cytokine gene variants that result in altered production of inflammatory (tumor necrosis factor-alpha [TNF-α] and interleukin-1beta [IL-1β]) or anti-inflammatory (interleukin-10 [IL-10]) cytokines may modify disease processes, including PVL.

Objective: The aim of this study was to evaluate if there is a relationship between the two proinflammatory polymorphisms (TNF-α-1031T/C and IL-1β-511C/T) and the anti-inflammatory polymorphism IL-10-1082G/A and PVL risk in Brazilian newborns with and without this injury. Read More

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TNF-α and IL10 gene polymorphisms in women with postmenopausal osteoporosis.

Eur J Obstet Gynecol Reprod Biol 2016 Apr 8;199:92-5. Epub 2016 Feb 8.

Department of Physiology, Pomeranian Medical University, Szczecin, Poland. Electronic address:

Objective: Postmenopausal osteoporosis is a common disorder characterized by decreased bone mineral density (BMD). Proinflammatory cytokines are among the significant factors involved in bone turnover. They are the stimulants of bone resorption, acting directly on osteoclasts and osteoclast precursors. Read More

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Inflammation-related cytokine gene polymorphisms in Behçet's disease.

J Inflamm Res 2015 28;8:173-80. Epub 2015 Sep 28.

Division of Molecular Biology and Genetics, Research Center, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Behçet's disease (BD) is a complex, multisystemic inflammatory disorder of unclear etiology. Single nucleotide polymorphisms in tumor necrosis factor (TNF) and interleukin (IL)-10 genes have been implicated in susceptibility to BD with inconsistent results in several ethnic populations. The aim of this case-control study was to evaluate the association of TNF-α (-308G/A), TNF-β (+252A/G), and IL-10 (-1082G/A, -819C/T, and -592 C/A) polymorphisms with susceptibility of BD in Saudi patients. Read More

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October 2015

TNF-α, TNF-β and IL-10 gene polymorphism and association with oral lichen planus risk in Saudi patients.

J Appl Oral Sci 2015 May-Jun;23(3):295-301

Research Center, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Objectives: Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease. Cytokines play an important role in the pathogenesis and disease progression of OLP. Various reports have implicated cytokine gene polymorphisms in susceptibility to develop some immune mediated conditions including OLP. Read More

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November 2015

Association of a Large Panel of Cytokine Gene Polymorphisms with Complications and Comorbidities in Type 2 Diabetes Patients.

J Diabetes Res 2015 6;2015:605965. Epub 2015 May 6.

Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil ; Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, No. 6627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil.

Aims: The polymorphisms of pro- and anti-inflammatory cytokines may be involved in type 2 diabetes (T2D) pathogenesis and its complications.

Methods: We investigated in 102 T2D patients the association of the cytokine polymorphisms in the TNF-α, IL-10, IL-6, TGF-β1, and IFN-γ genes with the T2D microvascular complications and comorbidities (hypertension, dyslipidemia, and obesity). Cytokine genotypes were determined by PCR using Cytokine Genotyping Tray kit. Read More

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February 2016

Associations of cytokine genes with Alzheimer's disease and depression in an elderly Korean population.

J Neurol Neurosurg Psychiatry 2015 Sep 14;86(9):1002-7. Epub 2014 Oct 14.

Department of Psychiatry, Depression Clinical Research Centre, Chonnam National University Medical School, Gwangju, Korea.

Background: Inflammatory processes regulated by cytokines are important in the aetiology of Alzheimer's disease (AD) and depression. Differences in transcriptional activities associated with several genetic polymorphisms affect cytokine production. We investigated the involvement of alleles associated with higher production of proinflammatory and lower production of anti-inflammatory cytokines in AD and depression in a community-dwelling sample of elderly individuals. Read More

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September 2015

Meta-analysis of association between cytokine gene polymorphisms and Behcet's disease risk.

Int J Rheum Dis 2013 Dec 25;16(6):616-24. Epub 2013 Nov 25.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.

The aim of this study was to perform a meta-analysis of eligible studies to derive precise estimation of the association of interleukin-1 (IL-1), IL-10 and tumor necrosis factor (TNF)-α polymorphisms with Behcet's disease (BD). Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association. A total of 4003 cases and 4748 controls in 19 eligible studies were included in the meta-analysis. Read More

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December 2013

IL-10 and TNF-alpha polymorphisms in subjects with irritable bowel syndrome in Mexico.

Rev Esp Enferm Dig 2013 Aug;105(7):392-9

Background: there has been recent evidence of an alteration in irritable bowel syndrome (IBS) immune regulation, as well as variations in cytokine polymorphisms.

Aims: to determine the frequency of the IL-10 (-1082G/A) and TNF-alpha (-308G/A) polymorphisms in subjects with IBS in Mexico.

Methods: volunteers answered the Rome II Questionnaire and were classified as IBS (n = 45) and controls (n = 92). Read More

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The association of the immune response genes to human papillomavirus-related cervical disease in a Brazilian population.

Biomed Res Int 2013 8;2013:146079. Epub 2013 Jul 8.

Campinas State University, Barão Geraldo, 13083878 Campinas, SP, Brazil.

The genetic variability of the host contributes to the risk of human papillomavirus (HPV)-related cervical disease. Immune response genes to HPV must be investigated to define patients with the highest risk of developing malignant disease. The aim of this study was to investigate the association of polymorphic immune response genes, namely KIR, HLA class I and II, and single-nucleotide polymorphisms (SNPs) of cytokines with HPV-related cervical disease. Read More

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TNF-alpha, IL-4R-alpha and IL-4 polymorphisms in mild to severe asthma from Italian Caucasians.

Int J Immunopathol Pharmacol 2013 Jan-Mar;26(1):75-84

Department of Clinical and Biological Sciences, University of Torino, Torino, Italy.

Asthma is a chronic airway inflammatory disease associated with airway hyperresponsiveness which affects subjects with genetic predisposition. An association has been reported between some polymorphisms in various cytokine genes and asthma. Most of them are single nucleotide polymorphisms (SNPs). Read More

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September 2013

Effect of donor tumor necrosis factor-alpha and interleukin-10 genotypes on delayed graft function and acute rejection in kidney transplantation.

Iran J Kidney Dis 2013 Mar;7(2):135-41

Physiology Research Center; Department of Nephrology and Renal Transplantation, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran.

Introduction: This study evaluated the influence of interleukin-10 (IL10) gene -1082G>A and tumor necrosis factor-alpha (TNF) gene -308G>A polymorphisms in the donor and recipients on the acute rejection (AR) episodes and delayed graft function (DGF) in kidney transplant recipients.

Materials And Methods: The IL10 -1082G>A and TNF -308G>A polymorphisms were determined in 100 kidney allograft recipients and their donors using the polymerase chain reaction-amplification refractory mutation system polymerase chain reaction-restriction fragment length polymorphism methods. Transplantation outcomes were determined in terms of AR and DGF criteria. Read More

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A one year longitudinal study of cytokine genes and depression in breast cancer.

J Affect Disord 2013 May 29;148(1):57-65. Epub 2012 Dec 29.

Department of Psychiatry, Chonnam National University Medical School, and Depression Clinical Research Center, Chonnam National University Hospital, Gwangju, Republic of Korea.

Background: Since inflammatory cytokines have been implicated in the pathophysiology of both cancer and depression, genes that contribute to determining cytokine functional activity are reasonable candidate risk factors for depression related to cancer. This study aimed to investigate whether alleles related to higher pro-inflammatory and/or lower anti-inflammatory cytokine production would associate with depression in a cohort with breast cancer.

Methods: A total of 309 women with breast cancer were evaluated one week after surgery, and 244 (79%) were followed one year later. Read More

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Specific genetic polymorphisms of IL10-592 AA and IL10-819 TT genotypes lead to the key role for inducing docetaxel-induced liver injury in breast cancer patients.

Clin Transl Oncol 2013 Apr 10;15(4):331-4. Epub 2012 Nov 10.

Department of Medical Oncology, Peking University Cancer Hospital and Institute, Beijing, China.

Aim: This study was designed to explore the genetic polymorphism of IL-10 (-1082A/G, -592A/C, -819T/C), TNF-α (-308G/A) with susceptibility to docetaxel-induced liver injury (DILI) in Chinese breast cancer patients.

Methods: The targeted genetic polymorphisms of IL10-1082G/A, IL10-592A/C, IL10-819T/C, TNF-308G/A from 40 patients with DILI were assayed by matrix-assisted laser desorption/ionization-time of flight of Sequenom.

Results: AA genotype of IL10-592 and TT of IL10-819 significantly increased incidence of DILI (P = 0. Read More

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Associations of ABCB1 and IL-10 genetic polymorphisms with sirolimus-induced dyslipidemia in renal transplant recipients.

Transplantation 2012 Nov;94(9):971-7

Clinical Center Pharmacy Department, National Institutes of Health, Bethesda, MD 20892, USA.

Background: Hyperlipidemia is a common adverse effect of sirolimus (SRL). We previously showed significant associations of ABCB1 3435C>T and IL-10 -1082G>A with log-transformed SRL dose-adjusted weighted-normalized trough. We further examined to see whether these polymorphisms were also associated with SRL-induced dyslipidemia. Read More

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November 2012

The association of promoter gene polymorphisms of the tumor necrosis factor-α and interleukin-10 with severity of lactic acidosis during liver transplantation surgery.

Transplant Proc 2012 Jun;44(5):1307-13

Department of Anesthesia, Kaser Al-Aini Hospital Cairo University, Cairo, Egypt.

Background: Orthotopic liver transplantation (OLT) is a major operation, causing cytokine release and other inflammatory responses that can contribute to postreperfusion syndrome occurrence. During the systemic inflammatory response syndrome, increased lactate levels result from excessive cytokine production despite normal oxygen delivery and carbohydrate metabolism. The goal of the study was to determine the relationship between genetic polymorphisms in interleukin (IL)-10 (-1082G/A) or tumor necrosis factor (TNF)-α (-376 G/A) and lactate levels in patients during OLT surgery. Read More

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Cytokine gene polymorphisms in the susceptibility to acute coronary syndrome.

Genet Test Mol Biomarkers 2012 May 28;16(5):359-65. Epub 2012 Feb 28.

Institute of Genetics and Hospital for Genetic Disease, Osmania University, Hyderabad, India.

Aim: Acute coronary syndrome (ACS) is an inflammatory disease. Cytokines are the central regulators of inflammation and may be a cause or marker of atherosclerosis. Accumulating evidence suggests that polymorphisms at promoter regions of various cytokine genes are known to be associated with their expression levels. Read More

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Meta-analysis of association between cytokine gene polymorphisms and lung cancer risk.

Mol Biol Rep 2012 May 9;39(5):5187-94. Epub 2011 Dec 9.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China.

The aim of this study was to evaluate the association between various cytokine gene polymorphisms and lung cancer (LC) susceptibility. We searched Pubmed, Elsevier Science Direct, China National Knowledge Infrastructure database, Chinese Biomedical database, Google scholar. Totally, 20 studies involving 6,467 cases and 8,320 controls were included in the meta-analysis. Read More

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Associations of ABCB1 3435C>T and IL-10-1082G>A polymorphisms with long-term sirolimus dose requirements in renal transplant patients.

Transplantation 2011 Dec;92(12):1342-7

Clinical Center Pharmacy Department, National Institutes of Health, Bethesda, MD, USA.

Backgrounds: Sirolimus (SRL) absorption and metabolism are affected by p-glycoprotein-mediated transport and CYP3A enzyme activity, which are further under the influences of cytokine concentrations. This retrospective study determined the associations of adenosine triphosphate-binding cassette, subfamily B, member 1 (ABCB1) 1236C>T, 2677 G>T/A, and 3435C>T, cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4) -392A>G, cytochrome P450, family 3, subfamily A, polypeptide 5 (CYP3A5) 6986A>G and 14690G>A, interleukin (IL)-10 -1082G>A, and tumor necrosis factor (TNF) -308G>A polymorphisms with SRL dose-adjusted, weight-normalized trough concentrations (C/D) at 7 days, and at 1, 3, 6, and 12 months after initiation of SRL.

Methods: Genotypes for 86 renal transplant patients who received SRL-based maintenance immunosuppressive therapy were determined using polymerase chain reaction followed by chip-based mass spectrometry. Read More

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December 2011