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Prediction of parasitological cure in children infected with Trypanosoma cruzi using a novel multiplex serological approach: an observational, retrospective cohort study.

Lancet Infect Dis 2021 Apr 6. Epub 2021 Apr 6.

Parasitology Service, Hospital de Niños "Ricardo Gutierrez" and Instituto Multidisciplinario de Investigacion en Patologias Pediatricas (IMIPP)-CONICET-GCBA, Buenos Aires, Argentina.

Background: Assessment of therapeutic response with standard serological diagnostic assays in patients with chronic Chagas disease is a major challenge due to the long persistence of parasite-specific antibodies. The current consensus for parasitological cure is to monitor conversion from positive to negative Trypanosoma cruzi serology (seroreversion). However, because of robust humoral immune response, seroreversion by standard serological tests can take years to decades. Read More

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Comparison of immune reconstitution between anti-T-lymphocyte globulin and post-transplant cyclophosphamide as acute graft-versus-host disease prophylaxis in allogeneic myeloablative peripheral blood stem cell transplantation.

Haematologica 2021 Apr 8. Epub 2021 Apr 8.

Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg.

Anti T-cell lymphocyte globulin (ATLG) and post-transplant cyclophosphamide (PTCy) are now widely used strategies to prevent graft-versus-host disease after allogeneic stem cell transplantation. Data comparing immune reconstitution (IR) between ATLG and PTCy is scarce. This retrospective study conducted at the University Medical-Center Hamburg- Eppendorf (UKE) compares after myeloablative PBSC allogeneic stem cell transplant between PTCy (n=123) and ATLG (n=476). Read More

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Effects of Ketamine Analgesia on Cardiorespiratory Responses and Survival to Trauma and Hemorrhage in Rats.

J Appl Physiol (1985) 2021 Apr 8. Epub 2021 Apr 8.

United States Army Institute of Surgical Research, United States.

Ketamine is the recommended analgesic on the battlefield for Soldiers with hemorrhage, despite a lack of supportive evidence from laboratory or clinical studies. Hence, this study determined the effects of ketamine analgesia on cardiorespiratory responses and survival to moderate (37% blood volume; n=8/group) or severe hemorrhage (50% blood volume; n=10/group) after trauma in rats. We used a conscious hemorrhage model with extremity trauma (fibular fracture + soft tissue injury) while measuring mean arterial pressure (MAP), heart rate (HR), and body temperature (T) by telemetry, and respiration rate (RR), minute volume (MV), and tidal volume (TV) via whole body plethysmography . Read More

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Quick Identification and Differentiation of Proteus spp. by PCR and RFLP Along with Their Antibiotic Resistance Pattern.

Mymensingh Med J 2021 Apr;30(2):355-361

Dr Hasnatul Jannat, Assistant Surgeon, Mymensingh Medical College Hospital, Mymensingh, Bangladesh; E-mail:

Different Proteus species are encountered in human infections and may vary with the type of infections they cause. So, the present study was conducted to detect species of Proteus by PCR and RFLP along with their antibiotic resistance pattern. This cross-sectional study was conducted in the Department of Microbiology of Dhaka Medical College, Dhaka, Bangladesh, from July 2018 to June 2019. Read More

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Enteral versus Parenteral Nutrition as Nutritional Support after Allogeneic Hematopoietic Stem Cell Transplantation: a Systematic Review and Meta-Analysis.

Transplant Cell Ther 2021 Feb 13;27(2):180.e1-180.e8. Epub 2020 Dec 13.

Pediatric Oncology and Hematology Unit "Lalla Seràgnoli", Department of Pediatrics, University of Bologna, Sant'Orsola Malpighi Hospital, Bologna, Italy.

Nutritional support for patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been widely debated. Enteral nutrition (EN) is recommended as first-line nutritional support by the main international guidelines. However, these recommendations are based on weak evidence, and there is wide variability in the types of nutritional support among transplantation centers, with the majority providing parenteral nutrition (PN) instead of EN. Read More

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February 2021

Long-term Outcomes with Nonmyeloablative HLA-Identical Related Hematopoietic Cell Transplantation Using Tacrolimus and Mycophenolate Mofetil for Graft-versus-Host Disease Prophylaxis.

Transplant Cell Ther 2021 Feb 11;27(2):163.e1-163.e7. Epub 2020 Dec 11.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, Washington.

Nonmyeloablative allogeneic hematopoietic cell transplantation (HCT) from HLA-identical related donors using cyclosporine (CSP) and mycophenolate mofetil (MMF) for postgrafting immunosuppression is effective therapy for hematologic cancers. However, graft-versus-host-disease (GVHD) remains a major cause of morbidity and mortality. Pilot data suggested lower acute GVHD incidence with tacrolimus/MMF compared to historical experience using CSP/MMF after nonmyeloablative HCT. Read More

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February 2021

[Genetic screening of prospective parents].

Ugeskr Laeger 2021 Mar;183(13)

Risk of genetic diseases with autosomal recessive or X-linked inheritance can be unknown to prospective parents until an affected child is born. New technology has enabled carrier screening for hundreds of genetic diseases (expanded carrier screening, ECS). I Denmark, each year estimated 100-180 children are born affected with a serious condition which could have been detected with ECS of the parents. Read More

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Robot-assisted boari flap and psoas hitch ureteral reimplantation: Technique insight and outcomes of a case series with at least 1 year of follow-up.

BJU Int 2021 Apr 8. Epub 2021 Apr 8.

Department of Urology, Onze Lieve Vrouw Hospital, Aalst, Belgium.

Objective: To describe step-by-step surgical techniques and report outcomes of the largest single centre series of patients with distal ureteral disease exclusively treated with robot-assisted ureteral reimplantation (RAUR) with Boari Flap (RABFUR) and Psoas Hitch (RAPHUR), with a minimum follow-up of 1 year and complete postoperative data.

Subjects/patients And Methods: 37 patients with distal ureteral disease were treated between 2010 and 2018. Of these, 81 and 19% underwent RAPHUR and RABFUR, respectively. Read More

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First report of the stubby-root nematode infecting , seashore paspalum grass in Georgia, USA.

J Nematol 2020 10;52. Epub 2020 Nov 10.

Department of Plant Pathology, University of Georgia, Griffin, GA, 30223.

We found that spp. was pathogenic to seashore paspalum () turfgrass as its population increased from 100 to 2,080 nematodes per pot 180 days after inoculation under greenhouse conditions. Morphological measurements of adult females were similar to those described for . Read More

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November 2020

Laparoscopic cholecystectomy after endoscopic trans-papillary gallbladder stenting for acute cholecystitis: a pilot study of surgical feasibility.

BMC Surg 2021 Apr 7;21(1):184. Epub 2021 Apr 7.

Department of Hepatobiliary-Pancreatic Surgery, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Background: Percutaneous transhepatic gallbladder drainage (PTGBD) is indicated for patients with acute cholecystitis (AC) who are not indicated for urgent surgery, but external tubes reduce quality of life (QOL) while waiting for elective surgery. The objective of the present study was to investigate the feasibility of laparoscopic cholecystectomy after endoscopic trans-papillary gallbladder stenting (ETGBS) comparing with after PTGBD.

Methods: Intraoperative and postoperative outcomes of patients with ETGBS and PTGBD were retrospectively compared. Read More

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Population-Based Observational Study of Adverse Drug Event-Related Mortality in the Super-Aged Society of Japan.

Drug Saf 2021 Apr 7. Epub 2021 Apr 7.

Department of Pharmaceutical Biomedicine, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, 1-1- Tsushima-naka, Kita-ku, Okayama, 700-8530, Japan.

Introduction: Adverse drug events (ADEs) are a major cause of mortality.

Objective: We examined long-term trends for ADE-related deaths in Japan.

Methods: This observational study was conducted using the Japanese Vital Statistics from 1999 to 2016. Read More

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Role of dual-time point F-FDG PET/CT imaging in the primary diagnosis and staging of hilar cholangiocarcinoma.

Abdom Radiol (NY) 2021 Apr 7. Epub 2021 Apr 7.

Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

Purpose: The aim of this study was to evaluate the role of dual-time point F-FDG PET/CT imaging in the primary diagnosis and staging of hilar cholangiocarcinoma (HCCA).

Methods: Dual-time point FDG PET/CT findings, including early phase whole-body scanning and abdominal delayed phased performed 1 and 2 h after radiotracer injection, respectively, were retrospective reviewed in 69 patients conformed HCCA by histology. PET/CT was evaluated based on visual interpretation and the semiquantitative index of SUVmax and tumor-to-normal liver tissue ratio (TNR) for both early and delayed images. Read More

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Randomised, phase I pharmacokinetic study of adalimumab biosimilar CT-P17 (40 mg/0.4 mL) by autoinjector and prefilled syringe in healthy subjects.

Br J Clin Pharmacol 2021 Apr 6. Epub 2021 Apr 6.

University of California, Los Angeles, California, USA.

Aim: To evaluate pharmacokinetic equivalence and preliminary safety of the adalimumab biosimilar CT-P17 administered via autoinjector (CT-P17 AI) or prefilled syringe (CT-P17 PFS) in healthy subjects.

Methods: This phase I, open-label study (ClinicalTrials.gov: NCT04295356) randomised subjects (1:1) to receive a single 40 mg (100 mg/mL) dose of CT-P17 AI or CT-P17 PFS. Read More

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Effect of Pulmonary Valve Replacement in the Repaired Tetralogy of Fallot Patients with Trans-annular Incision: More than 20 Years of Follow-up.

Korean Circ J 2021 Apr;51(4):360-372

Division of Cardiology, Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea.

Background And Objectives: We reviewed the long-term outcomes after tetralogy of Fallot (TOF) repair with trans-annular incision; and evaluated the effectiveness of pulmonary valve replacement (PVR) on outcomes.

Methods: This was a retrospective review of clinical outcomes of 180 of 196 TOF patients who underwent total correction with trans-annular incision from 1991 to 1997 (PVR group: 81; non-PVR group: 99).

Results: The median age of the patients was 14. Read More

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Brands with personalities - good for businesses, but bad for public health? A content analysis of how food and beverage brands personify themselves on Twitter.

Public Health Nutr 2021 Apr 6:1-23. Epub 2021 Apr 6.

Department of Population Health, NYU School of Medicine, 180 Madison Ave, 3rd Floor, New York, NY 10016.

Objective: To examine the extent to which food and beverage brands exhibit personalities on Twitter, quantify Twitter users' engagement with posts displaying personality features, and quantify advertising spending across these brands on Twitter.

Design: We identified 100 tweets from 10 food and beverage brands that displayed "personality," and 100 "control" tweets (i.e. Read More

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Selective reduction of nitrite to nitrogen gas by CO anion radical from the activation of oxalate.

Chemosphere 2021 Mar 27;278:130388. Epub 2021 Mar 27.

College of Chemistry and Materials Science, Sichuan Normal University, Chengdu, 610066, China; Key Laboratory of Treatment for Special Wastewater of Sichuan Province Higher Education System, Sichuan, Chengdu, 610066, China. Electronic address:

Nitrite (NO) reduction by carbon dioxide anion radical (CO) from the activation of small molecule carboxylic acid was investigated to selectively reduce nitrite to nitrogen gas (N) However, the CO generation efficiency from the activation of small molecule carboxylic acid needs to be enhanced to increase the NO reduction efficiency. In this study, a novel and promising process for selective NO reduction was proposed based on activation of oxalic acid (OA) by UV radiation coupled with Fe. In Fe(III)/OA/UV system, the activation of OA by photo-induced electron transfer process of Fe(III)-oxalate complex and by •OH radical from the photolysis of Fe or NO could promote the generation of CO radical, which enhanced the NO reduction. Read More

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A Real-Time PCR Assay for the Diagnosis of Intestinal Schistosomiasis and Cure Assessment After the Treatment of Individuals With Low Parasite Burden.

Front Immunol 2020 16;11:620417. Epub 2021 Mar 16.

Clinical Research and Public Politics in Infectious and Parasitic Diseases, Instituto René Rachou, Oswaldo Cruz Foundation, Belo Horizonte, Brazil.

The laboratorial diagnosis of the intestinal schistosomiasis is always performed using Kato-Katz technique. However, this technique presents low sensitivity for diagnosis of individuals with low parasite burden, which constitutes the majority in low endemicity Brazilian locations for the disease. The objective of this study was developed and to validate a real-time PCR assay (qPCR) targeting 121 bp sequence to detect spp. Read More

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Sharpening ECOSTRESS and VIIRS land surface temperature using harmonized Landsat-Sentinel surface reflectances.

Remote Sens Environ 2020 Dec 8;251:112055. Epub 2020 Sep 8.

Earth System Science Interdisciplinary Center, University of Maryland, College Park, MD 20742, USA.

Land surface temperature (LST) is a key diagnostic indicator of agricultural water use and crop stress. LST data retrieved from thermal infrared (TIR) band imagery, however, tend to have a coarser spatial resolution (e.g. Read More

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December 2020

A prospective randomized trial comparing computerized columnar insulin dosing chart (the Atlanta protocol) versus the joint British diabetes societies for inpatient care protocol in management of hyperglycemia in patients with acute coronary syndrome admitted to cardiac care unit in Alexandria, Egypt.

Diabetes Metab Syndr 2021 Mar 28;15(3):711-718. Epub 2021 Mar 28.

Department of Internal Medicine, Faculty of Medicine, University of Alexandria, Egypt. Electronic address:

Background: Hyperglycemia in acute coronary syndrome (ACS) is linked to raised morbidity and mortality. Insulin administration using insulin infusion protocols (IIP) is the preferred strategy to control hyperglycemia in critically ill patients. To date, no specific IIP has been identified as the most efficient for achieving glycemic control. Read More

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Chronic effects of different quercetin doses in penicillin-induced focal seizure model.

Neurosci Lett 2021 Apr 1;753:135848. Epub 2021 Apr 1.

Department of Physiology, Faculty of Medicine, Tokat Gaziosmanpasa University, Tokat, Turkey. Electronic address:

Aim: The aim of the present study was to examine the effects of different quercetin pretreatment doses on focal epileptiform activity induced by penicillin in adult male rat cortex.

Method: Twenty-eight male Wistar rats weighing 200-235 g were randomly divided into four groups: control (only penicillin-injected group) and penicillin + 25, 50 or 100 mg/kg quercetin doses. All quercetin-treated rats had a daily single dose of 25, 50 or 100 mg/kg intraperitoneally administered quercetin for 21 days, and the last dose was given 30 min before the penicillin injection. Read More

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A novel microwave stimulus remote-controlled anticancer drug release system based on Janus TiO&mSiO nanocarriers.

Mater Sci Eng C Mater Biol Appl 2021 Apr 16;123:111968. Epub 2021 Feb 16.

Key Laboratory of Synthetic and Natural Functional Molecule (Ministry of Education), Shaanxi Key Laboratory of Physico-Inorganic Chemistry, College of Chemistry & Materials Science, Northwest University, 1 Xuefu Ave., Chang'an District, Xi'an, Shaanxi 710127, China. Electronic address:

In this work, we used a simple method to construct Janus-shaped TiO&mSiO nanoparticles composed of gray-black titanium dioxide (TiO) and mesoporous silica (mSiO) serving as carriers to improve the microwave-controlled release performance. In the composite materials, on one hand, the rod-shaped mSiO could realize high-efficiency drug loading, on the other hand, spherical TiO featuring oxygen vacancy acted as the main microwave absorber. The overall spatial separation between titanium dioxide and silicon dioxide was crucial to enhance microwave conversion efficiency. Read More

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The Acute Effects of a Relative Dose of Pre-Sleep Protein on Recovery Following Evening Resistance Exercise in Active Young Men.

Sports (Basel) 2021 Mar 26;9(4). Epub 2021 Mar 26.

Energy Metabolism and Body Composition Laboratory, Department of Exercise Science, Elon University, 100 Campus Drive, Elon, NC 27244, USA.

The purpose of the present study was to assess the acute effects of pre-sleep consumption of isocaloric casein protein (CP), CP and whey protein (BLEND), or non-caloric control (CTRL) at a dose relative to lean body mass (LBM) on recovery following an evening lower-body resistance exercise (RE) bout. Fifteen active and previously resistance-trained males (age: 21 ± 1 years, body fat: 14.2 ± 2. Read More

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Determination of an Acceptable Portion Size of for a Bangladeshi Community-Based Iron Intervention in Adolescent Girls: A Feasibility Study.

Nutrients 2021 Mar 26;13(4). Epub 2021 Mar 26.

Department of Sports Medicine, King's College, 133 N River St, Wilkes-Barre, PA 18711, USA.

Widely consumed (lentils) in Bangladesh are an ideal vehicle for iron (Fe) fortification; however, an acceptable portion size in meals needs to be determined to carry out a community feeding study in at-risk adolescent girls. A non-randomized crossover trial was conducted with = 100 Bangladeshi girls (12.9 ± 2. Read More

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A Household-Based Survey of Iodine Nutrition in Moroccan Children Shows Iodine Sufficiency at the National Level But Risk of Deficient Intakes in Mountainous Areas.

Children (Basel) 2021 Mar 19;8(3). Epub 2021 Mar 19.

Ibn Tofail University-CNESTEN, Joint Research Unit in Nutrition and Food, RDC-Nutrition AFRA/IAEA, Rabat-Kénitra 1400, Morocco.

Historically, mountainous areas of Morocco have been affected by endemic goiter and severe iodine deficiency. In 1995, Morocco legislated salt iodization to reduce iodine deficiency. There has been no national survey of iodine nutrition in school-age children for nearly 3 decades. Read More

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Comparative Analysis of Conventional and Emerging Technologies for Seawater Desalination: Northern Chile as A Case Study.

Membranes (Basel) 2021 Mar 5;11(3). Epub 2021 Mar 5.

Gestionare Consultores, Carlos Antunez 2025 of. 608, Providencia 7500000, Chile.

The aim of this work was to study different desalination technologies as alternatives to conventional reverse osmosis (RO) through a systematic literature review. An expert panel evaluated thermal and membrane processes considering their possible implementation at a pilot plant scale (100 m/d of purified water) starting from seawater at 20 °C with an average salinity of 34,000 ppm. The desalination plant would be located in the Atacama Region (Chile), where the high solar radiation level justifies an off-grid installation using photovoltaic panels. Read More

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Residual Tensile Properties and Explosive Spalling of High-Performance Fiber-Reinforced Cementitious Composites Exposed to Thermal Damage.

Materials (Basel) 2021 Mar 25;14(7). Epub 2021 Mar 25.

Department of Infrastructure Safety Research, Korea Institute of Civil Engineering and Building Technology, 283 Goyangdae-Ro, Ilsanseo-Gu, Goyang-Si 10223, Korea.

This study examined the effect of adding synthetic fibers, that is, polypropylene (PP) and nylon (Ny), on explosive spalling and residual tensile mechanical properties of high-performance fiber-reinforced cementitious composites (HPFRCCs). Three different matrix strengths (100 MPa, 140 MPa, and 180 MPa), four different volume contents of the synthetic fibers (0%, 0.2%, 0. Read More

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Population Genetic Structure and Chemotype Diversity of Populations from Wheat in Canada and North Eastern United States.

Toxins (Basel) 2021 Mar 1;13(3). Epub 2021 Mar 1.

Department of Plant Science, University of Manitoba, 66 Dafoe Road, Winnipeg, MB R3T 2N2, Canada.

Fusarium head blight (FHB) is a major disease in wheat causing severe economic losses globally by reducing yield and contaminating grain with mycotoxins. In Canada, is the principal etiological agent of FHB in wheat, producing mainly the trichothecene mycotoxin, deoxynivalenol (DON) and its acetyl derivatives (15-acetyl deoxynivalenol (15ADON) and 3-acetyl deoxynivalenol (3ADON)). Understanding the population biology of such as the genetic variability, as well as mycotoxin chemotype diversity among isolates is important in developing sustainable disease management tools. Read More

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Real-World Evaluation of Modern Adjuvant Radiotherapy in Women with Stage IB Endometrial Cancer.

Cancers (Basel) 2021 Mar 18;13(6). Epub 2021 Mar 18.

Division of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, Taipei 100, Taiwan.

The optimal adjuvant treatment for stage IB endometrial cancer remains undefined. We investigated the benefit of modern adjuvant radiotherapy for women with stage IB endometrial cancer. We retrospectively reviewed patients with surgically staged, pure stage IB endometrioid adenocarcinoma (2010 to 2018). Read More

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Associations between Inter-Limb Asymmetries in Jump and Change of Direction Speed Tests and Physical Performance in Adolescent Female Soccer Players.

Int J Environ Res Public Health 2021 Mar 27;18(7). Epub 2021 Mar 27.

Health Sciences Faculty, Universidad San Jorge, Autov A23 km 299, 50830 Villanueva de Gállego, 50830 Zaragoza, Spain.

The association between asymmetries in jump and change of direction (COD) with physical performance in several sports show inconclusive results. The purposes of this study were to: (1) measure inter-limb asymmetries in three distinct groups in adolescent female soccer players and, (2) to determine the association between inter-limb asymmetries and physical performance in different age groups. Fifty-four players were distributed in three age groups: U-18, U-16 and U-14. Read More

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Hollow Mesoporous Polydopamine Nanospheres: Synthesis, Biocompatibility and Drug Delivery.

Nanotechnology 2021 Apr 2. Epub 2021 Apr 2.

Henan University, Kaifeng, Henan, CHINA.

Various polydopamine (PDA) nanospheres were synthesized by utilizing triblock copolymer Pluronic F127 and 1,3,5-trimethylbenzene (TMB) as soft templates. Precise morphology control of polydopamine nanospheres was realized from solid polydopamine nanospheres (PDANSs) to hollow polydopamine nanospheres (H-PDANSs), mesoporous polydopamine nanospheres (MPDANSs) and hollow mesoporous polydopamine nanospheres (H-MPDANSs) by adjusting the weight ratio of TMB to F127. The inner diameter of the prepared H-MPDANSs can be controlled in the range of 50-100 nm, and the outer diameter is about 180 nm. Read More

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