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The development of artificial livers.

Curr Opin Organ Transplant 2021 Jul 28. Epub 2021 Jul 28.

Department of Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

Purpose Of Review: While liver transplantation is an established treatment for liver failure, the number of patients with liver failure amenable to such intervention far outnumbers the donor supply of livers. Technologies serving to bridge this gap are required. Artificial livers may serve as an alternative. Read More

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Separation of cathode particles and aluminum current foil in lithium-ion battery by high-voltage pulsed discharge Part II: Prospective life cycle assessment based on experimental data.

Waste Manag 2021 Jul 26;132:86-95. Epub 2021 Jul 26.

Department of Resources and Environmental Engineering, Faculty of Science and Engineering, Waseda University, 3-4-1 Okubo Shinjuku-ku, Tokyo 169-8555, Japan; Department of Systems Innovation, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

This series of papers addresses the recycling of cathode particles and aluminum (Al) foil from positive electrode sheet (PE sheet) dismantled from spent lithium-ion batteries (LIBs) by applying a high-voltage pulsed discharge. As concluded in Part I of the series (Tokoro et al., 2021), cathode particles and Al foil were separated in water based on a single pulsed power application. Read More

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Predictive models to identify Holstein cows at risk of metritis and clinical cure and reproductive/productive failure following antimicrobial treatment.

Prev Vet Med 2021 Jul 13;194:105431. Epub 2021 Jul 13.

Department of Large Animal Clinical Sciences, University of Florida, Gainesville, 32610, USA; Department of Animal Sciences, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, 32610, USA. Electronic address:

Precision dairy farming, specifically the design of management strategies according to the animal's needs, may soon become the norm since automated technologies that generate large amounts of data for each individual are becoming more affordable. Our objectives were to determine whether the use of behavioral changes could improve the accuracy of prediction of the risk of metritis and the risk of clinical cure of cows diagnosed with metritis. Addition of behavioral data to the algorithms to predict the outcomes of interest increased their accuracy by 7 to 32%. Read More

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Hurricane/tropical storm rainwater chemistry in the US (from 2008 to 2019).

Sci Total Environ 2021 Jul 17;798:149009. Epub 2021 Jul 17.

Physical and Environmental Sciences Department, Texas A & M University - Corpus Christi, 6300 Ocean Drive, Corpus Christi, TX 78412, United States of America; Center for Water Supply Studies, Texas A & M University - Corpus Christi, 6300 Ocean Drive, Corpus Christi, TX 78412, United States of America.

Rainwater chemistry of extreme rain events is not well characterized. This is despite an increasing trend in intensity and frequency of extreme events and the potential excess loading of elements to ecosystems that can rival annual loading. Thus, an assessment of the loading imposed by hurricane/tropical storm (H/TS) can be valuable for future resiliency strategies. Read More

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Rare liver disease patients' and healthcare providers' view on mobile app requirements and functionality: a single center survey for the European Reference Network on Hepatological diseases (ERN RARE-LIVER‬)‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬.

Clin Res Hepatol Gastroenterol 2021 Jul 27:101760. Epub 2021 Jul 27.

I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; European Reference Network on Hepatological Diseases (ERN RARE-LIVER); Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: More patient data are needed to improve research on rare liver diseases. Mobile health apps enable an exhaustive data collection. Therefore, the European Reference Network on Hepatological diseases (ERN RARE-LIVER) intends to implement an app for patients with rare liver diseases communicating with a patient registry, but little is known about which features patients and their healthcare providers regard as being useful. Read More

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Effect of Biomodulina-T® and VA-MENGOC-BC® on lymphocyte subpopulations in older adults.

Exp Gerontol 2021 Jul 26:111497. Epub 2021 Jul 26.

Institute of Hematology and Immunology, Immunochemistry-Immunology Department, 19th St, between 8th and 10th St, Vedado, 10400 Plaza de la Revolución, Havana, Cuba.

Introduction: The elderly population suffers from the natural process called immunosenescence, which may be related to the high mortality rates it has against the SARS-CoV2 virus, which is why therapies that improve the immune status are required. The combined treatment of the VA-MENGOC-BC® (V-BC) vaccine and the Biomodulina T® (BT) drug could achieve this purpose. This treatment could immunomodulate both the innate and adaptive branches of the immune system simultaneously. Read More

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Facile one-pot synthesis of amphiphilic acid/hypoxia co-triggered degradable diblock polyprodrug for tumor selective drug delivery.

Int J Pharm 2021 Jul 26:120941. Epub 2021 Jul 26.

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China. Electronic address:

More precise drug release is expected by conjugating the drug structural units in the polyprodrugs with dynamic covalent bonds responding to different stimuli. Here, amphiphilic acid/hypoxia co-triggered degradable diblock polyprodrug was designed via a facile one-pot method with drug content of 78.6% (1. Read More

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Improvement of sensitivity and specificity for laminar BOLD fMRI with double spin-echo EPI in humans at 7 T.

Neuroimage 2021 Jul 26:118435. Epub 2021 Jul 26.

Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, South Korea; Department of Biomedical Engineering, Sungkyunkwan University, Suwon, South Korea; Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, South Korea. Electronic address:

Mapping mesoscopic cortical functional units such as columns or laminae is increasingly pursued by ultra-high field (UHF) functional magnetic resonance imaging (fMRI). The most popular approach for high-resolution fMRI is currently gradient-echo (GE) blood oxygenation level-dependent (BOLD) fMRI. However, its spatial accuracy is reduced due to its sensitivity to draining vessels, including pial veins, whereas spin-echo (SE) BOLD signal is expected to have higher spatial accuracy, albeit with lower sensitivity than the GE-BOLD signal. Read More

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Derivation and validation of a national multicenter mortality risk stratification model - the ExCare model: a study protocol.

Braz J Anesthesiol 2021 Jul 26. Epub 2021 Jul 26.

Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.

Introduction: Surgical care is essential for proper management of various diseases. However, it can result in unfavorable outcomes. In order to identify patients at higher risk of complications, several risk stratification models have been developed. Read More

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Urology 2021 Jul 26. Epub 2021 Jul 26.

Division of Pediatric Surgery, Federico II University of Naples, Naples, Italy. Electronic address:

This literature review aimed to assess the outcomes of robot-assisted laparoscopic extra-vesical ureteral reimplantation (RALUR/REVUR) in standard, complex and re-operative cases. Twenty-two studies (period 2008-2019) containing 1362 children receiving RALUR/REVUR, were included. Unilateral repair was faster compared to bilateral (p=0. Read More

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Dacryops and clinical diagnostic challenges.

Can J Ophthalmol 2021 Jul 26. Epub 2021 Jul 26.

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia; Department of Ophthalmology, King Saud University Medical City, Riyadh, Saudi Arabia.

Objective: The study aims to describe the clinical and histopathologic features of different types of dacryops and their clinical diagnostic challenges.

Methods: This is a retrospective cohort study of all surgically excised cases of dacryops in 2 tertiary eye hospitals in Riyadh, Saudi Arabia.

Results: The study included 58 dacryops specimens from 55 patients with an average age of 41. Read More

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Evolution of physiological performance in invasive plants under climate change.

Evolution 2021 Jul 29. Epub 2021 Jul 29.

Instituto de Ciencias Biológicas, Universidad de Talca, Talca, Chile.

Climate change is expected to promote biological invasions. Invasive species often undergo adaptive evolution, but whether invasive species show greater evolutionary potential than their native counterparts under climate change has rarely been evaluated. We conducted experimental evolution trials comparing the evolution of physiological performance (light-saturated photosynthetic rate, A ) of coexisting and closely related 1) invasive-native species pairs from Arid, Alpine and Antarctic ecosystems, and 2) an invasive-naturalized species pair from a Mediterranean ecosystem differing in invasiveness. Read More

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Environmental Life Cycle Assessment in Medical Practice: A User's Guide.

Obstet Gynecol Surv 2021 Jul;76(7):417-428

Efficiency and Sustainability Manager, Carilion Clinic, Roanoke, VA.

Importance: The environmental impacts of medical practice are becoming more important as the unsustainable activities of global societies continue to damage the environment and contribute to health problems. Life cycle assessment (LCA) is a methodology to quantify a wide range of environmental impacts, including global warming, over the full life cycle of products, processes, and systems, to allow for data-driven environmental decisions.

Objective: This article introduces the concepts, terminology, and methodology of LCA using examples from the medical industry. Read More

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Formation of multi-species biofilms and their resistance to disinfectants in food processing environments: A review.

J Food Prot 2021 Jul 29. Epub 2021 Jul 29.

College of Food Science and Technology, Huazhong Agriculture University, Wuhan 430070, China.

In food processing environments, various microorganisms can adhere and aggregate on the surface of equipment, resulting in the formation of multi-species biofilms. Complex interactions among microorganisms may affect the formation of multi-species biofilms and their resistance to disinfectants, which are food safety and quality concerns. This paper reviews the various interactions among microorganisms in multi-species biofilms, including competitive, cooperative and neutral interactions. Read More

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Early Responses to Low-Dose Ionizing Radiation in Cellular Lens Epithelial Models.

Radiat Res 2021 Jul 29. Epub 2021 Jul 29.

Genomic Instability and Cell Communication Research Group, Department of Biological and Medical Science, Oxford Brookes University, Oxford, United Kingdom.

Cataract is the leading cause of visual impairment which can result in blindness. Cataract formation has been associated with radiation exposure; however, the mechanistic understanding of this phenomenon is still lacking. The goal of this study was to investigate mechanisms of cataract induction in isolated lens epithelial cells (LEC) exposed to ionizing radiation. Read More

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Synthesis and electrochemical properties of ZnTiO/g-CN composites as anode materials for Li-ion batteries.

Dalton Trans 2021 Jul 29. Epub 2021 Jul 29.

School of Energy and Environment, Anhui University of Technology, Maanshan, Anhui 243002, PR China.

Zn2Ti3O8/g-C3N4 (0, 1, 3 and 8 wt%) composites were prepared via a simple solvothermal method, and their physical and electrochemical properties were systematically analyzed. SEM and HRTEM results show that the Zn2Ti3O8/g-C3N4 spherical structures with width sizes of about 500-700 nm are plump and uniform. Moreover, g-C3N4 with a large specific surface area can effectively buffer the deformation of Zn2Ti3O8 and reduce the resistance of Zn2Ti3O8 charge transfer and Li+ diffusion, thus improving the conductivity of Zn2Ti3O8. Read More

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Copper niobate nanowires boosted by a N, S co-doped carbon coating for superior lithium storage.

Dalton Trans 2021 Jul 29. Epub 2021 Jul 29.

School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, Zhejiang 315211, China.

With the development of electric vehicles, more and more attention has been paid to the kinetic performance of batteries, which is related to rapid charge/discharge and safety issues. To improve this aspect, Cu2Nb34O87 nanowires covered by nitrogen and sulfur co-doped carbon (Cu2Nb34O87/NSC nanowires) are prepared by electrospinning combined with surface coating. As-prepared Cu2Nb34O87/NSC nanowires present a high ion diffusion coefficient and electronic conductivity, showing good a kinetic performance. Read More

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Assessment of genetic diversity and population structure of oil palm (Elaeis guineensis Jacq.) field genebank: A step towards molecular-assisted germplasm conservation.

PLoS One 2021 29;16(7):e0255418. Epub 2021 Jul 29.

Plant Breeding Section, Advanced Agriecological Research Sdn. Bhd. (AAR), Paloh, Johor, Malaysia.

Oil palm (Elaeis guineensis) germplasm is exclusively maintained as ex situ living collections in the field for genetic conservation and evaluation. However, this is not for long term and the maintenance of field genebanks is expensive and challenging. Large area of land is required and the germplasms are exposed to extreme weather conditions and casualty from pests and diseases. Read More

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Analysis of the specificity of a COVID-19 antigen test in the Slovak mass testing program.

PLoS One 2021 29;16(7):e0255267. Epub 2021 Jul 29.

Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria.

Aims: Mass antigen testing programs have been challenged because of an alleged insufficient specificity, leading to a large number of false positives. The objective of this study is to derive a lower bound of the specificity of the SD Biosensor Standard Q Ag-Test in large scale practical use.

Methods: Based on county data from the nationwide tests for SARS-CoV-2 in Slovakia between 31. Read More

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Tumor infiltrating lymphocytes associated competitive endogenous RNA networks as predictors of outcome in hepatic carcinoma based on WGCNA analysis.

PLoS One 2021 29;16(7):e0254829. Epub 2021 Jul 29.

Department of Infectious Disease, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Background: The important regulatory role of competitive endogenous RNAs (ceRNAs) in hepatocellular carcinoma (HCC) has been confirmed. Tumor infiltrating lymphocytes (TILs) are of great significance to tumor outcome and prognosis. This study will systematically analyze the key factors affecting the prognosis of HCC from the perspective of ceRNA and TILs. Read More

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The influence of anger on empathy and theory of mind.

PLoS One 2021 29;16(7):e0255068. Epub 2021 Jul 29.

Department of Neurology, University of Lübeck, Lübeck, Germany.

Social cognition allows humans to understand and predict other people's behavior by inferring or sharing their emotions, intentions and beliefs. Few studies have investigated the impact of one's own emotional state on understanding others. Here, we tested the effect of being in an angry state on empathy and theory of mind (ToM). Read More

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Tolerability, Safety, and Effectiveness of Two Years of Treatment with Lurasidone in Children and Adolescents with Bipolar Depression.

J Child Adolesc Psychopharmacol 2021 Jul 29. Epub 2021 Jul 29.

Sunovion Pharmaceuticals, Inc., Marlborough, Massachusetts, USA.

To evaluate long-term safety and effectiveness of lurasidone in children and adolescents with bipolar depression. Participants, ages 10-17 years, with bipolar depression, who completed 6 weeks of double-blind (DB) treatment with lurasidone or placebo were enrolled in a 2-year, open-label (OL) extension study of lurasidone (20-80 mg/d). The primary effectiveness measure was the Children's Depression Rating Scale, Revised (CDRS-R). Read More

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Transient Electric Birefringence of Linear and Circular DNA: A Comparison of Kinetic Theory Predictions.

J Phys Chem B 2021 Jul 29. Epub 2021 Jul 29.

Department of Chemical Engineering, Princeton University, Princeton, New Jersey 08544, United States.

The use of monodisperse DNA and restriction enzyme modification allows the preparation of model samples of polymer rings and linear chains with a precision that is not possible by conventional synthetic routes. These samples allow direct comparisons of the predictions of polymer kinetic theories. Transient electric birefringence allows rapid imposition or forces (∼100 ns) and monitoring of conformational changes (∼0. Read More

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Grafted Nanoparticle Surface Wetting during Phase Separation in Polymer Nanocomposite Films.

ACS Appl Mater Interfaces 2021 Jul 29. Epub 2021 Jul 29.

Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.

Wetting of polymer-grafted nanoparticles (NPs) in a polymer nanocomposite (PNC) film is driven by a difference in surface energy between components as well as bulk thermodynamics, namely, the value of the interaction parameter, χ. The interplay between these contributions is investigated in a PNC containing 25 wt % polymethyl methacrylate (PMMA)-grafted silica NPs (PMMA-NPs) in poly(styrene--acrylonitrile) (SAN) upon annealing above the lower critical solution temperature (LCST, 160 °C). Atomic force microscopy (AFM) studies show that the areal density of particles increases rapidly and then approaches 80% of that expected for random close-packed hard spheres. Read More

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Modified ultrafiltration and postoperative course in patients undergoing repair of tetralogy of fallot.

J Card Surg 2021 Jul 29. Epub 2021 Jul 29.

Departments of Cardiothoracic and Vascular Surgery, All India Institute of Medical Sciences, New Delhi, India.

Background: Expected benefits of modified ultrafiltration (MUF) include increased hematocrit, reduction of total body water and inflammatory mediators, improved left ventricular systolic function, and improved systolic blood pressure and cardiac index (CI) following cardiopulmonary bypass (CPB). This prospective randomized trial tested this hypothesis.

Methods: Seventy-nine patients undergoing intracardiac repair of tetralogy of fallot were randomized to conventional ultrafiltration (CUF) + MUF (n = 39) or only CUF group (n = 40). Read More

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Cognitive performance was reduced by higher air temperature even when thermal comfort was maintained over the 24-28°C range.

Indoor Air 2021 Jul 29. Epub 2021 Jul 29.

Department of Architecture, School of Design, Shanghai Jiao Tong University, Shanghai, China.

This study managed to create thermal comfort conditions at three temperatures (24°C-T24, 26°C-T26, and 28°C-T28) by adjusting clothing and air velocity. Thirty-six subjects (18 males and 18 females) were exposed to each of the three conditions for 4.5 h in a design balanced for order of presentation of conditions. Read More

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Cancer Clinical Trial Participation at the 1-Year Anniversary of the Outbreak of the COVID-19 Pandemic.

JAMA Netw Open 2021 Jul 1;4(7):e2118433. Epub 2021 Jul 1.

SWOG Cancer Research Network Group Chair's Office, Portland, Oregon.

Importance: During the initial outbreak of the COVID-19 pandemic, cancer clinical trial participation decreased precipitously. Given the continued pandemic-especially the severe wave of new cases and deaths in winter 2020 to 2021-a vital question is whether trial enrollments have remained low or even worsened.

Objective: To examine the experience of cancer clinical trial enrollment 1 year after the COVID-19 outbreak. Read More

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Characterizing the Relationship Between Western Corn Rootworm (Coleoptera: Chrysomelidae) Larval Survival on Cry3Bb1-Expressing Corn and Larval Development Metrics.

J Econ Entomol 2021 Jul 29. Epub 2021 Jul 29.

Department of Entomology, University of Nebraska, Lincoln, NE 68583, USA.

The western corn rootworm, Diabrotica virgifera virgifera LeConte (Coleoptera: Chrysomelidae), is a significant pest of field corn, Zea mays L. (Poales: Poaceae), across the United States Corn Belt. Widespread adoption and continuous use of corn hybrids expressing the Cry3Bb1 protein to manage the western corn rootworm has resulted in greater than expected injury to Cry3Bb1-expressing hybrids in multiple areas of Nebraska. Read More

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The Effect of Zoom Magnification and Large Display on Video Comprehension in Individuals With Central Vision Loss.

Transl Vis Sci Technol 2021 Jul;10(8):30

Schepens Eye Research Institute, Massachusetts Eye and Ear, Boston, MA, USA.

Purpose: A larger display at the same viewing distance provides relative-size magnification for individuals with central vision loss (CVL). However, the resulting large visible area of the display is expected to result in more head rotation, which may cause discomfort. We created a zoom magnification technique that placed the center of interest (COI) in the center of the display to reduce the need for head rotation. Read More

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Predicting the catalytic activity of azolium-based halogen bond donors: an experimentally-verified theoretical study.

Org Biomol Chem 2021 Jul 29. Epub 2021 Jul 29.

Institute of Chemistry, Saint Petersburg State University, Universitetskaya Nab. 7/9, Saint Petersburg, 199034, Russian Federation.

This report demonstrates the successful application of electrostatic surface potential distribution analysis for evaluating the relative catalytic activity of a series of azolium-based halogen bond donors. A strong correlation (R2 > 0.97) was observed between the positive electrostatic potential of the σ-hole on the halogen atom and the Gibbs free energy of activation of the model reactions (i. Read More

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