498,326 results match your criteria “the white


U.S. racial and ethnic participation in global clinical trials by therapeutic areas.

J Clin Pharm Ther 2021 Sep 20. Epub 2021 Sep 20.

Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.

What Is Known And Objective: The discussion about health equity in the United States frequently involves concerns over racial and ethnic minority under-representation in clinical trials and particularly in trials conducted in support of product approvals. The FDA has long worked to encourage diverse participation in clinical trials and through its Drug Trials Snapshots (DTS) program, the U.S. Read More

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September 2021

Impact of State Prioritization of Safe Infant Sleep Programs on Supine Sleep Positioning for Non-Hispanic White and Non-Hispanic Black Infants.

Am J Perinatol 2021 Sep 20. Epub 2021 Sep 20.

Department of Biostatistics, Colorado School of Public Health, Aurora, Colorado.

Objective:  Investigate whether safe infant sleep prioritization by states through the Title V Maternal and Child Block Grant in 2010 differentially impacted maternal report of supine sleep positioning (SSP) for Non-Hispanic White (NHW) and Non-Hispanic Black (NHB) U.S.-born infants. Read More

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September 2021

Impact of correlation of angle α with ocular biometry variables.

J Cataract Refract Surg 2021 Oct;47(10):1279-1284

From the Anterior Segment Surgery Department, Asociación para Evitar la Ceguera en México I.A.P., Mexico City, Mexico.

Purpose: To analyze the association between angle α and ocular biometry in the general population at a third-level ophthalmology hospital.

Setting: Anterior Segment Surgery Department, Asociación para Evitar la Ceguera en México I.A. Read More

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October 2021

Optimizing spatial properties of a new checkerboard-like visual stimulus for user-friendly SSVEP-based BCIs.

J Neural Eng 2021 Sep 20. Epub 2021 Sep 20.

State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, No.A35, QingHua East Road, Haidian District, Beijing P R China , Beijing, 100083, CHINA.

Low-frequency steady-state visual evoked potential (SSVEP)-based brain-computer interface (BCI) systems with high performance are prone to cause visual discomfort and fatigue. High-frequency SSVEP-based BCI systems can alleviate the discomfort, but always obtain lower performance. This study optimized the spatial properties of a proposed checkerboard-like visual stimulus toward high-performance and user-friendly SSVEP-based BCI systems. Read More

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September 2021

Whole-genome resequencing reveals genetic structure and introgression in Pudong White pigs.

Animal 2021 Sep 16;15(10):100354. Epub 2021 Sep 16.

College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong Province, China.

Pudong White (PDW) pigs, historically originating from Shanghai, are the only Chinese indigenous pigs characterised by their completely white coats, with the exception of Rongchang pigs. However, there is limited information concerning their overall genetic structure or relationship with other breeds, especially the East Chinese (ECN) and European pigs. To uncover the genetic structure, selection signatures, and potential exotic introgression in PDW pigs, we sampled 15 PDW pigs using whole-genome sequencing (~20×). Read More

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September 2021

Early detection relationship of cerebral palsy markers using brain structure and general movements in infants born <32 weeks gestational age.

Early Hum Dev 2021 Aug 25;163:105452. Epub 2021 Aug 25.

Department of Rehabilitation, Children's Hospital, Fudan University, Shanghai 201102, China.

Aim: To detect early brain structural and clinical functional markers of brain injury and development based on a magnetic resonance imaging (MRI) scoring system and a general movement assessment (GMA) for preterm infants later diagnosed with cerebral palsy (CP).

Study Design: Retrospective cohort study. General movements (GMs) were scored according to a semiquantitative scoring system: the GMs optimality score (GMOS) at preterm and term ages and the Motor Optimality Score (MOS) at the corrected age of 3 months after birth. Read More

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Quantification of 397 pesticide residues in different types of commercial teas: Validation of high accuracy methods and quality assessment.

Food Chem 2021 Aug 31;370:130986. Epub 2021 Aug 31.

Faculty of Environmental and Food Engineering, Nguyen Tat Thanh University, Ho Chi Minh City, Viet Nam. Electronic address:

Analytical methods with high sensitivity and accuracy were successfully validated for the quantification of 397 pesticides in different types of tea. For the UPLC-MS/MS method, 191 pesticides of 200 ones in total had "soft" matrix effects and could be quantified by calibration curves in the solvent. For the GC-MS/MS method, matrix-matched calibration curves were established on a mixed blank including white, green, oolong and black organic teas. Read More

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Metabolomics profile responses to changing environments in a common bean (Phaseolus vulgaris L.) germplasm collection.

Food Chem 2021 Aug 31;370:131003. Epub 2021 Aug 31.

Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República, 2780-157 Oeiras, Portugal; iBET, Instituto de Biologia Experimental e Tecnológica, Av. da República, Apartado 12, 2781-901 Oeiras, Portugal; Faculdade de Farmácia, Universidade de Lisboa, Av. das Forças Armadas, 1649-019 Lisboa, Portugal. Electronic address:

Metabolomics is one of the most powerful -omics to assist plant breeding. Despite the recognized genetic diversity in Portuguese common bean germplasm, details on its metabolomics profiles are still missing. Aiming to promote their use and to understand the environment's effect in bean metabolomics profiles, 107 Portuguese common bean accessions, cropped under contrasting environments, were analyzed using spectrophotometric, untargeted and targeted mass spectrometry approaches. Read More

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The first case of C4-Blast related death in Malaysia: A multidisciplinary approach illustrated with emphasis on conjoint anthropologic and radiologic expertise in forensic identification of skeletal remains.

J Forensic Leg Med 2021 Sep 15;83:102253. Epub 2021 Sep 15.

National Institute of Forensic Medicine (NIFM), Hospital Kuala Lumpur, Ministry of Health Malaysia, Malaysia.

Background: Blast related deaths are often shrouded by diagnostic and medicolegal complexities requiring multidisciplinary expertise in order to gauge accurate identification of the victims and document scientific investigations comprehensively. In the advent of more sophisticated technology, anthropologic methods can now be applied into post mortem imaging interpretation. The traditional imaging roles of characterizing osseous fragmentation, detecting and localizing foreign bodies can be expanded to simulate and support physical anthropologic examination to assist in documentation for court proceedings. Read More

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September 2021

Ligand fishing via a monolithic column coated with white blood cell membranes: A useful technique for screening active compounds in Astractylodes lancea.

J Chromatogr A 2021 Sep 10;1656:462544. Epub 2021 Sep 10.

Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China. Electronic address:

The cell membrane-coated monolithic column (CMMC) ligand fishing assay is an interesting approach set up for the study of natural products (NPs). NPs such as Atractylodes lancea contain many compounds. Traditional methods used to separate compounds and determine active compounds by pharmacological tests are time-consuming and inefficient. Read More

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September 2021

Screening mammography mitigates breast cancer disparities through early detection of triple negative breast cancer.

Clin Imaging 2021 Aug 30;80:430-437. Epub 2021 Aug 30.

Weill Cornell Medicine, Department of Breast Surgery, 425 E. 61st St., 10th Floor, New York, NY 10065, USA. Electronic address:

Purpose: Screening mammography improves breast cancer survival through early detection, but Triple Negative Breast Cancer (TNBC) is more difficult to detect on mammography and has lower survival compared to non-TNBC, even when detected at early stages. TNBC is twice as common among African American (AA) compared to White American (WA) women, thereby contributing to the 40% higher breast cancer mortality rates observed in AA women. The role of screening mammography in addressing breast cancer disparities is therefore worthy of study. Read More

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Changes in negative symptoms are linked to white matter changes in superior longitudinal fasciculus in individuals at ultra-high risk for psychosis.

Schizophr Res 2021 Sep 17;237:192-201. Epub 2021 Sep 17.

Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS, and Center for Neuropsychiatric Schizophrenia Research, CNSR, Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark; Melbourne Neuropsychiatry Center, Department of Psychiatry, The University of Melbourne, and Melbourne Health, Carlton South, Victoria, Australia; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Aim: Growing evidence suggests that subtle white matter (WM) alterations are associated with psychopathology in individuals at ultra-high risk for psychosis (UHR). However, the longitudinal relationship between symptom progression and WM changes over time remains under-explored. Here, we examine associations between changes in clinical symptoms and changes in WM over six months in a large UHR-cohort. Read More

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September 2021

Using fiber tractography and diffusion kurtosis imaging to evaluate neuroimaging changes in patients with cerebrotendinous xanthomatosis after stopping chenodeoxycholic acid treatment for three years.

Biomed J 2021 Sep 17. Epub 2021 Sep 17.

Department of Neurology, Chang-Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:

Background: The aim of this study was to use tractography and diffusion kurtosis imaging (DKI) to evaluate cerebral white matter (WM) changes in patients with cerebrotendinous xanthomatosis (CTX) after stopping chenodeoxycholic acid (CDCA) treatment.

Material And Methods: Two siblings with CTX aged 40 and 38 years, respectively, who had been diagnosed with CTX for 16 years were enrolled. They had received CDCA treatment from 2005 until 2015, after which CDCA was no longer available in Taiwan. Read More

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September 2021

The Society for Vascular Surgery Objective Performance Goals for Critical Limb Ischemia are attainable in select patients with ischemic wounds managed with wound care alone.

Ann Vasc Surg 2021 Sep 17. Epub 2021 Sep 17.

Division of Vascular Surgery, Department of Surgery, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC. Electronic address:

Objectives: To set therapeutic benchmarks, in 2009 the Society for Vascular Surgery defined objective performance goals (OPG) for treatment of patients with chronic limb threatening ischemia (CLTI) with either open surgical bypass or endovascular intervention. The goal of these OPGs are to set standards of care from a revascularization standpoint and to provide performance benchmarks for 1 year patency rates for new endovascular therapies. While OPGs are useful in this regard, a critical decision point in the treatment of patients with CLTI is determining when revascularization is necessary. Read More

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September 2021

Kidney Disease, Hypertension Treatment, and Cerebral Perfusion and Structure.

Am J Kidney Dis 2021 Sep 17. Epub 2021 Sep 17.

Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia PA.

Rationale And Objective: The safety of intensive blood pressure (BP) targets is controversial for persons with chronic kidney disease (CKD). We studied the effects of hypertension treatment on cerebral perfusion and structure in those with and without CKD.

Study Design: Neuroimaging substudy of a randomized trial. Read More

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September 2021

CKD Progression From the Time of Estimated GFR-Based Waitlist Eligibility and Racial Disparities in Transplant Access.

Am J Kidney Dis 2021 Sep 17. Epub 2021 Sep 17.

Department of Medicine, University of California, San Francisco, San Francisco, CA; Department of Medicine, Priscilla Chan and Mark Zuckerberg San Francisco General Hospital, San Francisco, CA; Center for Vulnerable Populations, University of California, San Francisco, San Francisco, CA.

Rationale & Objective: eGFR equations that incorporate a term for race assign a higher value to Black individuals compared to non-Black individuals not attributable to sex, age, or serum creatinine. This difference may contribute to racial disparities in kidney transplant access. We sought to 1) compare time from meeting a transplant eligibility threshold of eGFR ≤20 ml/min/1. Read More

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September 2021

Replicating prediction algorithms for hospitalization and corticosteroid use in patients with inflammatory bowel disease.

PLoS One 2021 20;16(9):e0257520. Epub 2021 Sep 20.

University of Michigan Health System, Ann Arbor, Michigan, United States of America.

Introduction: Previous work had shown that machine learning models can predict inflammatory bowel disease (IBD)-related hospitalizations and outpatient corticosteroid use based on patient demographic and laboratory data in a cohort of United States Veterans. This study aimed to replicate this modeling framework in a nationally representative cohort.

Methods: A retrospective cohort design using Optum Electronic Health Records (EHR) were used to identify IBD patients, with at least 12 months of follow-up between 2007 and 2018. Read More

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September 2021

Reference and point-of-care testing for G6PD deficiency: Blood disorder interference, contrived specimens, and fingerstick equivalence and precision.

PLoS One 2021 20;16(9):e0257560. Epub 2021 Sep 20.

PATH, Seattle, Washington, United States of America.

Certain clinical indications and treatments such as the use of rasburicase in cancer therapy and 8-aminoquinolines for Plasmodium vivax malaria treatment would benefit from a point-of-care test for glucose-6-phosphate dehydrogenase (G6PD) deficiency. Three studies were conducted to evaluate the performance of one such test: the STANDARD™ G6PD Test (SD BIOSENSOR, South Korea). First, biological interference on the test performance was evaluated in specimens with common blood disorders, including high white blood cell (WBC) counts. Read More

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September 2021

Empathy and its associations with age and sociodemographic characteristics in a large UK population sample.

PLoS One 2021 20;16(9):e0257557. Epub 2021 Sep 20.

Department of Behavioural Science and Health, University College London, London, United Kingdom.

Objectives: Empathy is fundamental to social cognition, driving prosocial behaviour and mental health but associations with aging and other socio-demographic characteristics are unclear. We therefore aimed to characterise associations of these characteristics with two main self-reported components of empathy, namely empathic-concern (feeling compassion) and perspective-taking (understanding others' perspective).

Methods: We asked participants in an internet-based survey of UK-dwelling adults aged ≥18 years to complete the Interpersonal Reactivity Index subscales measuring empathic concern and perspective taking, and sociodemographic and personality questionnaires. Read More

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September 2021

Racial and ethnic disparities in HIV diagnoses among heterosexually active persons in the United States nationally and by state, 2018.

PLoS One 2021 20;16(9):e0257583. Epub 2021 Sep 20.

Center for Collaborative HIV Research in Practice and Policy, School of Public Health, University at Albany, Albany, New York, United States of America.

Background: Despite declining HIV infection rates, persistent racial and ethnic disparities remain. Appropriate calculations of diagnosis rates by HIV transmission category, race and ethnicity, and geography are needed to monitor progress towards reducing systematic disparities in health outcomes. We estimated the number of heterosexually active adults (HAAs) by sex and state to calculate appropriate HIV diagnosis rates and disparity measures within subnational regions. Read More

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September 2021

A multi-component, community-based strategy to facilitate COVID-19 vaccine uptake among Latinx populations: From theory to practice.

PLoS One 2021 20;16(9):e0257111. Epub 2021 Sep 20.

Division of HIV, Infectious Diseases and Global Medicine, Zuckerberg San Francisco General Hospital and Trauma Center, University of California San Francisco, San Francisco, California, United States of America.

Background: COVID-19 vaccine coverage in the Latinx community depends on delivery systems that overcome barriers such as institutional distrust, misinformation, and access to care. We hypothesized that a community-centered vaccination strategy that included mobilization, vaccination, and "activation" components could successfully reach an underserved Latinx population, utilizing its social networks to boost vaccination coverage.

Methods: Our community-academic-public health partnership, "Unidos en Salud," utilized a theory-informed approach to design our "Motivate, Vaccinate, and Activate" COVID-19 vaccination strategy. Read More

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September 2021

Levels of SARS-CoV-2 population exposure are considerably higher than suggested by seroprevalence surveys.

PLoS Comput Biol 2021 Sep 20;17(9):e1009436. Epub 2021 Sep 20.

Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Accurate knowledge of prior population exposure has critical ramifications for preparedness plans for future SARS-CoV-2 epidemic waves and vaccine prioritization strategies. Serological studies can be used to estimate levels of past exposure and thus position populations in their epidemic timeline. To circumvent biases introduced by the decay in antibody titers over time, methods for estimating population exposure should account for seroreversion, to reflect that changes in seroprevalence measures over time are the net effect of increases due to recent transmission and decreases due to antibody waning. Read More

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September 2021

REadmission PREvention in SepSis: Development and Validation of a Prediction Model.

J Healthc Qual 2021 Sep 15. Epub 2021 Sep 15.

Abstract: Hospital 30-day readmissions remain a major quality and cost indicator. Traditional readmission risk scores, such as LACE (length of stay, acuity of admission, Charlson comorbidity index, and emergency department visits), may be suboptimal in special patient populations, such as those with sepsis. As sepsis survivorship improves, there is a need to determine which variables might be associated with a decrease in 30-day readmission. Read More

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September 2021

The acute paraquat poisoning mortality (APPM) score to predict the risk of death in paraquat-poisoned patients.

Clin Toxicol (Phila) 2021 Sep 20:1-5. Epub 2021 Sep 20.

Department of Emergency Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Context: Mortality prediction in paraquat poisoning is a major issue since most prediction rules are inapplicable if the exact ingestion time cannot be determined and/or the serum paraquat concentration is not readily available, as in most countries. Therefore, we aimed to develop and validate a new prediction rule not requiring these two parameters.

Methods: We designed a 10-year observational cohort study including all consecutive paraquat-poisoned patients managed in two Taiwanese hospitals. Read More

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September 2021

A Multiple Excited-State Engineering of Boron-Functionalized Diazapentacene Via a Tuning of the Molecular Orbital Coupling.

J Phys Chem Lett 2021 Sep 20:9308-9314. Epub 2021 Sep 20.

School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, People's Republic of China.

Harvesting high-energy excited-state energy is still challenging in organic chromophores. An introduction of boron atoms along the short axis of the diazapentacene backbone induces multiple emission characteristics. Our studies reveal that the weak molecular orbital (MO) coupling of the S-S transition is responsible for the slow internal conversion rates. Read More

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September 2021

Thiamine deficiency in Gambian women of reproductive age.

Ann N Y Acad Sci 2021 Sep 20. Epub 2021 Sep 20.

MRC Unit The Gambia at London School of Hygiene & Tropical Medicine, Banjul, The Gambia.

Thiamine deficiency disorders are associated with a variety of clinical symptoms affecting the nervous and cardiovascular systems. There is growing recognition that thiamine deficiency can occur in populations well beyond the classical region of South Asia, and at-risk populations include those who receive a large proportion of their energy from polished white rice (or other low-thiamine staple foods) and with low dietary diversity. Reports of thiamine deficiency in West Africa over the last century have suggested that this has historically been an issue in this population, but in more recent decades, these reports have been limited to prison populations. Read More

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September 2021

Correlations of Serological Markers with Development of Systemic Involvement in Adult Immunoglobulin A Vasculitis: A Retrospective Study of 259 Patients in Central China.

Curr Med Sci 2021 Sep 20. Epub 2021 Sep 20.

Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Objective: Although relatively rare, adult immunoglobulin A vasculitis (IgAV) can lead to severe complications and longer hospitalization, and result in poor prognosis, when compared to childhood IgAV. Hence, early identification and prevention for patients prone to develop systemic involvement are essential. The purpose of this study was to explore the correlations of common serological markers with the development of systemic involvement in adult IgAV. Read More

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September 2021

Development and Validation of a PET/SPECT Radiopharmaceutical in Oncology.

Mol Imaging Biol 2021 Sep 20. Epub 2021 Sep 20.

Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, 48201, USA.

In oncology, biomarker research aimed to provide insights on cancer biology via positron emission tomography (PET) and single photon emission tomography (SPECT) imaging has seen an incredible growth in the past two decades. Despite the increased number of publications on PET/SPECT radiopharmaceuticals, the field lacked standardization of in vitro and in vivo parameters necessary for the characterization of any radiotracer. Through the efforts of the World Molecular Imaging Society Education Committee, this white paper lays down validation studies that are essential to chemically and biologically characterize new radiopharmaceuticals derived from small molecules, peptides or proteins. Read More

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September 2021

Change in Alcohol Use Based on Self-Report and a Quantitative Biomarker, Phosphatidylethanol, in People With HIV.

AIDS Behav 2021 Sep 20. Epub 2021 Sep 20.

Yale School of Medicine, New Haven, CT, USA.

The timeline followback (TLFB) takes more resources to collect than the Alcohol Use Disorder Identification Test (AUDIT-C). We assessed agreement of TLFB and AUDIT-C with the biomarker phosphatidylethanol (PEth) and compared changes in TLFB and PEth among persons with HIV (PWH) using secondary data from randomized trials. We calculated operating characteristics and agreement between TLFB (> 1 and > 2 average drinks/day), AUDIT-C ≥ 4 and PEth ≥ 20 among 275 men with HIV. Read More

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September 2021

Influence of Biological Model on the Formation of the Pathogenic Properties of the West Nile Virus Isolate.

Bull Exp Biol Med 2021 Sep 20. Epub 2021 Sep 20.

N. I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow Region, Russia.

Various biological models are used to isolate West Nile virus, but their role as a selection factor that facilitates selection of isolates with certain properties is usually not evaluated. We compared pathogenic properties of three strains of the West Nile virus obtained from one sample of virus-containing material using different models: WNV Volgograd 900m/18 (on the model of suckling mice), WNV Volgograd 900a/18 (on C6/36 cells) and WNV Volgograd 900v/18 (on Vero cells). WNV Volgograd 900m/18 strain demonstrated virulent (LD 5×10±0. Read More

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September 2021