19,831,603 results match your criteria ρ-oh-r humans


Environmental contamination and human exposure of polychlorinated biphenyls (PCBs) in China: A review.

Sci Total Environ 2021 Sep 11;805:150270. Epub 2021 Sep 11.

Key Laboratory of Ministry of Education on Pollution Control and Ecosystem Restoration in Industry Clusters, Guangdong Provincial Key Laboratory of Solid Wastes Pollution Control and Recycling, School of Environment and Energy, South China University of Technology, Guangzhou 510006, Guangdong, China.

Polychlorinated biphenyls (PCBs), together with 11 other organic compounds, were initially listed as persistent organic pollutants (POPs) by the Stockholm Convention because of their potential threat to ecosystems and humans. In China, many monitoring studies have been undertaken to reveal the level of PCBs in environment since 2005 due to the introduced stricter environmental regulations. However, there are still significant gaps in understanding the overall spatial and temporal distributions of PCBs in China. Read More

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September 2021

Occurrence of microplastics in commercial marine dried fish in Asian countries.

J Hazard Mater 2021 Sep 2;423(Pt B):127093. Epub 2021 Sep 2.

Department of Oceanography, National Sun Yat-sen University, 70 Lien-hai Rd., Kaohsiung 80424, Taiwan, ROC. Electronic address:

The major risk of microplastics in marine environments is the bioaccumulation in marine organisms. Plastic ingestion by marine organisms has been investigated and recently more attention has been given to microplastics in seafood. However, it is seldom reported the occurrence of microplastics in marine commercial dried fish products available for human consumption. Read More

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September 2021

Ruminant farmers' knowledge, attitude and practices towards zoonotic diseases in Selangor, Malaysia.

Prev Vet Med 2021 Sep 6;196:105489. Epub 2021 Sep 6.

Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400, UPM, Serdang, Selangor, Malaysia. Electronic address:

This study aimed to assess knowledge, attitude and practices about zoonotic diseases and associated factors among ruminant farmers in Selangor, Malaysia. A cross-sectional survey was conducted between January 2018 and December 2020. The survey was developed in English and Malay, validated, administered to ruminant farmers in Selangor. Read More

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September 2021

Mercury and selenium in squids from the Pacific Ocean and Indian Ocean: The distribution and human health implications.

Mar Pollut Bull 2021 Sep 16;173(Pt A):112926. Epub 2021 Sep 16.

College of Marine Science, Shanghai Ocean University, Shanghai 201306, China.

Squids are globally distributed. Hg-contaminated squids may have high risks on humans. With abundant Se (antagonistic effect on Hg), the risks can be reduced. Read More

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September 2021

Diurnal variations of cold-induced thermogenesis in young, healthy adults: A randomized crossover trial.

Clin Nutr 2021 Aug 24;40(10):5311-5321. Epub 2021 Aug 24.

PROFITH "PRO-moting FITness and Health Through Physical Activity" Research Group, Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sports Science, University of Granada, Granada, Spain. Electronic address:

Background: Harnessing cold-induced thermogenesis (CIT) and brown adipose tissue (BAT) activity has been proposed as a means of counteracting a positive energy balance, and thus of combating obesity and its related comorbidities. However, it has remained unclear whether CIT and BAT activity show diurnal variation in humans - knowledge that might allow treatments based on these factors to be time-optimized.

Methods: A randomized crossover experiment was designed to examine whether CIT shows morning/evening variation in young, healthy adults (n = 14, 5 women). Read More

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Talaromyces stipitatus, a novel agent causing superficial mycosis in a diabetic patient from North India.

Microbes Infect 2021 Sep 15:104887. Epub 2021 Sep 15.

Department of Botany, University of Jammu, Jammu, Jammu and Kashmir, 180006, India. Electronic address:

Among millions of reported fungal species, only a few hundred species are capable of causing diseases in humans and animals that range from superficial to life-threatening infections. Both immunocompetent as well as immunocompromised patients with underlying diseases, such as AIDS, diabetes, etc., are at higher risk of acquiring fungal infections. Read More

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September 2021

Ageing: Not only an age-related issue.

Mech Ageing Dev 2021 Sep 15;199:111568. Epub 2021 Sep 15.

School of Applied Psychology, University College Cork, North Mall Campus, Cork, Ireland. Electronic address:

Developments in the last century have led to an unprecedented increase in life expectancy. These changes open opportunities for humans to grow and develop in healthy and adaptive ways, adding life to years as well as years to life. There are also challenges, however - as we live longer, a greater number of people will experience chronic illness and disability, often linked to lifestyle factors. Read More

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September 2021

Early postnatal hypothyroidism reduces juvenile play behavior, but prenatal hypothyroidism compensates for these effects.

Physiol Behav 2021 Sep 15:113594. Epub 2021 Sep 15.

Biology Department and Neuroscience Program, Mercer University, 1501 Mercer University Dr., Macon, GA 31207 USA.

Perinatal hypothyroidism causes long-lasting effects on behavior, including hyperactivity, cognitive delays/deficits, and a reduction in anxiety. Although there is some evidence that hypothyroidism during fetal development in humans has been associated with later autism spectrum disorder diagnosis or autism-like traits, the relationships between early thyroid hormones and social behaviors are largely unknown. Previously, we found that a moderate dose of the hypothyroid-inducing drug methimazole during embryonic and postnatal development dramatically increased juvenile play in male and female rats. Read More

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September 2021

Phylogenetic analysis of West Nile virus: first report of lineage 1 in donkey in Turkey.

Trop Anim Health Prod 2021 Sep 18;53(5):453. Epub 2021 Sep 18.

Department of Virology, Izmir/Bornova Veterinary Control Institute, Izmir, Turkey.

West Nile virus (WNV), a member of the Flaviviridae, is a major arbovirus that causes West Nile fever. Previous data showed the prevalence of the WNV serologically and molecular in Turkey, and the presence of lineage 1 in horses and humans has been reported. This is the first notification of partial phylogeny of WNV detected in donkeys in the northeast of Turkey (on the Iranian border). Read More

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September 2021

Successful pregnancy after ovulation induction with human chorionic gonadotropin in a woman with selective luteinising hormone deficiency.

Hum Reprod 2021 Sep 18. Epub 2021 Sep 18.

Department of Endocrinology and Metabolism, University Hospital of Brasília, Brasília, Brazil.

Selective LH deficiency has been described in several men, but only in two women who presented normal pubertal development but secondary amenorrhoea due to anovulation. Despite its rarity, this condition represents a valuable model for studying the processes regulated by FSH or LH during late folliculogenesis and ovulation in humans. A woman previously diagnosed with selective LH deficiency due to a homozygous germline splice site mutation in LHB (IVS2 + 1G→C mutation) was submitted to an individualised ovarian induction protocol, first with recombinant LH and then with highly purified urinary hCG. Read More

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September 2021

Prevalence and multilocus sequence typing of Clostridium perfringens isolated from retail chicken products and diseased chickens in Tai'an region, China.

Vet Med Sci 2021 Sep 18. Epub 2021 Sep 18.

Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Tai'an, Shandong Agricultural University, China.

Background: Clostridium perfringens is an important zoonotic microorganism, which can cause diseases in animals and humans under suitable conditions. Contamination of C. perfringens in chicken products has been reported worldwide, but the genetic diversity and relationship of isolates were seldom analyzed. Read More

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September 2021

Human intestinal and circulating invariant Natural Killer T cells are cytotoxic against colorectal cancer cells via the perforin-granzyme pathway.

Mol Oncol 2021 Sep 18. Epub 2021 Sep 18.

Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, 20139, Milan, Italy.

Invariant Natural Killer T (iNKT) cells are lipid-specific T lymphocytes endowed with cytotoxic activities, and are thus considered important in antitumor immunity. While several studies have demonstrated iNKT cell cytotoxicity against different tumors, very little is known about their cell-killing activities in human colorectal cancer (CRC). Our aim was to assess whether human iNKT cells are cytotoxic against colon cancer cells and the mechanisms underlying this activity. Read More

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September 2021

Pax2a, but not pax2b, influences cell survival and periocular mesenchyme localization to facilitate zebrafish optic fissure closure.

Dev Dyn 2021 Sep 18. Epub 2021 Sep 18.

Department of Human Genetics, University of Utah, Salt Lake City, UT.

Background: Pax2 is required for optic fissure development in many organisms, including humans and zebrafish. Zebrafish loss-of-function mutations in pax2a display coloboma, yet the etiology of the morphogenetic defects is unclear. Further, pax2 is duplicated in zebrafish, and a role for pax2b in optic fissure development has not been examined. Read More

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September 2021

Colonic inflammation induces changes in glucose levels through modulation of incretin system.

Pharmacol Rep 2021 Sep 17. Epub 2021 Sep 17.

Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6/8, 92-215, Lodz, Poland.

Background: The role of the incretin hormone, glucagon-like peptide (GLP-1), in Crohn's disease (CD), is still poorly understood. The aim of this study was to investigate whether colitis is associated with changes in blood glucose levels and the possible involvement of the incretin system as an underlaying factor.

Methods: We used a murine model of colitis induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS). Read More

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September 2021

Erythrocyte flow through the interendothelial slits of the splenic venous sinus.

Biomech Model Mechanobiol 2021 Sep 18. Epub 2021 Sep 18.

Department of Structural Engineering, University of California, San Diego, La Jolla, CA, 92093, USA.

The flow patterns of red blood cells through the spleen are intimately linked to clearance of senescent RBCs, with clearance principally occurring within the open flow through the red pulp and slits of the venous sinus system that exists in humans, rats, and dogs. Passage through interendothelial slits (IESs) of the sinus has been shown by MacDonald et al. (Microvasc Res 33:118-134, 1987) to be mediated by the caliber, i. Read More

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September 2021

Retained medullary cord and terminal myelocystocele as a spectrum: case report.

Childs Nerv Syst 2021 Sep 17. Epub 2021 Sep 17.

Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, 101 Daehak-ro, Jongno-gu, 03080, Seoul, Republic of Korea.

The caudal portion of the spinal cord, the medullary cord, is formed by secondary neurulation. One of the distinctive features of secondary neurulation compared to primary neurulation is that the medullary cord normally degenerates into a filum in humans. Various anomalies have been known to originate from degenerating process errors. Read More

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September 2021

Stable isotope tracing to assess tumor metabolism in vivo.

Nat Protoc 2021 Sep 17. Epub 2021 Sep 17.

Children's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Cancer cells undergo diverse metabolic adaptations to meet the energetic demands imposed by dysregulated growth and proliferation. Assessing metabolism in intact tumors allows the investigator to observe the combined metabolic effects of numerous cancer cell-intrinsic and -extrinsic factors that cannot be fully captured in culture models. We have developed methods to use stable isotope-labeled nutrients (e. Read More

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September 2021

Discovery of a small protein-encoding cis-regulatory overlapping gene of the tumor suppressor gene Scribble in humans.

Commun Biol 2021 Sep 17;4(1):1098. Epub 2021 Sep 17.

Biomolecular Characterization Unit, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.

Intensive gene annotation has revealed many functional and regulatory elements in the human genome. Although eukaryotic protein-coding genes are generally transcribed into monocistronic mRNAs, recent studies have discovered additional short open reading frames (sORFs) in mRNAs. Here, we performed proteogenomic data mining for hidden proteins categorized into sORF-encoded polypeptides (SEPs) in human cancers. Read More

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September 2021

Larger muscle fibers and fiber bundles manifest smaller elastic modulus in paraspinal muscles of rats and humans.

Sci Rep 2021 Sep 17;11(1):18565. Epub 2021 Sep 17.

Department of Mechanical Engineering, University of British Columbia, Vancouver, Canada.

The passive elastic modulus of muscle fiber appears to be size-dependent. The objectives of this study were to determine whether this size effect was evident in the mechanical testing of muscle fiber bundles and to examine whether the muscle fiber bundle cross-section is circular. Muscle fibers and fiber bundles were extracted from lumbar spine multifidus and longissimus of three cohorts: group one (G1) and two (G2) included 13 (330 ± 14 g) and 6 (452 ± 28 g) rats, while Group 3 (G3) comprised 9 degenerative spine patients. Read More

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September 2021

Cross-species behavior analysis with attention-based domain-adversarial deep neural networks.

Nat Commun 2021 Sep 17;12(1):5519. Epub 2021 Sep 17.

Graduate School of Brain Science, Doshisha University, Kyoto, Japan.

Since the variables inherent to various diseases cannot be controlled directly in humans, behavioral dysfunctions have been examined in model organisms, leading to better understanding their underlying mechanisms. However, because the spatial and temporal scales of animal locomotion vary widely among species, conventional statistical analyses cannot be used to discover knowledge from the locomotion data. We propose a procedure to automatically discover locomotion features shared among animal species by means of domain-adversarial deep neural networks. Read More

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September 2021

Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions.

Nat Commun 2021 Sep 17;12(1):5501. Epub 2021 Sep 17.

Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.

Fibrotic scar tissue limits central nervous system regeneration in adult mammals. The extent of fibrotic tissue generation and distribution of stromal cells across different lesions in the brain and spinal cord has not been systematically investigated in mice and humans. Furthermore, it is unknown whether scar-forming stromal cells have the same origin throughout the central nervous system and in different types of lesions. Read More

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September 2021

Electrophysiological biomarkers of behavioral dimensions from cross-species paradigms.

Transl Psychiatry 2021 Sep 17;11(1):482. Epub 2021 Sep 17.

Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, USA.

There has been a fundamental failure to translate preclinically supported research into clinically efficacious treatments for psychiatric disorders. One of the greatest impediments toward improving this species gap has been the difficulty of identifying translatable neurophysiological signals that are related to specific behavioral constructs. Here, we present evidence from three paradigms that were completed by humans and mice using analogous procedures, with each task eliciting candidate a priori defined electrophysiological signals underlying effortful motivation, reinforcement learning, and cognitive control. Read More

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September 2021

Does Oral Monosodium Glutamate Have a Cochleotoxic Effect? An Experimental Study.

Audiol Neurootol 2021 Sep 14:1-13. Epub 2021 Sep 14.

Department of Otorhinolaryngology, Head and Neck Surgery, Trakya University Faculty of Medicine, Edirne, Turkey.

Introduction: The effect of orally consumed monosodium glutamate (MSG), which is a common additive in the food industry, on the cochlea has not been investigated. The present study aimed to investigate the possible cochleotoxic effects of oral MSG in guinea pigs using electrophysiological, biochemical, and histopathological methods.

Methods: Thirty guinea pigs were equally divided into control and intervention groups (MSG 100 mg/kg/day; MSG 300 mg/kg/day). Read More

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September 2021

Safety and effectiveness of dose-sparing strategies for intramuscular seasonal influenza vaccine: a rapid scoping review.

BMJ Open 2021 Sep 17;11(9):e050596. Epub 2021 Sep 17.

Knowledge Translation Program, St Michael's Hospital, Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada.

Background: The objective of this rapid scoping review was to identify studies of dose-sparing strategies for administration of intramuscular seasonal influenza vaccines in healthy individuals of all ages.

Methods: Comprehensive literature searches were executed in MEDLINE, Embase and the Cochrane library. The grey literature was searched via international clinical trial registries for relevant studies published in English in the last 20 years. Read More

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September 2021

Ongoing host-shift speciation in Plasmodium simium.

Trends Parasitol 2021 Sep 14. Epub 2021 Sep 14.

Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; Global Health and Tropical Medicine, Institute of Hygiene and Tropical Medicine, Nova University of Lisbon, Lisbon, Portugal. Electronic address:

Plasmodium simium, a malaria parasite that infects platyrrhine monkeys and humans in the New World, is nearly identical to Plasmodium vivax. Recent genomic comparative analyses of these sister species have identified elevated divergence in a gene that may underlie P. simium adaptation to non-human primates during its gradual speciation process. Read More

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September 2021

Severe Acute Respiratory Syndrome Coronavirus 2: Manifestations of Disease and Approaches to Treatment and Prevention in Humans.

Comp Med 2021 Sep 17. Epub 2021 Sep 17.

The coronavirus disease 2019 (COVID-19) pandemic was caused by a novel coronavirus, severe acute respiratory syndromecoronavirus 2 (SARS-CoV-2). This virus has challenged civilization and modern science in ways that few infectious diseases and natural disasters have previously, causing globally significant human morbidity and mortality and triggering economic downturns across financial markets that will be dealt with for generations. Despite this, the pandemic has also brought an opportunity for humanity to come together and participate in a shared scientific investigation. Read More

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September 2021

Mixture toxicity, cumulative risk, and environmental justice in United States federal policy, 1980-2016 : Why, with much known, was little done?

Environ Health 2021 Sep 17;20(1):104. Epub 2021 Sep 17.

Maryland Institute for Applied Environmental Health, School of Public Health, University of Maryland, College Park, MD, 20742, USA.

Toxic chemicals - "toxicants" - have been studied and regulated as single entities, and, carcinogens aside, almost all toxicants, single or mixed and however altered, have been thought harmless in very low doses or very weak concentrations. Yet much work in recent decades has shown that toxicants can injure wildlife, laboratory animals, and humans following exposures previously expected to be harmless. Additional work has shown that toxicants can act not only individually and cumulatively but also collectively and even synergistically and that they affect disadvantaged communities inordinately - and therefore, as argued by reformers, unjustly. Read More

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September 2021

Plasma fibulin-1 levels during pregnancy and delivery: a longitudinal observational study.

BMC Pregnancy Childbirth 2021 Sep 17;21(1):629. Epub 2021 Sep 17.

Department of Clinical Biochemistry, Copenhagen University Hospital Holbaek, Holbaek, Denmark.

Background: Fibulin-1 is an extracellular matrix protein expressed at high levels in the placenta. Elevated circulating fibulin-1 have been observed in women with severe pre-eclampsia, whereas low levels have been found in the fetal membranes, prior to membrane rupture. The aim of the study was primarily to evaluate plasma fibulin-1 during expected normal pregnancy and delivery, and secondarily to explore fibulin-1 levels in women developing pre-eclampsia or preterm premature rupture of fetal membranes (PPROM). Read More

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September 2021

DNA damage repair system in C57BL/6 J mice is evolutionarily stable.

BMC Genomics 2021 Sep 17;22(1):669. Epub 2021 Sep 17.

Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau.

Background: DNA damage repair (DDR) system is vital in maintaining genome stability and survival. DDR consists of over 160 genes in 7 different pathways to repair specific type of DNA damage caused by external and internal damaging factors. The functional importance of DDR system implies that evolution could play important roles in maintaining its functional intactness to perform its function. Read More

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September 2021