N Engl J Med 2013 Nov;369(21):1991-2000
From the Department of Medicine, Brigham and Women's Hospital (C.E.P.), Division of Nephrology, Massachusetts General Hospital (J.W., H.T., I.B., R.T.), Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School (A.H.B.), Division of Nephrology, Beth Israel Deaconess Medical Center (D.Z., S.A.K.), and Howard Hughes Medical Institute (D.Z., S.A.K.) - all in Boston; the Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore (M.K.E., A.B.Z.); the Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD (M.N.); and the Department of Medicine, San Francisco General Hospital and University of California, San Francisco, San Francisco (N.R.P.).
Background: Low levels of total 25-hydroxyvitamin D are common among black Americans. Vitamin D-binding protein has not been considered in the assessment of vitamin D deficiency.
Methods: In the Healthy Aging in Neighborhoods of Diversity across the Life Span cohort of blacks and whites (2085 participants), we measured levels of total 25-hydroxyvitamin D, vitamin D-binding protein, and parathyroid hormone as well as bone mineral density (BMD). Read More