63,219 results match your criteria αΑ66-80 examined

Characterising patterns of alcohol use among heavy drinkers: A cluster analysis utilising alcohol biosensor data.

Drug Alcohol Rev 2021 May 14. Epub 2021 May 14.

Department of Behavioral and Social Sciences, Center for Alcohol and Addiction Studies, Brown University School of Public Health, Providence, USA.

Introduction: Previous research has predominately relied on person-level or single characteristics of drinking episodes to characterise patterns of drinking that may confer risk. This research often relies on self-report measures. Advancements in wearable alcohol biosensors provide a multi-faceted objective measure of drinking. Read More

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Lipid profile of sperm cells in Thai native and commercial roosters and its impact on cryopreserved semen quality.

Trop Anim Health Prod 2021 May 14;53(2):321. Epub 2021 May 14.

Department of Animal Science, Faculty of Agriculture, Khon Kaen University, Khon Kaen, Thailand.

Plasma membrane lipids are the key factor in the ability of chicken sperm to be frozen. They ensure fluidity and flexibility of the sperm membrane for effective viability and motility during in vitro storage. The objective of this study was to compare the lipid profiles of different native and commercial chicken breeds: native Thai (Pradu Hang Dam) roosters and commercial (Rhode Island Red) roosters, with respect to their frozen sperm quality. Read More

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Ambulatory activity in stroke survivors associated with functional outcome and quality of life: an observational cohort study.

Ann Phys Rehabil Med 2021 May 10:101540. Epub 2021 May 10.

The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria, Australia; Department of Neurology, Austin Health, Heidelberg, Victoria, Australia.

Background: Physical activity is beneficial in stroke prevention and recovery. Understanding activity dynamics and its effect on outcome after stroke is important to improve recommendations and develop interventions.

Objectives: We examined serial changes in daily ambulatory activity (AA) averaged over 1 week in people with subacute to chronic stroke and its association with functional outcome (modified Rankin scale [mRS]) and quality of life (EQ-5D-3L). Read More

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Common genetic variants associated with obesity in an African-American and Hispanic/Latino population.

PLoS One 2021 13;16(5):e0250697. Epub 2021 May 13.

Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America.

Introduction: Over 35% of all adults in the world are currently obese and risk of obesity in racial or ethnic minority groups exist in the US, but the causes of these differences are not all known. As obesity is a leading cause of cardiovascular disease, an improved understanding of risk factors across racial and ethnic groups may improve outcomes.

Objective: The objective of this study was to determine if susceptibility to obesity is associated with genetic variation in candidate single nucleotide polymorphisms (SNPs) in African Americans and Hispanic/Latinos. Read More

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The human WNT5A isoforms display similar patterns of expression but distinct and overlapping activities in normal human osteoblasts.

J Cell Biochem 2021 May 13. Epub 2021 May 13.

Department of Biology, University of North Carolina Greensboro, Greensboro, North Carolina, USA.

WNT5A activates noncanonical Wnt signaling pathways and has critical functions in early development, differentiation, and tissue homeostasis. Two major WNT5A protein isoforms, which in this study we term WNT5A-L(A) and WNT5A-S(B), have been identified that differ by 18 AA at their amino terminus. Functional differences between the isoforms have been indicated in studies utilizing cancer cell lines but the activities of the isoforms in normal cells and during differentiation have not been explored. Read More

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Scorpion Venom Antimicrobial Peptides Induce Siderophore Biosynthesis and Oxidative Stress Responses in Escherichia coli.

mSphere 2021 May 12;6(3). Epub 2021 May 12.

Biomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield, United Kingdom

The increasing development of microbial resistance to classical antimicrobial agents has led to the search for novel antimicrobials. Antimicrobial peptides (AMPs) derived from scorpion and snake venoms offer an attractive source for the development of novel therapeutics. Smp24 (24 amino acids [aa]) and Smp43 (43 aa) are broad-spectrum AMPs that have been identified from the venom gland of the Egyptian scorpion and subsequently characterized. Read More

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A Prospective Study of Predictors and Consequences of Hooking Up for Sexual Minority Women.

Arch Sex Behav 2021 May 11. Epub 2021 May 11.

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.

Hooking up, which refers to a sexual encounter (ranging from kissing to penetrative sex) between individuals who are not in a committed relationship, is an increasingly normative form of sexual exploration among emerging adults. Past research has focused on hookups within a heteronormative context, and some of this work has examined hookups as a way to cope with distress. Building on this work, we examined the role of hookups as a means for lesbian and bisexual women to cope with minority stress through increasing connection and engagement with the LGBTQ (lesbian/gay/bisexual/transgender/queer or questioning) community. Read More

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Examining the heterogeneity of polysubstance use patterns in young adulthood by age and college attendance.

Exp Clin Psychopharmacol 2021 May 10. Epub 2021 May 10.

Center for Alcohol and Addiction Studies, Brown University School of Public Health.

Substance use in young adulthood and polysubstance users (PSU), in particular, pose unique risks for adverse consequences. Prior research on young adult PSU has identified multiple classes of users, but most work has focused on college students. We examined PSU patterns by age and college attendance during young adulthood in two nationally representative samples. Read More

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Genotype Distribution of Vitamin D Receptor Polymorphisms among Indonesian Patients with Chronic Hepatitis B.

Rep Biochem Mol Biol 2021 Jan;9(4):463-469

Department of Clinical Pathology, Faculty of Medicine, Universitas Riau, Pekanbaru, Indonesia.

Background: Chronic hepatitis B is a necro-inflammatory of the liver parenchyma caused by hepatitis B virus (HBV) infection leading to liver cirrhosis and hepatocellular carcinoma (HCC). Genetic variants including single nucleotide polymorphisms (SNPs) within genes regulating immune response may contribute to the progression of chronic hepatitis B (CHB) infection. This study aimed to examine the genotype distribution of vitamin D receptor (VDR) polymorphism among patients with CHB infection and to study its association with the development of cirrhosis and hepatoma. Read More

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January 2021

Feasibility of Methylated in Stool for Early Detection of Colorectal Cancer: A Training Study in Chinese Population.

Front Oncol 2021 22;11:647066. Epub 2021 Apr 22.

Department of Gastroenterology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Background: Early detection of colorectal cancer (CRC) and precancerous lesion is vitally important for mitigating CRC morbidity and mortality. Aberrant DNA methylations in certain promoter regions have been identified to be closely associated with CRC development and progression, suggesting their potential as diagnostic biomarkers for early detection. In this study, we evaluated the performance of methylated in stool specimens as a potential biomarker for CRC detection. Read More

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Treatment with ascorbic acid normalizes the aerobic capacity, antioxidant defence, and cell death pathways in thermally stressed Mytilus galloprovincialis.

Comp Biochem Physiol B Biochem Mol Biol 2021 May 7;255:110611. Epub 2021 May 7.

Laboratory of Animal Physiology, Department of Zoology, School of Biology, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.

Considering temperature's upcoming increase due to climate change, combined with the fact that Mediterranean mussels Mytilus galloprovincialis (Lamarck, 1819) live at their upper limits [critical temperatures (Tc) beyond 25 °C], we cannot be sure of this species' sustainable future in the Mediterranean Sea. Deviation from optimum temperatures leads to cellular damage due to oxidative stress. Although ascorbic acid (AA) is a major scavenger of reactive oxygen species (ROS), its capacity to minimize oxidative stress effects is scarcely studied in aquatic organisms. Read More

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Pediatric Asthma Incidence Rates in the United States from 1980-2017.

J Allergy Clin Immunol 2021 May 5. Epub 2021 May 5.

Background: Few studies have examined longitudinal asthma incidence rates from a public health surveillance perspective.

Objective: Calculate descriptive asthma incidence rates in children over time considering demographics and parental asthma history.

Methods: Data from nine US birth cohorts were pooled into one population covering 1980-2017. Read More

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[Association of glutathione S-transferase gene polymorphism with risk of male infertility in Moscow region].

Urologiia 2021 May(2):69-73

Peoples Friendship University of Russia, Moscow, Russia.

About 30% of male infertility is associated with genetic abnormalities. Genetic polymorphisms increase the level of individual susceptibility to adverse environmental factors and affect human reproductive function.

Aim: To study associations of glutathione S-transferase GSTP1(Ile/Val) gene polymorphisms (A313G; rs1695) with the risk of pathospermia in men of the Moscow region. Read More

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Pre-pregnancy and Prenatal Alcohol use Among American Indian and Alaska Native and Non-Hispanic White Women: Findings from PRAMS in Five States.

Matern Child Health J 2021 May 7. Epub 2021 May 7.

Colorado School of Public Health, University of Colorado Denver, 13055 E. 17th Place, F800 Nighthorse Campbell Native Health Bldg. Rm 342, Anschutz Medical Campus, Aurora, CO, 80045, USA.

Introduction: Estimates of prenatal alcohol use among American Indian and Alaska Native (AI/AN) women are limited. This study sought to characterize pre-pregnancy and prenatal alcohol use among AI/AN women in the Pregnancy Risk Assessment Monitoring System (PRAMS) dataset, evaluate variation in alcohol use by state and rural/urban residence, and evaluate associations between potential risk factors and prenatal alcohol use among AI/AN and non-Hispanic white (NHW) women.

Methods: We pooled PRAMS data from five states (Alaska, New Mexico, Oklahoma, South Dakota and Washington) from 2015 to 2017. Read More

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Platelet Reactivity and Response to Aspirin and Clopidogrel in Patients with Platelet Count Disorders.

Cardiol Res Pract 2021 17;2021:6637799. Epub 2021 Apr 17.

Department of Hematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Wrocław, Poland.

Background: Platelet reactivity and response to antiplatelet drugs, acetylsalicylic acid (ASA) and clopidogrel, in patients with thrombocytopenia and thrombocythemia can have a potentially important effect on the outcome. The effectiveness and safety of antiplatelet drugs in such patients has not been well examined. Measuring the effect of ASA and clopidogrel on platelets could help guide the therapy. Read More

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A TGFβ Signaling Inhibitor, SB431542, Inhibits Reovirus-mediated Lysis of Human Hepatocellular Carcinoma Cells in a TGFβ-independent Manner.

Anticancer Res 2021 May;41(5):2431-2440

Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan;

Background/aim: Oncolytic reovirus, which is a non-enveloped virus possessing a 10-segmented double-stranded RNA genome, has been anticipated as a novel class of antitumor agent. Hepatocellular carcinoma (HCC) is considered to be a target suitable for reovirus-mediated virotherapy. Transforming growth factor (TGF)-β plays an important role in the pathogenesis of HCC. Read More

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Association of Childhood Socioeconomic Status with Leukocyte Telomere Length Among African Americans and the Mediating Role of Behavioral and Psychosocial Factors: Results from the GENE-FORECAST Study.

J Racial Ethn Health Disparities 2021 May 4. Epub 2021 May 4.

Cardiovascular Section, Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, 10 Center Drive, Room 7N316 MSC 1644, Bethesda, MD, USA.

Purpose: We examined if childhood socioeconomic status (SES) was related to adult leucocyte telomere length (TL) using the data of 361 African American (AA) participants from the GENE-FORECAST Study. We also assessed the mediating role of behavioral and psychosocial factors in the association between childhood SES and adult TL.

Methods: Childhood SES was assessed individually by using participant's mother's education and occupation, father's education and occupation, parental home ownership, and family structure. Read More

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Cultivation of fractionated cells from a bioactive-alkaloid-bearing marine sponge Axinella sp.

In Vitro Cell Dev Biol Anim 2021 May 4. Epub 2021 May 4.

Center for Marine Drugs, State Key Laboratory of Oncogene and Related Genes, Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Sponges are among the most primitive multicellular organisms and well-known as a major source of marine natural products. Cultivation of sponge cells has long been an attractive topic due to the prominent evolutionary and cytological significance of sponges and as a potential approach to supply sponge-derived compounds. Sponge cell culture is carried out through culturing organized cell aggregates called 'primmorphs. Read More

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Neural correlates of inhibitory control are associated with stimulant-like effects of alcohol.

Neuropsychopharmacology 2021 May 4. Epub 2021 May 4.

Department of Psychiatry, University of Chicago, Chicago, IL, USA.

Poor inhibitory control and heightened feelings of stimulation after alcohol are two well-established risk factors for alcohol use disorder (AUD). Although these risk factors have traditionally been viewed as orthogonal, recent evidence suggests that the two are related and may share common neurobiological mechanisms. Here we examined the degree to which neural activity during inhibition was associated with subjective reports of stimulation following alcohol. Read More

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Fibroblast Growth Factor 20 Gene Polymorphism in Parkinson's Disease in Asian Population: A Meta-Analysis.

Genes (Basel) 2021 Apr 29;12(5). Epub 2021 Apr 29.

Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Department of Neurology, Chang Gung University, Taoyuan 333, Taiwan.

Parkinson's disease (PD) is a neurodegenerative disease with the pathological hallmark of Lewy bodies and Lewy neurites composed of α-synuclein. The SNP rs591323 is one of the risk loci located near the gene that has been implicated in PD. The variation of in the 3' untranslated region was shown to increase α-synuclein expression. Read More

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The Roles of Cullins E3 Ubiquitin Ligases in the Lipid Biosynthesis of the Green Microalgae .

Int J Mol Sci 2021 Apr 29;22(9). Epub 2021 Apr 29.

Guangdong Technology Research Center for Marine Algal Bioengineering, Guangdong Provincial Key Laboratory for Plant Epigenetics, Shenzhen Engineering Laboratory for Marine Algal Biotechnology, Longhua Innovation Institute for Biotechnology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.

Microalgae-based biodiesel production has many advantages over crude oil extraction and refinement, thus attracting more and more concern. Protein ubiquitination is a crucial mechanism in eukaryotes to regulate physiological responses and cell development, which is highly related to algal biodiesel production. Cullins as the molecular base of cullin-RING E3 ubiquitin ligases (CRLs), which are the largest known class of ubiquitin ligases, control the life activities of eukaryotic cells. Read More

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Cytotoxicity and genotoxicity of the carcinogen aristolochic acid I (AA-I) in human bladder RT4 cells.

Arch Toxicol 2021 May 3. Epub 2021 May 3.

Masonic Cancer Center and Department of Medicinal Chemistry, Cancer and Cardiovascular Research Building, University of Minnesota, 2231 6th Street, Minneapolis, MN, 55455, USA.

Aristolochic acid (AA-I) induces upper urothelial tract cancer (UUTC) and bladder cancer (BC) in humans. AA-I forms the 7-(2'-deoxyadenosin-N-yl)aristolactam I (dA-AL-I) adduct, which induces multiple A:T-to-T:A transversion mutations in TP53 of AA-I exposed UTUC patients. This mutation is rarely reported in TP53 of other transitional cell carcinomas and thus recognized as an AA-I mutational signature. Read More

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"It was just for us": qualitative evaluation of an exercise intervention for African-American couples.

BMC Public Health 2021 May 1;21(1):838. Epub 2021 May 1.

School of Nursing and Knight Cancer Institute, Oregon Health & Science University, 3455 SW US Veterans Hospital Road, Portland, OR, 97239, USA.

Background: Promoting long-term exercise adherence should be a key focus for health and fitness professionals working to reduce obesity and cardiometabolic health disparities, and all-cause mortality in inactive African-American (AA) adults. Data have suggested that romantic partners can improve long-term exercise adherence and that this dyadic approach should be examined in exercise interventions. Therefore, the purpose of this study was to conduct a qualitative evaluation of a pilot exercise intervention conducted in older AA couples. Read More

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Young Adults Underestimate How Well Peers Adhere to COVID-19 Preventive Behavioral Guidelines.

J Prim Prev 2021 May 1. Epub 2021 May 1.

Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA.

To combat the rampant spread of the SARS-CoV-2 virus that is responsible for the COVID-19 pandemic, the Centers for Disease Control and Prevention (CDC) has provided Americans with empirically supported preventive behavioral guidelines (e.g., wearing a face mask). Read More

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Plasma and cerebrospinal fluid inflammation and the blood-brain barrier in older surgical patients: the Role of Inflammation after Surgery for Elders (RISE) study.

J Neuroinflammation 2021 Apr 30;18(1):103. Epub 2021 Apr 30.

Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Background: Our understanding of the relationship between plasma and cerebrospinal fluid (CSF) remains limited, which poses an obstacle to the identification of blood-based markers of neuroinflammatory disorders. To better understand the relationship between peripheral and central nervous system (CNS) markers of inflammation before and after surgery, we aimed to examine whether surgery compromises the blood-brain barrier (BBB), evaluate postoperative changes in inflammatory markers, and assess the correlations between plasma and CSF levels of inflammation.

Methods: We examined the Role of Inflammation after Surgery for Elders (RISE) study of adults aged ≥ 65 who underwent elective hip or knee surgery under spinal anesthesia who had plasma and CSF samples collected at baseline and postoperative 1 month (PO1MO) (n = 29). Read More

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The and anti-inflammatory activities of triterpene saponins from .

Nat Prod Res 2020 Oct 14:1-4. Epub 2020 Oct 14.

Fujian Provincial Key Laboratory of Natural Medicine Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou, P. R. China.

is widely used in She Ethnopharmacy in China owing to its significant anti-inflammatory activities. This study aimed to investigate the anti-inflammatory effect of the active fraction of (CFAF) in an arthritis animal model and its possible mechanism. Pre-inflammatory cytokine levels were examined by ELISA. Read More

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October 2020

What if COVID-19 affects the child: which weapons and how to use them.

Eur Rev Med Pharmacol Sci 2021 Apr;25(8):3325-3337

School of Pediatrics, University of Cagliari, Cagliari, Italy.

Since the reports in Wuhan (China), in December 2019, of the first cluster of cases of pneumonia caused by the new Coronavirus called 2019-nCoV or SARS-CoV-2, there has been a pandemic spread of the infection. By now, we have no specific therapy to counteract this emergency. The latest epidemiological data suggest that children are just as likely as adults to get infected by the virus. Read More

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Mesenchymal Stem Cells Antagonize IFN-Induced Proinflammatory Changes and Growth Inhibition Effects via Wnt/β-Catenin and JAK/STAT Pathway in Human Outer Root Sheath Cells and Hair Follicles.

Int J Mol Sci 2021 Apr 27;22(9). Epub 2021 Apr 27.

Department of Dermatology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 03312, Korea.

Mesenchymal stem cell therapy (MSCT) has been shown to be a new therapeutic option for treating alopecia areata (AA). Outer root sheath cells (ORSCs) play key roles in maintaining the hair follicle structure and supporting the bulge area. In human ORSCs (hORSCs), the mechanism for this process has not been extensively studied. Read More

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The Role of Alcohol, LPS Toxicity, and ALDH2 in Dental Bony Defects.

Biomolecules 2021 Apr 28;11(5). Epub 2021 Apr 28.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei 100, Taiwan.

It is estimated that 560 million people carry an East Asian-specific ALDH2*2 dominant-negative mutation which leads to enzyme inactivation. This common ALDH2 polymorphism has a significant association with osteoporosis. We hypothesized that the ALDH2*2 mutation in conjunction with periodontal bacterial infection and alcohol drinking had an inhibitory effect on osteoblasts and bone regeneration. Read More

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