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Polycystic ovary syndrome and infertility: an update.

Int J Adolesc Med Health 2021 Jul 22. Epub 2021 Jul 22.

Regional Research Institute of Unani Medicine, Srinagar, Jammu and Kashmir, India.

Polycystic ovarian syndrome is the most well-known endocrine condition among women of this generation (PCOS). Symptoms of hyperandrogenism, irregular menstrual periods, and insulin resistance are all traits associated with PCOS. In women with PCOS, the chance of having problems including infertility, insulin resistance, and type 2 diabetes increases. Read More

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Synthesis, characterization, and reactivity of oxoiron(IV) porphyrin π-cation radical complexes bearing cationic N-methyl-2-pyridinium group.

J Inorg Biochem 2021 Jul 15;223:111542. Epub 2021 Jul 15.

Department of Chemistry, Biology, and Environmental Sciences, Graduate School of Humanities and Sciences, Nara Women's University, Nara 630-8506, Japan. Electronic address:

Electronic charge near the active site is an important factor for controlling the reactivity of metalloenzymes. Here, to investigate the effect of the cationic charge near the heme in heme proteins, we synthesized new iron porphyrin complexes (1 and 2) having cationic 3-methyl-N-methyl-2-pyrdinium group and N-methyl-2-pyridinium group at one of the four meso-positions, respectively. The N-methyl-2-pyridinium groups could be introduced by Stille coupling used palladium catalysts. Read More

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Systemic therapy and prognosis of older patients with stage II/III breast cancer: A large-scale analysis of the Japanese Breast Cancer Registry.

Eur J Cancer 2021 Jul 19;154:157-166. Epub 2021 Jul 19.

Department of Breast Oncology, Aichi Cancer Center, Nagoya, Japan. Electronic address:

Aim: This study aimed at investigating the real-world prognostic impact of systemic treatment in older patients with stage II/III breast cancer (BC).

Methods: This retrospective cohort study included patients with stage II/III primary BC, aged ≥55 years, and registered in the Japanese Breast Cancer Registry from 2004 to 2011. The clinicopathological characteristics, treatments, and prognosis of patients aged ≥75 years (older) were compared to those of younger patients. Read More

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Intensity-modulated radiation therapy and doxorubicin in thyroid cancer: A prospective phase 2 trial.

Cancer 2021 Jul 22. Epub 2021 Jul 22.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.

Background: The use of external-beam radiotherapy for locally advanced nonanaplastic thyroid cancer remains controversial. This prospective study evaluated the efficacy and tolerability of intensity-modulated radiation therapy (IMRT) with or without concurrent chemotherapy in patients with locally advanced thyroid cancer.

Methods: The authors conducted a nonrandomized phase 2 trial of IMRT with or without concurrent doxorubicin in patients with gross residual or unresectable nonanaplastic thyroid carcinoma (ClinicalTrials. Read More

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Estimating the net value of treating hepatitis C virus using sofosbuvir-velpatasvir in India.

PLoS One 2021 22;16(7):e0252764. Epub 2021 Jul 22.

Stanford Graduate School of Business, Stanford, California, United States of America.

Recently developed direct-acting antiviral (DAA) treatments for hepatitis C virus (HCV) have been groundbreaking for their high efficacy across disease genotypes and lack of severe side effects. This study uses a cost-of-illness (COI) approach to estimate the net value conferred by this class of drugs using the cost and efficacy of one of these novel drug combinations, sofosbuvir and velpatasvir (SOF/VEL), recently licensed for generic manufacture in India. This study considers COI of lifetime earnings lost by patients and potential secondarily infected individuals due to disability and premature death from HCV infection. Read More

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Effects of carbonation of liquids on penetration-aspiration and residue management.

Eur Arch Otorhinolaryngol 2021 Jul 22. Epub 2021 Jul 22.

Otorhinolaryngology-Head and Neck Surgery Department, The Chaim Sheba Medical Center, Tel Hashomer, Israel.

Objective: Carbonation as a sensory enhancement strategy for prevention of aspiration of thin liquids has not been thoroughly studied. The aim of our study was to examine the effect of carbonation on penetration-aspiration and pharyngeal residue in dysphagia patients using Fiber-Optic Endoscopic Evaluation of Swallowing (FEES) and to identify parameters associated with a response to carbonation.

Methods: A cross-sectional study of patients undergoing FEES in a dysphagia clinic. Read More

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Interleukin19 gene polymorphism and its serum level in acne vulgaris patients.

J Immunoassay Immunochem 2021 Jul 22. Epub 2021 Jul 22.

Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt.

Numerous cytokines are involved in acne vulgaris pathogenesis, though few studies correlate interleukin IL-19 to acne vulgaris. So this study aimed to assess the IL-19 (rs 2243191) gene polymorphism and its serum level in acne vulgaris. This case-control study involved 90 acne vulgaris cases and 90 age- and sex-matched controls. Read More

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Phase I study of napabucasin in combination with FOLFIRI + bevacizumab in Japanese patients with metastatic colorectal cancer.

Int J Clin Oncol 2021 Jul 21. Epub 2021 Jul 21.

Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan.

Background: Napabucasin is an oral NAD(P)H:quinone oxidoreductase 1 bioactivatable agent that generates reactive oxygen species, is hypothesised to affect multiple oncogenic cellular pathways, including STAT-3, and is expected to result in cancer cell death. This phase I study investigated the safety, tolerability, and pharmacokinetics of napabucasin co-administered with fluorouracil, l-leucovorin, and irinotecan (FOLFIRI) chemotherapy plus bevacizumab in Japanese patients with metastatic colorectal cancer (CRC).

Methods: Patients with histologically confirmed unresectable stage IV CRC received oral napabucasin 240 mg twice daily (BID). Read More

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Theoretical investigations on mechanisms and kinetics of methylketene with O(P) reaction in the atmosphere.

J Mol Model 2021 Jul 21;27(8):228. Epub 2021 Jul 21.

Key Laboratory of Photoinduced Functional Materials, Mianyang Normal University, Mianyang, 621000, People's Republic of China.

The O(P)-initiated conversion mechanism and dynamics of CHCHCO were researched in atmosphere by executing density functional theory (DFT) computations. Optimizations of all the species and single-point energy computations were implemented at the B3LYP/6-311++G(d,p) and CCSD(T)/cc-pVTZ level, respectively. The explicit oxidation mechanism was introduced and discussed. Read More

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Frequency of Vitamin-D deficiency in children with Urinary tract infection: A descriptive cross-sectional study.

Pak J Med Sci 2021 Jul-Aug;37(4):1058-1062

Dr. Yasmeen Memon, MBBS, FCPS. Professor of Pediatrics, Isra Medical University, Hyderabad, Sindh, Pakistan.

Objective: To determine Vitamin-D status in children with urinary tract infection.

Methods: A Cross-sectional study was done at Pediatric Department, Liaquat University Hospital Hyderabad, from July 2019 to March 2020. A total of 172 children of either gender from 2 to 60 months of age with confirmed urinary tract infection (UTI) (having positive urine C/S report) were included in the study. Read More

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November 2020

CCR2 Deficiency Impairs Ly6C and Ly6C Monocyte Responses in Infection.

Front Immunol 2021 5;12:670219. Epub 2021 Jul 5.

Department of Molecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.

, the causative agent of scrub typhus, is a neglected, obligate intracellular bacterium that has a prominent tropism for monocytes and macrophages. Complications often involve the lung, where interstitial pneumonia is a typical finding. The severity of scrub typhus in humans has been linked to altered plasma concentrations of chemokines which are known to act as chemoattractants for myeloid cells. Read More

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Function Follows Form: Using the Aesthetic Association Principle to Enhance Haptic Interface Design.

Front Psychol 2021 5;12:646986. Epub 2021 Jul 5.

Bamberg Graduate School of Affective and Cognitive Sciences (BaGrACS), Bamberg, Germany.

Novel tangible user interface technologies facilitate current trends toward seamless user interfaces. They enable the design of yet unseen interfaces and thus the creation of a new kind of haptic language. In order to use the benefits of a touch-and-feel design for a positive user experience, carefully designed haptic feedback plays an important role by providing aesthetically pleasing and sustainable product features. Read More

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A Cardiac Protection of Germinated Brown Rice During Cardiopulmonary Bypass Surgery and Simulated Myocardial Ischemia.

J Inflamm Res 2021 15;14:3307-3319. Epub 2021 Jul 15.

Department of Large Animal and Wildlife Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, KamphaengSaen Campus, Kamphaeng Saen, Thailand.

Purpose: The potential cardio-protective property of germinated brown rice (GBR) has been revealed by ameliorating risk factors related to cardiovascular diseases. This study hypothesized that the combination of GBR and cardioplegic solution could protect the cardiomyocytes exposed to simulated ischemic reperfusion injury in vitro study and preserve cardiac function during cardiopulmonary bypass surgery in animal models.

Methods: Primary porcine cardiomyocytes were isolated and experimented cell viability against simulated ischemic reperfusion injury. Read More

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Genetic association studies of alterations in protein function expose recessive effects on cancer predisposition.

Sci Rep 2021 Jul 21;11(1):14901. Epub 2021 Jul 21.

Department of Biological Chemistry, The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Jerusalem, Israel.

The characterization of germline genetic variation affecting cancer risk, known as cancer predisposition, is fundamental to preventive and personalized medicine. Studies of genetic cancer predisposition typically identify significant genomic regions based on family-based cohorts or genome-wide association studies (GWAS). However, the results of such studies rarely provide biological insight or functional interpretation. Read More

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Correlation between the γ passing rates of IMRT plans and the volumes of air cavities and bony structures in head and neck cancer.

Radiat Oncol 2021 Jul 21;16(1):134. Epub 2021 Jul 21.

Department of Radiation Oncology, Chongqing University Cancer Hospital, Chongqing, 400030, China.

Background: Both patient-specific dose recalculation and γ passing rate analysis are important for the quality assurance (QA) of intensity modulated radiotherapy (IMRT) plans. The aim of this study was to analyse the correlation between the γ passing rates and the volumes of air cavities (V) and bony structures (V) in target volume of head and neck cancer.

Methods: Twenty nasopharyngeal carcinoma and twenty nasal natural killer T-cell lymphoma patients were enrolled in this study. Read More

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Simulating NEMA characteristics of the modular total-body J-PET scanner - an economic total-body PET from plastic scintillators.

Phys Med Biol 2021 Jul 21. Epub 2021 Jul 21.

National Centre for Nuclear Research, Warsaw, POLAND.

The purpose of the presented research is estimation of the performance characteristics of the economic Total-Body Jagiellonian-PET system (TB-J-PET) constructed from plastic scintillators. The characteristics are estimated according to the NEMA NU-2-2018 standards utilizing the GATE package. The simulated detector consists of 24 modules, each built out of 32 plastic scintillator strips arranged in two layers in regular 24 sided polygon circumscribing a circle with the diameter of 78. Read More

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Prevalence of human papillomavirus genotypes in high-grade cervical precancer and invasive cervical cancer from cancer registries before and after vaccine introduction in the United States.

Cancer 2021 Jul 21. Epub 2021 Jul 21.

Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: US population-based cancer registries can be used for surveillance of human papillomavirus (HPV) types found in HPV-associated cancers. Using this framework, HPV prevalence among high-grade cervical precancers and invasive cervical cancers were compared before and after HPV vaccine availability.

Methods: Archived tissue from 2 studies of cervical precancers and invasive cervical cancers diagnosed from 1993-2005 (prevaccine) were identified from 7 central cancer registries in Florida; Hawaii; Iowa; Kentucky; Louisiana; Los Angeles County, California; and Michigan; from 2014 through 2015 (postvaccine) cases were identified from 3 registries in Iowa, Kentucky, and Louisiana. Read More

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Symptom-Related Differential Neuroimaging Biomarkers in Children with Corpus Callosum Abnormalities.

Cereb Cortex 2021 Jul 21. Epub 2021 Jul 21.

Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

We aimed to identify symptom-related neuroimaging biomarkers for patients with dysgenesis of the corpus callosum (dCC) by summarizing neurological symptoms reported in clinical evaluations and correlating them with retrospectively collected structural/diffusion brain magnetic resonance imaging (MRI) measures from 39 patients/controls (mean age 8.08 ± 3.98). Read More

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Multicentre post-implementation assessment of the positive-predictive value of SARS-CoV-2 antigen-based point-of-care tests used for asymptomatic screening of continuing care staff.

J Clin Microbiol 2021 Jul 21:JCM0141121. Epub 2021 Jul 21.

Department of Pathology and Laboratory Medicine, University of Calgary School of Medicine, 3535 Research Road NW, Calgary, AB, Canada, T2L 2K8.

Frequent screening of SARS-CoV-2 among asymptomatic populations using antigen-based point of care tests (APOCT) is occurring globally with limited clinical performance data. The positive predictive value (PPV) of two APOCT used in the asymptomatic screening of SARS-CoV-2 among healthcare workers (HCW) at continuing care (CC) sites across Alberta, Canada was evaluated. Between February 22 and May 2, 2021, CC sites implemented SARS-CoV-2 voluntary screening of their asymptomatic HCW. Read More

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Controllable Synthesis and Performance Modulation of 2D Covalent-Organic Frameworks.

Chenyu Li Gui Yu

Small 2021 Jul 19:e2100918. Epub 2021 Jul 19.

Beijing National Laboratory for Molecular Sciences, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.

Covalent-organic frameworks (COFs) are especially interesting and unique as their highly ordered topological structures entirely built from plentiful π-conjugated units through covalent bonds. Arranging tailorable organic building blocks into periodically reticular skeleton bestows predictable lattices and various properties upon COFs in respect of topology diagrams, pore size, properties of channel wall interfaces, etc. Indeed, these peculiar features in terms of crystallinity, conjugation degree, and topology diagrams fundamentally decide the applications of COFs including heterogeneous catalysis, energy conversion, proton conduction, light emission, and optoelectronic devices. Read More

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The use of collimator angle optimization and jaw tracking for VMAT-based single-isocenter multiple-target stereotactic radiosurgery for up to six targets in the Varian Eclipse treatment planning system.

J Appl Clin Med Phys 2021 Jul 19. Epub 2021 Jul 19.

Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW, Australia.

Purpose: Island blocking occurs in single-isocenter multiple-target (SIMT) stereotactic radiotherapy (SRS) whenever targets share multi-leaf collimator (MLC) leaf pairs. This study investigated the effect on plan quality and delivery, of reducing island blocking through collimator angle optimization (CAO). In addition, the effect of jaw tracking in this context was also investigated. Read More

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In vivo experiments provide evidence that Flavobacterium psychrophilum strains belonging to multilocus sequence typing clonal complex ST191 are virulent to Rainbow Trout Oncorhynchus mykiss.

J Aquat Anim Health 2021 Jul 20. Epub 2021 Jul 20.

Department of Fisheries and Wildlife, College of Agriculture and Natural Resources, Michigan State University, East Lansing, MI, 48824, USA.

Flavobacterium psychrophilum, the causative agent of bacterial coldwater disease (BCWD), causes significant economic losses worldwide, particularly in farmed Rainbow Trout Oncorhynchus mykiss. Over the last decade, multilocus sequence typing (MLST) has revealed >30 clonal complexes (CCs) globally, comprised of >320 F. psychrophilum sequence types (STs). Read More

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The ependymal cell cytoskeleton in the normal and injured spinal cord of mice.

J Neurosci Res 2021 Jul 20. Epub 2021 Jul 20.

Departamento de Neurofisiología Celular y Molecular, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay.

The cytoskeleton of ependymal cells is fundamental to organize and maintain the normal architecture of the central canal (CC). However, little is known about the plasticity of cytoskeletal components after spinal cord injury. Here, we focus on the structural organization of the cytoskeleton of ependymal cells in the normal and injured spinal cord of mice (both females and males) using immunohistochemical and electron microscopy techniques. Read More

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Cancer survival among World Trade Center rescue and recovery workers: A collaborative cohort study.

Am J Ind Med 2021 Jul 19. Epub 2021 Jul 19.

Department of Hematology and Oncology, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, New York, New York, USA.

Background: World Trade Center (WTC)-exposed responders may be eligible to receive no-cost medical monitoring and treatment for certified conditions, including cancer. The survival of responders with cancer has not previously been investigated.

Methods: This study compared the estimated relative survival of WTC-exposed responders who developed cancer while enrolled in two WTC medical monitoring and treatment programs in New York City (WTC-MMTP responders) and WTC-exposed responders not enrolled (WTC-non-MMTP responders) to non-responders from New York State (NYS-non-responders), all restricted to the 11-southernmost NYS counties, where most responders resided. Read More

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Glim criteria with different muscle assessments including muscle ultrasonography at hospitalized internal medicine patients.

JPEN J Parenter Enteral Nutr 2021 Jul 20. Epub 2021 Jul 20.

Department of Internal Medicine, Division of Geriatric Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Background: The aim of this study is to identify cut-off values for muscle ultrasound (US) to be used in Global Leadership Initiative on Malnutrition (GLIM) criteria, and to define the effect of reduced muscle mass assessment on malnutrition prevalence at hospital admission.

Methods: A total of 118 inpatients were enrolled in this cross-sectional study. Six different muscles were evaluated by US. Read More

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Association analysis and functional study of COL6A1 single nucleotide polymorphisms in thoracic ossification of the ligamentum flavum in the Chinese Han population.

Eur Spine J 2021 Jul 21. Epub 2021 Jul 21.

Department of Orthopaedics, Peking University Third Hospital, Beijing, People's Republic of China.

Purpose: Genetic factors play a crucial role in thoracic ossification of the ligamentum flavum (TOLF). This study aimed to better understand the association between single nucleotide polymorphisms (SNP) in functional regions of the collagen VI, alpha 1 gene (COL6A1) and TOLF, and to confirm COL6A1 as a TOLF susceptibility gene.

Methods: Ten tag SNPs in COL6A1 were genotyped using the SNaPshot assay, and allele and genotype frequencies were compared between TOLF patients and control individuals. Read More

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Both "Vitamin L for Life" and "One Milligram of Satan": A Multi-Perspective Qualitative Exploration of Adjuvant Endocrine Therapy Use after Breast Cancer.

Curr Oncol 2021 Jul 5;28(4):2496-2515. Epub 2021 Jul 5.

Department of Psychology, University of Calgary, Calgary, AB T2N 1N4, Canada.

Adjuvant endocrine therapy (AET) is recommended after hormone receptor-positive breast cancer to reduce risk of recurrence, but adherence is sub-optimal in many women. Behavioral interventions have been ineffective in improving adherence rates to AET. This qualitative descriptive study investigates factors that support women in AET use and suggestions for interventions to improve AET use and management. Read More

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Description of sp. nov., harboring antibiotic- and toxic compound-resistace genes, isolated from poultry manure.

Int J Syst Evol Microbiol 2021 Jul;71(7)

Department of Soil and Environmental Sciences, College of Agriculture and Natural Resources, National Chung Hsing University, Taichung, Taiwan, ROC.

A polyphasic taxonomic approach was used to characterize a Gram-stain-negative bacterium, designated strain CC-YST696, harbouring antibiotic- and toxic compound-resistace genes, isolated from poultry manure in Taiwan. Cells of CC-YST696 were short rods, motile with polar flagella, catalase- and oxidase-positive. Optimal growth occurred at 30 °С, pH 9 and with 1 % NaCl. Read More

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Associations of TLR4 and IL-8 genes polymorphisms with age-related macular degeneration (AMD): a systematic review and meta-analysis.

Ophthalmic Genet 2021 Jul 21:1-9. Epub 2021 Jul 21.

Medical Faculty, Research Center for Evidence-Based Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: The results of different studies have indicated the possible associations of TLR4 and IL-8 genes polymorphisms with Age-related Macular Degeneration (AMD). A meta-analysis study was designed to evaluate the possible associations of TLR4 (rs4986790/c.896A>G and rs4986791/ c. Read More

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CD44-Targeted and Enzyme-Responsive Photo-Cross-Linked Nanogels with Enhanced Stability for In Vivo Protein Delivery.

Biomacromolecules 2021 Jul 21. Epub 2021 Jul 21.

College of Materials Science and Engineering, Jilin Institute of Chemical Technology, Jilin City 132022, P. R. China.

One of the biggest challenges of the protein delivery system is to realize stable and high protein encapsulation efficiency in blood circulation and rapid release of protein in the targeted tumor cells. To overcome these hurdles, we fabricated enzyme-responsive photo-cross-linked nanogels (EPNGs) through UV-triggered chemical cross-linking of cinnamyloxy groups in the side chain of PEGylation hyaluronic acid (HA) for CD44-targeted transport of cytochrome (CC). The EPNGs showed high loading efficiency and excellent stability in different biological media. Read More

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