5,295,198 results match your criteria [the clinical


Longitudinal asthma and allergy study showed that childhood symptoms frequently persisted into adulthood.

Acta Paediatr 2021 Sep 18. Epub 2021 Sep 18.

University of Iceland, Faculty of Medicine, Reykjavík, Iceland.

Aims: The prevalence of allergic diseases is high and increasing in many countries. The aim of this study was to describe the prevalence of allergic diseases and changes in clinical expression in a birth cohort followed for three decades.

Methods: We followed Icelandic citizens born in 1987 for allergic diseases when they were two, four, eight, 15, 21 and 29 years of age. Read More

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September 2021

Final Nail in the Coffin.

Authors:
Swati Jha

BJOG 2021 Sep 18. Epub 2021 Sep 18.

Consultant Gynaecologist and Honorary Senior Clinical Lecturer, Sheffield University. Subspecialist in Urogynaecology, Sheffield Teaching Hospitals, Tree Root Walk, Level 4, Jessop Wing, Sheffield, S10 2SF, UK.

Synthetic midurethral slings (MUS) for the management of stress urinary incontinence (SUI) have come under intense scrutiny of late. The NICE (National Institute of Health and Clinical Excellence) guidelines for the management of urinary incontinence over the past 15 years have continued to be cautious in their recommendations of the obturator MUS whilst being supportive of the retropubic (RP) MUS. In the 2006 NICE clinical guidance (CG 40), the advice was to make women aware of the "lack of long-term data" for obturator MUS. Read More

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September 2021

Macroscopic characteristics of the native liver in children with MPV17-related mitochondrial DNA depletion syndrome: an indication for performing liver transplantation?

Liver Transpl 2021 Sep 18. Epub 2021 Sep 18.

Center for Medical Genetics, Department of Metabolism, Chiba Children's Hospital, Chiba, Japan.

Mitochondrial respiratory chain disorders (MRCDs) are rare conditions with various clinical manifestations that depend on the genetic type, with subsequent severity of the liver disease. Clinical presentations include acute liver failure or chronic liver failure with liver cirrhosis, which are cruelly progressive and fatal. We report six cases of LT for acute liver failure diagnosed pathogenic MPV17 variants. Read More

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September 2021

Saliva testing as a means to monitor therapeutic lithium levels in patients with psychiatric disorders: identification of clinical and environmental covariates, and their incorporation into a prediction model.

Bipolar Disord 2021 Sep 18. Epub 2021 Sep 18.

Department of Epidemiology, University of California Irvine, Irvine, 92697, CA, USA.

Objective: The narrow therapeutic window of lithium medications necessitates frequent serum monitoring, which can be expensive and inconvenient for the patient. Compared to blood, saliva collection is easier, non-invasive, requires less processing, and can be done without the need for trained personnel. This study investigated the utility of longitudinal salivary lithium level monitoring. Read More

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September 2021

Transcription factor SOX2 contributes to nonalcoholic fatty liver disease development by regulating the expression of the fatty acid transporter CD36.

FEBS Lett 2021 Sep 18. Epub 2021 Sep 18.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Jeonbuk National University Medical School, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Republic of Korea.

Nonalcoholic fatty liver disease (NAFLD) can lead to hepatocellular carcinoma (HCC). The level of the transcription factor SOX2 correlates with HCC progression, but its role in fat accumulation remains unclear. Here, a high-fat diet, with and without fructose, significantly upregulated SOX2 in murine liver tissue. Read More

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September 2021

Direct immunofluorescence analysis of oral Tzanck smears for pemphigus vulgaris: A diagnostic test.

J Oral Pathol Med 2021 Sep 18. Epub 2021 Sep 18.

Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials, Beijing, China.

Background: Pemphigus vulgaris (PV) is a rare and potentially fatal autoimmune blistering disease. Direct immunofluorescence (DIF) is an important method for PV diagnosis, but oral tissue biopsy for DIF analysis is difficult to perform because of the fragile characteristics of oral mucosa. However, no well-designed diagnostic studies addressing the validity of DIF analysis of oral Tzanck smears for the diagnosis of PV exist. Read More

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September 2021

Observations and report of incidents on how birthing persons are treated during childbirth in two public facilities of Argentina.

Int J Gynaecol Obstet 2021 Sep 18. Epub 2021 Sep 18.

Department of Mother and Child Health. Institute for Clinical Effectiveness and Health Policy (IECS), Buenos Aires, Argentina.

Objective: This study sought to estimate the frequency and types of mistreatment during childbirth and explore health professionals´ opinions on barriers/facilitators to providing respectful childbirth care.

Methods: This prospective mixed-methods investigation consisted of direct observations of childbirth (N=250), at-home surveys with birthing individuals (N=45), and qualitative in-depth health staff interviews (N=6); conducted January-July 2019, in two public facilities in Argentina. Frequencies of clinical practices and mistreatment and 5% confidence intervals were calculated. Read More

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September 2021

Recent improvement in survival outcomes and reappraisal of prognostic factors in pediatric living donor liver transplantation.

Liver Transpl 2021 Sep 18. Epub 2021 Sep 18.

Department of Pediatrics, Asan Medical Center Children's Hospital, University Ulsan College of Medicine, Seoul, Korea.

Background: Living donor liver transplantation (LDLT) is a significant advancement for the treatment of children with end-stage liver disease given the shortage of deceased donors. The ultimate goal of pediatric LT is to achieve complete donor safety and zero recipient mortality.

Methods: We conducted a retrospective, single center assessment of the outcomes as well as the clinical factors that may influence graft and patient survival after primary LDLTs conducted between 1994 and 2020. Read More

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September 2021

Can zirconia crowns be the first restorative choice after endodontic treatment of primary teeth?

Int J Clin Pract 2021 Sep 18:e14888. Epub 2021 Sep 18.

Department of Pediatric Dentistry, Faculty of Dentistry, Erciyes University, Kayseri, Turkey.

Objective: Early loss of primary teeth due to caries can cause temporary or permanent problems, such as occlusion disorders, aesthetic problems, nutritional problems, abnormal habits, and speech disorders. Although the development of restorative materials has led to significant improvements, failures are still frequent. The purpose of this study was to evaluate the success rates of zirconia crown with compare to other crowns for the restoration of endodonticly treated teeth with excessive loss of material. Read More

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September 2021

Acute Kidney Injury is a Common and Significant Complication Following Ileostomy Formation.

Colorectal Dis 2021 Sep 18. Epub 2021 Sep 18.

Department of Surgery, University of Rochester Medical Center, Rochester, New York, USA.

Aim: To characterize the incidence and short-term prognostic value of an acute kidney injury (AKI) during the admission where an ileostomy is formed.

Methods: Adults with a baseline creatinine discharged alive after ileostomy formation from 2014-2016 were included. All patients had daily basic metabolic panels (BMP) and the Kidney Diseases Improving Global Outcomes criteria were used to determine the presence and severity of any AKI. Read More

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September 2021

Real world data of cemiplimab in locally advanced and metastatic cutaneous squamous cell carcinoma.

Eur J Cancer 2021 Sep 15;157:250-258. Epub 2021 Sep 15.

University of Brescia, Department of Medical-Surgical Specialties, Radiological Sciences and Public Health, Medical Oncology, ASST-Spedali Civili, Brescia, Lombardia, Italy. Electronic address:

Background: Cutaneous squamous cell carcinoma (cSCC) has an overall favourable outcome, except for patients with an advanced stage disease. The programmed death protein-1 (PD-1) inhibitor cemiplimab has been approved for use in advanced cSCC. We report clinical outcomes from the named patient programme-compassionate use of cemiplimab for patients with advanced cSCC in Italy. Read More

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September 2021

Interleukin-6 blockade for prophylaxis and management of immune-related adverse events in cancer immunotherapy.

Eur J Cancer 2021 Sep 15;157:214-224. Epub 2021 Sep 15.

Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia; Department of Medical Oncology, Royal North Shore and Mater Hospitals, Sydney, NSW, Australia. Electronic address:

Background: Immune checkpoint inhibitors (ICIs) have activity across many tumor types, but activation of the immune system may also lead to significant, often steroid-refractory immune-related adverse events (irAEs). We sought to determine the activity of tocilizumab, an anti-interleukin-6 receptor monoclonal antibody, in treatment or prevention of auto-immune irAE in ICI-treated patients.

Methods: Institutional databases from 2 melanoma centers were reviewed for patients treated with ICIs and tocilizumab. Read More

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September 2021

Second Paediatric Strategy Forum for anaplastic lymphoma kinase (ALK) inhibition in paediatric malignancies: ACCELERATE in collaboration with the European Medicines Agency with the participation of the Food and Drug Administration.

Eur J Cancer 2021 Sep 15;157:198-213. Epub 2021 Sep 15.

Hospital for Sick Children, Toronto, Canada.

The first (2017) and sixth (2021) multistakeholder Paediatric Strategy Forums focused on anaplastic lymphoma kinase (ALK) inhibition in paediatric malignancies. ALK is an important oncogene and target in several paediatric tumours (anaplastic large cell lymphoma [ALCL], inflammatory myofibroblastic tumour [IMT], neuroblastoma and hemispheric gliomas in infants and young children) with unmet therapeutic needs. ALK tyrosine kinase inhibitors have been demonstrated to be active both in ALK fusion-kinase positive ALCL and IMT. Read More

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September 2021

Efficacy and safety of immune checkpoint inhibitors in elderly patients (≥70 years) with squamous cell carcinoma of the head and neck.

Eur J Cancer 2021 Sep 15;157:190-197. Epub 2021 Sep 15.

Department of Head and Neck Oncology, Gustave Roussy Cancer Campus, Villejuif, France.

Background: Recent meta-analysis showed that immune checkpoint inhibitors (ICIs) have comparable activity between younger and older patients. However, little is known about efficacy and safety of ICI in elderly patients with relapsed/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN). The aim of this study is to compare the efficacy of ICI for patients aged ≥70 y to that for younger patients, while taking into account potential confounding factors. Read More

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September 2021

Complications and prognosis associated with intra-tympanic steroid injection to treat sudden sensorineural hearing impairment.

Am J Otolaryngol 2021 Sep 10;43(1):103221. Epub 2021 Sep 10.

Division of Otology, Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan; School of Medicine, Chang Gung University, Taiwan. Electronic address:

Purpose: The purpose of this study was to measure the incidence of complications in sudden sensorineural hearing loss (SSNHL) patients treated with intra-tympanic steroid injection (ITSI) and compare hearing recovery rates.

Materials And Methods: 123 patients with unilateral SSNHL receiving ITSIs were included in this study. Post-ITSI complications were documented including otalgia, dysgeusia, vertigo (duration>1 h), and persistent eardrum perforation. Read More

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September 2021

Primary external auditory canal meningioma: Case report and review of the literature.

Am J Otolaryngol 2021 Sep 11;43(1):103215. Epub 2021 Sep 11.

Puget Sound Ear, Nose and Throat, 21911 76th Ave W, Edmonds, WA, 98026, United States of America.

Meningiomas are tumors that arise from arachnoid cells attached to both the pia mater and the inner portion of the arachnoid. They are common intracranial tumors, representing 12-25% of intracranial neoplasms. Intracranial meningiomas can spread extracranially to involve surrounding structures, including the ear and temporal bone. Read More

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September 2021

Efficacy of needle aspiration in patients with oral-maxillofacial abscesses: A retrospective study of 15 consecutive patients.

Am J Otolaryngol 2021 Sep 11;43(1):103216. Epub 2021 Sep 11.

Department of Oral and Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; College of Stomatology, Shanghai Jiao Tong University, Shanghai, China; National Center for Stomatology, Shanghai, China; National Clinical Research Center for oral Diseases, Shanghai, China; Shanghai Key Laboratory of Stomatalogy, Shanghai, China. Electronic address:

The aim of this study was to determine the adequacy and safety of needle aspiration (NA) as an alternative to open surgical drainage for oral-maxillofacial abscesses. Fifteen consecutive patients who were diagnosed with oral-maxillofacial abscesses via contrast-enhanced CT from January 2020 to December 2020 were included. All patients were on antibiotics and treated with NA under local anaesthesia using a 20 mL syringe. Read More

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September 2021

F-FDG-PET/CT interpretation pitfalls in patients with head and neck cancer.

Am J Otolaryngol 2021 Sep 10;43(1):103209. Epub 2021 Sep 10.

Department of Otorhinolaryngology-Head and Neck Surgery, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.

Aim: The aim of the present study is to raise awareness of ENT Surgeons on the limitations of F-FDG PET/CT in head and neck cancer by presenting illustrative cases from our department archives.

Materials And Methods: A retrospective chart review was conducted for all patients with head and neck cancer treated in our ENT department from 2015 to 2020. Cases with various interpretation pitfalls due to false-positive and false-negative PET/CT results that lead to diagnostic dilemmas and treatment delays either in their pre-therapeutic work-up or in their post-therapeutic monitoring were included. Read More

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September 2021

Evaluation of the impact of deep neuromuscular blockade on surgical conditions for laryngeal microsurgery with High Frequency Jet Ventilation. A comparison with no block during intravenous general anesthesia with topical lidocaine.

Am J Otolaryngol 2021 Sep 4;43(1):103187. Epub 2021 Sep 4.

Université catholique de Louvain, CHU UCL Namur, Department of Anesthesiology, Avenue Dr G Thérasse 1, 5530 Yvoir, Belgium.

Objective: Laryngeal transoral surgery classically requires a neuromuscular block (NMB) to facilitate tracheal intubation and to improve surgical conditions. However, the short duration of most procedures and the potential complications of residual NMB lead to consider a no block approach. The hypothesis that intravenous anesthesia (remifentanil and propofol infusions) without NMB but including glottis topical lidocaine anesthesia would allow clinically acceptable laryngeal exposure and good surgical conditions was tested in the specific context of procedures undergone with High Frequency Jet Ventilation (HFJV). Read More

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September 2021

Individual and organizational factors of nurses' job satisfaction in long-term care: A systematic review.

Int J Nurs Stud 2021 Aug 26;123:104073. Epub 2021 Aug 26.

University of Ottawa - School of Nursing, Ottawa Hospital Research Institute, General Campus, 501 Smyth Rd, Box 711, Ottawa, ON K1H 8L6, Canada. Electronic address:

Background: In long-term care facilities, nurses' job satisfaction predicts staff turnover, which adversely affects resident outcomes. Thus, it is important to develop a comprehensive understanding of factors affecting nurses' job satisfaction in long-term care facilities.

Objectives: To analyze factors associated with job satisfaction among nurses in nursing homes from individual and organizational perspectives utilizing a deductive approach. Read More

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Clinical Characterization of Epilepsy in Children With Angelman Syndrome.

Pediatr Neurol 2021 Aug 31;124:42-50. Epub 2021 Aug 31.

Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland. Electronic address:

Background: Epilepsy is highly prevalent in children with Angelman syndrome (AS), and its detailed characterization and relationship to the genotype (deletion vs nondeletion) is important both for medical practice and for clinical trial design.

Methods And Materials: We retrospectively analyzed the main clinical features of epilepsy in 265 children with AS who were enrolled in the AS Natural History Study, a multicenter, observational study conducted at six centers in the United States. Participants were prospectively followed up and classified by genotype. Read More

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Magnetic resonance imaging radiomics signatures for predicting endocrine resistance in hormone receptor-positive non-metastatic breast cancer.

Breast 2021 Sep 11;60:90-97. Epub 2021 Sep 11.

Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, China; Department of Medical Oncology, Phase I Clinical Trial Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, China. Electronic address:

Background: One-third of patients with hormone receptor (HR)-positive breast cancers fail to respond to hormone therapy, and some patients even progress within two years of adjuvant endocrine therapy (ET) toward primary endocrine resistance. However, there is no effective way to predict endocrine resistance.

Objective: To build a model that incorporates the radiomic signature of pretreatment magnetic resonance imaging (MRI) with clinical information to predict endocrine resistance. Read More

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September 2021

Partitioning of phytocannabinoids between faeces and water - Implications for wastewater-based epidemiology.

Sci Total Environ 2021 Sep 14;805:150269. Epub 2021 Sep 14.

University of South Australia, Clinical and Health Sciences (CHS), Health and Biomedical Innovation, South Australia 5000, Australia. Electronic address:

Evaluating consumption estimates for lipophilic drugs in wastewater has proven to be a challenge. A common feature for these compounds is that they are excreted in faeces and in conjugated form in urine. Limited research with no obvious experimental evidence has been conducted to investigate the degree to which faecal-bound chemical markers contribute towards mass loads in wastewater. Read More

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September 2021

Genetic diversity of Listeria monocytogenes isolated from ready-to-eat food products in retail in Poland.

Int J Food Microbiol 2021 Sep 9;358:109397. Epub 2021 Sep 9.

Department of Food Safety, National Institute of Public Health NIH - National Research Institute, Warsaw, Poland.

The study describes the characterization of Listeria monocytogenes isolated from the general 2017-2019 national official control and monitoring sampling program. A total of 60,928 of ready-to-eat (RTE) food products were collected in retail in Poland, while the number of L. monocytogenes contaminated samples was 67 (0. Read More

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September 2021

A multi-evaluating strategy for Weikangling capsules: Chemical profiling, fingerprinting combined with quantitative analysis, quantity transfer, and dissolution curve.

J Pharm Biomed Anal 2021 Sep 3;206:114347. Epub 2021 Sep 3.

School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.

Weikangling capsules (WKLCs), a Chinese patent medicine consisting of 8 Chinese drugs, have been widely used in clinic to treat gastrointestinal diseases for more than 30 years. The current "Chinese Pharmacopoeia" (2020 Edition, ChP2020) uses paeoniflorin content (≥ 1.0 mg per capsule) as the standard of quality control, but it is insufficient to evaluate the overall quality of WKLCs. Read More

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September 2021

Upregulation of UGT1A1 expression by ursolic acid and oleanolic acid via the inhibition of the PKC/NF-κB signaling pathway.

Phytomedicine 2021 Aug 25;92:153726. Epub 2021 Aug 25.

Clinical Pharmacology Institute, Nanchang University, Nanchang 330006, PR China. Electronic address:

Background: Isomeric ursolic acid (UA) and oleanolic acid (OA) compounds have recently garnered great attention due to their biological effects. Previously, it had been shown that UA and OA can exert important pharmacological action via the protein kinase C (PKC) and nuclear factor-κB (NF-κB) signaling, and that they can induce the expression of UDP-glucuronosyltransferase 1A1 (UGT1A1) in HepG2 cells. This study aims to investigate the role of PKC/NF-κB signaling in regulating the expression of UGT1A1 and examine how UA and OA induce UGT1A1 based on this signaling pathway. Read More

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Arthroscopic debridement of osteochondral lesions of the talus: A systematic review.

Foot (Edinb) 2021 Jul 12;49:101852. Epub 2021 Jul 12.

Aspetar Orthopedic and Sports Medicine Hospital, Doha, Qatar.

Background: Arthroscopic debridement (AD) for the osteochondral lesions of the talar dome (OLT) was widely documented in the nineties with satisfactory results. However, in modern treatment algorithms, its role is not described. The present systematic review aims to evaluate the current evidence on the clinical outcomes of AD in the management of OLT. Read More

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Vaccination after prior COVID-19 infection: Implications for dose sparing and booster shots.

EBioMedicine 2021 Sep 15;72:103586. Epub 2021 Sep 15.

Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia. Electronic address:

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September 2021

Hemicraniectomy for Dominant vs Nondominant Middle Cerebral Artery Infarction: A Systematic Review and Meta-Analysis.

J Stroke Cerebrovasc Dis 2021 Sep 15;30(11):106102. Epub 2021 Sep 15.

Department of Neurology, Helsinki University Hospital and University of Helsinki, Haartmaninkatu 4, Helsinki 00290, Finland.

Objectives: Decompressive hemicraniectomy decreases mortality and severe disability from space-occupying middle cerebral artery infarction in selected patients. However, attitudes towards hemicraniectomy for dominant-hemispheric stroke have been hesitant. This systematic review and meta-analysis examines the association of stroke laterality with outcome after hemicraniectomy. Read More

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September 2021

Predictors of Infarction in Tuberculous Meningitis in Indian Patients.

J Stroke Cerebrovasc Dis 2021 Sep 15;30(11):106088. Epub 2021 Sep 15.

Department OF Neurology, AIIMS, New Delhi. Electronic address:

Background: Stroke is a devastating complication of tuberculous meningitis (TBM) and is an important determinant of its outcome. We propose a model which would help to predict development of infarction or cerebrovascular events in patients of TBM.

Methods: A prospective study with n=129 patients of TBM were evaluated for predictors and outcomes of stroke. Read More

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September 2021