586,423 results match your criteria [significance

Improvement of exhausted cerebral autoregulation in patients with idiopathic intracranial hypertension benefit of venous sinus stenting.

Physiol Meas 2021 Jul 22. Epub 2021 Jul 22.

Neurology, Beijing Tiantan Hospital, Beijing, CHINA.

Objective: Utilizing transfer function analysis to assess the cerebral autoregulation in patients with idiopathic intracranial hypertension (IIH), and to explore its improvement after venous sinus stenting.

Approach: In total, 15 consecutive IIH patients with venous sinus stenosis and 15 controls were recruited. All the patients underwent digital subtraction angiography and venous manometry. Read More

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Tumor Budding is a reliable predictor for death and metastasis in invasive ductal breast cancer and correlates with other prognostic clinicopathological parameters.

Ann Diagn Pathol 2021 Jul 15;54:151792. Epub 2021 Jul 15.

Recep Tayyip Erdoğan University, Faculty of Medicine, Department of Pathology, Turkey.

Background And Objective: Breast cancers are the most common type of cancer and the most common cause of mortality in women worldwide. Different prognostic factors are the subject of research to differentiate the prognosis even between cases at a similar stage and identify risky patients earlier and create individual treatment approaches. Tumor budding (TB) has been identified as a poor prognostic factor in many types of cancer, especially colorectal carcinomas. Read More

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Highly sensitive magnetic relaxation sensing method for aflatoxin B1 detection based on Au NP-assisted triple self-assembly cascade signal amplification.

Biosens Bioelectron 2021 Jul 9;192:113489. Epub 2021 Jul 9.

Institute of Quality Standard and Testing Technology for Agro-Products, Chinese Academy of Agricultural Science/Key Laboratory of Agro-Products Quality and Safety of MOA, Beijing, 100081, PR China. Electronic address:

Highly sensitive detection of aflatoxin B (AFB) is of great significance because of its high toxicity and carcinogenesis. We propose a magnetic relaxation sensing method based on gold nanoparticles (Au NPs)-assisted triple self-assembly cascade signal amplification for highly sensitive detection of AFB. Both AFB antibody and initiator DNA (iDNA) are labeled on Au NPs to form Ab-Au-iDNA probe. Read More

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Acute autoimmune-like hepatitis with atypical anti-mitochondrial antibody after mRNA COVID-19 vaccination: A novel clinical entity?

J Autoimmun 2021 Jul 15;123:102706. Epub 2021 Jul 15.

Epatocentro Ticino, Via Soldino 5, 6900, Lugano, Switzerland; King's College London Faculty of Life Sciences & Medicine, Institute of Liver Studies, MowatLabs, London, UK; Faculty of Biomedical Sciences, Università Della Svizzera Italiana, 6900, Lugano, Switzerland. Electronic address:

Autoimmune phenomena and clinically apparent autoimmune diseases, including autoimmune hepatitis, are increasingly been reported not only after natural infection with the SARS-CoV-2 virus, but also after vaccination against it. We report the case of a 63-year old man without a history of autoimmunity or SARS-CoV-2 natural infection who experienced acute severe autoimmune-like hepatitis seven days after the first dose of the mRNA-1273 SARS-CoV-2 vaccine. Liver histology showed inflammatory portal infiltrate with interface hepatitis, lobular and centrilobular inflammation with centrilobular necrosis, in absence of fibrosis and steatosis. Read More

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Exploring the nexus between agriculture and greenhouse gas emissions in BIMSTEC region: The role of renewable energy and human capital as moderators.

J Environ Manage 2021 Jul 20;297:113316. Epub 2021 Jul 20.

University School of Management Studies, Guru Gobind Singh Indraprastha University, Sector 16C, Dwarka, New Delhi, 110078, India. Electronic address:

Agriculture and the food system emit a considerable amount of Greenhouse Gas (GHG) emissions in the atmosphere. Hence, current researchers, policymakers, and other stakeholders are calling for improving the environmental performance of agriculture. This study utilizes the countries of The Bay of Bengal Initiative for Multi-Sectoral Technical and Economic Cooperation (BIMSTEC) to investigate the effect of agriculture value-added, pesticide use, renewable energy adoption, human capital, and economic growth on greenhouse gas emissions. Read More

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Insights for applying erythrosine B as a green fluorescence probe for estimation of anticancer tamoxifen and its analog; clomiphene in nanogram concentration.

M M Tolba M M Salim

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 12;263:120156. Epub 2021 Jul 12.

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University - Egypt, New Damietta 34511, Egypt. Electronic address:

The growth of tumor tissue is extremely pervasive among post-menopausal women. Commonly, from the clinical application, adjuvant selective estrogen receptor modulators such as tamoxifen are prescribed for prohibiting metastatic breast cancer, while its analog, clomiphene, is used to treat infertility in women. Lately, the significance of green chemistry on our environment was through reducing the influence of hazardous chemicals. Read More

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Monomeric C-reactive protein promotes platelets to release mitochondrial DNA in anti-neutrophil cytoplasmic antibody-associated vasculitis.

Mol Immunol 2021 Jul 19;137:228-237. Epub 2021 Jul 19.

Department of Nephrology, Tianjin Medical University General Hospital, Tianjin, 300052, China. Electronic address:

Although high level of circulating C-reactive protein (pCRP) is considered as a biomarker for disease activity, the significance of CRP in the pathogenesis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) has not been clarified. We once reported in AAV, pentameric CRP (pCRP) could dissociate into monomeric CRP (mCRP) and activate platelets. Recent studies have demonstrated that the activated platelets can release mitochondrial DNA (mtDNA). Read More

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Altered sensorimotor integration in multiple sclerosis: A combined neurophysiological and functional MRI study.

Clin Neurophysiol 2021 Jun 25;132(9):2191-2198. Epub 2021 Jun 25.

IRCCS Neuromed, Pozzilli, IS, Italy; Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.

Objective: To explore whether abnormal thalamic resting-state functional connectivity (rsFC) contributes to altered sensorimotor integration and hand dexterity impairment in multiple sclerosis (MS).

Methods: To evaluate sensorimotor integration, we recorded kinematic features of index finger abductions during somatosensory temporal discrimination threshold (STDT) testing in 36 patients with relapsing-remitting MS and 39 healthy controls (HC). Participants underwent a multimodal 3T structural and functional MRI protocol. Read More

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Electrophysiological predictors of response to subcutaneous immunoglobulin therapy in chronic inflammatory demyelinating polyneuropathy.

Clin Neurophysiol 2021 Jun 12;132(9):2184-2190. Epub 2021 Jun 12.

Ellen & Martin Prosserman Centre for Neuromuscular Diseases, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada. Electronic address:

Objective: To assess axonal function prior to subcutaneous immunoglobulin (SCIG) therapy or placebo in relation to relapse in chronic inflammatory demyelinating polyneuropathy (CIDP) to determine whether axonal damage can predict therapy response.

Methods: Relapse rates in patients from the Polyneuropathy and Treatment with Hizentra (PATH) study, where patients were treated with placebo or SCIG (IgPro20), were analyzed by baseline (post-intravenous immunoglobulin stabilization) axonal damage (≤1 mV peroneal compound muscle action potential) status.

Results: In patients with non-axonal damage, relapses were significantly higher with placebo (73. Read More

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Biomechanical strategies to reach a compromise between stiffness and flexibility in hind femora of desert locusts.

Acta Biomater 2021 Jul 19. Epub 2021 Jul 19.

Functional Morphology and Biomechanics, Institute of Zoology, Kiel University, Kiel, Germany; Division of Mechanical Engineering and Design, School of Engineering, London South Bank University, London, UK.

Insect cuticle can reach a wide range of material properties, which is thought to be the result of adaptations to applied mechanical stresses. Biomechanical mechanisms behind these property variations remain largely unknown. To fill this gap, here we performed a comprehensive study by simultaneous investigation of the microstructure, sclerotization and the elasticity modulus of the specialized cuticle of the femora of desert locusts. Read More

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Glenohumeral osteoarthritis with intact rotator cuff treated with reverse shoulder arthroplasty: a systematic review.

J Shoulder Elbow Surg 2021 Jul 19. Epub 2021 Jul 19.

Division of Upper Extremity Surgery, Department of Orthopaedic Surgery, Director of Upper Extremity Surgery Research, Emory University 59 Executive Park South, Atlanta, GA 30329, USA.

Background: While reverse shoulder arthroplasty has shown satisfactory outcomes in rotator cuff deficient shoulders, its performance in shoulders with an intact rotator cuff has not been fully elucidated. Shoulder osteoarthritis can present with alterations in glenoid morphology which have contributed to inconsistent outcomes in anatomic shoulder replacement. A predominance of these arthroplasty complications is due to the glenoid component. Read More

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Experimental respiratory exposure to putative Gulf War toxins promotes persistent alveolar macrophage recruitment and pulmonary inflammation.

Life Sci 2021 Jul 19:119839. Epub 2021 Jul 19.

Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

Aims: Respiratory disorders are a prominent component of Gulf War Illness. Although much of the underlying mechanisms of Gulf War Illness remain undefined, chronic immune dysfunction is a consistent feature of this multi-symptomatic, multi-organ disorder. Alveolar macrophages represent the predominant mononuclear phagocytes of the pulmonary mucosa, orchestrating the host response to pathogens and environmental stimuli. Read More

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Antitumor effect of dimethyl itaconate on thymic carcinoma by targeting LDHA-mTOR axis.

Life Sci 2021 Jul 19;282:119847. Epub 2021 Jul 19.

Department of General Thoracic Surgery, Dokkyo Medical University School of Medicine, Shimotsuga, Japan.

Aims: Thymic carcinoma is a rare type of cancer without an established standard pharmaceutical treatment. This study investigated the antitumor effect of dimethyl itaconate (DI), a cell-permeable derivative of itaconate, on human thymic carcinoma cell line.

Main Methods: Human thymic carcinoma cell line Ty82 was used to evaluate the effect of DI on cell viability. Read More

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Pan-cancer analysis reveals that neurotrophin signaling correlates positively with anti-tumor immunity, clinical outcomes, and response to targeted therapies and immunotherapies in cancer.

Life Sci 2021 Jul 19;282:119848. Epub 2021 Jul 19.

Biomedical Informatics Research Lab, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China; Cancer Genomics Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China; Big Data Research Institute, China Pharmaceutical University, Nanjing 211198, China. Electronic address:

Aims: The crosstalk between cancer cells and nerves plays an important role in tumor biology. However, the correlation between the neurotrophin signaling (NS) and anti-tumor immunity and immunotherapy response in cancer remains unexplored.

Materials And Methods: We analyzed associations of NS with anti-tumor immune signatures, tumor immunity-related molecular and genomic features, and clinical features in 33 TCGA cancer types. Read More

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Acute gene expression changes in the mouse hippocampus following a combined Gulf War toxicant exposure.

Life Sci 2021 Jul 19:119845. Epub 2021 Jul 19.

Laboratory of Molecular Biology, VA New Jersey Health Care System, Research & Development (Mailstop 15), Bldg. 16, Rm. 16-176, 385 Tremont Ave, East Orange, NJ 07018, United States of America; Rutgers School of Graduate Studies, Newark, NJ 07103, United States of America; Laboratory of Molecular Biology, Bay Pines VA Healthcare System, Research and Development, 151, Bldg. 22, Rm. 123, 10000 Bay Pines Blvd, Bay Pines, FL 33744, United States of America; Pharmacology, Physiology, and Neuroscience, Rutgers-New Jersey Medical School, Newark, NJ 07103, United States of America. Electronic address:

Aims: Approximately 30% of the nearly 700,000 Veterans who were deployed to the Gulf War from 1990 to 1991 have reported experiencing a variety of symptoms including difficulties with learning and memory, depression and anxiety, and increased incidence of neurodegenerative diseases. Combined toxicant exposure to acetylcholinesterase (AChE) inhibitors has been studied extensively as a likely risk factor. In this study, we modeled Gulf War exposure in male C57Bl/6J mice with simultaneous administration of three chemicals implicated as exposure hazards for Gulf War Veterans: pyridostigmine bromide, the anti-sarin prophylactic; chlorpyrifos, an organophosphate insecticide; and the repellant N,N-diethyl-m-toluamide (DEET). Read More

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Urology 2021 Jul 19. Epub 2021 Jul 19.

Department of Urology, Emory University School of Medicine, 1365 Clifton Road NE, Building B, Suite 1403, Atlanta GA 30322. Electronic address:

Objective: To investigate the association between paternal race and reproductive outcomes following in vitro fertilization (IVF).

Materials And Methods: We compared demographic and clinical characteristics, IVF cycle characteristics, and reproductive outcomes (pregnancy, miscarriage, and live birth), stratified by male and female partner race, for all IVF cycles performed at our institution between 2014-2019. Wilcoxon Rank Sum test and Pearson's Chi Square test were used to compare continuous and categorical data, respectively. Read More

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Point-of-Care Virtual Radiology Consultations in Primary Care: A Feasibility Study of a New Model for Patient-Centered Care in Radiology.

J Am Coll Radiol 2021 Jul 19. Epub 2021 Jul 19.

Department of Radiology, University of Washington School of Medicine, Seattle, Washington.

Background: The goal of this study is to assess the value of point-of-care virtual consultations in radiology.

Methods: We conducted an institutional review board-approved feasibility study of video-based radiology consultations in an internal medicine primary care clinic at a quaternary academic medical center. The study included 3 primary care providers (PCPs) and enrolled 43 patients. Read More

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Genetically predicted insulin-like growth factor-I in relation to muscle mass and strength.

Clin Endocrinol (Oxf) 2021 Jul 22. Epub 2021 Jul 22.

Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Objective: Insulin-like growth factor I (IGF-I) has been associated with muscle status in animal- and population-based studies. We conducted a Mendelian randomisation study to assess the causality of the associations of IGF-I with muscle strength and mass.

Design And Patients: Genetic variants associated with serum IGF-I at genome-wide significance in the UK Biobank study (358,072 individuals of European descent) were selected as instrumental variables. Read More

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Comparison of lean mass indices as predictors of mortality in incident peritoneal dialysis patients.

PLoS One 2021 22;16(7):e0254942. Epub 2021 Jul 22.

Division of Nephrology, Department of Internal Medicine, Yeungnam University Medical Center, Daegu, Republic of Korea.

Background: Few studies have considered optimal adjusted lean mass indices for prediction of clinical outcomes in peritoneal dialysis (PD) patients. We aimed to evaluate clinical variables using various adjusted indices in PD patients.

Methods: Total 528 incident PD patients were included. Read More

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Peer video feedback builds basic life support skills: A randomized controlled non-inferiority trial.

PLoS One 2021 22;16(7):e0254923. Epub 2021 Jul 22.

Medical Faculty, AIXTRA-Competency Center for Training and Patient Safety, RWTH Aachen University, Aachen, Germany.

Introduction: Training Basic Life Support saves lives. However, current BLS training approaches are time-consuming and costly. Alternative cost-efficient and effective training methods are highly needed. Read More

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Assessing the level of digitalization and robotization in the enterprises of the European Union Member States.

PLoS One 2021 22;16(7):e0254993. Epub 2021 Jul 22.

Silesian University of Technology, Gliwice, Poland.

One of the main reasons for the dynamic global economic development observed in recent years is the process of digitalization, referred to as Industry 4.0. The significance of digitalization for this development is appreciated by the EU-27. Read More

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Miltefosine enhances infectivity of a miltefosine-resistant Leishmania infantum strain by attenuating its innate immune recognition.

PLoS Negl Trop Dis 2021 Jul 22;15(7):e0009622. Epub 2021 Jul 22.

University of Antwerp, Department of Biomedical Sciences, Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Wilrijk, Belgium.

Background: Miltefosine (MIL) is currently the only oral drug available to treat visceral leishmaniasis but its use as first-line monotherapy has been compromised by an increasing treatment failure. Despite the scarce number of resistant clinical isolates, MIL-resistance by mutations in a single aminophospholipid transporter gene can easily be selected in a laboratory environment. These mutations result in a reduced survival in the mammalian host, which can partially be restored by exposure to MIL, suggesting a kind of drug-dependency. Read More

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Mattering: How Organizations, Patients, and Peers Can Affect Nurse Burnout and Engagement.

J Nurs Adm 2020 May;50(5):267-273

Author Affiliations: Clinical Professor of Nursing (Dr Haizlip), University of Virginia; Postdoctoral Fellow (Dr McCluney), University of Virginia School of Nursing and Darden School of Business; Associate Professor of Business Administration (Dr Hernandez), University of Virginia Darden School of Business; and Assistant Professor of Nursing (Dr Quatrara) and Professor of Nursing, Emerita (Dr Brashers), University of Virginia, Charlottesville.

Objective: The aim of this study was to explore professional mattering in a broad cohort of nurses.

Background: Mattering is a construct from social psychology that describes the feeling that one makes a difference in the lives of others and has significance in one's community.

Methods: A cross-sectional survey assessing mattering, meaning, social support, burnout, and engagement was administered to nurses and nurse practitioners working in various specialties in the United States. Read More

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Anterior Cruciate Ligament Reconstruction Graft Technique Reliably Yields Grafts With 8.0-mm Diameter or Larger.

Orthopedics 2021 Jul-Aug;44(4):e539-e545. Epub 2021 Jul 1.

The significance of graft diameter in anterior cruciate ligament reconstruction (ACLR) with soft tissue grafts is well established, with a minimum graft diameter of 8.0 mm associated with lower rates of revision surgery. Consistently achieving grafts that meet or exceed the ideal diameter of 8. Read More

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Studies on stabilization effect of calcium dihydrogen phosphate (Ca(HPO)) -on Lead(Pb)-contaminated Soil.

Int J Phytoremediation 2021 Jul 22:1-7. Epub 2021 Jul 22.

College of Chemistry and Chemical Engineering, Chongqing University of Technology, Chongqing, China.

This study investigated the effect of Ca(HPO) on pH, leaching toxicity and speciations of soil before and after leaching on it. Different amounts of Ca(HPO) were added to Pb-contaminated soil and stabilized for 30 days. The changes of pH and leaching toxicity of Pb-contaminated soil were tracked during that period. Read More

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Sputum-Based Tumor Fluid Biopsy: Isolation and High-Throughput Single-Cell Analysis of Exfoliated Tumor Cells for Lung Cancer Diagnosis.

Anal Chem 2021 Jul 22. Epub 2021 Jul 22.

College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China.

Timely and effective diagnosis is of great significance for improving the survival rate of lung cancer patients. Although histopathology is the main diagnostic tool among the existing methods for lung cancer diagnosis, it is not suitable for high-risk groups, early lung cancer patients, patients with advanced-stage disease, and other situations wherein tumor tissues cannot be obtained. In view of this, we proposed an innovative lung cancer diagnosis method employing for the first time a microfluidic technology for high-efficiency isolation and high-throughput single-cell analysis of exfoliated tumor cells (ETCs) in sputum. Read More

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Oriented Electrostatic Effects on O and CO Reduction by a Polycationic Iron Porphyrin.

J Am Chem Soc 2021 Jul 22. Epub 2021 Jul 22.

Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States.

Next-generation energy technologies require improved methods for rapid and efficient chemical-to-electrical energy transformations. One new approach has been to include atomically positioned, electrostatic motifs in molecular catalysts to stabilize high-energy, charged intermediates. For example, an iron porphyrin bearing four cationic, -,,-trimethylanilinium groups (-[N(CH)]) has recently been used to catalyze the complex, multistep O and CO reduction reactions (ORR and CORR) with fast rates and at low overpotentials. Read More

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Light-induced Nonoxidative Coupling of Methane using Stable Solid-Solutions.

Angew Chem Int Ed Engl 2021 Jul 22. Epub 2021 Jul 22.

Jilin University, Chemistry, 2699 Qianjin Street, 130012, Changchun, CHINA.

Achieving efficient and direct conversion of methane under mild conditions is of great significance to the innovation of the chemical industry. However, the efficiency and lifetime of most catalysts remain too far from the practical requirement, since it is difficult to break the first C-H bond of methane as well as to suppress the following complete dehydrogenation (or overoxidation) and the resulting carbonaceous deposition (or CO 2 ). Here, we report that wurtzite GaN:ZnO solid solutions exhibit unique and unprecedented photocatalytic performances for the nonoxidative coupling of methane at room temperature, exclusively generating ethane with nearly stoichiometric H 2 . Read More

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What is the best anthropometric predictor for identifying higher risk for cardiovascular diseases in afro-descendant Brazilian women? A cross-sectional population-based study.

Am J Hum Biol 2021 Jul 22:e23652. Epub 2021 Jul 22.

Department of Social Nutrition and Nutritional Sciences Graduate Program, Fluminense Federal University, Rio de Janeiro, Brazil.

Objectives: Excessive adiposity is associated with cardiovascular disease (CVD). Anthropometric indices are useful in screening individuals at higher risk for these diseases. However, there are no studies that show which of these indices has the best discriminatory power among Afro-descendant Brazilian women. Read More

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Fascial plane mapping for superficial tumor resection in dogs. Part II: Forelimb.

Vet Surg 2021 Jul 22. Epub 2021 Jul 22.

Department of Veterinary Medicine and Surgery, University of Missouri Veterinary Medical Center, Columbia, Missouri, USA.

Objective: To detail the qualitative fascial categories and fascial intersections of the forelimb of the dog to facilitate preoperative planning for superficial cancers.

Study Design: Qualitative anatomical study.

Sample Population: Three male and four female mixed breed canine cadavers weighing approximately 20-35 kg. Read More

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