77,791 results match your criteria [injury 2016


Absence of significant clinical benefit for a systematic routine creatine phosphokinase measurement in asymptomatic patients treated with anti-programmed death protein (ligand) 1 immune checkpoint inhibitor to screen cardiac or neuromuscular immune-related toxicities.

Eur J Cancer 2021 Sep 23;157:383-390. Epub 2021 Sep 23.

Drug Development Department (DITEP), Gustave Roussy, Université Paris-Sud, Université Paris-Saclay, F-94805, Villejuif, France. Electronic address:

Aim: Despite unprecedented results of anti-programmed death protein (ligand) 1 (PD-(L)1) immune checkpoint inhibitor in the oncology's armamentarium, immune-related adverse events (irAEs) represent a therapeutic hurdle. Currently, there is no consensual recommendation on a routinely monitored biomarker to early detect irAE. Biological markers such as serum creatine phosphokinase (CPK) are commonly used to measure muscular tissue injury. Read More

View Article and Full-Text PDF
September 2021

An Exploration of Emergency Department Visits for Home Unintentional Injuries Among Children With Autism Spectrum Disorder for Evidence to Modify Injury Prevention Guidelines.

Pediatr Emerg Care 2021 Sep 20. Epub 2021 Sep 20.

From the Johns Hopkins Bloomberg School of Public Health Johns Hopkins University School of Medicine Kennedy Krieger Institute, Baltimore, MD Wake Forest School of Medicine Winston-Salem, NC.

Objectives: Current childhood injury prevention guidance is anchored by a child's age. For example, children are considered at high risk for falls at ages 4 years and less, and guidance for prevention focuses on these ages. However, these guidelines may not be adequate for children with autism spectrum disorders (ASD). Read More

View Article and Full-Text PDF
September 2021

[Application of pie-crusting technique of deep medial collateral ligament under arthroscopy in repairing posterior horn of medial meniscus tears].

Zhongguo Gu Shang 2021 Sep;34(9):840-6

Department of Sports Medicine and Arthroscope, the Sports Hospital Affiliated to Chengdu Sport University, Chengdu 610041, Sichuan, China.

Objective: To explore effectiveness and safety of an inside-out, arthroscopic deep medial collateral ligament pie-crusting release in treating posterior horn of medial meniscus (PHMM) tear in tight medial tibiofemoral compartment of knee joint.

Methods: From January 2016 to December 2017, 61 patients (61 knees) were underwent arthroscopic partial meniscectomies for PHMM tear in tight medial tibiofemoral compartment of knee joint, who were divided into valgus group and pie-crusting group according to exposure of PHMM region . There were 28 patients in valgus group, including 12 males and 16 females aged from 27 to 60 years old with an average age of (35. Read More

View Article and Full-Text PDF
September 2021

Outcomes of Revascularization and Factors Associated With Major Amputation in Patients With Lower Limb Arterial Injury: A Single-Center Retrospective Analysis.

Cureus 2021 Aug 18;13(8):e17290. Epub 2021 Aug 18.

Internal Medicine, Dow University of Health Sciences, Karachi, PAK.

Objective To identify the amputation rates and causative factors for failed revascularization leading to amputation in patients undergoing primary limb salvage procedures for lower-extremity vascular injuries. Methods This retrospective study was conducted at the vascular surgery department, Shaheed Mohtarma Benazir Bhutto (SMBB) Institute of Trauma, Karachi, Pakistan. The data were collected from hospital record using the non-probability sampling technique. Read More

View Article and Full-Text PDF

Facial Trauma Patterns Among Young Athletes.

Craniomaxillofac Trauma Reconstr 2021 Sep 14;14(3):218-223. Epub 2020 Oct 14.

Department of Otolaryngology, SUNY Upstate Medical University, Syracuse, NY, USA.

Study Design: Retrospective case series review.

Objective: Participation in athletics is common in high school and college students and presents an increased risk of injury in this age-group. Previous studies have included National Collegiate Athletic Association athletes but not high school athletes. Read More

View Article and Full-Text PDF
September 2021

A Retrospective Cohort Study: Safety and Effectiveness of Elbasvir/Grazoprevir ± Ribavirin Compared With Ombitasvir/Paritaprevir/Ritonavir/Dasabuvir ± Ribavirin in Patients With Chronic Hepatitis C Genotype 1 Infection.

Front Pharmacol 2021 9;12:640317. Epub 2021 Sep 9.

Chinese Medical Department, Park One International Hospital, Kaohsiung, Taiwan.

The direct-acting antiviral (DAA) agents are widely used to treat hepatitis C virus (HCV) genotype (GT) 1 infection, while it may cause severe liver damage. The objectives of the study were to evaluate the incidence of drug-induced liver injury (DILI), sustained virologic response at post-treatment week 12 (SVR12), and recurrence rates in HCV GT 1 infection. This was a retrospective cohort study that included patients diagnosed with HCV GT 1 infection, who had received intervention and treatment with elbasvir/grazoprevir (EBR/GZR) ± ribavirin (RBV) versus ombitasvir/paritaprevir/ritonavir (OBV/PTV/r) + dasabuvir ± RBV (as control group) for 12 or 24 weeks at a regional hospital in southern Taiwan between April 2016 and August 2018. Read More

View Article and Full-Text PDF
September 2021

Outcomes following traumatic inhalational airway injury - Predictors of mortality and effect of procedural intervention.

Injury 2021 Sep 17. Epub 2021 Sep 17.

Department of Otorhinolaryngology - Head & Neck Surgery, University of Pennsylvania, Philadelphia, PA, United States; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, United States. Electronic address:

Objective: Study outcomes, predictors of mortality, and effects of procedural interventions on patients following traumatic inhalational airway injury.

Study: Design: Retrospective study.

Setting: National Trauma Data Bank METHODS: Patients over the age of eighteen admitted between 2008 and 2016 to NTDB-participating sites were included. Read More

View Article and Full-Text PDF
September 2021

Pulmonary Complications of Alcohol Withdrawal Syndrome in Trauma Patients. A Matched Analysis From a National Trauma Database.

Am Surg 2021 Sep 25:31348211041568. Epub 2021 Sep 25.

Office of Research Administration, 23498Jersey Shore University Medical Center, Neptune NJ, USA.

Background: The purpose of the study is to find a national estimate of pulmonary complications in AWS patients using the National Trauma Quality Improvement Program (TQIP) database.

Methods: We accessed the TQIP database focusing on the calendar years 2013-2016 and included all adult admitted trauma patients. The two groups (AWS and no AWS) were compared on baseline characteristics, injury, comorbidities, and outcomes. Read More

View Article and Full-Text PDF
September 2021

Outcomes and Practice Patterns of Medical Management of Blunt Thoracic Aortic Injury from the Aortic Trauma Foundation Global Registry.

J Vasc Surg 2021 Sep 21. Epub 2021 Sep 21.

Division of Vascular Surgery, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA. Electronic address:

Objectives: Blunt Thoracic Aortic Injury (BTAI) is the second leading cause of death from blunt trauma. This study aims to determine the outcomes of medical management for BTAI. We hypothesized based on several previously published articles, that patients with minimal aortic injury (BTAI Grades 1 & 2) could safely be treated with definitive medical management (MM) alone. Read More

View Article and Full-Text PDF
September 2021

Does shock index, pediatric age-adjusted predict mortality by trauma center type?

J Trauma Acute Care Surg 2021 Oct;91(4):649-654

From the Division of Pediatric Surgery, Department of Surgery (J.R.A., C.Y., S.D.C.) and Department of Emergency Medicine (M.O.L.), Stanford University School of Medicine, Stanford, California.

Background: Pediatric trauma patients are treated at adult trauma centers (ATCs), mixed pediatric and ATCs (MTC), or pediatric trauma centers (PTCs). Shock index, pediatric age-adjusted (SIPA) can prospectively identify severely injured children. This study characterized the differences in mortality and hospital length of stay (LOS) among pediatric trauma patients with elevated SIPA (eSIPA) at different trauma centers types. Read More

View Article and Full-Text PDF
October 2021

Nasal packing with Merocel in a glove finger after endoscopic endonasal reduction of medial blowout fracture.

Medicine (Baltimore) 2021 Sep;100(38):e27277

Department of Otorhinolaryngology-Head and Neck Surgery, Chungbuk National University College of Medicine, Chungbuk National University Hospital, Cheongju, Korea.

Abstract: After endoscopic endonasal reduction (EER) for medial blowout fracture (BOF), nasal packing may be necessary for sustaining the reduced orbital contents. This study aimed to introduce a new packing technique using Merocel in a glove finger.We retrospectively reviewed 131 patients with a mean age of 42. Read More

View Article and Full-Text PDF
September 2021

Identification of Fall-related Injuries in Nursing Home Residents using Administrative Claims Data.

J Gerontol A Biol Sci Med Sci 2021 Sep 24. Epub 2021 Sep 24.

Hinda and Arthur Marcus Institute for Aging Research, Hebrew Senior Life Roslindale, MA.

Background: Fall-related injuries (FRIs) are a leading cause of morbidity, mortality, and costs among nursing home (NH) residents. Carefully defining FRIs in administrative data is essential for improving injury-reduction efforts. We developed a series of novel claims-based algorithms for identifying FRIs in long-stay NH residents. Read More

View Article and Full-Text PDF
September 2021

M1-type microglia can induce astrocytes to deposit chondroitin sulfate proteoglycan after spinal cord injury.

Neural Regen Res 2022 May;17(5):1072-1079

Department of Orthopedics, The Second Hospital of Anhui Medical University, Hefei, Anhui Province, China.

After spinal cord injury (SCI), astrocytes gradually migrate to and surround the lesion, depositing chondroitin sulfate proteoglycan-rich extracellular matrix and forming astrocytic scar, which limits the spread of inflammation but hinders axon regeneration. Meanwhile, microglia gradually accumulate at the lesion border to form microglial scar and can polarize to generate a pro-inflammatory M1 phenotype or an anti-inflammatory M2 phenotype. However, the effect of microglia polarization on astrocytes is unclear. Read More

View Article and Full-Text PDF

Clinical Characteristics and Risk Factors for Mortality in Older Patients with Dialysis-Receiving Community-Acquired Acute Kidney Injury.

Int J Gen Med 2021 16;14:5693-5701. Epub 2021 Sep 16.

Department of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Provincial Geriatrics Institute, Guangzhou, 510080, People's Republic of China.

Introduction: Older people in community are susceptible to acute kidney injury (AKI) and hemodialysis is the most important supportive measure used in the management of severe AKI. This study aims to investigate the clinical characteristics, outcomes and risk factors for mortality in older patients with dialysis-receiving-community-acquired AKI (CA-AKI).

Methods: A total of 1953 CA-AKI patients aged 65 years old and above were recruited from 2013 to 2016. Read More

View Article and Full-Text PDF
September 2021

Are postoperative NLR and PLR associated with the magnitude of surgery-related trauma in young and middle-aged patients with bicondylar tibial plateau fractures? A retrospective study.

BMC Musculoskelet Disord 2021 Sep 23;22(1):816. Epub 2021 Sep 23.

Department of Orthopaedic Surgery, Third Hospital of Hebei Medical University, 050051, Shijiazhuang, Hebei, People's Republic of China.

Background: The invasiveness of different surgical procedures is variable. The purpose of this study was to investigate the value of the postoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as biomarkers in assessing the magnitude of surgery-related trauma in young and middle-aged patients with bicondylar tibial plateau fractures (TPFs).

Methods: A total of 136 young and middle-aged patients with bicondylar TPFs who underwent surgical treatment between May 2016 and April 2020 were included. Read More

View Article and Full-Text PDF
September 2021

Minimally invasive management of juvenile cystic adenomyoma: report of three cases.

Facts Views Vis Obgyn 2021 Sep;13(3):271-276

Background: Juvenile cystic adenomyosis (JCA) represents a rare form of focal adenomyosis in young women.

Objectives: To determine safety and effectiveness of minimally invasive surgery (MIS for JCA).

Materials And Methods: Three patients aged 16-30 years old presented with chronic pelvic pain [2016 - 2019]. Read More

View Article and Full-Text PDF
September 2021

Self-harm in children and adolescents by ethnic group: an observational cohort study from the Multicentre Study of Self-Harm in England.

Lancet Child Adolesc Health 2021 Sep 20. Epub 2021 Sep 20.

Centre for Mental Health and Safety, School of Health Sciences, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK; Greater Manchester Mental Health NHS Foundation Trust, Manchester, UK; The National Institute for Health Research Greater Manchester Patient Safety Translational Research Centre, Manchester, UK.

Background: Studies report an increasing incidence of self-harm in children and adolescents, but the extent to which this is seen in different ethnic groups is unclear. We aimed to investigate rates of emergency department presentations for self-harm in children and adolescents by ethnicity, as well as to examine their demographic characteristics, clinical characteristics, and outcomes.

Methods: In this observational cohort study, we used data on hospital emergency department presentations for self-harm in children and adolescents aged 10-19 years between 2000 and 2016 from the Multicentre Study of Self-harm in England. Read More

View Article and Full-Text PDF
September 2021

Prevalence and incidence of young onset dementia and associations with comorbidities: A study of data from the French national health data system.

PLoS Med 2021 Sep 23;18(9):e1003801. Epub 2021 Sep 23.

Santé publique France, Saint-Maurice, France.

Background: Dementia onset in those aged <65 years (young onset dementia, YOD) has dramatic individual and societal consequences. In the context of population aging, data on YOD are of major importance to anticipate needs for planning and allocation of health and social resources. Few studies have provided precise frequency estimates of YOD. Read More

View Article and Full-Text PDF
September 2021

Adverse outcomes after partner bereavement in people with reduced kidney function: Parallel cohort studies in England and Denmark.

PLoS One 2021 23;16(9):e0257255. Epub 2021 Sep 23.

Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Objectives: To investigate whether partner bereavement is associated with adverse cardiovascular and kidney-related events in people with reduced kidney function.

Design: Two parallel matched cohort studies using linked routinely collected health data.

Setting: England (general practices and hospitals using linked Clinical Practice Research Datalink, Hospital Episode Statistics, and Office of National Statistics) and Denmark (hospitals and community pharmacies using the Danish National Patient, Prescription and Education Registries and the Civil Registration System). Read More

View Article and Full-Text PDF
September 2021

Developing a National Trauma Research Action Plan (NTRAP): Results from the Burn Research Gap Delphi Survey.

J Trauma Acute Care Surg 2021 Sep 20. Epub 2021 Sep 20.

Harborview Medical Center UW Department of Surgery, Seattle WA UW Department of Biomedical Informatics and Medical Education, Seattle WA Coalition for National Trauma Research, San Antonio Texas.

Introduction: The 2016 NASEM call for a national integrated, military-civilian trauma action plan to achieve zero preventable deaths and disability after injury included a proposal to establish a National Trauma Research Action Plan (NTRAP) to "strengthen trauma research and ensure that the resources available for this research are commensurate with the importance of injury and the potential for improvement in patient outcomes". The Department of Defense funded the Coalition for National Trauma Research to generate a comprehensive research agenda spanning the continuum of trauma / burn care from prehospital to rehabilitation. The Burn / Reconstructive Surgery group represents one focus area for this research agenda development. Read More

View Article and Full-Text PDF
September 2021

Implementation of an Injury Prevention Program in NCAA Division I Athletics Reduces Injury-Related Health Care Costs.

Orthop J Sports Med 2021 Sep 16;9(9):23259671211029898. Epub 2021 Sep 16.

Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Background: The estimated cost per year of injuries in collegiate athletics has been reported to be billions of dollars in the United States. Injury prevention programs are often assessed only by their ability to reduce injuries, and there is little evidence of any potential reduction in associated health care costs.

Purpose: To investigate changes in injury-related health care costs at a National Collegiate Athletic Association (NCAA) Division I university after the implementation of an injury prevention program. Read More

View Article and Full-Text PDF
September 2021

Differences in Evaluating Fall Risk by Primary Care Provider Type.

J Nurse Pract 2020 Aug;16(7):528-532

Centers for Disease Control and Prevention, Division of Injury Prevention, 4770 Buford Hwy NE, MS S106-9, Atlanta, GA, USA 30341.

This study assessed differences in clinical fall risk assessment of older adults (65+) and clinical resources used by primary care providers (PCP). We used Porter Novelli's 2016 DocStyles survey to examine clinical behavior data from PCPs (n=1128). Compared to other practitioners, nurse practitioners (NP) reported a higher percentage of their patients were older adults. Read More

View Article and Full-Text PDF

Treatment of humeral shaft fractures: a new minimally-invasive plate osteosynthesis versus open reduction and internal fixation: a case control study.

BMC Surg 2021 Sep 23;21(1):349. Epub 2021 Sep 23.

Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, 410000, Hunan, China.

Background: To evaluate the feasibility and safety of a new minimally-invasive surgical approach-anteromedial minimally-invasive plate osteosynthesis (MIPO)-in the treatment of middle and distal humeral shaft fractures.

Methods: Fourteen patients with humeral shaft fracture treated with anteromedial MIPO from November 2016 to March 2020 (MIPO Group) were selected as the study subjects. Open reduction and internal fixation (ORIF) were used to treat 14 patients with humeral shaft fractures as the control group (ORIF group). Read More

View Article and Full-Text PDF
September 2021

Identification of soluble thrombomodulin and tissue plasminogen activator-inhibitor complex as biomarkers for prognosis and early evaluation of septic shock and sepsis-induced disseminated intravascular coagulation.

Ann Palliat Med 2021 Sep 14. Epub 2021 Sep 14.

Department of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: Endothelium injury and coagulation dysfunction play an important role in the pathogenesis of sepsis. Soluble thrombomodulin (sTM), tissue plasminogen activator-inhibitor complex (t-PAIC), thrombin-antithrombin complex (TAT) and α2-plasmin inhibitor-plasmin complex (PIC) are biomarkers of endothelium injury and coagulation dysfunction. This study aimed to explore the prognostic values and diagnostic performance for septic shock and sepsis-induced disseminated intravascular coagulation (DIC) of endothelial biomarkers. Read More

View Article and Full-Text PDF
September 2021

Performance of Focused Assessment with Sonography for Trauma Following Resuscitative Thoracotomy for Traumatic Cardiac Arrest.

World J Surg 2021 Sep 22. Epub 2021 Sep 22.

Division of Acute Care Surgery, LAC+USC Medical Center, University of Southern California, 2051 Marengo Street, Inpatient Tower (C), C5L100, Los Angeles, CA, 90033, USA.

Background: In patients undergoing resuscitative thoracotomy (RT) for traumatic cardiac arrest, focused assessment with sonography for trauma (FAST) is often used to look for intraperitoneal fluid. These findings can help determine whether abdominal exploration is warranted once return of spontaneous circulation is achieved; however, the diagnostic accuracy of FAST in this clinical scenario has yet to be evaluated. The purpose of this study was to assess the performance of FAST in identifying intra-abdominal hemorrhage following RT. Read More

View Article and Full-Text PDF
September 2021

Surgeon volume and the risk of deep surgical site infection following open reduction and internal fixation of closed tibial plateau fracture.

Int Orthop 2021 Sep 22. Epub 2021 Sep 22.

Department of Orthopaedic Surgery, the 3Rd Hospital of Hebei Medical University, Shijiazhuang, 050051, Hebei, People's Republic of China.

Background: Emerging evidences supported that the surgeon case volume significantly affected post-operative complications or outcomes following a range of elective or non-elective orthopaedic surgery; no data has been available for surgically treated tibial plateau fractures. We aimed to investigate the relationship between surgeon volume and the risk of deep surgical site infection (DSSI) following open reduction and internal fixation (ORIF) of closed tibial plateau fracture.

Methods: This was a further analysis of the prospectively collected data. Read More

View Article and Full-Text PDF
September 2021

The use of babosa (Aloe vera) in treating burns: a literature review.

Braz J Biol 2021 20;83:e249209. Epub 2021 Sep 20.

Centro Universitário São Camilo, Curso de Medicina, São Paulo, SP, Brasil.

Alo vera is a centenary remedy use for minor wounds and burns, but its mechanism of wound healing has not been know since. This article will evaluate and gather evidence of the effectiveness and safety of the use of aloe vera in the treatment of burns. A systematic review was carried out on the databases: MEDLINE, LILACS, DECS, SCIELO, in the last 7 years, with the descriptors: "Aloe", "Burns" and "treatment". Read More

View Article and Full-Text PDF
September 2021

Obstructive sleep apnea screening, diagnosis, and treatment in the transportation industry.

J Clin Sleep Med 2021 Sep 23. Epub 2021 Sep 23.

Division of Sleep Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Obstructive sleep apnea (OSA) is a common, identifiable, and treatable disorder with serious health, safety, and financial implications - including sleepiness-related crashes and incidents - in workers who perform safety-sensitive functions in the transportation industry. Up to one third of crashes of large trucks are attributable to sleepiness, and large truck crashes result in more than 4,000 deaths annually. For each occupant of a truck who is killed, 6 to 7 occupants of other vehicles are killed. Read More

View Article and Full-Text PDF
September 2021

Primary Repair of Upper Extremity Peripheral Nerve Injuries: An NSQIP Analysis From 2010 to 2016.

Hand (N Y) 2021 Sep 21:15589447211044768. Epub 2021 Sep 21.

Medical University of South Carolina, Charleston, USA.

Background: To identify the rate of 30-day complications after primary repair of upper extremity peripheral nerve injuries, associated diagnoses, and postoperative complication rate.

Methods: The American College of Surgeons National Surgical Quality Improvement Program database was reviewed from 2010 to 2016. Current Procedural Terminology codes consistent with primary nerve repair of the upper extremity were identified and included in the analysis. Read More

View Article and Full-Text PDF
September 2021

Left Atrial Reverse Remodeling Following the Modified Box Isolation with Centerline in Patients with Persistent Atrial Fibrillation.

Int Heart J 2021 Sep 17. Epub 2021 Sep 17.

Department of Cardiovascular Medicine, Kyorin University Hospital.

Esophageal injury is a rare but serious complication of atrial fibrillation (AF) ablation. To minimize esophageal injury, our persistent AF (PerAF) protocol involves complete left atrial posterior wall (LAPW) and pulmonary vein (PV) isolation (box isolation), with a centerline away from the esophagus. However, there has been a concern that extensive LA isolation might deteriorate LA function. Read More

View Article and Full-Text PDF
September 2021